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Well Differentiated Fibrosarcoma

MedGen UID:
234998
•Concept ID:
C1337015
•
Neoplastic Process

Definition

A well-differentiated malignant neoplasm arising from the deep soft tissues. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWell Differentiated Fibrosarcoma

Professional guidelines

PubMed

Diagnosis and differential diagnosis of dermatofibrosarcoma protuberans: Utility of high-resolution dynamic contrast-enhanced (DCE) MRI.
Yu Q, Zhu Y, Huang R, Li Y, Song L, Zhang X, Tang M, Gu Q, Li P, Zhou N, Li Y
Skin Res Technol 2022 Sep;28(5):651-663. Epub 2022 May 31 doi: 10.1111/srt.13164. PMID: 35639715Free PMC Article
The discovery and development of sorafenib for the treatment of thyroid cancer.
White PT, Cohen MS
Expert Opin Drug Discov 2015 Apr;10(4):427-39. Epub 2015 Feb 8 doi: 10.1517/17460441.2015.1006194. PMID: 25662396Free PMC Article
Dermatofibrosarcoma protuberans: a comprehensive review and update on diagnosis and management.
Llombart B, Serra-Guillén C, Monteagudo C, López Guerrero JA, Sanmartín O
Semin Diagn Pathol 2013 Feb;30(1):13-28. doi: 10.1053/j.semdp.2012.01.002. PMID: 23327727

Recent clinical studies

Etiology

Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation.
Henricks WH, Chu YC, Goldblum JR, Weiss SW
Am J Surg Pathol 1997 Mar;21(3):271-81. doi: 10.1097/00000478-199703000-00002. PMID: 9060596
Juvenile fibromatosis of the periorbital region and eyelid. A clinicopathologic study of six cases.
Hidayat AA, Font RL
Arch Ophthalmol 1980 Feb;98(2):280-5. doi: 10.1001/archopht.1980.01020030276007. PMID: 7352876

Diagnosis

Aggressive juvenile mandibular fibromatosis.
Ivanov GP, Atanasov DT, Anavi BL
Folia Med (Plovdiv) 2013 Jul-Dec;55(3-4):90-3. doi: 10.2478/folmed-2013-0034. PMID: 24712289
Fibromatosis of the mesoappendix.
Pilichowska M, Kimura N, Yamazaki H, Ohuchi A, Yamamoto K
Pathol Int 2000 Jun;50(6):505-8. doi: 10.1046/j.1440-1827.2000.01063.x. PMID: 10886729
Well differentiated adult-type fibrosarcoma arising from the occipital subcutaneous tissue in a 17-year-old man: case report with immunohistochemical study.
Nakayama H, Kamiji I, Naruse K, Miyazaki E, Hiroi M, Kiyoku H, Kitamura M, Enzan H
Jpn J Clin Oncol 1998 Aug;28(8):511-6. doi: 10.1093/jjco/28.8.511. PMID: 9769787
Musculoaponeurotic fibromatosis. A report of 28 cases and review of the literature.
Taylor LJ
Clin Orthop Relat Res 1987 Nov;(224):294-302. PMID: 3311517
Fibrosarcoma mimicking breast fibromatosis.
Payan HM, England DM
Am J Med Genet Suppl 1987;3:257-62. doi: 10.1002/ajmg.1320280530. PMID: 3130861

Prognosis

Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation.
Henricks WH, Chu YC, Goldblum JR, Weiss SW
Am J Surg Pathol 1997 Mar;21(3):271-81. doi: 10.1097/00000478-199703000-00002. PMID: 9060596
Juvenile fibromatosis of the periorbital region and eyelid. A clinicopathologic study of six cases.
Hidayat AA, Font RL
Arch Ophthalmol 1980 Feb;98(2):280-5. doi: 10.1001/archopht.1980.01020030276007. PMID: 7352876

Clinical prediction guides

Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation.
Henricks WH, Chu YC, Goldblum JR, Weiss SW
Am J Surg Pathol 1997 Mar;21(3):271-81. doi: 10.1097/00000478-199703000-00002. PMID: 9060596
Fibrosarcoma of the neck in an adult female.
Hirabayashi H, Ohgaki H, Uno K, Koshii K, Hinohara T
Auris Nasus Larynx 1989;16(1):51-8. doi: 10.1016/s0385-8146(89)80008-2. PMID: 2764793
Juvenile fibromatosis of the periorbital region and eyelid. A clinicopathologic study of six cases.
Hidayat AA, Font RL
Arch Ophthalmol 1980 Feb;98(2):280-5. doi: 10.1001/archopht.1980.01020030276007. PMID: 7352876

Supplemental Content

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