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Splenic manifestation of leukemia

MedGen UID:
234813
•Concept ID:
C1336065
•
Neoplastic Process
Synonyms: leukaemia (disease) of spleen; leukemia (disease) of spleen; spleen leukaemia (disease); spleen leukemia (disease); splenic leukaemia; splenic leukemia; Splenic Manifestation of Leukemia; splenic manifestation of leukemia
 
Monarch Initiative: MONDO:0004107

Definition

Infiltration and expansion of the white and/or red pulp and sinusoids of the spleen by leukemic cells. [from NCI]

Professional guidelines

PubMed

Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Hairy cell leukaemia-variant: Disease features and treatment.
Matutes E, Martínez-Trillos A, Campo E
Best Pract Res Clin Haematol 2015 Dec;28(4):253-63. Epub 2015 Oct 8 doi: 10.1016/j.beha.2015.09.002. PMID: 26614904
Myelofibrosis: a review of clinical and pathologic features and treatment.
Smith RE, Chelmowski MK, Szabo EJ
Crit Rev Oncol Hematol 1990;10(4):305-14. doi: 10.1016/1040-8428(90)90007-f. PMID: 2278639

Recent clinical studies

Etiology

MANIFEST: Pelabresib in Combination With Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Myelofibrosis.
Mascarenhas J, Kremyanskaya M, Patriarca A, Palandri F, Devos T, Passamonti F, Rampal RK, Mead AJ, Hobbs G, Scandura JM, Talpaz M, Granacher N, Somervaille TCP, Hoffman R, Wondergem MJ, Salama ME, Colak G, Cui J, Kiladjian JJ, Vannucchi AM, Verstovsek S, Curto-García N, Harrison C, Gupta V
J Clin Oncol 2023 Nov 10;41(32):4993-5004. Epub 2023 Mar 7 doi: 10.1200/JCO.22.01972. PMID: 36881782Free PMC Article
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
Essential thrombocythemia.
Brière JB
Orphanet J Rare Dis 2007 Jan 8;2:3. doi: 10.1186/1750-1172-2-3. PMID: 17210076Free PMC Article
Clinical presentations and complications of hairy cell leukemia.
Hoffman MA
Hematol Oncol Clin North Am 2006 Oct;20(5):1065-73. doi: 10.1016/j.hoc.2006.06.003. PMID: 16990107

Diagnosis

Matching-adjusted indirect comparison of the pelabresib-ruxolitinib combination vs JAKi monotherapy in myelofibrosis.
Gupta V, Mascarenhas J, Kremyanskaya M, Rampal RK, Talpaz M, Kiladjian JJ, Vannucchi AM, Verstovsek S, Colak G, Dey D, Harrison C
Blood Adv 2023 Sep 26;7(18):5421-5432. doi: 10.1182/bloodadvances.2023010628. PMID: 37530627Free PMC Article
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Gastrointestinal manifestations of leukemia.
Ebert EC, Hagspiel KD
J Gastroenterol Hepatol 2012 Mar;27(3):458-63. doi: 10.1111/j.1440-1746.2011.06908.x. PMID: 21913980
Essential thrombocythemia.
Brière JB
Orphanet J Rare Dis 2007 Jan 8;2:3. doi: 10.1186/1750-1172-2-3. PMID: 17210076Free PMC Article
Pathology of peliosis.
Tsokos M, Erbersdobler A
Forensic Sci Int 2005 Apr 20;149(1):25-33. doi: 10.1016/j.forsciint.2004.05.010. PMID: 15734106

Therapy

Matching-adjusted indirect comparison of the pelabresib-ruxolitinib combination vs JAKi monotherapy in myelofibrosis.
Gupta V, Mascarenhas J, Kremyanskaya M, Rampal RK, Talpaz M, Kiladjian JJ, Vannucchi AM, Verstovsek S, Colak G, Dey D, Harrison C
Blood Adv 2023 Sep 26;7(18):5421-5432. doi: 10.1182/bloodadvances.2023010628. PMID: 37530627Free PMC Article
MANIFEST: Pelabresib in Combination With Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Myelofibrosis.
Mascarenhas J, Kremyanskaya M, Patriarca A, Palandri F, Devos T, Passamonti F, Rampal RK, Mead AJ, Hobbs G, Scandura JM, Talpaz M, Granacher N, Somervaille TCP, Hoffman R, Wondergem MJ, Salama ME, Colak G, Cui J, Kiladjian JJ, Vannucchi AM, Verstovsek S, Curto-García N, Harrison C, Gupta V
J Clin Oncol 2023 Nov 10;41(32):4993-5004. Epub 2023 Mar 7 doi: 10.1200/JCO.22.01972. PMID: 36881782Free PMC Article
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Hairy cell leukaemia-variant: Disease features and treatment.
Matutes E, Martínez-Trillos A, Campo E
Best Pract Res Clin Haematol 2015 Dec;28(4):253-63. Epub 2015 Oct 8 doi: 10.1016/j.beha.2015.09.002. PMID: 26614904
Essential thrombocythemia.
Brière JB
Orphanet J Rare Dis 2007 Jan 8;2:3. doi: 10.1186/1750-1172-2-3. PMID: 17210076Free PMC Article

Prognosis

Large granular lymphocyte leukemia: An indolent clonal proliferative disease associated with an array of various immunologic disorders.
Drillet G, Pastoret C, Moignet A, Lamy T, Marchand T
Rev Med Interne 2023 Jun;44(6):295-306. Epub 2023 Apr 21 doi: 10.1016/j.revmed.2023.03.014. PMID: 37087371
MANIFEST: Pelabresib in Combination With Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Myelofibrosis.
Mascarenhas J, Kremyanskaya M, Patriarca A, Palandri F, Devos T, Passamonti F, Rampal RK, Mead AJ, Hobbs G, Scandura JM, Talpaz M, Granacher N, Somervaille TCP, Hoffman R, Wondergem MJ, Salama ME, Colak G, Cui J, Kiladjian JJ, Vannucchi AM, Verstovsek S, Curto-García N, Harrison C, Gupta V
J Clin Oncol 2023 Nov 10;41(32):4993-5004. Epub 2023 Mar 7 doi: 10.1200/JCO.22.01972. PMID: 36881782Free PMC Article
How to Diagnose and Treat CD5-Positive Lymphomas Involving the Spleen.
Cabeçadas J, Nava VE, Ascensao JL, Gomes da Silva M
Curr Oncol 2021 Nov 11;28(6):4611-4633. doi: 10.3390/curroncol28060390. PMID: 34898558Free PMC Article
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
Essential thrombocythemia.
Brière JB
Orphanet J Rare Dis 2007 Jan 8;2:3. doi: 10.1186/1750-1172-2-3. PMID: 17210076Free PMC Article

Clinical prediction guides

Matching-adjusted indirect comparison of the pelabresib-ruxolitinib combination vs JAKi monotherapy in myelofibrosis.
Gupta V, Mascarenhas J, Kremyanskaya M, Rampal RK, Talpaz M, Kiladjian JJ, Vannucchi AM, Verstovsek S, Colak G, Dey D, Harrison C
Blood Adv 2023 Sep 26;7(18):5421-5432. doi: 10.1182/bloodadvances.2023010628. PMID: 37530627Free PMC Article
MANIFEST: Pelabresib in Combination With Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Myelofibrosis.
Mascarenhas J, Kremyanskaya M, Patriarca A, Palandri F, Devos T, Passamonti F, Rampal RK, Mead AJ, Hobbs G, Scandura JM, Talpaz M, Granacher N, Somervaille TCP, Hoffman R, Wondergem MJ, Salama ME, Colak G, Cui J, Kiladjian JJ, Vannucchi AM, Verstovsek S, Curto-García N, Harrison C, Gupta V
J Clin Oncol 2023 Nov 10;41(32):4993-5004. Epub 2023 Mar 7 doi: 10.1200/JCO.22.01972. PMID: 36881782Free PMC Article
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Hepatitis C virus and lymphoma.
Viswanatha DS, Dogan A
J Clin Pathol 2007 Dec;60(12):1378-83. doi: 10.1136/jcp.2007.051870. PMID: 18042694Free PMC Article
Autoimmune disease and chronic lymphocytic leukemia: autoimmune hemolytic anemia, pure red cell aplasia, and autoimmune thrombocytopenia.
Diehl LF, Ketchum LH
Semin Oncol 1998 Feb;25(1):80-97. PMID: 9482530

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