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FNCLCC Sarcoma Grade 3

MedGen UID:
235578
•Concept ID:
C1335915
•
Neoplastic Process
Synonyms: Sarcoma Differentiation Score 3; Sarcoma FNCLCC Grade 3

Definition

A sarcoma with a total score of 6 or higher according to the FNCLCC guidelines. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFNCLCC Sarcoma Grade 3

Professional guidelines

PubMed

Soft Tissue Sarcomas of the Head and Neck Region with Skull Base/Intracranial Invasion: Review of Surgical Outcomes and Multimodal Treatment Strategies: A Retrospective Case Series.
Habib A, Edem I, Bell D, Su SY, Hanna EY, Kupferman ME, DeMonte F, Raza SM
Curr Oncol 2022 Sep 14;29(9):6540-6550. doi: 10.3390/curroncol29090514. PMID: 36135083Free PMC Article
Does pre-operative MRI predict the risk of local recurrence in primary myxofibrosarcoma of the extremities?
Sambri A, Spinnato P, Bazzocchi A, Tuzzato GM, Donati D, Bianchi G
Asia Pac J Clin Oncol 2019 Oct;15(5):e181-e186. Epub 2019 May 20 doi: 10.1111/ajco.13161. PMID: 31111597
Safety and efficacy of intensity-modulated radiotherapy in the management of spermatic cord sarcoma.
Cerda T, Martin É, Truc G, Créhange G, Maingon P
Cancer Radiother 2017 Feb;21(1):16-20. Epub 2016 Dec 29 doi: 10.1016/j.canrad.2016.07.102. PMID: 28041814

Recent clinical studies

Etiology

Macrophage numbers in the marginal area of sarcomas predict clinical prognosis.
Umakoshi M, Nakamura A, Tsuchie H, Li Z, Kudo-Asabe Y, Miyabe K, Ito Y, Yoshida M, Nagasawa H, Okada K, Nanjo H, Maeda D, Miyakoshi N, Tanaka M, Goto A
Sci Rep 2023 Jan 23;13(1):1290. doi: 10.1038/s41598-023-28024-1. PMID: 36690825Free PMC Article
Configuration of soft-tissue sarcoma on MRI correlates with grade of malignancy.
Sedaghat S, Salehi Ravesh M, Sedaghat M, Both M, Jansen O
Radiol Oncol 2021 Jan 29;55(2):158-163. doi: 10.2478/raon-2021-0007. PMID: 33600679Free PMC Article
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma.
Li CP, Liu DN, Zhou NN, Tian XY, Wang Z, Liu BN, Hao CY
Contrast Media Mol Imaging 2021;2021:7191363. Epub 2021 Jan 6 doi: 10.1155/2021/7191363. PMID: 33505228Free PMC Article
Hyperthermia in soft tissue sarcoma.
Lindner LH, Issels RD
Curr Treat Options Oncol 2011 Mar;12(1):12-20. doi: 10.1007/s11864-011-0144-6. PMID: 21360087
Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database.
Italiano A, Delva F, Mathoulin-Pelissier S, Le Cesne A, Bonvalot S, Terrier P, Trassard M, Michels JJ, Blay JY, Coindre JM, Bui B
Ann Oncol 2010 Dec;21(12):2436-2441. Epub 2010 May 3 doi: 10.1093/annonc/mdq238. PMID: 20439343

Diagnosis

Relationship between magnetic resonance imaging findings and histological grade in spinal peripheral nerve sheath tumors in dogs.
Morabito S, Specchi S, Di Donato P, Pollard D, Dennis R, De Risio L, Bacon NJ, Potamopoulou M, Rupp S, Corlazzoli D, Ribeiro J, Cozzi F, Jurina K, Cappello R, Mercuriali E, Beckmann K, Flegel T, Menchetti M, König F, Matiasek K, Rosati M
J Vet Intern Med 2023 Nov-Dec;37(6):2278-2290. Epub 2023 Sep 19 doi: 10.1111/jvim.16839. PMID: 37726924Free PMC Article
Primary Synovial Sarcoma of the Bone: A Case Report and Literature Review.
Ichikawa J, Kawasaki T, Imada H, Kanno S, Ookita G, Taniguchi N, Ashizawa T, Tatsuno R, Jyubashi T, Haro H
Anticancer Res 2023 Sep;43(9):4241-4247. doi: 10.21873/anticanres.16617. PMID: 37648290
Role of the Immunohistochemical ZEB1 Expression in Uterine Mesenchymal Neoplasms.
Çelik M, Çelik ZE
Int J Surg Pathol 2022 Aug;30(5):520-527. Epub 2022 Jan 7 doi: 10.1177/10668969211070180. PMID: 34994578
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma.
Li CP, Liu DN, Zhou NN, Tian XY, Wang Z, Liu BN, Hao CY
Contrast Media Mol Imaging 2021;2021:7191363. Epub 2021 Jan 6 doi: 10.1155/2021/7191363. PMID: 33505228Free PMC Article
Alveolar soft part sarcoma in children and adolescents: The European Paediatric Soft Tissue Sarcoma study group prospective trial (EpSSG NRSTS 2005).
Brennan B, Zanetti I, Orbach D, Gallego S, Francotte N, Van Noesel M, Kelsey A, Casanova M, De Salvo GL, Bisogno G, Ferrari A
Pediatr Blood Cancer 2018 Apr;65(4) Epub 2017 Dec 29 doi: 10.1002/pbc.26942. PMID: 29286582

Therapy

Nomogram predicting overall survival after surgical resection for retroperitoneal leiomyosarcoma patients.
Zhuang A, Yue X, Tong H, Zhang Y, He F, Lu W
Front Endocrinol (Lausanne) 2023;14:1160817. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1160817. PMID: 37534215Free PMC Article
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma.
Li CP, Liu DN, Zhou NN, Tian XY, Wang Z, Liu BN, Hao CY
Contrast Media Mol Imaging 2021;2021:7191363. Epub 2021 Jan 6 doi: 10.1155/2021/7191363. PMID: 33505228Free PMC Article
Phase II clinical trial of pazopanib for patients with unresectable or metastatic malignant peripheral nerve sheath tumors.
Nishida Y, Urakawa H, Nakayama R, Kobayashi E, Ozaki T, Ae K, Matsumoto Y, Tsuchiya H, Goto T, Hiraga H, Naka N, Takahashi S, Ando Y, Ando M, Kuwatsuka Y, Hamada S, Ueda T, Kawai A
Int J Cancer 2021 Jan 1;148(1):140-149. Epub 2020 Aug 3 doi: 10.1002/ijc.33201. PMID: 32638374
Alveolar soft part sarcoma in children and adolescents: The European Paediatric Soft Tissue Sarcoma study group prospective trial (EpSSG NRSTS 2005).
Brennan B, Zanetti I, Orbach D, Gallego S, Francotte N, Van Noesel M, Kelsey A, Casanova M, De Salvo GL, Bisogno G, Ferrari A
Pediatr Blood Cancer 2018 Apr;65(4) Epub 2017 Dec 29 doi: 10.1002/pbc.26942. PMID: 29286582
Efficacy and safety of docetaxel in clinical trials.
Fumoleau P
Am J Health Syst Pharm 1997 Dec 15;54(24 Suppl 2):S19-24. doi: 10.1093/ajhp/54.suppl_2.S19. PMID: 9435929

Prognosis

Configuration of soft-tissue sarcoma on MRI correlates with grade of malignancy.
Sedaghat S, Salehi Ravesh M, Sedaghat M, Both M, Jansen O
Radiol Oncol 2021 Jan 29;55(2):158-163. doi: 10.2478/raon-2021-0007. PMID: 33600679Free PMC Article
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma.
Li CP, Liu DN, Zhou NN, Tian XY, Wang Z, Liu BN, Hao CY
Contrast Media Mol Imaging 2021;2021:7191363. Epub 2021 Jan 6 doi: 10.1155/2021/7191363. PMID: 33505228Free PMC Article
Alveolar soft part sarcoma in children and adolescents: The European Paediatric Soft Tissue Sarcoma study group prospective trial (EpSSG NRSTS 2005).
Brennan B, Zanetti I, Orbach D, Gallego S, Francotte N, Van Noesel M, Kelsey A, Casanova M, De Salvo GL, Bisogno G, Ferrari A
Pediatr Blood Cancer 2018 Apr;65(4) Epub 2017 Dec 29 doi: 10.1002/pbc.26942. PMID: 29286582
Surgical margins do not affect prognosis in high grade myxofibrosarcoma.
Sambri A, Bianchi G, Righi A, Ferrari C, Donati D
Eur J Surg Oncol 2016 Jul;42(7):1042-8. Epub 2016 May 27 doi: 10.1016/j.ejso.2016.05.015. PMID: 27260849
Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database.
Italiano A, Delva F, Mathoulin-Pelissier S, Le Cesne A, Bonvalot S, Terrier P, Trassard M, Michels JJ, Blay JY, Coindre JM, Bui B
Ann Oncol 2010 Dec;21(12):2436-2441. Epub 2010 May 3 doi: 10.1093/annonc/mdq238. PMID: 20439343

Clinical prediction guides

Nomogram predicting overall survival after surgical resection for retroperitoneal leiomyosarcoma patients.
Zhuang A, Yue X, Tong H, Zhang Y, He F, Lu W
Front Endocrinol (Lausanne) 2023;14:1160817. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1160817. PMID: 37534215Free PMC Article
Role of the Immunohistochemical ZEB1 Expression in Uterine Mesenchymal Neoplasms.
Çelik M, Çelik ZE
Int J Surg Pathol 2022 Aug;30(5):520-527. Epub 2022 Jan 7 doi: 10.1177/10668969211070180. PMID: 34994578
Configuration of soft-tissue sarcoma on MRI correlates with grade of malignancy.
Sedaghat S, Salehi Ravesh M, Sedaghat M, Both M, Jansen O
Radiol Oncol 2021 Jan 29;55(2):158-163. doi: 10.2478/raon-2021-0007. PMID: 33600679Free PMC Article
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma.
Li CP, Liu DN, Zhou NN, Tian XY, Wang Z, Liu BN, Hao CY
Contrast Media Mol Imaging 2021;2021:7191363. Epub 2021 Jan 6 doi: 10.1155/2021/7191363. PMID: 33505228Free PMC Article
Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database.
Italiano A, Delva F, Mathoulin-Pelissier S, Le Cesne A, Bonvalot S, Terrier P, Trassard M, Michels JJ, Blay JY, Coindre JM, Bui B
Ann Oncol 2010 Dec;21(12):2436-2441. Epub 2010 May 3 doi: 10.1093/annonc/mdq238. PMID: 20439343

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