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Mediastinal Choriocarcinoma

MedGen UID:
235307
•Concept ID:
C1334651
•
Neoplastic Process
Synonyms: Choriocarcinoma of Mediastinum; Choriocarcinoma of the Mediastinum

Definition

An extragonadal malignant germ cell tumor that arises from the mediastinum and is composed of syncytiotrophoblasts, cytotrophoblasts, and intermediate trophoblasts. The prognosis is usually poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinal Choriocarcinoma

Professional guidelines

PubMed

Surgical treatment confers prognostic significance in pediatric malignant mediastinal germ cell tumors.
Huang TH, Hung GY, Weng TF, Wang FM, Lee CY, Lin DT, Chen BW, Lin KH, Wu KH, Liu HC, Chen JS, Jou ST, Hou JY, Yang YL, Chen SH, Chang HH, Chiou SS, Lin PC, Chen RL, Hsiao CC, Yen HJ, Yang CP, Chang TK, Lu MY, Cheng CN, Sheen JM, Liao YM, Su MY, Yeh TC; Taiwan Pediatric Oncology Group
Cancer 2022 Dec 1;128(23):4139-4149. Epub 2022 Oct 12 doi: 10.1002/cncr.34494. PMID: 36223226
Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846

Recent clinical studies

Etiology

Sexual precocity and recurrent beta-human chorionic gonadotropin upsurges preceding the diagnosis of a malignant mediastinal germ-cell tumor in a 9-year-old boy.
Schwabe J, Calaminus G, Vorhoff W, Engelbrecht V, Hauffa BP, Göbel U
Ann Oncol 2002 Jun;13(6):975-7. doi: 10.1093/annonc/mdf085. PMID: 12123344

Diagnosis

Extragonadal Germ Cell Tumors of the Mediastinum and Retroperitoneum: A Surveillance, Epidemiology, and End Results-based Study.
Aguiar Bujanda D, Pérez Cabrera D, Croissier Sánchez L
Am J Clin Oncol 2022 Dec 1;45(12):493-500. Epub 2022 Nov 17 doi: 10.1097/COC.0000000000000959. PMID: 36394133
Primary non-gestational mediastinal choriocarcinoma metastatic to the brainstem.
De Jesus O, Pellot Cestero JE, Gómez-González FM, Vélez R
BMJ Case Rep 2022 Apr 1;15(4) doi: 10.1136/bcr-2021-248389. PMID: 35365470Free PMC Article
Male primary mediastinal choriocarcinoma with diffuse metastases: A case report.
Qiu Z, Wu Y, Wang Y, Hu C
Medicine (Baltimore) 2019 Jul;98(28):e16411. doi: 10.1097/MD.0000000000016411. PMID: 31305456Free PMC Article
Primary mediastinal choriocarcinoma.
Br Med J 1969 Apr 19;2(5650):135-6. PMID: 5813550Free PMC Article
Primary mediastinal choriocarcinoma.
Wenger ME, Dines DE, Ahmann DL, Good CA
Mayo Clin Proc 1968 Aug;43(8):570-5. PMID: 5751793

Therapy

Primary mediastinal choriocarcinoma with brain metastasis in a female patient.
Kuno I, Matsumoto Y, Kasai M, Fukuda T, Hashiguchi Y, Ichimura T, Yasui T, Sumi T
Eur J Gynaecol Oncol 2016;37(2):265-6. PMID: 27172760
Mediastinal choriocarcinoma presenting with syncope.
Dasanu CA, Shimanovsky A, Jain K, Codreanu I
Conn Med 2013 Sep;77(8):473-5. PMID: 24156175
Primary mediastinal choriocarcinoma in a man.
Cohen BA, Needle MA
Chest 1975 Jan;67(1):106-8. doi: 10.1378/chest.67.1.106. PMID: 1088117
Primary mediastinal choriocarcinoma.
Prusty S, Bhayana JN, Nayak NC, Singh S, Singhal VS, Sharma SR, Goel PP
Dis Chest 1969 Dec;56(6):543-6. doi: 10.1378/chest.56.6.543. PMID: 5389350
Primary mediastinal choriocarcinoma.
Wenger ME, Dines DE, Ahmann DL, Good CA
Mayo Clin Proc 1968 Aug;43(8):570-5. PMID: 5751793

Prognosis

Primary mediastinal choriocarcinoma in an 18-year-old male with pulmonary and brain metastasis: A case report.
Wang H, Chen X, Zhang R
Clin Respir J 2023 Oct;17(10):1082-1087. Epub 2023 Aug 23 doi: 10.1111/crj.13691. PMID: 37614074Free PMC Article
Extragonadal Germ Cell Tumors of the Mediastinum and Retroperitoneum: A Surveillance, Epidemiology, and End Results-based Study.
Aguiar Bujanda D, Pérez Cabrera D, Croissier Sánchez L
Am J Clin Oncol 2022 Dec 1;45(12):493-500. Epub 2022 Nov 17 doi: 10.1097/COC.0000000000000959. PMID: 36394133
Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review.
Murshed KA, Kanbour A, Akhtar M, Al Hyassat S
J Cutan Pathol 2021 Jan;48(1):81-85. Epub 2020 Jun 29 doi: 10.1111/cup.13777. PMID: 32542793
Primary mediastinal choriocarcinoma.
Br Med J 1969 Apr 19;2(5650):135-6. PMID: 5813550Free PMC Article
Primary mediastinal choriocarcinoma.
Prusty S, Bhayana JN, Nayak NC, Singh S, Singhal VS, Sharma SR, Goel PP
Dis Chest 1969 Dec;56(6):543-6. doi: 10.1378/chest.56.6.543. PMID: 5389350

Clinical prediction guides

Extragonadal Germ Cell Tumors of the Mediastinum and Retroperitoneum: A Surveillance, Epidemiology, and End Results-based Study.
Aguiar Bujanda D, Pérez Cabrera D, Croissier Sánchez L
Am J Clin Oncol 2022 Dec 1;45(12):493-500. Epub 2022 Nov 17 doi: 10.1097/COC.0000000000000959. PMID: 36394133

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