U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Megaloblastic erythroid hyperplasia

MedGen UID:
235316
•Concept ID:
C1334688
•
Finding
Synonyms: Bone marrow biopsy shows megaloblastic erythroid hyperplasia; Megaloblastic Erythroid Hyperplasia
 
HPO: HP:0200143

Definition

A laboratory test result indicating an abnormally high quantity of abnormal immature red blood cells with megaloblastic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMegaloblastic erythroid hyperplasia

Conditions with this feature

Hereditary intrinsic factor deficiency
MedGen UID:
235598
•Concept ID:
C1394891
•
Disease or Syndrome
Congenital pernicious anemia (PA), or intrinsic factor deficiency, is a rare disorder characterized by the lack of gastric intrinsic factor in the presence of normal acid secretion and mucosal cytology and the absence of GIF antibodies that are found in the acquired form of pernicious anemia (170900). See also pernicious anemia due to defect in the receptor for vitamin B12/intrinsic factor (261100).
See: Condition Record
Hereditary intrinsic factor deficiency

Recent clinical studies

Etiology

Bone marrow examination in cases of pancytopenia.
Jha A, Sayami G, Adhikari RC, Panta AD, Jha R
JNMA J Nepal Med Assoc 2008 Jan-Mar;47(169):12-7. PMID: 18552886
Paroxysmal nocturnal hemoglobinuria: a study of 17 cases.
Parab RB
J Postgrad Med 1990 Jan;36(1):23-6. PMID: 2097351
The prevention of anaemia in pregnancy in primigravidae in the guinea savanna of Nigeria.
Fleming AF, Ghatoura GB, Harrison KA, Briggs ND, Dunn DT
Ann Trop Med Parasitol 1986 Apr;80(2):211-33. doi: 10.1080/00034983.1986.11812006. PMID: 3530158
Postleukemic dysmyelopoiesis.
Foucar K, Vaughan WP, Armitage JO, Patil S, Dick F, Karp JE
Am J Hematol 1983 Dec;15(4):321-34. doi: 10.1002/ajh.2830150403. PMID: 6650493
Erythroleukemia: a study of 15 cases and literature review.
Roggli VL, Saleem A
Cancer 1982 Jan 1;49(1):101-8. doi: 10.1002/1097-0142(19820101)49:1<101::aid-cncr2820490121>3.0.co;2-o. PMID: 6947855

Diagnosis

A clinical, histopathological, and molecular study of two cases of VEXAS syndrome without a definitive myeloid neoplasm.
Li P, Venkatachalam S, Ospina Cordona D, Wilson L, Kovacsovics T, Moser KA, Miles RR, Beck DB, George T, Tantravahi SK
Blood Adv 2022 Jan 25;6(2):405-409. doi: 10.1182/bloodadvances.2021005243. PMID: 34649277Free PMC Article
Bone marrow examination in cases of pancytopenia.
Jha A, Sayami G, Adhikari RC, Panta AD, Jha R
JNMA J Nepal Med Assoc 2008 Jan-Mar;47(169):12-7. PMID: 18552886
Bone marrow in sickle cell anaemia at time of anaemic crisis.
Nkrumah FK, Neequaye JE, Ankra-Badu G
Arch Dis Child 1984 Jun;59(6):561-5. doi: 10.1136/adc.59.6.561. PMID: 6742877Free PMC Article
Erythroleukemia: a study of 15 cases and literature review.
Roggli VL, Saleem A
Cancer 1982 Jan 1;49(1):101-8. doi: 10.1002/1097-0142(19820101)49:1<101::aid-cncr2820490121>3.0.co;2-o. PMID: 6947855
Intracellular hemoglobin-a specific marker for erythroid cells in paraffin sections. An immunoperoxidase study of normal, megaloblastic, and dysplastic erythropoiesis, including erythroleukemia and other myeloproliferative disorders.
Pinkus GS, Said JW
Am J Pathol 1981 Mar;102(3):308-13. PMID: 7011040Free PMC Article

Therapy

Severe megaloblastic anaemia presenting as pancytopenia with red cell hypoplasia and elevated serum cobalamin and cobalamin binding proteins.
O'Brien HA, Sourial NA
Clin Lab Haematol 1991;13(3):307-10. doi: 10.1111/j.1365-2257.1991.tb00286.x. PMID: 1794233
The prevention of anaemia in pregnancy in primigravidae in the guinea savanna of Nigeria.
Fleming AF, Ghatoura GB, Harrison KA, Briggs ND, Dunn DT
Ann Trop Med Parasitol 1986 Apr;80(2):211-33. doi: 10.1080/00034983.1986.11812006. PMID: 3530158
Postleukemic dysmyelopoiesis.
Foucar K, Vaughan WP, Armitage JO, Patil S, Dick F, Karp JE
Am J Hematol 1983 Dec;15(4):321-34. doi: 10.1002/ajh.2830150403. PMID: 6650493
Effects of transfusion on serum iron, serum lactate dehydrogenase and platelets in megaloblastic anemia.
Fillet G, Andrien JM, Bury J
Am J Clin Pathol 1977 Oct;68(4):458-62. doi: 10.1093/ajcp/68.4.458. PMID: 906975

Prognosis

Erythroleukemia: a study of 15 cases and literature review.
Roggli VL, Saleem A
Cancer 1982 Jan 1;49(1):101-8. doi: 10.1002/1097-0142(19820101)49:1<101::aid-cncr2820490121>3.0.co;2-o. PMID: 6947855

Clinical prediction guides

A study of cell proliferation in formalin-fixed, wax-embedded bone marrow trephine biopsies using the monoclonal antibody PC10, reactive with proliferating cell nuclear antigen (PCNA).
Wilkins BS, Harris S, Waseem NH, Lane DP, Jones DB
J Pathol 1992 Jan;166(1):45-52. doi: 10.1002/path.1711660108. PMID: 1347081
Paroxysmal nocturnal hemoglobinuria: a study of 17 cases.
Parab RB
J Postgrad Med 1990 Jan;36(1):23-6. PMID: 2097351
The prevention of anaemia in pregnancy in primigravidae in the guinea savanna of Nigeria.
Fleming AF, Ghatoura GB, Harrison KA, Briggs ND, Dunn DT
Ann Trop Med Parasitol 1986 Apr;80(2):211-33. doi: 10.1080/00034983.1986.11812006. PMID: 3530158
Effects of transfusion on serum iron, serum lactate dehydrogenase and platelets in megaloblastic anemia.
Fillet G, Andrien JM, Bury J
Am J Clin Pathol 1977 Oct;68(4):458-62. doi: 10.1093/ajcp/68.4.458. PMID: 906975
Arsenic intoxication as a cause of megaloblastic anemia.
Westhoff DD, Samaha RJ, Barnes A Jr
Blood 1975 Feb;45(2):241-6. PMID: 1120185

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...