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Megaloblastic erythroid hyperplasia

MedGen UID:
235316
Concept ID:
C1334688
Finding
Synonyms: Bone marrow biopsy shows megaloblastic erythroid hyperplasia; Megaloblastic Erythroid Hyperplasia
 
HPO: HP:0200143

Definition

A laboratory test result indicating an abnormally high quantity of abnormal immature red blood cells with megaloblastic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMegaloblastic erythroid hyperplasia

Conditions with this feature

Hereditary intrinsic factor deficiency
MedGen UID:
235598
Concept ID:
C1394891
Disease or Syndrome
Congenital pernicious anemia (PA), or intrinsic factor deficiency, is a rare disorder characterized by the lack of gastric intrinsic factor in the presence of normal acid secretion and mucosal cytology and the absence of GIF antibodies that are found in the acquired form of pernicious anemia (170900). See also pernicious anemia due to defect in the receptor for vitamin B12/intrinsic factor (261100).

Recent clinical studies

Etiology

Jha A, Sayami G, Adhikari RC, Panta AD, Jha R
JNMA J Nepal Med Assoc 2008 Jan-Mar;47(169):12-7. PMID: 18552886
Parab RB
J Postgrad Med 1990 Jan;36(1):23-6. PMID: 2097351
Fleming AF, Ghatoura GB, Harrison KA, Briggs ND, Dunn DT
Ann Trop Med Parasitol 1986 Apr;80(2):211-33. doi: 10.1080/00034983.1986.11812006. PMID: 3530158
Foucar K, Vaughan WP, Armitage JO, Patil S, Dick F, Karp JE
Am J Hematol 1983 Dec;15(4):321-34. doi: 10.1002/ajh.2830150403. PMID: 6650493
Roggli VL, Saleem A
Cancer 1982 Jan 1;49(1):101-8. doi: 10.1002/1097-0142(19820101)49:1<101::aid-cncr2820490121>3.0.co;2-o. PMID: 6947855

Diagnosis

Li P, Venkatachalam S, Ospina Cordona D, Wilson L, Kovacsovics T, Moser KA, Miles RR, Beck DB, George T, Tantravahi SK
Blood Adv 2022 Jan 25;6(2):405-409. doi: 10.1182/bloodadvances.2021005243. PMID: 34649277Free PMC Article
Mokhtari M, Kumar PV
Arch Iran Med 2013 Aug;16(8):471-3. PMID: 23906252
Jha A, Sayami G, Adhikari RC, Panta AD, Jha R
JNMA J Nepal Med Assoc 2008 Jan-Mar;47(169):12-7. PMID: 18552886
Roggli VL, Saleem A
Cancer 1982 Jan 1;49(1):101-8. doi: 10.1002/1097-0142(19820101)49:1<101::aid-cncr2820490121>3.0.co;2-o. PMID: 6947855
Pinkus GS, Said JW
Am J Pathol 1981 Mar;102(3):308-13. PMID: 7011040Free PMC Article

Therapy

O'Brien HA, Sourial NA
Clin Lab Haematol 1991;13(3):307-10. doi: 10.1111/j.1365-2257.1991.tb00286.x. PMID: 1794233
Fleming AF, Ghatoura GB, Harrison KA, Briggs ND, Dunn DT
Ann Trop Med Parasitol 1986 Apr;80(2):211-33. doi: 10.1080/00034983.1986.11812006. PMID: 3530158
Foucar K, Vaughan WP, Armitage JO, Patil S, Dick F, Karp JE
Am J Hematol 1983 Dec;15(4):321-34. doi: 10.1002/ajh.2830150403. PMID: 6650493
Fillet G, Andrien JM, Bury J
Am J Clin Pathol 1977 Oct;68(4):458-62. doi: 10.1093/ajcp/68.4.458. PMID: 906975

Prognosis

Roggli VL, Saleem A
Cancer 1982 Jan 1;49(1):101-8. doi: 10.1002/1097-0142(19820101)49:1<101::aid-cncr2820490121>3.0.co;2-o. PMID: 6947855

Clinical prediction guides

Wilkins BS, Harris S, Waseem NH, Lane DP, Jones DB
J Pathol 1992 Jan;166(1):45-52. doi: 10.1002/path.1711660108. PMID: 1347081
Parab RB
J Postgrad Med 1990 Jan;36(1):23-6. PMID: 2097351
Fleming AF, Ghatoura GB, Harrison KA, Briggs ND, Dunn DT
Ann Trop Med Parasitol 1986 Apr;80(2):211-33. doi: 10.1080/00034983.1986.11812006. PMID: 3530158
Fillet G, Andrien JM, Bury J
Am J Clin Pathol 1977 Oct;68(4):458-62. doi: 10.1093/ajcp/68.4.458. PMID: 906975
Westhoff DD, Samaha RJ, Barnes A Jr
Blood 1975 Feb;45(2):241-6. PMID: 1120185

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