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Moderately Differentiated Malignant Neoplasm

MedGen UID:
235332
•Concept ID:
C1334791
•
Neoplastic Process

Definition

A neoplasm whose histologic characteristics are intermediate between poorly differentiated and well differentiated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerately Differentiated Malignant Neoplasm

Professional guidelines

PubMed

AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Endoscopic diagnosis and treatment of esophageal adenocarcinoma: introduction of Japan Esophageal Society classification of Barrett's esophagus.
Ishihara R, Goda K, Oyama T
J Gastroenterol 2019 Jan;54(1):1-9. Epub 2018 Jun 30 doi: 10.1007/s00535-018-1491-x. PMID: 29961130Free PMC Article
Neuroblastoma: clinical and biological approach to risk stratification and treatment.
Tolbert VP, Matthay KK
Cell Tissue Res 2018 May;372(2):195-209. Epub 2018 Mar 23 doi: 10.1007/s00441-018-2821-2. PMID: 29572647Free PMC Article

Recent clinical studies

Etiology

Redifferentiation of radioiodine-refractory thyroid cancers.
Buffet C, Wassermann J, Hecht F, Leenhardt L, Dupuy C, Groussin L, Lussey-Lepoutre C
Endocr Relat Cancer 2020 May;27(5):R113-R132. doi: 10.1530/ERC-19-0491. PMID: 32191916
Neuroendocrine Carcinomas of the Larynx and Head and Neck: Challenges in Classification and Grading.
Perez-Ordoñez B
Head Neck Pathol 2018 Mar;12(1):1-8. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0894-6. PMID: 29557536Free PMC Article
Optimizing Somatostatin Analog Use in Well or Moderately Differentiated Gastroenteropancreatic Neuroendocrine Tumors.
Carmona-Bayonas A, Jiménez-Fonseca P, Custodio A, Grande E, Capdevila J, López C, Teule A, Garcia-Carbonero R; Spanish Neuroendocrine Tumor Group (GETNE)
Curr Oncol Rep 2017 Sep 18;19(11):72. doi: 10.1007/s11912-017-0633-2. PMID: 28920153
Classification of thyroid follicular cell tumors: with special reference to borderline lesions.
Kakudo K, Bai Y, Liu Z, Li Y, Ito Y, Ozaki T
Endocr J 2012;59(1):1-12. Epub 2011 Sep 9 doi: 10.1507/endocrj.ej11-0184. PMID: 21908930
Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas.
Mills SE
Mod Pathol 2002 Mar;15(3):264-78. doi: 10.1038/modpathol.3880522. PMID: 11904342

Diagnosis

Imaging of oligodendroglioma.
Smits M
Br J Radiol 2016;89(1060):20150857. Epub 2016 Feb 5 doi: 10.1259/bjr.20150857. PMID: 26849038Free PMC Article
Classification of thyroid follicular cell tumors: with special reference to borderline lesions.
Kakudo K, Bai Y, Liu Z, Li Y, Ito Y, Ozaki T
Endocr J 2012;59(1):1-12. Epub 2011 Sep 9 doi: 10.1507/endocrj.ej11-0184. PMID: 21908930
Management of neuroendocrine tumors of unknown origin.
Polish A, Vergo MT, Agulnik M
J Natl Compr Canc Netw 2011 Dec;9(12):1397-402; quiz 1403. doi: 10.6004/jnccn.2011.0118. PMID: 22157557
Intrahepatic sarcomatoid cholangiocarcinoma.
Kaibori M, Kawaguchi Y, Yokoigawa N, Yanagida H, Takai S, Kwon AH, Uemura Y, Kamiyama Y
J Gastroenterol 2003;38(11):1097-101. doi: 10.1007/s00535-003-1203-y. PMID: 14673730
Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas.
Mills SE
Mod Pathol 2002 Mar;15(3):264-78. doi: 10.1038/modpathol.3880522. PMID: 11904342

Therapy

Bufalin for an innovative therapeutic approach against cancer.
Soumoy L, Ghanem GE, Saussez S, Journe F
Pharmacol Res 2022 Oct;184:106442. Epub 2022 Sep 9 doi: 10.1016/j.phrs.2022.106442. PMID: 36096424
Endoscopic diagnosis and treatment of esophageal adenocarcinoma: introduction of Japan Esophageal Society classification of Barrett's esophagus.
Ishihara R, Goda K, Oyama T
J Gastroenterol 2019 Jan;54(1):1-9. Epub 2018 Jun 30 doi: 10.1007/s00535-018-1491-x. PMID: 29961130Free PMC Article
Selenium for preventing cancer.
Vinceti M, Filippini T, Del Giovane C, Dennert G, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Crespi CM
Cochrane Database Syst Rev 2018 Jan 29;1(1):CD005195. doi: 10.1002/14651858.CD005195.pub4. PMID: 29376219Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

Prognosis

Optimizing Somatostatin Analog Use in Well or Moderately Differentiated Gastroenteropancreatic Neuroendocrine Tumors.
Carmona-Bayonas A, Jiménez-Fonseca P, Custodio A, Grande E, Capdevila J, López C, Teule A, Garcia-Carbonero R; Spanish Neuroendocrine Tumor Group (GETNE)
Curr Oncol Rep 2017 Sep 18;19(11):72. doi: 10.1007/s11912-017-0633-2. PMID: 28920153
Imaging of oligodendroglioma.
Smits M
Br J Radiol 2016;89(1060):20150857. Epub 2016 Feb 5 doi: 10.1259/bjr.20150857. PMID: 26849038Free PMC Article
Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma.
Kimura N, Takayanagi R, Takizawa N, Itagaki E, Katabami T, Kakoi N, Rakugi H, Ikeda Y, Tanabe A, Nigawara T, Ito S, Kimura I, Naruse M; Phaeochromocytoma Study Group in Japan
Endocr Relat Cancer 2014 Jun;21(3):405-14. Epub 2014 May 6 doi: 10.1530/ERC-13-0494. PMID: 24521857
Classification of thyroid follicular cell tumors: with special reference to borderline lesions.
Kakudo K, Bai Y, Liu Z, Li Y, Ito Y, Ozaki T
Endocr J 2012;59(1):1-12. Epub 2011 Sep 9 doi: 10.1507/endocrj.ej11-0184. PMID: 21908930
Intrahepatic sarcomatoid cholangiocarcinoma.
Kaibori M, Kawaguchi Y, Yokoigawa N, Yanagida H, Takai S, Kwon AH, Uemura Y, Kamiyama Y
J Gastroenterol 2003;38(11):1097-101. doi: 10.1007/s00535-003-1203-y. PMID: 14673730

Clinical prediction guides

Matched-pair analysis of survival in patients with poorly differentiated versus well and moderately differentiated hypopharyngeal squamous cell carcinoma.
Xia X, Liang Y, Zhu Y, Zhu X, Diao W, Chen X
Medicine (Baltimore) 2022 Jul 8;101(27):e29880. doi: 10.1097/MD.0000000000029880. PMID: 35801797Free PMC Article
Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells.
Rodríguez-Hernández MA, Chapresto-Garzón R, Cadenas M, Navarro-Villarán E, Negrete M, Gómez-Bravo MA, Victor VM, Padillo FJ, Muntané J
Cell Death Dis 2020 May 7;11(5):339. doi: 10.1038/s41419-020-2558-1. PMID: 32382022Free PMC Article
Optimizing Somatostatin Analog Use in Well or Moderately Differentiated Gastroenteropancreatic Neuroendocrine Tumors.
Carmona-Bayonas A, Jiménez-Fonseca P, Custodio A, Grande E, Capdevila J, López C, Teule A, Garcia-Carbonero R; Spanish Neuroendocrine Tumor Group (GETNE)
Curr Oncol Rep 2017 Sep 18;19(11):72. doi: 10.1007/s11912-017-0633-2. PMID: 28920153
Extraocular Sebaceous Carcinoma-A Clinicopathologic Reassessment.
Candelario NM, Sánchez JE, Sánchez JL, Martín-García RF, Rochet NM
Am J Dermatopathol 2016 Nov;38(11):809-812. doi: 10.1097/DAD.0000000000000591. PMID: 27763901
Imaging of oligodendroglioma.
Smits M
Br J Radiol 2016;89(1060):20150857. Epub 2016 Feb 5 doi: 10.1259/bjr.20150857. PMID: 26849038Free PMC Article

Recent systematic reviews

Penile Rehabilitation Strategy after Nerve Sparing Radical Prostatectomy: A Systematic Review and Network Meta-Analysis of Randomized Trials.
Sari Motlagh R, Abufaraj M, Yang L, Mori K, Pradere B, Laukhtina E, Mostafaei H, Schuettfort VM, Quhal F, Montorsi F, Amjadi M, Gratzke C, Shariat SF
J Urol 2021 Apr;205(4):1018-1030. Epub 2021 Jan 14 doi: 10.1097/JU.0000000000001584. PMID: 33443457
Radiomics of computed tomography and magnetic resonance imaging in renal cell carcinoma-a systematic review and meta-analysis.
Ursprung S, Beer L, Bruining A, Woitek R, Stewart GD, Gallagher FA, Sala E
Eur Radiol 2020 Jun;30(6):3558-3566. Epub 2020 Feb 14 doi: 10.1007/s00330-020-06666-3. PMID: 32060715Free PMC Article
Selenium for preventing cancer.
Vinceti M, Filippini T, Del Giovane C, Dennert G, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Crespi CM
Cochrane Database Syst Rev 2018 Jan 29;1(1):CD005195. doi: 10.1002/14651858.CD005195.pub4. PMID: 29376219Free PMC Article
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article
The accuracy of thyroid nodule ultrasound to predict thyroid cancer: systematic review and meta-analysis.
Brito JP, Gionfriddo MR, Al Nofal A, Boehmer KR, Leppin AL, Reading C, Callstrom M, Elraiyah TA, Prokop LJ, Stan MN, Murad MH, Morris JC, Montori VM
J Clin Endocrinol Metab 2014 Apr;99(4):1253-63. Epub 2013 Nov 25 doi: 10.1210/jc.2013-2928. PMID: 24276450Free PMC Article

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