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Splenic Manifestation of Chronic Lymphocytic Leukemia

MedGen UID:
234810
•Concept ID:
C1336062
•
Neoplastic Process

Definition

Infiltration of the spleen by chronic lymphocytic leukemia. It primarily involves the white pulp. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic Manifestation of Chronic Lymphocytic Leukemia

Professional guidelines

PubMed

Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Cytogenetic analysis of B cell chronic lymphoid leukemias classified according to morphologic and immunophenotypic (FAB) criteria.
Hernandez JM, Mecucci C, Criel A, Meeus P, Michaux I, Van Hoof A, Verhoef G, Louwagie A, Scheiff JM, Michaux JL
Leukemia 1995 Dec;9(12):2140-6. PMID: 8609731
Role of radiation therapy in management of adult leukemia.
Johnson RE
Cancer 1977 Feb;39(2 Suppl):852-5. doi: 10.1002/1097-0142(197702)39:2+<852::aid-cncr2820390721>3.0.co;2-e. PMID: 264799

Recent clinical studies

Etiology

Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
Expression of adhesion molecules on leukemic B cells from chronic lymphocytic leukemia patients with predominantly splenic manifestations.
Bairey O, Zimra Y, Rabizadeh E, Shaklai M
Isr Med Assoc J 2004 Mar;6(3):147-51. PMID: 15055269
Primary nodal marginal zone lymphomas of splenic and MALT type.
Campo E, Miquel R, Krenacs L, Sorbara L, Raffeld M, Jaffe ES
Am J Surg Pathol 1999 Jan;23(1):59-68. doi: 10.1097/00000478-199901000-00006. PMID: 9888704
Cytogenetic analysis of B cell chronic lymphoid leukemias classified according to morphologic and immunophenotypic (FAB) criteria.
Hernandez JM, Mecucci C, Criel A, Meeus P, Michaux I, Van Hoof A, Verhoef G, Louwagie A, Scheiff JM, Michaux JL
Leukemia 1995 Dec;9(12):2140-6. PMID: 8609731

Diagnosis

Large granular lymphocyte leukemia: An indolent clonal proliferative disease associated with an array of various immunologic disorders.
Drillet G, Pastoret C, Moignet A, Lamy T, Marchand T
Rev Med Interne 2023 Jun;44(6):295-306. Epub 2023 Apr 21 doi: 10.1016/j.revmed.2023.03.014. PMID: 37087371
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
A Review on Splenic Diffuse Red Pulp Small B-Cell Lymphoma.
Yilmaz E, Chhina A, Nava VE, Aggarwal A
Curr Oncol 2021 Dec 6;28(6):5148-5154. doi: 10.3390/curroncol28060431. PMID: 34940070Free PMC Article
How to Diagnose and Treat CD5-Positive Lymphomas Involving the Spleen.
Cabeçadas J, Nava VE, Ascensao JL, Gomes da Silva M
Curr Oncol 2021 Nov 11;28(6):4611-4633. doi: 10.3390/curroncol28060390. PMID: 34898558Free PMC Article
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697

Therapy

Splenic marginal zone lymphoma with monoclonal IgG: A case report.
Zhang X, Ren S, Zhang N, Wang X, Qiu L, Sun H, Yi H, Fan F
Medicine (Baltimore) 2024 Feb 9;103(6):e37158. doi: 10.1097/MD.0000000000037158. PMID: 38335376Free PMC Article
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Leishmania in a Patient with Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia.
Nicolas G, Koury E, Osman D, Saliba C, Nehme L, Mitri S, El Sayegh JA, Rached L, Khoury G
Am J Case Rep 2018 May 1;19:512-516. doi: 10.12659/AJCR.907584. PMID: 29712885Free PMC Article
Hepatitis C virus and lymphoma.
Viswanatha DS, Dogan A
J Clin Pathol 2007 Dec;60(12):1378-83. doi: 10.1136/jcp.2007.051870. PMID: 18042694Free PMC Article
Splenectomy in chronic lymphocytic leukaemia.
Christensen BE, Hansen MM, Videbaek A
Scand J Haematol 1977 Apr;18(4):279-87. doi: 10.1111/j.1600-0609.1977.tb01197.x. PMID: 67631

Prognosis

Large granular lymphocyte leukemia: An indolent clonal proliferative disease associated with an array of various immunologic disorders.
Drillet G, Pastoret C, Moignet A, Lamy T, Marchand T
Rev Med Interne 2023 Jun;44(6):295-306. Epub 2023 Apr 21 doi: 10.1016/j.revmed.2023.03.014. PMID: 37087371
How to Diagnose and Treat CD5-Positive Lymphomas Involving the Spleen.
Cabeçadas J, Nava VE, Ascensao JL, Gomes da Silva M
Curr Oncol 2021 Nov 11;28(6):4611-4633. doi: 10.3390/curroncol28060390. PMID: 34898558Free PMC Article
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
Expression of adhesion molecules on leukemic B cells from chronic lymphocytic leukemia patients with predominantly splenic manifestations.
Bairey O, Zimra Y, Rabizadeh E, Shaklai M
Isr Med Assoc J 2004 Mar;6(3):147-51. PMID: 15055269
Autoimmune disease and chronic lymphocytic leukemia: autoimmune hemolytic anemia, pure red cell aplasia, and autoimmune thrombocytopenia.
Diehl LF, Ketchum LH
Semin Oncol 1998 Feb;25(1):80-97. PMID: 9482530

Clinical prediction guides

Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Hepatitis C virus and lymphoma.
Viswanatha DS, Dogan A
J Clin Pathol 2007 Dec;60(12):1378-83. doi: 10.1136/jcp.2007.051870. PMID: 18042694Free PMC Article
Clinicopathologic features of Waldenstrom's macroglobulinemia and marginal zone lymphoma: are they distinct or the same entity?
Berger F, Traverse-Glehen A, Felman P, Callet-Bauchu E, Baseggio L, Gazzo S, Thieblemont C, Ffrench M, Magaud JP, Salles G, Coiffer B
Clin Lymphoma 2005 Mar;5(4):220-4. doi: 10.3816/clm.2005.n.003. PMID: 15794852
Autoimmune disease and chronic lymphocytic leukemia: autoimmune hemolytic anemia, pure red cell aplasia, and autoimmune thrombocytopenia.
Diehl LF, Ketchum LH
Semin Oncol 1998 Feb;25(1):80-97. PMID: 9482530
The influential T cell in B-cell neoplasms.
Kay NE, Oken MM, Perri RT
J Clin Oncol 1983 Dec;1(12):810-6. doi: 10.1200/JCO.1983.1.12.810. PMID: 6230420

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