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Mesonephric Hyperplasia

MedGen UID:
235320
•Concept ID:
C1334702
•
Pathologic Function

Definition

A hyperplasia of the mesonephric cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesonephric Hyperplasia

Professional guidelines

PubMed

Immunohistochemical staining for Ki-67 antigen, carcinoembryonic antigen, and p53 in the differential diagnosis of glandular lesions of the cervix.
Cina SJ, Richardson MS, Austin RM, Kurman RJ
Mod Pathol 1997 Mar;10(3):176-80. PMID: 9071723
The differential diagnosis of prostatic carcinoma. Its distinction from premalignant and pseudocarcinomatous lesions of the prostate gland.
Jones EC, Young RH
Am J Clin Pathol 1994 Jan;101(1):48-64. doi: 10.1093/ajcp/101.1.48. PMID: 7506479

Recent clinical studies

Etiology

Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy.
Chen YB, Fine SW, Epstein JI
Am J Surg Pathol 2011 Jul;35(7):1054-61. doi: 10.1097/PAS.0b013e318218df97. PMID: 21606823

Diagnosis

Mesonephric proliferations of the female genital tract.
Howitt BE, Nucci MR
Pathology 2018 Feb;50(2):141-150. Epub 2017 Dec 19 doi: 10.1016/j.pathol.2017.11.084. PMID: 29269124
Pseudoneoplastic glandular lesions of the uterine cervix: a selective review.
Nucci MR
Int J Gynecol Pathol 2014 Jul;33(4):330-8. doi: 10.1097/PGP.0000000000000139. PMID: 24901392
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature.
Meguro S, Yasuda M, Shimizu M, Kurosaki A, Fujiwara K
Diagn Pathol 2013 May 7;8:74. doi: 10.1186/1746-1596-8-74. PMID: 23651629Free PMC Article
Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy.
Chen YB, Fine SW, Epstein JI
Am J Surg Pathol 2011 Jul;35(7):1054-61. doi: 10.1097/PAS.0b013e318218df97. PMID: 21606823
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
Rabban JT, McAlhany S, Lerwill MF, Grenert JP, Zaloudek CJ
Am J Surg Pathol 2010 Feb;34(2):137-46. doi: 10.1097/PAS.0b013e3181c89c98. PMID: 20061933

Therapy

Clear cell tumors of the female genital tract.
Matias-Guiu X, Lerma E, Prat J
Semin Diagn Pathol 1997 Nov;14(4):233-9. PMID: 9383823

Prognosis

Incidental mesonephric remnant hyperplasia of the jejunal mesentery: A diagnostic challenge.
Val-Bernal JF, Mayorga MM, Calapaquí-Terán AK, Toledo E
Pathol Res Pract 2021 Apr;220:153388. Epub 2021 Feb 18 doi: 10.1016/j.prp.2021.153388. PMID: 33647867
Atypical Mesonephric Hyperplasia of the Uterus Harbors Pathogenic Mutation of Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (KRAS) and Gain of Chromosome 1q.
Kim H, Yoon N, Woo HY, Lee EJ, DO SI, Na K, Kim HS
Cancer Genomics Proteomics 2020 Nov-Dec;17(6):813-826. doi: 10.21873/cgp.20235. PMID: 33099482Free PMC Article
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
Rabban JT, McAlhany S, Lerwill MF, Grenert JP, Zaloudek CJ
Am J Surg Pathol 2010 Feb;34(2):137-46. doi: 10.1097/PAS.0b013e3181c89c98. PMID: 20061933
Malignant mesonephric neoplasms of the uterine cervix. A report of eight cases, including four with a malignant spindle cell component.
Clement PB, Young RH, Keh P, Ostör AG, Scully RE
Am J Surg Pathol 1995 Oct;19(10):1158-71. doi: 10.1097/00000478-199510000-00006. PMID: 7573674
Florid mesonephric hyperplasia of the cervix: a report of a case with review of the literature.
Ayroud Y, Gelfand MM, Ferenczy A
Int J Gynecol Pathol 1985;4(3):245-54. doi: 10.1097/00004347-198509000-00009. PMID: 2414240

Clinical prediction guides

Incidental mesonephric remnant hyperplasia of the jejunal mesentery: A diagnostic challenge.
Val-Bernal JF, Mayorga MM, Calapaquí-Terán AK, Toledo E
Pathol Res Pract 2021 Apr;220:153388. Epub 2021 Feb 18 doi: 10.1016/j.prp.2021.153388. PMID: 33647867
Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy.
Chen YB, Fine SW, Epstein JI
Am J Surg Pathol 2011 Jul;35(7):1054-61. doi: 10.1097/PAS.0b013e318218df97. PMID: 21606823
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
Rabban JT, McAlhany S, Lerwill MF, Grenert JP, Zaloudek CJ
Am J Surg Pathol 2010 Feb;34(2):137-46. doi: 10.1097/PAS.0b013e3181c89c98. PMID: 20061933
CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma.
McCluggage WG, Oliva E, Herrington CS, McBride H, Young RH
Histopathology 2003 Aug;43(2):144-50. doi: 10.1046/j.1365-2559.2003.01684.x. PMID: 12877729
Malignant mesonephric neoplasms of the uterine cervix. A report of eight cases, including four with a malignant spindle cell component.
Clement PB, Young RH, Keh P, Ostör AG, Scully RE
Am J Surg Pathol 1995 Oct;19(10):1158-71. doi: 10.1097/00000478-199510000-00006. PMID: 7573674

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