Neoplastic Post-Transplant Lymphoproliferative Disorder

MedGen UID:: 235365
•Concept ID:: C1334942
•: Neoplastic Process

Synonyms:

Neoplastic PTLD; Post-Transplant Lymphocytic Neoplasm; Post-Transplant Lymphoproliferative Neoplasm; Post-Transplant Neoplastic Lymphoproliferative Disorder

Definition

A lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by the presence of tissue destruction and effacement of the architecture of the involved tissues. There is clonal rearrangement of the immunoglobulin or the T-cell receptor genes. It includes the following variants: polymorphic, monomorphic, and classical Hodgkin lymphoma type post-transplant lymphoproliferative disorders. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeoplastic Post-Transplant Lymphoproliferative Disorder

Pathological process
- Disease
  - Disorder by Site
    - Immune System and Related Disorders
      - Immunodeficiency-related disorder
        Immunodeficiency-Related Neoplasm
        Neoplastic Post-Transplant Lymphoproliferative Disorder
        EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder
        Classic Hodgkin Lymphoma Type Post-Transplant Lymphoproliferative Disorder
        Hodgkin-Like Post-Transplant Lymphoproliferative Disorder
        Monomorphic Post-Transplant Lymphoproliferative Disorder
        Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder
        Burkitt Lymphoma Post-Transplant Lymphoproliferative Disorder
        Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder
        Plasma Cell Post-Transplant Lymphoproliferative Disorder
        Monomorphic T/NK-Cell Post-Transplant Lymphoproliferative Disorder
        Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder
        Refractory Monomorphic Post-Transplant Lymphoproliferative Disorder
        Polymorphic Post-Transplant Lymphoproliferative Disorder
        Recurrent Polymorphic Post-Transplant Lymphoproliferative Disorder
        Refractory Polymorphic Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Long-term side effects of treatment with mTOR inhibitors in children after renal transplantation.

Kranz B, Wingen AM, Vester U, König J, Hoyer PF
Pediatr Nephrol 2013 Aug;28(8):1293-8. Epub 2013 Apr 13 doi: 10.1007/s00467-013-2459-y. PMID: 23584849

Role of fine-needle aspiration in clinical management of transplant patients.

Siddiqui MT, Reddy VB, Castelli MJ, Gattuso P
Diagn Cytopathol 1997 Dec;17(6):429-35. doi: 10.1002/(sici)1097-0339(199712)17:6<429::aid-dc10>3.0.co;2-o. PMID: 9407203

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