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Cellular Angiofibroma

MedGen UID:
235072
•Concept ID:
C1367534
•
Neoplastic Process

Definition

A benign mesenchymal neoplasm that usually arises in the superficial soft tissues of the vulva or inguinal and scrotal regions. It is characterized by the presence of a cellular fibroblastic proliferation in an edematous to fibrous stroma containing numerous vessels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular Angiofibroma

Professional guidelines

PubMed

Pathology and Differential Diagnosis of Anterior Skull Base Tumours.
Williams MD, El-Naggar AK
Adv Otorhinolaryngol 2020;84:13-27. Epub 2020 Jul 30 doi: 10.1159/000457922. PMID: 32731232
Contemporary management of juvenile angiofibroma.
Bertazzoni G, Schreiber A, Ferrari M, Nicolai P
Curr Opin Otolaryngol Head Neck Surg 2019 Feb;27(1):47-53. doi: 10.1097/MOO.0000000000000505. PMID: 30507688
Imaging Evaluation and Treatment of Vascular Lesions at the Skull Base.
Jindal G, Miller T, Raghavan P, Gandhi D
Radiol Clin North Am 2017 Jan;55(1):151-166. Epub 2016 Oct 25 doi: 10.1016/j.rcl.2016.08.003. PMID: 27890183

Recent clinical studies

Etiology

Mesenchymal lesions of the vulva.
Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293
Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component.
McCarthy AJ, Chetty R
J Clin Pathol 2018 Jun;71(6):483-492. Epub 2018 Jan 22 doi: 10.1136/jclinpath-2017-204975. PMID: 29358476
Cellular Angiofibroma Presenting as an Inguinal Subcutaneous Mass: a Case Report and Review of the Literature.
Schiebel F, Cassim R
W V Med J 2016 Nov-Dec;112(6):40-3. PMID: 29368830
Genital soft tissue tumors.
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211
A review and update of morphologically bland vulvovaginal mesenchymal lesions.
McCluggage WG
Int J Gynecol Pathol 2005 Jan;24(1):26-38. PMID: 15626915

Diagnosis

Rare Mesenchymal Tumors of the Pelvis: Imaging and Pathologic Correlation.
Figueiredo G, O'Shea A, Neville GM, Lee SI
Radiographics 2022 Jan-Feb;42(1):143-158. Epub 2021 Nov 19 doi: 10.1148/rg.210049. PMID: 34797733
Mesenchymal lesions of the vulva.
Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293
Cervicovaginal cellular angiofibroma.
Van Mulders S, Faes E, Broeckx G, Jacquemyn Y
BMJ Case Rep 2020 Jul 16;13(7) doi: 10.1136/bcr-2020-235241. PMID: 32675122Free PMC Article
Cellular angiofibroma in women: a review of the literature.
Mandato VD, Santagni S, Cavazza A, Aguzzoli L, Abrate M, La Sala GB
Diagn Pathol 2015 Jul 19;10:114. doi: 10.1186/s13000-015-0361-6. PMID: 26187500Free PMC Article
Genital soft tissue tumors.
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211

Therapy

Radioguided surgery of mesenchymal tumors with (125)I seeds.
Barranquero AG, Corral Moreno S, Martínez Lorca A, Hernández-Cosido L, Rioja Martín ME, Mena Mateo A, Cabañas Montero J, Fernández-Cebrián JM
Rev Esp Med Nucl Imagen Mol (Engl Ed) 2023 Sep-Oct;42(5):296-301. Epub 2023 Apr 14 doi: 10.1016/j.remnie.2023.04.004. PMID: 37062451
Combination of high-frequency electric with 5-ALA photodynamic therapy in cellular angiofibroma of vulva: A case report.
Yu YT, Nong X, Neng YJ, Wu WJ, Li Y, Zhang M
Photodiagnosis Photodyn Ther 2023 Jun;42:103289. Epub 2023 Feb 3 doi: 10.1016/j.pdpdt.2023.103289. PMID: 36738906
Evidence for an association between increased oxidative stress and derangement of FOXO1 signaling in tumorigenesis of a cellular angiofibroma with monoallelic 13q14: a case report.
Arakaki K, Chinen K, Kamiya M, Tanabe Y, Tawata N, Ikehara F, Uehara K, Shimabukuro H, Kinjo T
Int J Clin Exp Pathol 2014;7(12):8972-9. Epub 2014 Dec 1 PMID: 25674275Free PMC Article
Angiomyofibroblastoma-like tumor (cellular angiofibroma) in the male inguinal region.
Miyajima K, Hasegawa S, Oda Y, Toyoshima S, Tsuneyoshi M, Motooka M, Matsuura Y, Ishioka H, Ono M
Radiat Med 2007 May;25(4):173-7. Epub 2007 May 28 doi: 10.1007/s11604-006-0114-2. PMID: 17514368
Para-testicular cellular angiofibroma: a rare tumour in a male renal transplant patient.
Sabah M, Mohan P, Kay E
Virchows Arch 2006 Oct;449(4):489-92. Epub 2006 Sep 7 doi: 10.1007/s00428-006-0289-z. PMID: 16957933

Prognosis

Cellular angiofibroma arising in the anorectal region: clinicopathologic and immunohistochemical analysis of five cases.
Matsumoto NP, Ahmed M, Rottmann D, Laskin WB
Hum Pathol 2022 Feb;120:1-8. Epub 2021 Nov 20 doi: 10.1016/j.humpath.2021.11.006. PMID: 34808212
Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component.
McCarthy AJ, Chetty R
J Clin Pathol 2018 Jun;71(6):483-492. Epub 2018 Jan 22 doi: 10.1136/jclinpath-2017-204975. PMID: 29358476
Paratesticular cellular angiofibroma with atypical (bizarre) cells: case report and literature review.
Val-Bernal JF, Azueta A, Parra A, Mediavilla E, Zubillaga S
Pathol Res Pract 2013 Jun;209(6):388-92. Epub 2013 Mar 26 doi: 10.1016/j.prp.2013.03.008. PMID: 23582366
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

Clinical prediction guides

Cellular angiofibroma of the vagina: A case report and literature review.
Cai XQ, Ye XG, Zhang YZ, Shen ZL, Hong K, Zhang SZ
Medicine (Baltimore) 2022 Sep 2;101(35):e30293. doi: 10.1097/MD.0000000000030293. PMID: 36107545Free PMC Article
Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component.
McCarthy AJ, Chetty R
J Clin Pathol 2018 Jun;71(6):483-492. Epub 2018 Jan 22 doi: 10.1136/jclinpath-2017-204975. PMID: 29358476
Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma.
Flucke U, van Krieken JH, Mentzel T
Mod Pathol 2011 Jan;24(1):82-9. Epub 2010 Sep 17 doi: 10.1038/modpathol.2010.170. PMID: 20852591
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

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