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Papillary urothelial hyperplasia

MedGen UID:
235457
•Concept ID:
C1335328
•
Pathologic Function
Synonyms: Papillary Urothelial Hyperplasia; papillary urothelial hyperplasia
 
Monarch Initiative: MONDO:0024485

Definition

A type of hyperplasia that is characterized by variable thickening of the urinary tract epithelium and a slight papillary growth. The latter is not associated with the presence of fibrovascular cores. There is no evidence of atypia. The relationship between this lesion and papillary urothelial neoplasia is not clear. -- 2003 [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPapillary urothelial hyperplasia

Professional guidelines

PubMed

Value of multicolour fluorescence in situ hybridisation (UroVysion) in the differential diagnosis of flat urothelial lesions.
Schwarz S, Rechenmacher M, Filbeck T, Knuechel R, Blaszyk H, Hartmann A, Brockhoff G
J Clin Pathol 2008 Mar;61(3):272-7. Epub 2007 Aug 10 doi: 10.1136/jcp.2007.049684. PMID: 17693577

Recent clinical studies

Etiology

Tumour-like lesions of the urinary bladder.
Samaratunga H, Delahunt B, Yaxley J, Egevad L
Pathology 2021 Jan;53(1):44-55. Epub 2020 Oct 15 doi: 10.1016/j.pathol.2020.08.005. PMID: 33070959
Urothelial Proliferation of Unknown Malignant Potential Involving the Bladder: Histopathologic Features and Risk of Progression in De Novo Cases and Cases With Prior Neoplasia.
Lowenthal BM, Sahoo D, Amin MB, Hansel DE
Arch Pathol Lab Med 2020 Jul 1;144(7):853-862. doi: 10.5858/arpa.2019-0005-OA. PMID: 31825667Free PMC Article
Incidence of benign results after laparoscopic radical nephroureterectomy.
Hong S, Kwon T, You D, Jeong IG, Hong B, Hong JH, Ahn H, Kim CS
JSLS 2014 Oct-Dec;18(4) doi: 10.4293/JSLS.2014.00335. PMID: 25408605Free PMC Article
Pseudocarcinomatous urothelial hyperplasia of the bladder: clinical findings and followup of 70 patients.
Kryvenko ON, Epstein JI
J Urol 2013 Jun;189(6):2083-6. Epub 2012 Dec 7 doi: 10.1016/j.juro.2012.12.005. PMID: 23228381
Papillary urothelial hyperplasia: relationship to urothelial neoplasms.
Readal N, Epstein JI
Pathology 2010 Jun;42(4):360-3. doi: 10.3109/00313021003767322. PMID: 20438409

Diagnosis

Tumour-like lesions of the urinary bladder.
Samaratunga H, Delahunt B, Yaxley J, Egevad L
Pathology 2021 Jan;53(1):44-55. Epub 2020 Oct 15 doi: 10.1016/j.pathol.2020.08.005. PMID: 33070959
Pseudocarcinomatous urothelial hyperplasia of the bladder: clinical findings and followup of 70 patients.
Kryvenko ON, Epstein JI
J Urol 2013 Jun;189(6):2083-6. Epub 2012 Dec 7 doi: 10.1016/j.juro.2012.12.005. PMID: 23228381
The origins of urothelial carcinoma.
Cheng L, Davidson DD, Maclennan GT, Williamson SR, Zhang S, Koch MO, Montironi R, Lopez-Beltran A
Expert Rev Anticancer Ther 2010 Jun;10(6):865-80. doi: 10.1586/era.10.73. PMID: 20553211
Papillary urothelial hyperplasia: relationship to urothelial neoplasms.
Readal N, Epstein JI
Pathology 2010 Jun;42(4):360-3. doi: 10.3109/00313021003767322. PMID: 20438409
Prognostic significance of atypical papillary urothelial hyperplasia.
Swierczynski SL, Epstein JI
Hum Pathol 2002 May;33(5):512-7. doi: 10.1053/hupa.2002.124031. PMID: 12094376

Prognosis

Tumour-like lesions of the urinary bladder.
Samaratunga H, Delahunt B, Yaxley J, Egevad L
Pathology 2021 Jan;53(1):44-55. Epub 2020 Oct 15 doi: 10.1016/j.pathol.2020.08.005. PMID: 33070959
Urothelial Proliferation of Unknown Malignant Potential Involving the Bladder: Histopathologic Features and Risk of Progression in De Novo Cases and Cases With Prior Neoplasia.
Lowenthal BM, Sahoo D, Amin MB, Hansel DE
Arch Pathol Lab Med 2020 Jul 1;144(7):853-862. doi: 10.5858/arpa.2019-0005-OA. PMID: 31825667Free PMC Article
Pseudocarcinomatous urothelial hyperplasia of the bladder: clinical findings and followup of 70 patients.
Kryvenko ON, Epstein JI
J Urol 2013 Jun;189(6):2083-6. Epub 2012 Dec 7 doi: 10.1016/j.juro.2012.12.005. PMID: 23228381
Papillary urothelial hyperplasia: relationship to urothelial neoplasms.
Readal N, Epstein JI
Pathology 2010 Jun;42(4):360-3. doi: 10.3109/00313021003767322. PMID: 20438409
Prognostic significance of atypical papillary urothelial hyperplasia.
Swierczynski SL, Epstein JI
Hum Pathol 2002 May;33(5):512-7. doi: 10.1053/hupa.2002.124031. PMID: 12094376

Clinical prediction guides

Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer.
Chow NH, Cairns P, Eisenberger CF, Schoenberg MP, Taylor DC, Epstein JI, Sidransky D
Int J Cancer 2000 Nov 20;89(6):514-8. PMID: 11102896

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