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Uveal Spindle Cell Type A Melanoma

MedGen UID:
234808
Concept ID:
C1336054
Neoplastic Process
Synonyms: Spindle Cell Type A Melanoma of the Uvea; Spindle Cell Type A Melanoma of Uvea; Spindle Cell Type A Uveal Melanoma

Definition

A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUveal Spindle Cell Type A Melanoma

Professional guidelines

PubMed

Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Folberg R, Arbieva Z, Moses J, Hayee A, Sandal T, Kadkol S, Lin AY, Valyi-Nagy K, Setty S, Leach L, Chévez-Barrios P, Larsen P, Majumdar D, Pe'er J, Maniotis AJ
Am J Pathol 2006 Oct;169(4):1376-89. doi: 10.2353/ajpath.2006.060223. PMID: 17003493Free PMC Article
Maat W, Haasnoot GW, Claas FH, Schalij-Delfos NE, Schreuder GM, Jager MJ
Invest Ophthalmol Vis Sci 2006 Jan;47(1):3-6. doi: 10.1167/iovs.05-1122. PMID: 16384937

Recent clinical studies

Etiology

Taskaeva I, Shatruk A, Bgatova N, Yeremina A, Trunov A, Kononova N, Chernykh V
Microsc Res Tech 2024 Jan;87(1):122-132. Epub 2023 Sep 12 doi: 10.1002/jemt.24417. PMID: 37698482
Bustamante P, Miyamoto D, Goyeneche A, de Alba Graue PG, Jin E, Tsering T, Dias AB, Burnier MN, Burnier JV
Cancer Med 2019 Dec;8(17):7265-7277. Epub 2019 Oct 7 doi: 10.1002/cam4.2594. PMID: 31588689Free PMC Article
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Griewank KG, van de Nes J, Schilling B, Moll I, Sucker A, Kakavand H, Haydu LE, Asher M, Zimmer L, Hillen U, Thompson JF, Scolyer RA, Schadendorf D, Murali R
Mod Pathol 2014 Feb;27(2):175-83. Epub 2013 Jul 26 doi: 10.1038/modpathol.2013.138. PMID: 23887304
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Diagnosis

Berger T, Flockerzi F, Löw U, Flockerzi E, Aljundi W, Abdin A, Daas L, Seitz B
Klin Monbl Augenheilkd 2023 Jul;240(7):871-877. Epub 2023 May 24 doi: 10.1055/a-2069-2354. PMID: 37224861
Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Murali R, Wiesner T, Scolyer RA
Pathology 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. PMID: 23277170
Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR
Can J Ophthalmol 2005 Oct;40(5):619-22. doi: 10.1016/S0008-4182(05)80057-2. PMID: 16391628
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Therapy

Ambrosini G, Natale CA, Musi E, Garyantes T, Schwartz GK
Cancer Res Commun 2023 Apr;3(4):540-547. Epub 2023 Apr 5 doi: 10.1158/2767-9764.CRC-22-0399. PMID: 37035582Free PMC Article
Zahorjanová P, Sekáč J, Babál P, Štubňa M
Cesk Slov Oftalmol 2020 Winter;76(1):46-51. doi: 10.31348/2020/6. PMID: 32917094
Gonçalves J, Emmons MF, Faião-Flores F, Aplin AE, Harbour JW, Licht JD, Wink MR, Smalley KSM
Pigment Cell Melanoma Res 2020 May;33(3):507-514. Epub 2019 Dec 6 doi: 10.1111/pcmr.12849. PMID: 31758842Free PMC Article
Bustamante P, Miyamoto D, Goyeneche A, de Alba Graue PG, Jin E, Tsering T, Dias AB, Burnier MN, Burnier JV
Cancer Med 2019 Dec;8(17):7265-7277. Epub 2019 Oct 7 doi: 10.1002/cam4.2594. PMID: 31588689Free PMC Article
Pe'er J, Stefani FH, Seregard S, Kivela T, Lommatzsch P, Prause JU, Sobottka B, Damato B, Chowers I
Br J Ophthalmol 2001 Oct;85(10):1208-12. doi: 10.1136/bjo.85.10.1208. PMID: 11567966Free PMC Article

Prognosis

Pérez-Pérez M, Agostino A, de Sola-Llamas CG, Ruvolo M, Vilches-Arenas A, Relimpio-López MI, Espejo-Arjona F, Macías-García L, De Miguel-Rodríguez M, García-Escudero A, Idoate MA, Ríos-Martín JJ
Clin Exp Ophthalmol 2023 Nov;51(8):822-834. Epub 2023 Oct 6 doi: 10.1111/ceo.14302. PMID: 37803816
Longhitano L, Giallongo S, Orlando L, Broggi G, Longo A, Russo A, Caltabiano R, Giallongo C, Barbagallo I, Di Rosa M, Giuffrida R, Parenti R, Li Volti G, Vicario N, Tibullo D
Int J Mol Sci 2022 Dec 20;24(1) doi: 10.3390/ijms24010024. PMID: 36613471Free PMC Article
Sabat-Pośpiech D, Fabian-Kolpanowicz K, Kalirai H, Kipling N, Coupland SE, Coulson JM, Fielding AB
J Pathol Clin Res 2022 Jul;8(4):383-394. Epub 2022 Apr 26 doi: 10.1002/cjp2.272. PMID: 35474453Free PMC Article
Murali R, Wiesner T, Scolyer RA
Pathology 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. PMID: 23277170
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Clinical prediction guides

Sabat-Pośpiech D, Fabian-Kolpanowicz K, Kalirai H, Kipling N, Coupland SE, Coulson JM, Fielding AB
J Pathol Clin Res 2022 Jul;8(4):383-394. Epub 2022 Apr 26 doi: 10.1002/cjp2.272. PMID: 35474453Free PMC Article
Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098

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