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Splenic manifestation of leukemia

MedGen UID:
234813
•Concept ID:
C1336065
•
Neoplastic Process
Synonyms: leukemia (disease) of spleen; spleen leukemia (disease); splenic leukemia; Splenic Manifestation of Leukemia; splenic manifestation of leukemia
 
Monarch Initiative: MONDO:0004107

Definition

Infiltration and expansion of the white and/or red pulp and sinusoids of the spleen by leukemic cells. [from NCI]

Professional guidelines

PubMed

Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
The platelet-refractory bone marrow transplant patient: prophylaxis and treatment of bleeding.
Benson K, Fields K, Hiemenz J, Zorsky P, Ballester O, Perkins J, Elfenbein G
Semin Oncol 1993 Oct;20(5 Suppl 6):102-9. PMID: 8211211
Myelofibrosis: a review of clinical and pathologic features and treatment.
Smith RE, Chelmowski MK, Szabo EJ
Crit Rev Oncol Hematol 1990;10(4):305-14. doi: 10.1016/1040-8428(90)90007-f. PMID: 2278639

Recent clinical studies

Etiology

Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
Essential thrombocythemia.
Brière JB
Orphanet J Rare Dis 2007 Jan 8;2:3. doi: 10.1186/1750-1172-2-3. PMID: 17210076Free PMC Article
Transient leukemia (transient myeloproliferative disorder, transient abnormal myelopoiesis) of Down syndrome.
Brink DS
Adv Anat Pathol 2006 Sep;13(5):256-62. doi: 10.1097/01.pap.0000213039.93328.44. PMID: 16998319
Clinical presentations and complications of hairy cell leukemia.
Hoffman MA
Hematol Oncol Clin North Am 2006 Oct;20(5):1065-73. doi: 10.1016/j.hoc.2006.06.003. PMID: 16990107

Diagnosis

Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
A Review on Splenic Diffuse Red Pulp Small B-Cell Lymphoma.
Yilmaz E, Chhina A, Nava VE, Aggarwal A
Curr Oncol 2021 Dec 6;28(6):5148-5154. doi: 10.3390/curroncol28060431. PMID: 34940070Free PMC Article
Gastrointestinal manifestations of leukemia.
Ebert EC, Hagspiel KD
J Gastroenterol Hepatol 2012 Mar;27(3):458-63. doi: 10.1111/j.1440-1746.2011.06908.x. PMID: 21913980
Essential thrombocythemia.
Brière JB
Orphanet J Rare Dis 2007 Jan 8;2:3. doi: 10.1186/1750-1172-2-3. PMID: 17210076Free PMC Article
Pathology of peliosis.
Tsokos M, Erbersdobler A
Forensic Sci Int 2005 Apr 20;149(1):25-33. doi: 10.1016/j.forsciint.2004.05.010. PMID: 15734106

Therapy

MPN-375 BET Inhibitor Pelabresib (CPI-0610) Combined With Ruxolitinib in Patients With Myelofibrosis - JAK Inhibitor-Naïe or With Suboptimal Response to Ruxolitinib - Preliminary Data From the MANIFEST Study.
Mascarenhas J, Kremyanskaya M, Patriarca A, Harrison C, Bose P, Rampal RK, Palandri F, Devos T, Passamonti F, Hobbs G, Talpaz M, Vannucchi A, Kiladjian JJ, Verstovsek S, Hoffman R, Salama ME, Chen D, Taverna P, Chang A, Colak G, Klein S, Gupta V
Clin Lymphoma Myeloma Leuk 2022 Oct;22 Suppl 2:S335-S336. doi: 10.1016/S2152-2650(22)01456-2. PMID: 36164005
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Hairy cell leukaemia-variant: Disease features and treatment.
Matutes E, Martínez-Trillos A, Campo E
Best Pract Res Clin Haematol 2015 Dec;28(4):253-63. Epub 2015 Oct 8 doi: 10.1016/j.beha.2015.09.002. PMID: 26614904
New insights into hepatosplenic candidosis, a manifestation of chronic disseminated candidosis.
Rammaert B, Desjardins A, Lortholary O
Mycoses 2012 May;55(3):e74-84. Epub 2012 Feb 24 doi: 10.1111/j.1439-0507.2012.02182.x. PMID: 22360318
Essential thrombocythemia.
Brière JB
Orphanet J Rare Dis 2007 Jan 8;2:3. doi: 10.1186/1750-1172-2-3. PMID: 17210076Free PMC Article

Prognosis

How to Diagnose and Treat CD5-Positive Lymphomas Involving the Spleen.
Cabeçadas J, Nava VE, Ascensao JL, Gomes da Silva M
Curr Oncol 2021 Nov 11;28(6):4611-4633. doi: 10.3390/curroncol28060390. PMID: 34898558Free PMC Article
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
Hairy cell leukaemia-variant: Disease features and treatment.
Matutes E, Martínez-Trillos A, Campo E
Best Pract Res Clin Haematol 2015 Dec;28(4):253-63. Epub 2015 Oct 8 doi: 10.1016/j.beha.2015.09.002. PMID: 26614904
Essential thrombocythemia.
Brière JB
Orphanet J Rare Dis 2007 Jan 8;2:3. doi: 10.1186/1750-1172-2-3. PMID: 17210076Free PMC Article
Myelofibrosis: a review of clinical and pathologic features and treatment.
Smith RE, Chelmowski MK, Szabo EJ
Crit Rev Oncol Hematol 1990;10(4):305-14. doi: 10.1016/1040-8428(90)90007-f. PMID: 2278639

Clinical prediction guides

MPN-375 BET Inhibitor Pelabresib (CPI-0610) Combined With Ruxolitinib in Patients With Myelofibrosis - JAK Inhibitor-Naïe or With Suboptimal Response to Ruxolitinib - Preliminary Data From the MANIFEST Study.
Mascarenhas J, Kremyanskaya M, Patriarca A, Harrison C, Bose P, Rampal RK, Palandri F, Devos T, Passamonti F, Hobbs G, Talpaz M, Vannucchi A, Kiladjian JJ, Verstovsek S, Hoffman R, Salama ME, Chen D, Taverna P, Chang A, Colak G, Klein S, Gupta V
Clin Lymphoma Myeloma Leuk 2022 Oct;22 Suppl 2:S335-S336. doi: 10.1016/S2152-2650(22)01456-2. PMID: 36164005
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Clinicopathologic features of Waldenstrom's macroglobulinemia and marginal zone lymphoma: are they distinct or the same entity?
Berger F, Traverse-Glehen A, Felman P, Callet-Bauchu E, Baseggio L, Gazzo S, Thieblemont C, Ffrench M, Magaud JP, Salles G, Coiffer B
Clin Lymphoma 2005 Mar;5(4):220-4. doi: 10.3816/clm.2005.n.003. PMID: 15794852
Primary nodal marginal zone lymphomas of splenic and MALT type.
Campo E, Miquel R, Krenacs L, Sorbara L, Raffeld M, Jaffe ES
Am J Surg Pathol 1999 Jan;23(1):59-68. doi: 10.1097/00000478-199901000-00006. PMID: 9888704
Autoimmune disease and chronic lymphocytic leukemia: autoimmune hemolytic anemia, pure red cell aplasia, and autoimmune thrombocytopenia.
Diehl LF, Ketchum LH
Semin Oncol 1998 Feb;25(1):80-97. PMID: 9482530

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