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Pancreatic Precancerous Condition

MedGen UID:
235454
Concept ID:
C1335314
Neoplastic Process
Synonym: Pancreatic Premalignant Condition

Definition

A pathologic process that arises from the pancreas and has the potential to evolve into a malignant neoplasm. [from NCI]

Professional guidelines

PubMed

McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Keutgen XM, Hammel P, Choyke PL, Libutti SK, Jonasch E, Kebebew E
Nat Rev Clin Oncol 2016 Sep;13(9):537-49. Epub 2016 Mar 31 doi: 10.1038/nrclinonc.2016.37. PMID: 27030075
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent clinical studies

Etiology

Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, Perez-Machado M, Weynand B, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS
Acta Cytol 2023;67(3):304-320. Epub 2022 Dec 14 doi: 10.1159/000527912. PMID: 36516741
Kröner PT, Engels MM, Glicksberg BS, Johnson KW, Mzaik O, van Hooft JE, Wallace MB, El-Serag HB, Krittanawong C
World J Gastroenterol 2021 Oct 28;27(40):6794-6824. doi: 10.3748/wjg.v27.i40.6794. PMID: 34790008Free PMC Article
Perri G, Marchegiani G, Frigerio I, Dervenis CG, Conlon KC, Bassi C, Salvia R
Dig Surg 2020;37(1):1-9. Epub 2019 Jan 11 doi: 10.1159/000496509. PMID: 30636253Free PMC Article
Singhi AD, Koay EJ, Chari ST, Maitra A
Gastroenterology 2019 May;156(7):2024-2040. Epub 2019 Feb 2 doi: 10.1053/j.gastro.2019.01.259. PMID: 30721664Free PMC Article
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article

Diagnosis

Kröner PT, Engels MM, Glicksberg BS, Johnson KW, Mzaik O, van Hooft JE, Wallace MB, El-Serag HB, Krittanawong C
World J Gastroenterol 2021 Oct 28;27(40):6794-6824. doi: 10.3748/wjg.v27.i40.6794. PMID: 34790008Free PMC Article
Perri G, Marchegiani G, Frigerio I, Dervenis CG, Conlon KC, Bassi C, Salvia R
Dig Surg 2020;37(1):1-9. Epub 2019 Jan 11 doi: 10.1159/000496509. PMID: 30636253Free PMC Article
Singhi AD, Koay EJ, Chari ST, Maitra A
Gastroenterology 2019 May;156(7):2024-2040. Epub 2019 Feb 2 doi: 10.1053/j.gastro.2019.01.259. PMID: 30721664Free PMC Article
Okamoto A, Watanabe T, Kamata K, Minaga K, Kudo M
Intern Med 2019 Jun 1;58(11):1533-1539. Epub 2019 Feb 1 doi: 10.2169/internalmedicine.2210-18. PMID: 30713326Free PMC Article
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article

Therapy

Yamamoto K, Iwasaki E, Itoi T
Expert Rev Gastroenterol Hepatol 2020 Jun;14(6):435-444. Epub 2020 May 22 doi: 10.1080/17474124.2020.1766965. PMID: 32380873
Dalal V, Carmicheal J, Dhaliwal A, Jain M, Kaur S, Batra SK
Cancer Lett 2020 Jan 28;469:228-237. Epub 2019 Oct 17 doi: 10.1016/j.canlet.2019.10.023. PMID: 31629933Free PMC Article
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Mohammed S, Van Buren G 2nd, Fisher WE
World J Gastroenterol 2014 Jul 28;20(28):9354-60. doi: 10.3748/wjg.v20.i28.9354. PMID: 25071330Free PMC Article
Hsu CH, Cheng AL
Adv Exp Med Biol 2007;595:471-80. doi: 10.1007/978-0-387-46401-5_21. PMID: 17569225

Prognosis

Kröner PT, Engels MM, Glicksberg BS, Johnson KW, Mzaik O, van Hooft JE, Wallace MB, El-Serag HB, Krittanawong C
World J Gastroenterol 2021 Oct 28;27(40):6794-6824. doi: 10.3748/wjg.v27.i40.6794. PMID: 34790008Free PMC Article
Singhi AD, Koay EJ, Chari ST, Maitra A
Gastroenterology 2019 May;156(7):2024-2040. Epub 2019 Feb 2 doi: 10.1053/j.gastro.2019.01.259. PMID: 30721664Free PMC Article
Okamoto A, Watanabe T, Kamata K, Minaga K, Kudo M
Intern Med 2019 Jun 1;58(11):1533-1539. Epub 2019 Feb 1 doi: 10.2169/internalmedicine.2210-18. PMID: 30713326Free PMC Article
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BK, Becker A, Hoshino A, Mark MT, Molina H, Xiang J, Zhang T, Theilen TM, García-Santos G, Williams C, Ararso Y, Huang Y, Rodrigues G, Shen TL, Labori KJ, Lothe IM, Kure EH, Hernandez J, Doussot A, Ebbesen SH, Grandgenett PM, Hollingsworth MA, Jain M, Mallya K, Batra SK, Jarnagin WR, Schwartz RE, Matei I, Peinado H, Stanger BZ, Bromberg J, Lyden D
Nat Cell Biol 2015 Jun;17(6):816-26. Epub 2015 May 18 doi: 10.1038/ncb3169. PMID: 25985394Free PMC Article

Clinical prediction guides

Kröner PT, Engels MM, Glicksberg BS, Johnson KW, Mzaik O, van Hooft JE, Wallace MB, El-Serag HB, Krittanawong C
World J Gastroenterol 2021 Oct 28;27(40):6794-6824. doi: 10.3748/wjg.v27.i40.6794. PMID: 34790008Free PMC Article
Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775
Singhi AD, Koay EJ, Chari ST, Maitra A
Gastroenterology 2019 May;156(7):2024-2040. Epub 2019 Feb 2 doi: 10.1053/j.gastro.2019.01.259. PMID: 30721664Free PMC Article
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent systematic reviews

Pollini T, Marchegiani G, Facciorusso A, Balduzzi A, Biancotto M, Bassi C, Maker AV, Salvia R
HPB (Oxford) 2023 Jul;25(7):747-757. Epub 2023 Mar 9 doi: 10.1016/j.hpb.2023.03.001. PMID: 37003852
Bararia A, Dey S, Gulati S, Ghatak S, Ghosh S, Banerjee S, Sikdar N
Hepatobiliary Pancreat Dis Int 2020 Jun;19(3):205-217. Epub 2020 Apr 8 doi: 10.1016/j.hbpd.2020.03.010. PMID: 32312637
Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775
Fugazza A, Gaiani F, Carra MC, Brunetti F, Lévy M, Sobhani I, Azoulay D, Catena F, de'Angelis GL, de'Angelis N
Biomed Res Int 2016;2016:4638683. Epub 2016 Feb 17 doi: 10.1155/2016/4638683. PMID: 26989684Free PMC Article
Liang Y, Yang Z, Zhong R
Hepatology 2012 Oct;56(4):1409-17. Epub 2012 Aug 27 doi: 10.1002/hep.25788. PMID: 22504852

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