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Small Intestinal Small Cell Neuroendocrine Carcinoma

MedGen UID:
236825
Concept ID:
C1336008
Neoplastic Process
Synonym: Small Intestinal Small Cell Carcinoma

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the small intestine. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Thomas KEH, Voros BA, Boudreaux JP, Thiagarajan R, Woltering EA, Ramirez RA
Oncologist 2019 Aug;24(8):1076-1088. Epub 2019 Jan 11 doi: 10.1634/theoncologist.2018-0604. PMID: 30635447Free PMC Article
Nishida T, Goto O, Raut CP, Yahagi N
Cancer 2016 Oct 15;122(20):3110-3118. Epub 2016 Aug 1 doi: 10.1002/cncr.30239. PMID: 27478963Free PMC Article
Hussain S
Adv Exp Med Biol 2016;890:137-47. doi: 10.1007/978-3-319-24932-2_8. PMID: 26703803

Recent clinical studies

Etiology

Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Zhang J, Liu X, Huang Z, Wu C, Zhang F, Han A, Stalin A, Lu S, Guo S, Huang J, Liu P, Shi R, Zhai Y, Chen M, Zhou W, Bai M, Wu J
Comput Biol Med 2023 Jan;152:106460. Epub 2022 Dec 21 doi: 10.1016/j.compbiomed.2022.106460. PMID: 36565482
Bureš J, Kohoutová D, Zavoral M
Klin Onkol 2022 Fall;35(5):346-357. doi: 10.48095/ccko2022346. PMID: 36443091
Lu S, Wu L, Jian H, Chen Y, Wang Q, Fang J, Wang Z, Hu Y, Sun M, Han L, Miao L, Ding C, Cui J, Li B, Pan Y, Li X, Ye F, Liu A, Wang K, Cang S, Zhou H, Sun X, Ferry D, Lin Y, Wang S, Zhang W, Zhang C
Lancet Oncol 2022 Sep;23(9):1167-1179. Epub 2022 Jul 28 doi: 10.1016/S1470-2045(22)00382-5. PMID: 35908558
Derosa L, Routy B, Thomas AM, Iebba V, Zalcman G, Friard S, Mazieres J, Audigier-Valette C, Moro-Sibilot D, Goldwasser F, Silva CAC, Terrisse S, Bonvalet M, Scherpereel A, Pegliasco H, Richard C, Ghiringhelli F, Elkrief A, Desilets A, Blanc-Durand F, Cumbo F, Blanco A, Boidot R, Chevrier S, Daillère R, Kroemer G, Alla L, Pons N, Le Chatelier E, Galleron N, Roume H, Dubuisson A, Bouchard N, Messaoudene M, Drubay D, Deutsch E, Barlesi F, Planchard D, Segata N, Martinez S, Zitvogel L, Soria JC, Besse B
Nat Med 2022 Feb;28(2):315-324. Epub 2022 Feb 3 doi: 10.1038/s41591-021-01655-5. PMID: 35115705Free PMC Article

Diagnosis

Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
Lee JE, Hong SH, Jung HI, Son MW, Ahn TS, Han SW, Cho JH
BMC Surg 2019 Sep 12;19(1):135. doi: 10.1186/s12893-019-0591-8. PMID: 31510991Free PMC Article
Hussain S
Adv Exp Med Biol 2016;890:137-47. doi: 10.1007/978-3-319-24932-2_8. PMID: 26703803
Thomas RM, Sobin LH
Cancer 1995 Jan 1;75(1 Suppl):154-70. doi: 10.1002/1097-0142(19950101)75:1+<154::aid-cncr2820751305>3.0.co;2-z. PMID: 8000994

Therapy

Subbiah V, Kreitman RJ, Wainberg ZA, Gazzah A, Lassen U, Stein A, Wen PY, Dietrich S, de Jonge MJA, Blay JY, Italiano A, Yonemori K, Cho DC, de Vos FYFL, Moreau P, Fernandez EE, Schellens JHM, Zielinski CC, Redhu S, Boran A, Passos VQ, Ilankumaran P, Bang YJ
Nat Med 2023 May;29(5):1103-1112. Epub 2023 Apr 14 doi: 10.1038/s41591-023-02321-8. PMID: 37059834Free PMC Article
Lu S, Wu L, Jian H, Chen Y, Wang Q, Fang J, Wang Z, Hu Y, Sun M, Han L, Miao L, Ding C, Cui J, Li B, Pan Y, Li X, Ye F, Liu A, Wang K, Cang S, Zhou H, Sun X, Ferry D, Lin Y, Wang S, Zhang W, Zhang C
Lancet Oncol 2022 Sep;23(9):1167-1179. Epub 2022 Jul 28 doi: 10.1016/S1470-2045(22)00382-5. PMID: 35908558
Lee SH, Cho SY, Yoon Y, Park C, Sohn J, Jeong JJ, Jeon BN, Jang M, An C, Lee S, Kim YY, Kim G, Kim S, Kim Y, Lee GB, Lee EJ, Kim SG, Kim HS, Kim Y, Kim H, Yang HS, Kim S, Kim S, Chung H, Moon MH, Nam MH, Kwon JY, Won S, Park JS, Weinstock GM, Lee C, Yoon KW, Park H
Nat Microbiol 2021 Mar;6(3):277-288. Epub 2021 Jan 11 doi: 10.1038/s41564-020-00831-6. PMID: 33432149
Li AY, McCusker MG, Russo A, Scilla KA, Gittens A, Arensmeyer K, Mehra R, Adamo V, Rolfo C
Cancer Treat Rev 2019 Dec;81:101911. Epub 2019 Oct 30 doi: 10.1016/j.ctrv.2019.101911. PMID: 31715421
Perez-Ruiz E, Minute L, Otano I, Alvarez M, Ochoa MC, Belsue V, de Andrea C, Rodriguez-Ruiz ME, Perez-Gracia JL, Marquez-Rodas I, Llacer C, Alvarez M, de Luque V, Molina C, Teijeira A, Berraondo P, Melero I
Nature 2019 May;569(7756):428-432. Epub 2019 May 1 doi: 10.1038/s41586-019-1162-y. PMID: 31043740

Prognosis

Zhang J, Liu X, Huang Z, Wu C, Zhang F, Han A, Stalin A, Lu S, Guo S, Huang J, Liu P, Shi R, Zhai Y, Chen M, Zhou W, Bai M, Wu J
Comput Biol Med 2023 Jan;152:106460. Epub 2022 Dec 21 doi: 10.1016/j.compbiomed.2022.106460. PMID: 36565482
Bureš J, Kohoutová D, Zavoral M
Klin Onkol 2022 Fall;35(5):346-357. doi: 10.48095/ccko2022346. PMID: 36443091
Wu H, Yu Z, Liu Y, Guo L, Teng L, Guo L, Liang L, Wang J, Gao J, Li R, Yang L, Nie X, Su D, Liang Z
Cancer Commun (Lond) 2022 Dec;42(12):1367-1386. Epub 2022 Oct 20 doi: 10.1002/cac2.12372. PMID: 36264285Free PMC Article
Derosa L, Routy B, Thomas AM, Iebba V, Zalcman G, Friard S, Mazieres J, Audigier-Valette C, Moro-Sibilot D, Goldwasser F, Silva CAC, Terrisse S, Bonvalet M, Scherpereel A, Pegliasco H, Richard C, Ghiringhelli F, Elkrief A, Desilets A, Blanc-Durand F, Cumbo F, Blanco A, Boidot R, Chevrier S, Daillère R, Kroemer G, Alla L, Pons N, Le Chatelier E, Galleron N, Roume H, Dubuisson A, Bouchard N, Messaoudene M, Drubay D, Deutsch E, Barlesi F, Planchard D, Segata N, Martinez S, Zitvogel L, Soria JC, Besse B
Nat Med 2022 Feb;28(2):315-324. Epub 2022 Feb 3 doi: 10.1038/s41591-021-01655-5. PMID: 35115705Free PMC Article
Thomas RM, Sobin LH
Cancer 1995 Jan 1;75(1 Suppl):154-70. doi: 10.1002/1097-0142(19950101)75:1+<154::aid-cncr2820751305>3.0.co;2-z. PMID: 8000994

Clinical prediction guides

Zhang J, Liu X, Huang Z, Wu C, Zhang F, Han A, Stalin A, Lu S, Guo S, Huang J, Liu P, Shi R, Zhai Y, Chen M, Zhou W, Bai M, Wu J
Comput Biol Med 2023 Jan;152:106460. Epub 2022 Dec 21 doi: 10.1016/j.compbiomed.2022.106460. PMID: 36565482
Derosa L, Routy B, Thomas AM, Iebba V, Zalcman G, Friard S, Mazieres J, Audigier-Valette C, Moro-Sibilot D, Goldwasser F, Silva CAC, Terrisse S, Bonvalet M, Scherpereel A, Pegliasco H, Richard C, Ghiringhelli F, Elkrief A, Desilets A, Blanc-Durand F, Cumbo F, Blanco A, Boidot R, Chevrier S, Daillère R, Kroemer G, Alla L, Pons N, Le Chatelier E, Galleron N, Roume H, Dubuisson A, Bouchard N, Messaoudene M, Drubay D, Deutsch E, Barlesi F, Planchard D, Segata N, Martinez S, Zitvogel L, Soria JC, Besse B
Nat Med 2022 Feb;28(2):315-324. Epub 2022 Feb 3 doi: 10.1038/s41591-021-01655-5. PMID: 35115705Free PMC Article
Chen D, Jin D, Huang S, Wu J, Xu M, Liu T, Dong W, Liu X, Wang S, Zhong W, Liu Y, Jiang R, Piao M, Wang B, Cao H
Cancer Lett 2020 Jan 28;469:456-467. Epub 2019 Nov 14 doi: 10.1016/j.canlet.2019.11.019. PMID: 31734354
Yu FX, Meng Z, Plouffe SW, Guan KL
Annu Rev Physiol 2015;77:201-27. Epub 2014 Sep 29 doi: 10.1146/annurev-physiol-021014-071733. PMID: 25293527
Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F
Hepatogastroenterology 2007 Jun;54(76):1247-9. PMID: 17629080

Recent systematic reviews

Piovani D, Hassan C, Repici A, Rimassa L, Carlo-Stella C, Nikolopoulos GK, Riboli E, Bonovas S
Gastroenterology 2022 Sep;163(3):671-684. Epub 2022 May 26 doi: 10.1053/j.gastro.2022.05.038. PMID: 35643170
Parra-Medina R, Moreno-Lucero P, Jimenez-Moreno J, Parra-Morales AM, Romero-Rojas A
PLoS One 2019;14(5):e0216647. Epub 2019 May 14 doi: 10.1371/journal.pone.0216647. PMID: 31086397Free PMC Article
Bara T Jr, Gurzu S, Sugimura H, Bara T, Beleaua MA, Jung I
Rom J Morphol Embryol 2017;58(1):41-44. PMID: 28523296

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