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Laryngeal Paraganglioma

MedGen UID:
235253
•Concept ID:
C1334375
•
Neoplastic Process
Synonyms: Larynx Paraganglioma; Paraganglioma of Larynx; Paraganglioma of the Larynx

Definition

An extra-adrenal parasympathetic paraganglioma arising from paraganglia adjacent to the larynx. Patients may present with hoarseness and dysphagia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Paraganglioma

Professional guidelines

PubMed

A review of neuroendocrine neoplasms of the larynx: update on diagnosis and treatment.
Ferlito A, Barnes L, Rinaldo A, Gnepp DR, Milroy CM
J Laryngol Otol 1998 Sep;112(9):827-34. doi: 10.1017/s0022215100141830. PMID: 9876371
Identification, classification, treatment, and prognosis of laryngeal paraganglioma. Review of the literature and eight new cases.
Ferlito A, Barnes L, Wenig BM
Ann Otol Rhinol Laryngol 1994 Jul;103(7):525-36. doi: 10.1177/000348949410300705. PMID: 8024215
Treatment of neuroendocrine neoplasms of the larynx.
Moisa II, Silver CE
ORL J Otorhinolaryngol Relat Spec 1991;53(4):259-64. doi: 10.1159/000276225. PMID: 1653932

Recent clinical studies

Etiology

Laryngeal paraganglioma: The analysis of misdiagnosed cases and literature review.
Dong YJ, Zhang HH, Liang JQ, Gao YY, Xiong M, Yang H
Head Neck 2024 May;46(5):1234-1247. Epub 2024 Mar 27 doi: 10.1002/hed.27762. PMID: 38533762
Supraglottic laryngeal paraganglioma.
Buiret G, Merrot O, Le Breton F, Landry G, Poupart M, Pignat JC
Eur Ann Otorhinolaryngol Head Neck Dis 2010 Jun;127(3):117-9. Epub 2010 May 13 doi: 10.1016/j.anorl.2010.04.002. PMID: 20822766
Neuroendocrine neoplasms of the larynx: an overview.
Ferlito A, Silver CE, Bradford CR, Rinaldo A
Head Neck 2009 Dec;31(12):1634-46. doi: 10.1002/hed.21162. PMID: 19536850
A review of neuroendocrine neoplasms of the larynx: update on diagnosis and treatment.
Ferlito A, Barnes L, Rinaldo A, Gnepp DR, Milroy CM
J Laryngol Otol 1998 Sep;112(9):827-34. doi: 10.1017/s0022215100141830. PMID: 9876371
Neuroendocrine carcinomas of the larynx. A study of two types, one of which mimics thyroid medullary carcinoma.
Woodruff JM, Huvos AG, Erlandson RA, Shah JP, Gerold FP
Am J Surg Pathol 1985 Nov;9(11):771-90. PMID: 2866724

Diagnosis

Laryngeal paraganglioma: The analysis of misdiagnosed cases and literature review.
Dong YJ, Zhang HH, Liang JQ, Gao YY, Xiong M, Yang H
Head Neck 2024 May;46(5):1234-1247. Epub 2024 Mar 27 doi: 10.1002/hed.27762. PMID: 38533762
Laryngeal Paraganglioma-A Case Report.
Palade DO, Severin F, Vrinceanu D, Hainarosie R, Maniu A, Ahmed H, Manole F, Mocanu F, Voiosu C
Medicina (Kaunas) 2024 Jan 24;60(2) doi: 10.3390/medicina60020198. PMID: 38399485Free PMC Article
Supraglottic laryngeal paraganglioma.
Buiret G, Merrot O, Le Breton F, Landry G, Poupart M, Pignat JC
Eur Ann Otorhinolaryngol Head Neck Dis 2010 Jun;127(3):117-9. Epub 2010 May 13 doi: 10.1016/j.anorl.2010.04.002. PMID: 20822766
Diagnosis and treatment of supraglottic laryngeal paraganglioma: report of a case.
Del Gaudio JM, Muller S
Head Neck 2004 Jan;26(1):94-8. doi: 10.1002/hed.10346. PMID: 14724913
Subglottic laryngeal paraganglioma.
Maisel R, Schmidt D, Pambuccian S
Laryngoscope 2003 Mar;113(3):401-5. doi: 10.1097/00005537-200303000-00002. PMID: 12616186

Therapy

Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature.
Angouridakis N, Goudakos J, Karayannopoulou G, Triaridis S, Nikolaou A, Markou K
Head Neck 2013 Jun;35(6):E187-93. Epub 2012 Feb 6 doi: 10.1002/hed.22955. PMID: 22308009

Prognosis

Supraglottic laryngeal paraganglioma.
Buiret G, Merrot O, Le Breton F, Landry G, Poupart M, Pignat JC
Eur Ann Otorhinolaryngol Head Neck Dis 2010 Jun;127(3):117-9. Epub 2010 May 13 doi: 10.1016/j.anorl.2010.04.002. PMID: 20822766
Neuroendocrine neoplasms of the larynx: an overview.
Ferlito A, Silver CE, Bradford CR, Rinaldo A
Head Neck 2009 Dec;31(12):1634-46. doi: 10.1002/hed.21162. PMID: 19536850
Laryngeal paraganglioma: an updated critical review.
Myssiorek D, Rinaldo A, Barnes L, Ferlito A
Acta Otolaryngol 2004 Nov;124(9):995-9. doi: 10.1080/00016480410017576. PMID: 15513540
Identification, classification, treatment, and prognosis of laryngeal paraganglioma. Review of the literature and eight new cases.
Ferlito A, Barnes L, Wenig BM
Ann Otol Rhinol Laryngol 1994 Jul;103(7):525-36. doi: 10.1177/000348949410300705. PMID: 8024215
Laryngeal paraganglioma and pregnancy.
Werner JA, Hansmann ML, Lippert BM, Rudert H
ORL J Otorhinolaryngol Relat Spec 1992;54(3):163-7. doi: 10.1159/000276290. PMID: 1518667

Clinical prediction guides

Laryngeal paraganglioma: an endoscopic diode-laser-assisted surgical approach: a case report.
Capolunghi B, Bertolini G, Grillo della Berta L, Tinelli N, Cascio F, Bertoletti F
B-ENT 2005;1(2):97-100. PMID: 16044742
Inferior laryngeal paraganglioma presenting as plunging goiter.
Aribas OK, Kanat F, Avunduk MC
Eur J Cardiothorac Surg 2004 Apr;25(4):655-7. doi: 10.1016/j.ejcts.2004.01.021. PMID: 15037293
Laryngeal paraganglioma. Report of two tumors with immunohistochemical and ultrastructural analysis.
Sneige N, Mackay B, Ordonez NG, Batsakis JG
Arch Otolaryngol 1983 Feb;109(2):113-7. doi: 10.1001/archotol.1983.00800160047012. PMID: 6849664
Laryngeal paraganglioma. Case report with ultrastructural analysis and literature review.
Gallivan MV, Chun B, Rowden G, Lack EE
Am J Surg Pathol 1979 Feb;3(1):85-92. doi: 10.1097/00000478-197902000-00010. PMID: 393115

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