U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent Peripheral Primitive Neuroectodermal Tumor

MedGen UID:
235542
Concept ID:
C1335719
Neoplastic Process

Definition

The reemergence of a small round cell tumor with neural differentiation after a period of remission. [from NCI]

Professional guidelines

PubMed

Espinosa-Cotton M, Cheung NV
Pharmacol Ther 2022 Sep;237:108241. Epub 2022 Jul 10 doi: 10.1016/j.pharmthera.2022.108241. PMID: 35830901Free PMC Article
Fiani B, Quadri SA, Cathel A, Farooqui M, Ramachandran A, Siddiqi I, Ghanchi H, Zafar A, Berman BW, Siddiqi J
World Neurosurg 2019 Jun;126:194-211. Epub 2019 Mar 9 doi: 10.1016/j.wneu.2019.03.014. PMID: 30862589
Whittle SB, Smith V, Doherty E, Zhao S, McCarty S, Zage PE
Expert Rev Anticancer Ther 2017 Apr;17(4):369-386. Epub 2017 Mar 15 doi: 10.1080/14737140.2017.1285230. PMID: 28142287

Recent clinical studies

Etiology

Anderson J, Majzner RG, Sondel PM
Clin Cancer Res 2022 Aug 2;28(15):3196-3206. doi: 10.1158/1078-0432.CCR-21-1356. PMID: 35435953Free PMC Article
Chan GC, Chan CM
Biomolecules 2022 Feb 24;12(3) doi: 10.3390/biom12030358. PMID: 35327550Free PMC Article
Whittle SB, Smith V, Doherty E, Zhao S, McCarty S, Zage PE
Expert Rev Anticancer Ther 2017 Apr;17(4):369-386. Epub 2017 Mar 15 doi: 10.1080/14737140.2017.1285230. PMID: 28142287
Pugh TJ, Morozova O, Attiyeh EF, Asgharzadeh S, Wei JS, Auclair D, Carter SL, Cibulskis K, Hanna M, Kiezun A, Kim J, Lawrence MS, Lichenstein L, McKenna A, Pedamallu CS, Ramos AH, Shefler E, Sivachenko A, Sougnez C, Stewart C, Ally A, Birol I, Chiu R, Corbett RD, Hirst M, Jackman SD, Kamoh B, Khodabakshi AH, Krzywinski M, Lo A, Moore RA, Mungall KL, Qian J, Tam A, Thiessen N, Zhao Y, Cole KA, Diamond M, Diskin SJ, Mosse YP, Wood AC, Ji L, Sposto R, Badgett T, London WB, Moyer Y, Gastier-Foster JM, Smith MA, Guidry Auvil JM, Gerhard DS, Hogarty MD, Jones SJ, Lander ES, Gabriel SB, Getz G, Seeger RC, Khan J, Marra MA, Meyerson M, Maris JM
Nat Genet 2013 Mar;45(3):279-84. Epub 2013 Jan 20 doi: 10.1038/ng.2529. PMID: 23334666Free PMC Article
Maris JM
N Engl J Med 2010 Jun 10;362(23):2202-11. doi: 10.1056/NEJMra0804577. PMID: 20558371Free PMC Article

Diagnosis

Zanotti S, Decaesteker B, Vanhauwaert S, De Wilde B, De Vos WH, Speleman F
Br J Cancer 2022 Jun;126(11):1529-1538. Epub 2022 Feb 23 doi: 10.1038/s41416-022-01755-0. PMID: 35197583Free PMC Article
Fiani B, Quadri SA, Cathel A, Farooqui M, Ramachandran A, Siddiqi I, Ghanchi H, Zafar A, Berman BW, Siddiqi J
World Neurosurg 2019 Jun;126:194-211. Epub 2019 Mar 9 doi: 10.1016/j.wneu.2019.03.014. PMID: 30862589
Abdelmeguid AS
Curr Oncol Rep 2018 Feb 7;20(1):7. doi: 10.1007/s11912-018-0661-6. PMID: 29411144
Whittle SB, Smith V, Doherty E, Zhao S, McCarty S, Zage PE
Expert Rev Anticancer Ther 2017 Apr;17(4):369-386. Epub 2017 Mar 15 doi: 10.1080/14737140.2017.1285230. PMID: 28142287
Shah JP, Feghali J
CA Cancer J Clin 1983 May-Jun;33(3):154-9. doi: 10.3322/canjclin.33.3.154. PMID: 6404523

Therapy

Del Bufalo F, De Angelis B, Caruana I, Del Baldo G, De Ioris MA, Serra A, Mastronuzzi A, Cefalo MG, Pagliara D, Amicucci M, Li Pira G, Leone G, Bertaina V, Sinibaldi M, Di Cecca S, Guercio M, Abbaszadeh Z, Iaffaldano L, Gunetti M, Iacovelli S, Bugianesi R, Macchia S, Algeri M, Merli P, Galaverna F, Abbas R, Garganese MC, Villani MF, Colafati GS, Bonetti F, Rabusin M, Perruccio K, Folsi V, Quintarelli C, Locatelli F; Precision Medicine Team–IRCCS Ospedale Pediatrico Bambino Gesù
N Engl J Med 2023 Apr 6;388(14):1284-1295. doi: 10.1056/NEJMoa2210859. PMID: 37018492
Anderson J, Majzner RG, Sondel PM
Clin Cancer Res 2022 Aug 2;28(15):3196-3206. doi: 10.1158/1078-0432.CCR-21-1356. PMID: 35435953Free PMC Article
Fiani B, Quadri SA, Cathel A, Farooqui M, Ramachandran A, Siddiqi I, Ghanchi H, Zafar A, Berman BW, Siddiqi J
World Neurosurg 2019 Jun;126:194-211. Epub 2019 Mar 9 doi: 10.1016/j.wneu.2019.03.014. PMID: 30862589
Sait S, Modak S
Expert Rev Anticancer Ther 2017 Oct;17(10):889-904. Epub 2017 Aug 14 doi: 10.1080/14737140.2017.1364995. PMID: 28780888Free PMC Article
Maris JM
N Engl J Med 2010 Jun 10;362(23):2202-11. doi: 10.1056/NEJMra0804577. PMID: 20558371Free PMC Article

Prognosis

Sait S, Modak S
Expert Rev Anticancer Ther 2017 Oct;17(10):889-904. Epub 2017 Aug 14 doi: 10.1080/14737140.2017.1364995. PMID: 28780888Free PMC Article
Whittle SB, Smith V, Doherty E, Zhao S, McCarty S, Zage PE
Expert Rev Anticancer Ther 2017 Apr;17(4):369-386. Epub 2017 Mar 15 doi: 10.1080/14737140.2017.1285230. PMID: 28142287
Davidoff AM
Semin Pediatr Surg 2012 Feb;21(1):2-14. doi: 10.1053/j.sempedsurg.2011.10.009. PMID: 22248965Free PMC Article
Maris JM
N Engl J Med 2010 Jun 10;362(23):2202-11. doi: 10.1056/NEJMra0804577. PMID: 20558371Free PMC Article
Elkon D, Hightower SI, Lim ML, Cantrell RW, Constable WC
Cancer 1979 Sep;44(3):1087-94. doi: 10.1002/1097-0142(197909)44:3<1087::aid-cncr2820440343>3.0.co;2-a. PMID: 383268

Clinical prediction guides

Del Bufalo F, De Angelis B, Caruana I, Del Baldo G, De Ioris MA, Serra A, Mastronuzzi A, Cefalo MG, Pagliara D, Amicucci M, Li Pira G, Leone G, Bertaina V, Sinibaldi M, Di Cecca S, Guercio M, Abbaszadeh Z, Iaffaldano L, Gunetti M, Iacovelli S, Bugianesi R, Macchia S, Algeri M, Merli P, Galaverna F, Abbas R, Garganese MC, Villani MF, Colafati GS, Bonetti F, Rabusin M, Perruccio K, Folsi V, Quintarelli C, Locatelli F; Precision Medicine Team–IRCCS Ospedale Pediatrico Bambino Gesù
N Engl J Med 2023 Apr 6;388(14):1284-1295. doi: 10.1056/NEJMoa2210859. PMID: 37018492
Flaadt T, Ladenstein RL, Ebinger M, Lode HN, Arnardóttir HB, Poetschger U, Schwinger W, Meisel R, Schuster FR, Döring M, Ambros PF, Queudeville M, Fuchs J, Warmann SW, Schäfer J, Seitz C, Schlegel P, Brecht IB, Holzer U, Feuchtinger T, Simon T, Schulte JH, Eggert A, Teltschik HM, Illhardt T, Handgretinger R, Lang P
J Clin Oncol 2023 Jun 10;41(17):3135-3148. Epub 2023 Feb 28 doi: 10.1200/JCO.22.01630. PMID: 36854071Free PMC Article
Zanotti S, Decaesteker B, Vanhauwaert S, De Wilde B, De Vos WH, Speleman F
Br J Cancer 2022 Jun;126(11):1529-1538. Epub 2022 Feb 23 doi: 10.1038/s41416-022-01755-0. PMID: 35197583Free PMC Article
Su Y, Luo B, Lu Y, Wang D, Yan J, Zheng J, Xiao J, Wang Y, Xue Z, Yin J, Chen P, Li L, Zhao Q
Clin Cancer Res 2022 Feb 15;28(4):793-809. doi: 10.1158/1078-0432.CCR-21-2241. PMID: 34844980Free PMC Article
Davidoff AM
Semin Pediatr Surg 2012 Feb;21(1):2-14. doi: 10.1053/j.sempedsurg.2011.10.009. PMID: 22248965Free PMC Article

Recent systematic reviews

Yalçin B, Kremer LC, van Dalen EC
Cochrane Database Syst Rev 2015 Oct 5;2015(10):CD006301. doi: 10.1002/14651858.CD006301.pub4. PMID: 26436598Free PMC Article
Dingemann C, Ure B, Dingemann J
Eur J Pediatr Surg 2014 Feb;24(1):14-9. Epub 2013 Jul 12 doi: 10.1055/s-0033-1350060. PMID: 23852720
Komotar RJ, Starke RM, Raper DM, Anand VK, Schwartz TH
World Neurosurg 2013 Jul-Aug;80(1-2):148-59. Epub 2012 Dec 7 doi: 10.1016/j.wneu.2012.12.003. PMID: 23228365
Heloury Y, Muthucumaru M, Panabokke G, Cheng W, Kimber C, Leclair MD
J Pediatr Surg 2012 Feb;47(2):415-21. doi: 10.1016/j.jpedsurg.2011.08.003. PMID: 22325405
Yalçin B, Kremer LC, Caron HN, van Dalen EC
Cochrane Database Syst Rev 2010 May 12;(5):CD006301. doi: 10.1002/14651858.CD006301.pub2. PMID: 20464740

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...