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Adenoid cystic carcinoma of oropharynx

MedGen UID:
235411
•Concept ID:
C1335139
•
Neoplastic Process
Synonyms: Adenoid Cystic Carcinoma of Oropharynx; adenoid cystic carcinoma of oropharynx; Adenoid Cystic Carcinoma of the Oropharynx; adenoid cystic carcinoma of the oropharynx; Oropharyngeal Adenoid Cystic Carcinoma; oropharyngeal adenoid cystic carcinoma; oropharyngeal throat adenoid cystic cancer; oropharynx adenoid cystic carcinoma
SNOMED CT: Adenoid cystic carcinoma of oropharynx (423318000)
 
Monarch Initiative: MONDO:0021300

Definition

A rare adenoid cystic carcinoma that arises from the oropharynx. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenoid cystic carcinoma of oropharynx

Professional guidelines

PubMed

Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers.
Bellizzi AM, Woodford RL, Moskaluk CA, Jones DR, Kozower BD, Stelow EB
Am J Surg Pathol 2009 Nov;33(11):1608-14. doi: 10.1097/PAS.0b013e3181b46fd4. PMID: 19738459
Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors.
Truong MT, Kamat UR, Liebsch NJ, Curry WT, Lin DT, Barker FG 2nd, Loeffler JS, Chan AW
Head Neck 2009 Oct;31(10):1297-308. doi: 10.1002/hed.21092. PMID: 19536762

Recent clinical studies

Etiology

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.
Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Adenoid cystic carcinoma of the base of tongue: A population-based study.
Kirke DN, Chitguppi C, Rubin SJ, Truong MT, Jalisi S
Am J Otolaryngol 2017 May-Jun;38(3):279-284. Epub 2017 Jan 18 doi: 10.1016/j.amjoto.2017.01.010. PMID: 28173954
Human papillomavirus-associated neoplasms of the sinonasal tract and nasopharynx.
Thavaraj S
Semin Diagn Pathol 2016 Mar;33(2):104-11. Epub 2015 Sep 9 doi: 10.1053/j.semdp.2015.09.011. PMID: 26482046

Diagnosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.
Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Adenoid cystic carcinoma of the base of tongue: A population-based study.
Kirke DN, Chitguppi C, Rubin SJ, Truong MT, Jalisi S
Am J Otolaryngol 2017 May-Jun;38(3):279-284. Epub 2017 Jan 18 doi: 10.1016/j.amjoto.2017.01.010. PMID: 28173954
Human Papillomavirus-Associated Neoplasms of the Head and Neck.
Udager AM, McHugh JB
Surg Pathol Clin 2017 Mar;10(1):35-55. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.007. PMID: 28153135

Therapy

First-in-Human Study of OBI-999, a Globo H-Targeting Antibody-Drug Conjugate, in Patients With Advanced Solid Tumors.
Tsimberidou AM, Vo HH, Beck J, Shia CS, Hsu P, Pearce TE
JCO Precis Oncol 2023 Jan;7:e2200496. doi: 10.1200/PO.22.00496. PMID: 36701651Free PMC Article
Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.
Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Adenoid Cystic Carcinoma of the Cavernous Sinus - Otolaryngological Sequelae of Therapy: Case Report.
Dzięciołowska-Baran E, Gawlikowska-Sroka A
Adv Exp Med Biol 2018;1040:23-27. doi: 10.1007/5584_2017_95. PMID: 28889233
Concurrent chemoradiation for adenoid cystic carcinoma of the head and neck.
Samant S, van den Brekel MW, Kies MS, Wan J, Robbins KT, Rosenthal DI, Rasch C, Weber RS
Head Neck 2012 Sep;34(9):1263-8. Epub 2011 Nov 15 doi: 10.1002/hed.21905. PMID: 22083968

Prognosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.
Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Adenoid cystic carcinoma of the base of tongue: A population-based study.
Kirke DN, Chitguppi C, Rubin SJ, Truong MT, Jalisi S
Am J Otolaryngol 2017 May-Jun;38(3):279-284. Epub 2017 Jan 18 doi: 10.1016/j.amjoto.2017.01.010. PMID: 28173954
Human Papillomavirus-Associated Neoplasms of the Head and Neck.
Udager AM, McHugh JB
Surg Pathol Clin 2017 Mar;10(1):35-55. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.007. PMID: 28153135

Clinical prediction guides

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.
Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Human papillomavirus-associated neoplasms of the sinonasal tract and nasopharynx.
Thavaraj S
Semin Diagn Pathol 2016 Mar;33(2):104-11. Epub 2015 Sep 9 doi: 10.1053/j.semdp.2015.09.011. PMID: 26482046
Intraoral adenoid cystic carcinoma: prognostic factors and outcome.
Agarwal JP, Jain S, Gupta T, Tiwari M, Laskar SG, Dinshaw KA, Chaturvedi P, D'cruz AK, Shrivastava SK
Oral Oncol 2008 Oct;44(10):986-93. Epub 2008 Mar 7 doi: 10.1016/j.oraloncology.2008.01.004. PMID: 18329324
Adenoid cystic carcinoma: a retrospective clinical review.
Khan AJ, DiGiovanna MP, Ross DA, Sasaki CT, Carter D, Son YH, Haffty BG
Int J Cancer 2001 Jun 20;96(3):149-58. doi: 10.1002/ijc.1013. PMID: 11410883

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