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Giant Cell Angiofibroma

MedGen UID:
235073
•Concept ID:
C1367539
•
Neoplastic Process

Definition

A morphologic variant of angiofibroma characterized by the presence of multinucleated giant cells, collagenous or myxoid stroma, focal sclerotic areas, and angiectoid spaces. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant Cell Angiofibroma

Professional guidelines

PubMed

Pathology and Differential Diagnosis of Anterior Skull Base Tumours.
Williams MD, El-Naggar AK
Adv Otorhinolaryngol 2020;84:13-27. Epub 2020 Jul 30 doi: 10.1159/000457922. PMID: 32731232
Contemporary management of juvenile angiofibroma.
Bertazzoni G, Schreiber A, Ferrari M, Nicolai P
Curr Opin Otolaryngol Head Neck Surg 2019 Feb;27(1):47-53. doi: 10.1097/MOO.0000000000000505. PMID: 30507688
Imaging Evaluation and Treatment of Vascular Lesions at the Skull Base.
Jindal G, Miller T, Raghavan P, Gandhi D
Radiol Clin North Am 2017 Jan;55(1):151-166. Epub 2016 Oct 25 doi: 10.1016/j.rcl.2016.08.003. PMID: 27890183

Recent clinical studies

Etiology

A review of solitary fibrous tumours of the orbit and ocular adnexa.
René C, Scollo P, O'Donovan D
Eye (Lond) 2023 Apr;37(5):858-865. Epub 2022 Jul 13 doi: 10.1038/s41433-022-02160-w. PMID: 35831617Free PMC Article
The clinicopathological significance of NAB2-STAT6 gene fusions in 52 cases of intrathoracic solitary fibrous tumors.
Huang SC, Li CF, Kao YC, Chuang IC, Tai HC, Tsai JW, Yu SC, Huang HY, Lan J, Yen SL, Lin PC, Chen TC
Cancer Med 2016 Feb;5(2):159-68. Epub 2015 Dec 21 doi: 10.1002/cam4.572. PMID: 26686340Free PMC Article
Giant cell angiofibroma of parapharyngeal space: a report of a new location for a rare tumour.
González-Pérez LM, Sánchez-Gallego F, Haro-Luna JJ, Infante-Cossío P
Int J Oral Maxillofac Surg 2010 Oct;39(10):1024-7. Epub 2010 May 26 doi: 10.1016/j.ijom.2010.04.044. PMID: 20537864
Recent developments in soft tissue tumors.
Fletcher CD
Verh Dtsch Ges Pathol 1998;82:33-46. PMID: 10095415

Diagnosis

The Current Status of Solitary Fibrous Tumor: Diagnostic Features, Variants, and Genetics.
Thway K, Ng W, Noujaim J, Jones RL, Fisher C
Int J Surg Pathol 2016 Jun;24(4):281-92. Epub 2016 Jan 25 doi: 10.1177/1066896915627485. PMID: 26811389
Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature.
He Y, Zhang C, Liu G, Tian Z, Wang L, Kalfarentzos E
World J Surg Oncol 2014 Apr 24;12:117. doi: 10.1186/1477-7819-12-117. PMID: 24758544Free PMC Article
Giant cell angiofibroma of the oral cavity: A case report and review of the literature.
de Andrade CR, Lopes MA, de Almeida OP, León JE, Mistro F, Kignel S
Med Oral Patol Oral Cir Bucal 2008 Sep 1;13(9):E540-3. PMID: 18758395
Orbital giant cell angiofibroma.
Ereño C, López JI, Pérez J, Grande J, Bilbao FJ
APMIS 2006 Sep;114(9):663-5. doi: 10.1111/j.1600-0463.2006.apm_382.x. PMID: 16948822
Orbital and extraorbital giant cell angiofibroma: a giant cell-rich variant of solitary fibrous tumor? Clinicopathologic and immunohistochemical analysis of a series in favor of a unifying concept.
Guillou L, Gebhard S, Coindre JM
Am J Surg Pathol 2000 Jul;24(7):971-9. doi: 10.1097/00000478-200007000-00008. PMID: 10895819

Therapy

Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature.
He Y, Zhang C, Liu G, Tian Z, Wang L, Kalfarentzos E
World J Surg Oncol 2014 Apr 24;12:117. doi: 10.1186/1477-7819-12-117. PMID: 24758544Free PMC Article
Endovascular preoperative embolization of orbital hemangiopericytoma with n-butyl cyanoacrylate glue.
Wallace KM, Alaraj A, Aakalu VK, Aletich V, Setabutr P
Ophthalmic Plast Reconstr Surg 2014 Jul-Aug;30(4):e97-100. doi: 10.1097/IOP.0b013e3182a22bd8. PMID: 24317100Free PMC Article
Four cases of solitary fibrous tumour of the eye and orbit: one with sarcomatous transformation after radiotherapy and one in a 5-year-old child's eyelid.
Blandamura S, Alaggio R, Bettini G, Guzzardo V, Valentini E, Bedogni A
J Clin Pathol 2014 Mar;67(3):263-7. Epub 2013 Oct 9 doi: 10.1136/jclinpath-2013-201820. PMID: 24108432
Extraorbital giant cell angiofibroma.
Husek K, Veselý K
Cesk Patol 2002 Jul;38(3):117-20. PMID: 12325476

Prognosis

A review of solitary fibrous tumours of the orbit and ocular adnexa.
René C, Scollo P, O'Donovan D
Eye (Lond) 2023 Apr;37(5):858-865. Epub 2022 Jul 13 doi: 10.1038/s41433-022-02160-w. PMID: 35831617Free PMC Article
The Current Status of Solitary Fibrous Tumor: Diagnostic Features, Variants, and Genetics.
Thway K, Ng W, Noujaim J, Jones RL, Fisher C
Int J Surg Pathol 2016 Jun;24(4):281-92. Epub 2016 Jan 25 doi: 10.1177/1066896915627485. PMID: 26811389
The clinicopathological significance of NAB2-STAT6 gene fusions in 52 cases of intrathoracic solitary fibrous tumors.
Huang SC, Li CF, Kao YC, Chuang IC, Tai HC, Tsai JW, Yu SC, Huang HY, Lan J, Yen SL, Lin PC, Chen TC
Cancer Med 2016 Feb;5(2):159-68. Epub 2015 Dec 21 doi: 10.1002/cam4.572. PMID: 26686340Free PMC Article
Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature.
He Y, Zhang C, Liu G, Tian Z, Wang L, Kalfarentzos E
World J Surg Oncol 2014 Apr 24;12:117. doi: 10.1186/1477-7819-12-117. PMID: 24758544Free PMC Article
Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior.
Hasegawa T, Matsuno Y, Shimoda T, Hasegawa F, Sano T, Hirohashi S
Hum Pathol 1999 Dec;30(12):1464-73. doi: 10.1016/s0046-8177(99)90169-7. PMID: 10667425

Clinical prediction guides

The clinicopathological significance of NAB2-STAT6 gene fusions in 52 cases of intrathoracic solitary fibrous tumors.
Huang SC, Li CF, Kao YC, Chuang IC, Tai HC, Tsai JW, Yu SC, Huang HY, Lan J, Yen SL, Lin PC, Chen TC
Cancer Med 2016 Feb;5(2):159-68. Epub 2015 Dec 21 doi: 10.1002/cam4.572. PMID: 26686340Free PMC Article
Pleomorphic hyalinizing angiectatic tumor.
Husek K, Veselý K
Cesk Patol 2001 Nov;37(4):177-81. PMID: 11813637
A study of four cases of extra-orbital giant cell angiofibroma with documentation of some unusual features.
Thomas R, Banerjee SS, Eyden BP, Shanks JH, Bisset DL, Hunt R, Byers RJ, Oogarah P, Harris M
Histopathology 2001 Oct;39(4):390-6. doi: 10.1046/j.1365-2559.2001.01227.x. PMID: 11683940
Orbital and extraorbital giant cell angiofibroma: a giant cell-rich variant of solitary fibrous tumor? Clinicopathologic and immunohistochemical analysis of a series in favor of a unifying concept.
Guillou L, Gebhard S, Coindre JM
Am J Surg Pathol 2000 Jul;24(7):971-9. doi: 10.1097/00000478-200007000-00008. PMID: 10895819
Giant cell angiofibroma of the orbit and eyelid.
Hayashi N, Borodic G, Karesh JW, Tolentino MJ, Remulla HD, Van Wesep RA, Grossniklaus HE, Jakobiec FA, Green WR
Ophthalmology 1999 Jun;106(6):1223-9. doi: 10.1016/S0161-6420(99)90270-1. PMID: 10366097

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