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Cervical spondylosis

MedGen UID:
235174
Concept ID:
C1384641
Disease or Syndrome
Synonyms: Cervical Spondylosis; Spondylosis, Cervical
SNOMED CT: Cervical spondylosis (387800004); CS - Cervical spondylosis (387800004); Cervical spine degeneration (387800004)
 
HPO: HP:0008480
Monarch Initiative: MONDO:0008481
OMIM®: 184300

Definition

Arthrosis, i.e., of degenerative joint disease, affecting the cervical vertebral column. [from HPO]

Clinical features

From HPO
Spina bifida occulta
MedGen UID:
36380
Concept ID:
C0080174
Congenital Abnormality
The closed form of spina bifida with incomplete closure of a vertebral body with intact overlying skin.
Osteoarthritis
MedGen UID:
45244
Concept ID:
C0029408
Disease or Syndrome
Osteoarthritis (OA) is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis (Meulenbelt et al., 2006). Clinical problems include pain and joint stiffness often leading to significant disability and joint replacement. Osteoarthritis exhibits a clear predilection for specific joints; it appears most commonly in the hip and knee joints and lumbar and cervical spine, as well as in the distal interphalangeal and the first carpometacarpal (base of thumb) and proximal interphalangeal joints of the hand; however, patients with osteoarthritis may have 1, a few, or all of these sites affected (Stefansson et al., 2003). According to a conservative estimate, greater than 70% of the population of the United States at age 65 years is affected by the disease, reflecting its age dependence. Genetic Heterogeneity of Susceptibility to Osteoarthritis Susceptibility to osteoarthritis has been associated with variation in other genes: OS2 (140600) with variation in the MATN3 gene (602109) on chromosome 2p24; OS3 (607850) with variation in the ASPN gene (608135) on chromosome 9q22; and OS5 (612400) with variation in the GDF5 gene (601146) on chromosome 20q11. Other susceptibility loci for osteoarthritis have been mapped to chromosomes 2q33 (OS4; 610839) and 3p24 (OS6; 612401).
Spondylolisthesis
MedGen UID:
52470
Concept ID:
C0038016
Disease or Syndrome
Spondylolisthesis is defined as forward slipping of a vertebral body on the one below it. Spondylolysis is defined as a defect in the pars interarticularis without vertebral slipping (summary by Wiltse et al., 1975).
Spondylolysis
MedGen UID:
21294
Concept ID:
C0038018
Disease or Syndrome
Spondylolysis is an osseous defect of the pars interarticularis, thought to be a developmental or acquired stress fracture secondary to chronic low-grade trauma.
Cervical spondylosis
MedGen UID:
235174
Concept ID:
C1384641
Disease or Syndrome
Arthrosis, i.e., of degenerative joint disease, affecting the cervical vertebral column.

Conditions with this feature

Cervical spondylosis
MedGen UID:
235174
Concept ID:
C1384641
Disease or Syndrome
Arthrosis, i.e., of degenerative joint disease, affecting the cervical vertebral column.

Professional guidelines

PubMed

Prablek M, Gadot R, Xu DS, Ropper AE
Neurol Clin 2023 Feb;41(1):77-85. Epub 2022 Oct 29 doi: 10.1016/j.ncl.2022.07.003. PMID: 36400560
Li Y, Peng B
Pain Physician 2015 Jul-Aug;18(4):E583-95. PMID: 26218949
Manchikanti L, Hirsch JA
Expert Rev Neurother 2015 Jun;15(6):681-93. Epub 2015 May 17 doi: 10.1586/14737175.2015.1048226. PMID: 25982996

Curated

UK NICE Clinical guideline (CG148), Urinary incontinence in neurological disease: assessment and management, 2023

Recent clinical studies

Etiology

Wang P, Zuo G, Du SQ, Gao TC, Liu RJ, Hou XZ, Ji X, Yin J, Li KM, Zhang Q
Medicine (Baltimore) 2020 Jan;99(5):e18851. doi: 10.1097/MD.0000000000018851. PMID: 32000386Free PMC Article
Zuo G, Gao TC, Xue BH, Gu CC, Yan YT, Zhang YW, Liu RJ, Du SQ
Medicine (Baltimore) 2019 Nov;98(48):e17974. doi: 10.1097/MD.0000000000017974. PMID: 31770206Free PMC Article
Reddy RS, Tedla JS, Dixit S, Abohashrh M
BMC Musculoskelet Disord 2019 Oct 15;20(1):447. doi: 10.1186/s12891-019-2846-z. PMID: 31615495Free PMC Article
Liang H, Yang X, Liu C, Sun Z, Wang X
J Musculoskelet Neuronal Interact 2018 Dec 1;18(4):551-556. PMID: 30511959Free PMC Article
Miao Q, Qiang JH, Jin YL
Medicine (Baltimore) 2018 Jun;97(26):e11080. doi: 10.1097/MD.0000000000011080. PMID: 29952946Free PMC Article

Diagnosis

Prablek M, Gadot R, Xu DS, Ropper AE
Neurol Clin 2023 Feb;41(1):77-85. Epub 2022 Oct 29 doi: 10.1016/j.ncl.2022.07.003. PMID: 36400560
Williams J, D'Amore P, Redlich N, Darlow M, Suwak P, Sarkovich S, Bhandutia AK
Orthop Clin North Am 2022 Oct;53(4):509-521. Epub 2022 Sep 14 doi: 10.1016/j.ocl.2022.05.007. PMID: 36208893
Theodore N
N Engl J Med 2020 Jul 9;383(2):159-168. doi: 10.1056/NEJMra2003558. PMID: 32640134
Li Y, Peng B
Pain Physician 2015 Jul-Aug;18(4):E583-95. PMID: 26218949
Abbed KM, Coumans JV
Neurosurgery 2007 Jan;60(1 Supp1 1):S28-34. doi: 10.1227/01.NEU.0000249223.51871.C2. PMID: 17204882

Therapy

Prablek M, Gadot R, Xu DS, Ropper AE
Neurol Clin 2023 Feb;41(1):77-85. Epub 2022 Oct 29 doi: 10.1016/j.ncl.2022.07.003. PMID: 36400560
Zhang YP, Hu RX, Han M, Lai BY, Liang SB, Chen BJ, Robinson N, Chen K, Liu JP
Complement Ther Med 2020 May;50:102392. Epub 2020 Apr 6 doi: 10.1016/j.ctim.2020.102392. PMID: 32444061
Wang P, Zuo G, Du SQ, Gao TC, Liu RJ, Hou XZ, Ji X, Yin J, Li KM, Zhang Q
Medicine (Baltimore) 2020 Jan;99(5):e18851. doi: 10.1097/MD.0000000000018851. PMID: 32000386Free PMC Article
Zuo G, Gao TC, Xue BH, Gu CC, Yan YT, Zhang YW, Liu RJ, Du SQ
Medicine (Baltimore) 2019 Nov;98(48):e17974. doi: 10.1097/MD.0000000000017974. PMID: 31770206Free PMC Article
Miao Q, Qiang JH, Jin YL
Medicine (Baltimore) 2018 Jun;97(26):e11080. doi: 10.1097/MD.0000000000011080. PMID: 29952946Free PMC Article

Prognosis

Lin WS, Huang TF, Chuang TY, Lin CL, Kao CH
Int J Environ Res Public Health 2018 Mar 25;15(4) doi: 10.3390/ijerph15040587. PMID: 29587400Free PMC Article
Yamaguchi S, Mitsuhara T, Abiko M, Takeda M, Kurisu K
Neurosurg Clin N Am 2018 Jan;29(1):1-12. Epub 2017 Oct 27 doi: 10.1016/j.nec.2017.09.001. PMID: 29173421
Nowak DD, Lee JK, Gelb DE, Poelstra KA, Ludwig SC
J Am Acad Orthop Surg 2009 Dec;17(12):756-65. doi: 10.5435/00124635-200912000-00004. PMID: 19948700
Yonenobu K
Eur Spine J 2000 Feb;9(1):1-7. doi: 10.1007/s005860050001. PMID: 10766070Free PMC Article
McCormack BM, Weinstein PR
West J Med 1996 Jul-Aug;165(1-2):43-51. PMID: 8855684Free PMC Article

Clinical prediction guides

Garg K, Aggarwal A
World Neurosurg 2022 Jan;157:207-217.e1. Epub 2021 Oct 14 doi: 10.1016/j.wneu.2021.09.110. PMID: 34655819
Wang P, Zuo G, Du SQ, Gao TC, Liu RJ, Hou XZ, Ji X, Yin J, Li KM, Zhang Q
Medicine (Baltimore) 2020 Jan;99(5):e18851. doi: 10.1097/MD.0000000000018851. PMID: 32000386Free PMC Article
Zuo G, Gao TC, Xue BH, Gu CC, Yan YT, Zhang YW, Liu RJ, Du SQ
Medicine (Baltimore) 2019 Nov;98(48):e17974. doi: 10.1097/MD.0000000000017974. PMID: 31770206Free PMC Article
Liang H, Yang X, Liu C, Sun Z, Wang X
J Musculoskelet Neuronal Interact 2018 Dec 1;18(4):551-556. PMID: 30511959Free PMC Article
Miao Q, Qiang JH, Jin YL
Medicine (Baltimore) 2018 Jun;97(26):e11080. doi: 10.1097/MD.0000000000011080. PMID: 29952946Free PMC Article

Recent systematic reviews

Lv J, Mei J, Feng X, Tian X, Sun L
J Orthop Surg Res 2022 Aug 13;17(1):389. doi: 10.1186/s13018-022-03274-3. PMID: 35964065Free PMC Article
Zuo G, Gao TC, Xue BH, Gu CC, Yan YT, Zhang YW, Liu RJ, Du SQ
Medicine (Baltimore) 2019 Nov;98(48):e17974. doi: 10.1097/MD.0000000000017974. PMID: 31770206Free PMC Article
Jiang L, Tan M, Yang F, Yi P, Tang X, Hao Q
Clin Spine Surg 2016 Dec;29(10):419-426. doi: 10.1097/BSD.0000000000000399. PMID: 27322653
Fallah A, Akl EA, Ebrahim S, Ibrahim GM, Mansouri A, Foote CJ, Zhang Y, Fehlings MG
PLoS One 2012;7(8):e43407. Epub 2012 Aug 17 doi: 10.1371/journal.pone.0043407. PMID: 22912869Free PMC Article
Wang MY, Tsai PS, Lee PH, Chang WY, Yang CM
J Clin Nurs 2008 Oct;17(19):2531-8. doi: 10.1111/j.1365-2702.2008.02446.x. PMID: 18808620

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Clinical guideline (CG148), Urinary incontinence in neurological disease: assessment and management, 2023

    Consumer resources

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