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Malignant prostate phyllodes tumor

MedGen UID:
235301
•Concept ID:
C1334615
•
Neoplastic Process
Synonyms: Malignant Phyllodes Tumor of Prostate; Phyllodes Tumor of the Prostate
 
Monarch Initiative: MONDO:0000994

Definition

An unusual malignant tumor that arises from the prostate gland. It is characterized by the presence of glandular elements and a cellular stroma that exhibits mitotic activity and nuclear atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant prostate phyllodes tumor

Recent clinical studies

Etiology

Re-evaluating tumors of purported specialized prostatic stromal origin reveals molecular heterogeneity, including non-recurring gene fusions characteristic of uterine and soft tissue sarcoma subtypes.
Acosta AM, Sholl LM, Dickson BC, McKenney JK, Gordetsky JB, Pins MR, Marino-Enriquez A, Dong F, Dubuc AM, Cin PD, Fletcher CDM
Mod Pathol 2021 Sep;34(9):1763-1779. Epub 2021 May 13 doi: 10.1038/s41379-021-00818-6. PMID: 33986460
Giant cystosarcoma phyllodes tumor of prostate: case report of a rare entity.
Bhat DM, Poflee SV, Kotwal MN, Pangarkar MA, Gadkari RU, Bobhate SK
Indian J Cancer 2004 Jul-Sep;41(3):129-32. PMID: 15472412
Phyllodes tumor of the prostate: long-term followup study of 23 cases.
Bostwick DG, Hossain D, Qian J, Neumann RM, Yang P, Young RH, di Sant'agnese PA, Jones EC
J Urol 2004 Sep;172(3):894-9. doi: 10.1097/01.ju.0000134580.71261.57. PMID: 15310992
Malignant phyllodes tumor of the prostate: retrospective review of specimens obtained by sequential transurethral resection.
Watanabe M, Yamada Y, Kato H, Imai H, Nakano H, Araki T, Shiraishi T
Pathol Int 2002 Dec;52(12):777-83. doi: 10.1046/j.1440-1827.2002.01417.x. PMID: 12588447
Relative frequency and morphology of cancers in carriers of germline TP53 mutations.
Birch JM, Alston RD, McNally RJ, Evans DG, Kelsey AM, Harris M, Eden OB, Varley JM
Oncogene 2001 Aug 2;20(34):4621-8. doi: 10.1038/sj.onc.1204621. PMID: 11498785

Diagnosis

Adult NTRK-rearranged spindle cell neoplasms of the viscera: with an emphasis on rare locations and heterologous elements.
Tsai JW, Lee JC, Hsieh TH, Huang SC, Lee PH, Liu TT, Kao YC, Chang CD, Weng TF, Li CF, Lin JC, Liang CW, Su YL, Chang IY, Wang YT, Chang NY, Yu SC, Wang JC, Huang HY
Mod Pathol 2022 Jul;35(7):911-921. Epub 2022 Feb 11 doi: 10.1038/s41379-021-01005-3. PMID: 35149769
Multicystic Prostate Tumor.
Lorenz U, Samaseika Y, Balsmeyer U, Neumann N, Ritter M, Froehner M
Urology 2021 Nov;157:41. Epub 2021 Jun 15 doi: 10.1016/j.urology.2021.06.003. PMID: 34139252
Prostatic stromal proliferations: a review.
Bostwick DG, Egevad L
Pathology 2021 Jan;53(1):12-25. Epub 2020 Nov 13 doi: 10.1016/j.pathol.2020.09.017. PMID: 33190920
Rapidly progressing malignant phyllodes tumor of the prostate with normal prostate-specific antigen levels: A case report.
Zhang X, Hu J, Xu X, Cheng L
Indian J Pathol Microbiol 2020 Feb;63(Supplement):S50-S52. doi: 10.4103/IJPM.IJPM_427_18. PMID: 32108628
Nonepithelial tumors and tumor-like lesions of the prostate gland.
Shabaik A
Crit Rev Clin Lab Sci 2003 Aug;40(4):429-72. doi: 10.1080/10408360390247823. PMID: 14582603

Therapy

Solitary Fibrous Tumor With Extensive Epithelial Inclusions.
Zhao M, He H, Cao D, Fan D, Xu M, Zhang X, Ru G
Am J Clin Pathol 2022 Jul 1;158(1):35-46. doi: 10.1093/ajcp/aqab211. PMID: 34999741
Does Prophylactic Radiation Therapy to Avoid Gynecomastia in Patients With Prostate Cancer Increase the Risk of Breast Cancer?
Aksnessæther BY, Solberg A, Klepp OH, Myklebust TÅ, Skovlund E, Hoff SR, Vatten LJ, Lund JÅ
Int J Radiat Oncol Biol Phys 2018 May 1;101(1):211-216. Epub 2018 Feb 5 doi: 10.1016/j.ijrobp.2018.01.096. PMID: 29534900
Male Malignant Phyllodes Breast Tumor After Prophylactic Breast Radiotherapy and Bicalutamide Treatment: A Case Report.
Karihtala P, Rissanen T, Tuominen H
Anticancer Res 2016 Jul;36(7):3433-6. PMID: 27354604
Chemotherapy induced complete remission in malignant phyllodes tumor of the prostate metastasizing to the lung.
Lam KC, Yeo W
J Urol 2002 Sep;168(3):1104-5. doi: 10.1016/S0022-5347(05)64590-9. PMID: 12187238
Cystosarcoma phyllodes of the prostate with rhabdomyoblastic differentiation.
De Raeve H, Jeuris W, Wyndaele JJ, Van Marck E
Pathol Res Pract 2001;197(10):657-62. doi: 10.1078/0344-0338-00142. PMID: 11700886

Prognosis

Solitary Fibrous Tumor With Extensive Epithelial Inclusions.
Zhao M, He H, Cao D, Fan D, Xu M, Zhang X, Ru G
Am J Clin Pathol 2022 Jul 1;158(1):35-46. doi: 10.1093/ajcp/aqab211. PMID: 34999741
Rapidly progressing malignant phyllodes tumor of the prostate with normal prostate-specific antigen levels: A case report.
Zhang X, Hu J, Xu X, Cheng L
Indian J Pathol Microbiol 2020 Feb;63(Supplement):S50-S52. doi: 10.4103/IJPM.IJPM_427_18. PMID: 32108628
Phyllodes tumor of the prostate.
Aguilar B, Villalobos M, Sotomayor M
Urology 2009 Feb;73(2):272. Epub 2008 Oct 18 doi: 10.1016/j.urology.2008.08.466. PMID: 18930515
Lung metastases of low grade phyllodes tumor of the prostate: histopathologic confirmation.
Parada D, Ugas G, Peña K, Caricote L, Mujica N
Arch Esp Urol 2008 Jun;61(5):658-62. doi: 10.4321/s0004-06142008000500017. PMID: 18709826
Nonepithelial tumors and tumor-like lesions of the prostate gland.
Shabaik A
Crit Rev Clin Lab Sci 2003 Aug;40(4):429-72. doi: 10.1080/10408360390247823. PMID: 14582603

Clinical prediction guides

Adult NTRK-rearranged spindle cell neoplasms of the viscera: with an emphasis on rare locations and heterologous elements.
Tsai JW, Lee JC, Hsieh TH, Huang SC, Lee PH, Liu TT, Kao YC, Chang CD, Weng TF, Li CF, Lin JC, Liang CW, Su YL, Chang IY, Wang YT, Chang NY, Yu SC, Wang JC, Huang HY
Mod Pathol 2022 Jul;35(7):911-921. Epub 2022 Feb 11 doi: 10.1038/s41379-021-01005-3. PMID: 35149769
Solitary Fibrous Tumor With Extensive Epithelial Inclusions.
Zhao M, He H, Cao D, Fan D, Xu M, Zhang X, Ru G
Am J Clin Pathol 2022 Jul 1;158(1):35-46. doi: 10.1093/ajcp/aqab211. PMID: 34999741
Mixed epithelial-stromal tumor (MEST) of seminal vesicle: a proposal for unified nomenclature.
Reikie BA, Yilmaz A, Medlicott S, Trpkov K
Adv Anat Pathol 2015 Mar;22(2):113-20. doi: 10.1097/PAP.0000000000000057. PMID: 25664946
Lung metastases of low grade phyllodes tumor of the prostate: histopathologic confirmation.
Parada D, Ugas G, Peña K, Caricote L, Mujica N
Arch Esp Urol 2008 Jun;61(5):658-62. doi: 10.4321/s0004-06142008000500017. PMID: 18709826
Phyllodes tumor of the prostate: long-term followup study of 23 cases.
Bostwick DG, Hossain D, Qian J, Neumann RM, Yang P, Young RH, di Sant'agnese PA, Jones EC
J Urol 2004 Sep;172(3):894-9. doi: 10.1097/01.ju.0000134580.71261.57. PMID: 15310992

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