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Sebaceous gland cancer

MedGen UID:
235134
•Concept ID:
C1382026
•
Neoplastic Process
Synonyms: cancer of sebaceous gland; Malignant Neoplasm of Sebaceous Gland; malignant neoplasm of sebaceous gland; Malignant Neoplasm of the Sebaceous Gland; malignant neoplasm of the sebaceous gland; Malignant Sebaceous Gland Neoplasm; malignant sebaceous gland neoplasm; Malignant Sebaceous Gland Tumor; malignant sebaceous gland tumor; malignant sebaceous gland tumour; Malignant Sebaceous Neoplasm; malignant sebaceous neoplasm; Malignant Sebaceous Tumor; malignant sebaceous tumor; malignant sebaceous tumour; Malignant Tumor of Sebaceous Gland; malignant tumor of sebaceous gland; Malignant Tumor of the Sebaceous Gland; malignant tumor of the sebaceous gland; malignant tumour of sebaceous gland; malignant tumour of the sebaceous gland; sebaceous gland cancer
 
Monarch Initiative: MONDO:0037735

Definition

A rare malignant neoplasm that arises from the sebaceous glands. [from NCI]

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796

Recent clinical studies

Etiology

Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist.
Fulton EH, Kaley JR, Gardner JM
Arch Pathol Lab Med 2019 Jul;143(7):832-851. Epub 2019 Jan 14 doi: 10.5858/arpa.2018-0189-RA. PMID: 30638401
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
Skin of color: biology, structure, function, and implications for dermatologic disease.
Taylor SC
J Am Acad Dermatol 2002 Feb;46(2 Suppl Understanding):S41-62. doi: 10.1067/mjd.2002.120790. PMID: 11807469

Diagnosis

The lowly chalazion.
Kim ES, Afshin EE, Elahi E
Surv Ophthalmol 2023 Jul-Aug;68(4):784-793. Epub 2022 Nov 15 doi: 10.1016/j.survophthal.2022.11.002. PMID: 36395826
Muir-Torre Syndrome.
Gamret AC, Klingbeil KD, Fertig RM, Jahan-Tigh RR, Silapunt S, Uzoma M, Gaudi S, Romanelli P
Skinmed 2020;18(6):382-384. Epub 2020 Dec 1 PMID: 33397571
Cutaneous sebaceous carcinoma.
Wu A, Rajak SN, Huilgol SC, James C, Selva D
Australas J Dermatol 2020 Aug;61(3):e283-e292. Epub 2020 Jan 19 doi: 10.1111/ajd.13234. PMID: 31956994
Androgens in women: Androgen-mediated skin disease and patient evaluation.
Bienenfeld A, Azarchi S, Lo Sicco K, Marchbein S, Shapiro J, Nagler AR
J Am Acad Dermatol 2019 Jun;80(6):1497-1506. Epub 2018 Oct 10 doi: 10.1016/j.jaad.2018.08.062. PMID: 30312644
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886

Therapy

Current Treatment Options for Cutaneous Adnexal Malignancies.
Goto H
Curr Treat Options Oncol 2022 May;23(5):736-748. Epub 2022 Mar 26 doi: 10.1007/s11864-022-00971-3. PMID: 35347560
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
From pathogenesis of acne vulgaris to anti-acne agents.
Cong TX, Hao D, Wen X, Li XH, He G, Jiang X
Arch Dermatol Res 2019 Jul;311(5):337-349. Epub 2019 Mar 11 doi: 10.1007/s00403-019-01908-x. PMID: 30859308
The influence of exposome on acne.
Dréno B, Bettoli V, Araviiskaia E, Sanchez Viera M, Bouloc A
J Eur Acad Dermatol Venereol 2018 May;32(5):812-819. Epub 2018 Feb 15 doi: 10.1111/jdv.14820. PMID: 29377341Free PMC Article
Sebaceous Carcinoma: A Review of the Scientific Literature.
Knackstedt T, Samie FH
Curr Treat Options Oncol 2017 Aug;18(8):47. doi: 10.1007/s11864-017-0490-0. PMID: 28681210

Prognosis

Adnexal and Sebaceous Carcinomas.
Seger EW, Neill BC, Tolkachjov SN
Dermatol Clin 2023 Jan;41(1):117-132. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.010. PMID: 36410972
Epithelial-Myoepithelial Carcinoma.
Nakaguro M, Nagao T
Surg Pathol Clin 2021 Mar;14(1):97-109. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.10.002. PMID: 33526226
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796
The influence of exposome on acne.
Dréno B, Bettoli V, Araviiskaia E, Sanchez Viera M, Bouloc A
J Eur Acad Dermatol Venereol 2018 May;32(5):812-819. Epub 2018 Feb 15 doi: 10.1111/jdv.14820. PMID: 29377341Free PMC Article
Skin of color: biology, structure, function, and implications for dermatologic disease.
Taylor SC
J Am Acad Dermatol 2002 Feb;46(2 Suppl Understanding):S41-62. doi: 10.1067/mjd.2002.120790. PMID: 11807469

Clinical prediction guides

NECTIN4 expression in sebaceous and sweat gland carcinoma.
Ito T, Hashimoto H, Tanaka Y, Tanegashima K, Murata M, Oda Y, Kaku-Ito Y
Eur J Dermatol 2022 Apr 1;32(2):181-186. doi: 10.1684/ejd.2022.4241. PMID: 35866909
The Role of Podoplanin in Skin Diseases.
Asai J
Int J Mol Sci 2022 Jan 24;23(3) doi: 10.3390/ijms23031310. PMID: 35163233Free PMC Article
Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.
Oulès B, Rognoni E, Hoste E, Goss G, Fiehler R, Natsuga K, Quist S, Mentink R, Donati G, Watt FM
EMBO J 2019 May 2;38(9) Epub 2019 Mar 18 doi: 10.15252/embj.2018100526. PMID: 30886049Free PMC Article
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Skin of color: biology, structure, function, and implications for dermatologic disease.
Taylor SC
J Am Acad Dermatol 2002 Feb;46(2 Suppl Understanding):S41-62. doi: 10.1067/mjd.2002.120790. PMID: 11807469

Recent systematic reviews

Characterization of sebaceous and non-sebaceous cutaneous manifestations in patients with lynch syndrome: a systematic review.
Aziz S, O'Sullivan H, Heelan K, Alam A, McVeigh TP
Fam Cancer 2023 Apr;22(2):167-175. Epub 2022 Nov 23 doi: 10.1007/s10689-022-00319-8. PMID: 36418753Free PMC Article
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Sebaceous Carcinoma of the Eyelid: A Systematic Review and Meta-Analysis.
Desiato VM, Byun YJ, Nguyen SA, Thiers BH, Day TA
Dermatol Surg 2021 Jan 1;47(1):104-110. doi: 10.1097/DSS.0000000000002660. PMID: 33347004
Impact of surgery and adjuvant treatment on the outcome of extraocular sebaceous carcinoma: a systematic review and individual patient's data analysis of 206 cases.
Giridhar P, Kashyap L, Mallick S, Dutt Upadhyay A, Rath GK
Int J Dermatol 2020 Apr;59(4):494-505. Epub 2019 Dec 18 doi: 10.1111/ijd.14739. PMID: 31850516
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
Ford J, Thakar S, Thuro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324. doi: 10.1097/IOP.0000000000000901. PMID: 28350693

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