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Malignant Extraskeletal Cartilaginous and Osseous Neoplasm

MedGen UID:
235293
•Concept ID:
C1334583
•
Neoplastic Process
Synonym: Malignant Extraskeletal Cartilaginous and Osseous Tumor

Definition

A malignant mesenchymal neoplasm with cartilaginous or osseous differentiation arising from the soft tissues exclusively. Extraskeletal osteosarcoma is a representative example. [from NCI]

Professional guidelines

PubMed

Keratin subsets and monoclonal antibody HBME-1 in chordoma: immunohistochemical differential diagnosis between tumors simulating chordoma.
O'Hara BJ, Paetau A, Miettinen M
Hum Pathol 1998 Feb;29(2):119-26. doi: 10.1016/s0046-8177(98)90220-9. PMID: 9490269

Recent clinical studies

Etiology

Falcine and parasagittal chondrosarcomas.
Safaee M, Clark AJ, Tihan T, Parsa AT, Bloch O
J Clin Neurosci 2013 Sep;20(9):1232-6. Epub 2013 Jun 10 doi: 10.1016/j.jocn.2013.01.004. PMID: 23759737
Update on chondrosarcomas.
Chow WA
Curr Opin Oncol 2007 Jul;19(4):371-6. doi: 10.1097/CCO.0b013e32812143d9. PMID: 17545802
Genetics of chondrosarcoma and related tumors.
Sandberg AA
Curr Opin Oncol 2004 Jul;16(4):342-54. doi: 10.1097/01.cco.0000129678.72521.e5. PMID: 15187889
Extraskeletal chondromas.
Marcial-Seoane RA, Marcial-Seoane MA, Ramos E, Marcial-Rojas RA
Bol Asoc Med P R 1990 Sep;82(9):394-402. PMID: 2076144
Extraskeletal osteosarcoma.
Chung EB, Enzinger FM
Cancer 1987 Sep 1;60(5):1132-42. doi: 10.1002/1097-0142(19870901)60:5<1132::aid-cncr2820600536>3.0.co;2-l. PMID: 3475157

Diagnosis

Extraskeletal cartilaginous, osseous, and chordoid tumors in children and adolescents.
Cates JM, Coffin CM
Pediatr Dev Pathol 2012;15(1 Suppl):255-66. doi: 10.2350/10-07-0875-PB.1. PMID: 22420731
Genetics of chondrosarcoma and related tumors.
Sandberg AA
Curr Opin Oncol 2004 Jul;16(4):342-54. doi: 10.1097/01.cco.0000129678.72521.e5. PMID: 15187889
From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation.
Murphey MD, Walker EA, Wilson AJ, Kransdorf MJ, Temple HT, Gannon FH
Radiographics 2003 Sep-Oct;23(5):1245-78. doi: 10.1148/rg.235035134. PMID: 12975513
Extraskeletal chondromas.
Marcial-Seoane RA, Marcial-Seoane MA, Ramos E, Marcial-Rojas RA
Bol Asoc Med P R 1990 Sep;82(9):394-402. PMID: 2076144
Polyhistioma: a malignant tumor of bone and extraskeletal tissues.
Jacobson SA
Cancer 1977 Nov;40(5):2116-30. doi: 10.1002/1097-0142(197711)40:5<2116::aid-cncr2820400522>3.0.co;2-l. PMID: 336183

Therapy

Extraskeletal osteosarcoma of the pleura:report of a case.
Shiota H, Yasukawa T, Hirai A, Chiyo M, Yusa T, Hiroshima K
Ann Thorac Cardiovasc Surg 2013;19(4):297-301. Epub 2012 Nov 17 doi: 10.5761/atcs.cr.12.01964. PMID: 23232263
Quiz. Correct answer to the quiz. Check your diagnosis. Mesenchymal chondrosarcoma of the orbit: two cases and a brief review of the literature.
Szumera-Ciećkiewicz A, Ptaszyński K, Grabowski P, Krajewski R, Tacikowska M
Pol J Pathol 2012 Mar;63(1):80-4. PMID: 22535612
Mesenchymal chondrosarcoma of the orbit: a report of two cases and review of the literature.
Kaur A, Kishore P, Agrawal A, Gupta A
Orbit 2008;27(1):63-7. doi: 10.1080/01676830601169007. PMID: 18307151

Prognosis

Bone Tumors Occurring in the Soft Tissues: A Review of the Clinical, Imaging, and Histopathologic Findings.
Veselis CA, Awan O, Thomas A, Ling S, Jonnalagadda P, Aneja A, Ali S
Curr Probl Diagn Radiol 2021 May-Jun;50(3):419-429. Epub 2020 Jun 26 doi: 10.1067/j.cpradiol.2020.06.004. PMID: 32665061
Falcine and parasagittal chondrosarcomas.
Safaee M, Clark AJ, Tihan T, Parsa AT, Bloch O
J Clin Neurosci 2013 Sep;20(9):1232-6. Epub 2013 Jun 10 doi: 10.1016/j.jocn.2013.01.004. PMID: 23759737
Update on chondrosarcomas.
Chow WA
Curr Opin Oncol 2007 Jul;19(4):371-6. doi: 10.1097/CCO.0b013e32812143d9. PMID: 17545802
From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation.
Murphey MD, Walker EA, Wilson AJ, Kransdorf MJ, Temple HT, Gannon FH
Radiographics 2003 Sep-Oct;23(5):1245-78. doi: 10.1148/rg.235035134. PMID: 12975513
Malignant cartilaginous tumors of the mediastinum: clinicopathological study of six cases presenting as extraskeletal soft tissue masses.
Suster S, Moran CA
Hum Pathol 1997 May;28(5):588-94. doi: 10.1016/s0046-8177(97)90081-2. PMID: 9158707

Clinical prediction guides

GRM1 Immunohistochemistry Distinguishes Chondromyxoid Fibroma From its Histologic Mimics.
Toland AMS, Lam SW, Varma S, Wang A, Howitt BE, Kunder CA, Kerr DA, Szuhai K, Bovée JVMG, Charville GW
Am J Surg Pathol 2022 Oct 1;46(10):1407-1414. Epub 2022 Jun 1 doi: 10.1097/PAS.0000000000001921. PMID: 35650682Free PMC Article
Extraskeletal osteosarcoma of the pleura:report of a case.
Shiota H, Yasukawa T, Hirai A, Chiyo M, Yusa T, Hiroshima K
Ann Thorac Cardiovasc Surg 2013;19(4):297-301. Epub 2012 Nov 17 doi: 10.5761/atcs.cr.12.01964. PMID: 23232263
A low-grade extraskeletal osteosarcoma.
Okada K, Ito H, Miyakoshi N, Sageshima M, Nishida J, Itoi E
Skeletal Radiol 2003 Mar;32(3):165-9. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0589-6. PMID: 12605283
Malignant cartilaginous tumors of the mediastinum: clinicopathological study of six cases presenting as extraskeletal soft tissue masses.
Suster S, Moran CA
Hum Pathol 1997 May;28(5):588-94. doi: 10.1016/s0046-8177(97)90081-2. PMID: 9158707
From the archives of the AFIP. Extraskeletal osseous and cartilaginous tumors of the extremities.
Kransdorf MJ, Meis JM
Radiographics 1993 Jul;13(4):853-84. doi: 10.1148/radiographics.13.4.8356273. PMID: 8356273

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