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Minor Salivary Gland Carcinoma ex Pleomorphic Adenoma

MedGen UID:
235329
•Concept ID:
C1334772
•
Neoplastic Process
Synonyms: Carcinoma ex Pleomorphic Adenoma of Minor Salivary Gland; Carcinoma ex Pleomorphic Adenoma of the Minor Salivary Gland

Definition

A carcinoma that arises from a pleomorphic adenoma in the minor salivary glands. Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months. Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis. In cases where there is invasion of the surrounding tissues, the clinical course is aggressive. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMinor Salivary Gland Carcinoma ex Pleomorphic Adenoma

Professional guidelines

PubMed

Multimodal treatment of patients with minor salivary gland cancer in the case of recurrent disease.
Erovic BM, Schopper C, Pammer J, Vormittag L, Maleki A, Brunner M, Heiduschka G, Grasl MCh, Thurnher D
Head Neck 2010 Sep;32(9):1167-72. doi: 10.1002/hed.21312. PMID: 20191625

Recent clinical studies

Etiology

Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma.
Seok J, Hyun SJ, Jeong WJ, Ahn SH, Kim H, Jung YH
Ear Nose Throat J 2019 Sep;98(8):504-509. Epub 2019 Jun 13 doi: 10.1177/0145561319855376. PMID: 31189352
Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence.
Valstar MH, de Ridder M, van den Broek EC, Stuiver MM, van Dijk BAC, van Velthuysen MLF, Balm AJM, Smeele LE
Oral Oncol 2017 Mar;66:93-99. Epub 2017 Jan 23 doi: 10.1016/j.oraloncology.2017.01.004. PMID: 28249655
Minimally invasive carcinosarcoma ex pleomorphic adenoma: A case report and literature review with cytohistological correlation.
Mok Y, Min En N, Chwee Ming L, Petersson F
Head Neck 2016 Sep;38(9):E2483-9. Epub 2016 Apr 15 doi: 10.1002/hed.24462. PMID: 27080524
A retrospective review of 139 major and minor salivary gland tumors.
Trenkić Božinović M, Krasić D, Katić V, Krstić M
Med Glas (Zenica) 2015 Feb;12(1):73-8. PMID: 25669341

Diagnosis

Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Carcinoma ex pleomorphic adenoma: a case report and review of literature.
Khanna D, Chaubal T, Bapat R, Abdulla AM, Philip ST, Arora S
Afr Health Sci 2019 Dec;19(4):3253-3263. doi: 10.4314/ahs.v19i4.50. PMID: 32127904Free PMC Article
Margin Analysis: Malignant Salivary Gland Neoplasms of the Head and Neck.
Ord RA, Ghazali N
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):315-324. Epub 2017 May 24 doi: 10.1016/j.coms.2017.03.008. PMID: 28551337
A retrospective review of 139 major and minor salivary gland tumors.
Trenkić Božinović M, Krasić D, Katić V, Krstić M
Med Glas (Zenica) 2015 Feb;12(1):73-8. PMID: 25669341
Fine-needle aspiration cytology of salivary gland: a review of 341 cases.
Stewart CJ, MacKenzie K, McGarry GW, Mowat A
Diagn Cytopathol 2000 Mar;22(3):139-46. doi: 10.1002/(sici)1097-0339(20000301)22:3<139::aid-dc2>3.0.co;2-a. PMID: 10679992

Therapy

Karyotypic variability and evolutionary characteristics of a polymorphous low grade adenocarcinoma in the parotid gland.
Mark J, Wedell B, Dahlenfors R, Stenman G
Cancer Genet Cytogenet 1991 Aug;55(1):19-29. doi: 10.1016/0165-4608(91)90230-r. PMID: 1913603

Prognosis

Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Margin Analysis: Malignant Salivary Gland Neoplasms of the Head and Neck.
Ord RA, Ghazali N
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):315-324. Epub 2017 May 24 doi: 10.1016/j.coms.2017.03.008. PMID: 28551337
Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence.
Valstar MH, de Ridder M, van den Broek EC, Stuiver MM, van Dijk BAC, van Velthuysen MLF, Balm AJM, Smeele LE
Oral Oncol 2017 Mar;66:93-99. Epub 2017 Jan 23 doi: 10.1016/j.oraloncology.2017.01.004. PMID: 28249655
Minimally invasive carcinosarcoma ex pleomorphic adenoma: A case report and literature review with cytohistological correlation.
Mok Y, Min En N, Chwee Ming L, Petersson F
Head Neck 2016 Sep;38(9):E2483-9. Epub 2016 Apr 15 doi: 10.1002/hed.24462. PMID: 27080524
Carcinoma ex pleomorphic adenoma. Case report.
Pallagatti S, Sheikh S, Gupta D, Das A, Singh R
N Y State Dent J 2013 Jun-Jul;79(4):52-4. PMID: 24027900

Clinical prediction guides

The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma.
Seok J, Hyun SJ, Jeong WJ, Ahn SH, Kim H, Jung YH
Ear Nose Throat J 2019 Sep;98(8):504-509. Epub 2019 Jun 13 doi: 10.1177/0145561319855376. PMID: 31189352
Cripto-1 is overexpressed in carcinoma ex pleomorphic adenoma of salivary gland.
Silva LP, da Silva LAB, Sedassari BT, de Sousa SCOM, Dos Santos Pereira J, de Souza LB, da Costa Miguel MC
Eur Arch Otorhinolaryngol 2018 Jun;275(6):1595-1600. Epub 2018 Mar 29 doi: 10.1007/s00405-018-4960-1. PMID: 29594385
Apurinic/apyrimidinic endonuclease 1 (APE1) is overexpressed in malignant transformation of salivary gland pleomorphic adenoma.
Silva LP, Santana T, Sedassari BT, de Sousa SM, Sobral APV, Freitas RA, Barboza CAG, de Souza LB
Eur Arch Otorhinolaryngol 2017 Aug;274(8):3203-3209. Epub 2017 May 18 doi: 10.1007/s00405-017-4605-9. PMID: 28523411
Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence.
Valstar MH, de Ridder M, van den Broek EC, Stuiver MM, van Dijk BAC, van Velthuysen MLF, Balm AJM, Smeele LE
Oral Oncol 2017 Mar;66:93-99. Epub 2017 Jan 23 doi: 10.1016/j.oraloncology.2017.01.004. PMID: 28249655
Multimodal treatment of patients with minor salivary gland cancer in the case of recurrent disease.
Erovic BM, Schopper C, Pammer J, Vormittag L, Maleki A, Brunner M, Heiduschka G, Grasl MCh, Thurnher D
Head Neck 2010 Sep;32(9):1167-72. doi: 10.1002/hed.21312. PMID: 20191625

Recent systematic reviews

Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695

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