U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Moderately Differentiated Malignant Neoplasm

MedGen UID:
235332
•Concept ID:
C1334791
•
Neoplastic Process

Definition

A neoplasm whose histologic characteristics are intermediate between poorly differentiated and well differentiated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerately Differentiated Malignant Neoplasm

Professional guidelines

PubMed

Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: summary and recommendations.
ASGE standards of practice committee, Forbes N, Elhanafi SE, Al-Haddad MA, Thosani NC, Draganov PV, Othman MO, Ceppa EP, Kaul V, Feely MM, Sahin I, Buxbaum JL, Calderwood AH, Chalhoub JM, Coelho-Prabhu N, Desai M, Fujii-Lau LL, Kohli DR, Kwon RS, Machicado JD, Marya NB, Pawa S, Ruan W, Sheth SG, Storm AC, Thiruvengadam NR, Qumseya BJ; (ASGE Standards of Practice Committee Chair)
Gastrointest Endosc 2023 Sep;98(3):271-284. Epub 2023 Jul 25 doi: 10.1016/j.gie.2023.03.015. PMID: 37498266
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766

Recent clinical studies

Etiology

Defining clonal hematopoiesis of indeterminate potential: evolutionary dynamics and detection under aging and inflammation.
Goldman EA, Spellman PT, Agarwal A
Cold Spring Harb Mol Case Stud 2023 Apr;9(2) Epub 2023 May 9 doi: 10.1101/mcs.a006251. PMID: 36889927Free PMC Article
Very Small Embryonic-Like Stem Cells Transform Into Cancer Stem Cells and Are Novel Candidates for Detecting/Monitoring Cancer by a Simple Blood Test.
Bhartiya D, Sharma N, Dutta S, Kumar P, Tripathi A, Tripathi A
Stem Cells 2023 Apr 25;41(4):310-318. doi: 10.1093/stmcls/sxad015. PMID: 36881778
Redifferentiation of radioiodine-refractory thyroid cancers.
Buffet C, Wassermann J, Hecht F, Leenhardt L, Dupuy C, Groussin L, Lussey-Lepoutre C
Endocr Relat Cancer 2020 May;27(5):R113-R132. doi: 10.1530/ERC-19-0491. PMID: 32191916
Optimizing Somatostatin Analog Use in Well or Moderately Differentiated Gastroenteropancreatic Neuroendocrine Tumors.
Carmona-Bayonas A, Jiménez-Fonseca P, Custodio A, Grande E, Capdevila J, López C, Teule A, Garcia-Carbonero R; Spanish Neuroendocrine Tumor Group (GETNE)
Curr Oncol Rep 2017 Sep 18;19(11):72. doi: 10.1007/s11912-017-0633-2. PMID: 28920153
Classification of thyroid follicular cell tumors: with special reference to borderline lesions.
Kakudo K, Bai Y, Liu Z, Li Y, Ito Y, Ozaki T
Endocr J 2012;59(1):1-12. Epub 2011 Sep 9 doi: 10.1507/endocrj.ej11-0184. PMID: 21908930

Diagnosis

Very Small Embryonic-Like Stem Cells Transform Into Cancer Stem Cells and Are Novel Candidates for Detecting/Monitoring Cancer by a Simple Blood Test.
Bhartiya D, Sharma N, Dutta S, Kumar P, Tripathi A, Tripathi A
Stem Cells 2023 Apr 25;41(4):310-318. doi: 10.1093/stmcls/sxad015. PMID: 36881778
Redifferentiation of radioiodine-refractory thyroid cancers.
Buffet C, Wassermann J, Hecht F, Leenhardt L, Dupuy C, Groussin L, Lussey-Lepoutre C
Endocr Relat Cancer 2020 May;27(5):R113-R132. doi: 10.1530/ERC-19-0491. PMID: 32191916
Myoepithelial tumor of soft tissue and bone: A current perspective.
Verma A, Rekhi B
Histol Histopathol 2017 Sep;32(9):861-877. Epub 2017 Feb 1 doi: 10.14670/HH-11-879. PMID: 28145559
Imaging of oligodendroglioma.
Smits M
Br J Radiol 2016;89(1060):20150857. Epub 2016 Feb 5 doi: 10.1259/bjr.20150857. PMID: 26849038Free PMC Article
Management of neuroendocrine tumors of unknown origin.
Polish A, Vergo MT, Agulnik M
J Natl Compr Canc Netw 2011 Dec;9(12):1397-402; quiz 1403. doi: 10.6004/jnccn.2011.0118. PMID: 22157557

Therapy

Selenium for preventing cancer.
Vinceti M, Filippini T, Del Giovane C, Dennert G, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Crespi CM
Cochrane Database Syst Rev 2018 Jan 29;1(1):CD005195. doi: 10.1002/14651858.CD005195.pub4. PMID: 29376219Free PMC Article
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article
Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Peto R, Davies C, Godwin J, Gray R, Pan HC, Clarke M, Cutter D, Darby S, McGale P, Taylor C, Wang YC, Bergh J, Di Leo A, Albain K, Swain S, Piccart M, Pritchard K
Lancet 2012 Feb 4;379(9814):432-44. Epub 2011 Dec 5 doi: 10.1016/S0140-6736(11)61625-5. PMID: 22152853Free PMC Article
Bexarotene.
Lowe MN, Plosker GL
Am J Clin Dermatol 2000 Jul-Aug;1(4):245-50; discussion 251-2. doi: 10.2165/00128071-200001040-00006. PMID: 11702369
Hairy cell leukemia.
Jansen J
Crit Rev Oncol Hematol 1987;7(3):183-217. doi: 10.1016/s1040-8428(87)80008-2. PMID: 3315275

Prognosis

Clinical and pathological risk factors for worse stage and mortality of eyelid and periocular squamous cell carcinoma.
Luo Y, Chen H, Ge S, Rao Y, Yu J, Fan X, Jia R, Xu S, Wang Y
Br J Ophthalmol 2022 Oct;106(10):1338-1343. Epub 2021 Apr 20 doi: 10.1136/bjophthalmol-2020-317546. PMID: 33879470
Optimizing Somatostatin Analog Use in Well or Moderately Differentiated Gastroenteropancreatic Neuroendocrine Tumors.
Carmona-Bayonas A, Jiménez-Fonseca P, Custodio A, Grande E, Capdevila J, López C, Teule A, Garcia-Carbonero R; Spanish Neuroendocrine Tumor Group (GETNE)
Curr Oncol Rep 2017 Sep 18;19(11):72. doi: 10.1007/s11912-017-0633-2. PMID: 28920153
Imaging of oligodendroglioma.
Smits M
Br J Radiol 2016;89(1060):20150857. Epub 2016 Feb 5 doi: 10.1259/bjr.20150857. PMID: 26849038Free PMC Article
Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma.
Kimura N, Takayanagi R, Takizawa N, Itagaki E, Katabami T, Kakoi N, Rakugi H, Ikeda Y, Tanabe A, Nigawara T, Ito S, Kimura I, Naruse M; Phaeochromocytoma Study Group in Japan
Endocr Relat Cancer 2014 Jun;21(3):405-14. Epub 2014 May 6 doi: 10.1530/ERC-13-0494. PMID: 24521857
Classification of thyroid follicular cell tumors: with special reference to borderline lesions.
Kakudo K, Bai Y, Liu Z, Li Y, Ito Y, Ozaki T
Endocr J 2012;59(1):1-12. Epub 2011 Sep 9 doi: 10.1507/endocrj.ej11-0184. PMID: 21908930

Clinical prediction guides

Differentiation of benign and malignant superficial soft tissue lesions using real-time strain elastography.
Annaç G, Canyiğit M, Tan S, Akşam E, Süngü Adıyaman N, Arslan H
Turk J Med Sci 2021 Dec 13;51(6):2959-2967. doi: 10.3906/sag-2101-166. PMID: 34391320Free PMC Article
Colon cancer: clinical, macroscopic and microscopic aspects.
Florescu-Ţenea RM, Kamal AM, Mitruţ P, Mitruţ R, Ilie DS, Nicolaescu AC, Marinescu SA
Rom J Morphol Embryol 2018;59(4):1179-1188. PMID: 30845299
Prognostic value of differentiation status in gastric cancer.
Feng F, Liu J, Wang F, Zheng G, Wang Q, Liu S, Xu G, Guo M, Lian X, Zhang H
BMC Cancer 2018 Sep 3;18(1):865. doi: 10.1186/s12885-018-4780-0. PMID: 30176846Free PMC Article
Optimizing Somatostatin Analog Use in Well or Moderately Differentiated Gastroenteropancreatic Neuroendocrine Tumors.
Carmona-Bayonas A, Jiménez-Fonseca P, Custodio A, Grande E, Capdevila J, López C, Teule A, Garcia-Carbonero R; Spanish Neuroendocrine Tumor Group (GETNE)
Curr Oncol Rep 2017 Sep 18;19(11):72. doi: 10.1007/s11912-017-0633-2. PMID: 28920153
Imaging of oligodendroglioma.
Smits M
Br J Radiol 2016;89(1060):20150857. Epub 2016 Feb 5 doi: 10.1259/bjr.20150857. PMID: 26849038Free PMC Article

Recent systematic reviews

Vitamin D and gastric cancer - A systematic review and meta-analysis.
Zhao X, Wang J, Zou L
Nutr Hosp 2023 Oct 6;40(5):1080-1087. doi: 10.20960/nh.04410. PMID: 37334809
For whom and what outcomes does cognitive-behavioral-therapy work among cancer survivors: a systematic review and meta-analysis.
Zhang A, Wang K, Blumenstein K, Brose A, Kemp C, Meister D, Solomon P
Support Care Cancer 2022 Nov;30(11):8625-8636. Epub 2022 Aug 30 doi: 10.1007/s00520-022-07337-3. PMID: 36040671
Selenium for preventing cancer.
Vinceti M, Filippini T, Del Giovane C, Dennert G, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Crespi CM
Cochrane Database Syst Rev 2018 Jan 29;1(1):CD005195. doi: 10.1002/14651858.CD005195.pub4. PMID: 29376219Free PMC Article
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article
Prostate cancer (early).
James ML
BMJ Clin Evid 2006 Oct 1;2006 PMID: 19454100Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...