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Spinal Degenerative Disorder

MedGen UID:
236838
•Concept ID:
C1336050
•
Disease or Syndrome
Synonym: Spinal Degenerative Disease

Professional guidelines

PubMed

Cervical Spondylotic Myelopathy: A Guide to Diagnosis and Management.
McCormick JR, Sama AJ, Schiller NC, Butler AJ, Donnally CJ 3rd
J Am Board Fam Med 2020 Mar-Apr;33(2):303-313. doi: 10.3122/jabfm.2020.02.190195. PMID: 32179614
Cervical radiculopathy: epidemiology, etiology, diagnosis, and treatment.
Woods BI, Hilibrand AS
J Spinal Disord Tech 2015 Jun;28(5):E251-9. doi: 10.1097/BSD.0000000000000284. PMID: 25985461
Diagnosis and conservative management of degenerative lumbar spondylolisthesis.
Kalichman L, Hunter DJ
Eur Spine J 2008 Mar;17(3):327-335. Epub 2007 Nov 17 doi: 10.1007/s00586-007-0543-3. PMID: 18026865Free PMC Article

Recent clinical studies

Etiology

Nusinersen for the treatment of spinal muscular atrophy.
Chiriboga CA
Expert Rev Neurother 2017 Oct;17(10):955-962. Epub 2017 Sep 8 doi: 10.1080/14737175.2017.1364159. PMID: 28884620
Neurological and spinal manifestations of the Ehlers-Danlos syndromes.
Henderson FC Sr, Austin C, Benzel E, Bolognese P, Ellenbogen R, Francomano CA, Ireton C, Klinge P, Koby M, Long D, Patel S, Singman EL, Voermans NC
Am J Med Genet C Semin Med Genet 2017 Mar;175(1):195-211. Epub 2017 Feb 21 doi: 10.1002/ajmg.c.31549. PMID: 28220607
Temporomandibular disorders: Old ideas and new concepts.
List T, Jensen RH
Cephalalgia 2017 Jun;37(7):692-704. Epub 2017 Jan 9 doi: 10.1177/0333102416686302. PMID: 28068790
Cervical Spondylotic Myelopathy.
Iyer A, Azad TD, Tharin S
Clin Spine Surg 2016 Dec;29(10):408-414. doi: 10.1097/BSD.0000000000000397. PMID: 27352369
Degenerative Cervical Myelopathy: Epidemiology, Genetics, and Pathogenesis.
Nouri A, Tetreault L, Singh A, Karadimas SK, Fehlings MG
Spine (Phila Pa 1976) 2015 Jun 15;40(12):E675-93. doi: 10.1097/BRS.0000000000000913. PMID: 25839387

Diagnosis

Degenerative Cervical Myelopathy: Evaluation and Management.
Williams J, D'Amore P, Redlich N, Darlow M, Suwak P, Sarkovich S, Bhandutia AK
Orthop Clin North Am 2022 Oct;53(4):509-521. Epub 2022 Sep 14 doi: 10.1016/j.ocl.2022.05.007. PMID: 36208893
Neurological and spinal manifestations of the Ehlers-Danlos syndromes.
Henderson FC Sr, Austin C, Benzel E, Bolognese P, Ellenbogen R, Francomano CA, Ireton C, Klinge P, Koby M, Long D, Patel S, Singman EL, Voermans NC
Am J Med Genet C Semin Med Genet 2017 Mar;175(1):195-211. Epub 2017 Feb 21 doi: 10.1002/ajmg.c.31549. PMID: 28220607
Cervical Spondylotic Myelopathy.
Iyer A, Azad TD, Tharin S
Clin Spine Surg 2016 Dec;29(10):408-414. doi: 10.1097/BSD.0000000000000397. PMID: 27352369
Diagnosis and conservative management of degenerative lumbar spondylolisthesis.
Kalichman L, Hunter DJ
Eur Spine J 2008 Mar;17(3):327-335. Epub 2007 Nov 17 doi: 10.1007/s00586-007-0543-3. PMID: 18026865Free PMC Article
Lumbosacral radiculopathy.
Tarulli AW, Raynor EM
Neurol Clin 2007 May;25(2):387-405. doi: 10.1016/j.ncl.2007.01.008. PMID: 17445735

Therapy

Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial.
Hara S, Andresen H, Solheim O, Carlsen SM, Sundstrøm T, Lønne G, Lønne VV, Taraldsen K, Tronvik EA, Øie LR, Gulati AM, Sagberg LM, Jakola AS, Solberg TK, Nygaard ØP, Salvesen ØO, Gulati S
JAMA 2022 Oct 18;328(15):1506-1514. doi: 10.1001/jama.2022.18231. PMID: 36255427Free PMC Article
Prevalence of Work-Related Musculoskeletal Disorders Among Surgeons and Interventionalists: A Systematic Review and Meta-analysis.
Epstein S, Sparer EH, Tran BN, Ruan QZ, Dennerlein JT, Singhal D, Lee BT
JAMA Surg 2018 Feb 21;153(2):e174947. doi: 10.1001/jamasurg.2017.4947. PMID: 29282463Free PMC Article
PREPARE: presurgery physiotherapy for patients with degenerative lumbar spine disorder: a randomized controlled trial.
Lindbäck Y, Tropp H, Enthoven P, Abbott A, Öberg B
Spine J 2018 Aug;18(8):1347-1355. Epub 2017 Dec 15 doi: 10.1016/j.spinee.2017.12.009. PMID: 29253630
Nusinersen for the treatment of spinal muscular atrophy.
Chiriboga CA
Expert Rev Neurother 2017 Oct;17(10):955-962. Epub 2017 Sep 8 doi: 10.1080/14737175.2017.1364159. PMID: 28884620
Diagnosis and conservative management of degenerative lumbar spondylolisthesis.
Kalichman L, Hunter DJ
Eur Spine J 2008 Mar;17(3):327-335. Epub 2007 Nov 17 doi: 10.1007/s00586-007-0543-3. PMID: 18026865Free PMC Article

Prognosis

Cervical Total Disc Replacement: Expanded Indications.
Alves ÓL
Neurosurg Clin N Am 2021 Oct;32(4):437-448. Epub 2021 Jul 29 doi: 10.1016/j.nec.2021.05.002. PMID: 34538470
High bone mass in adults.
Paccou J, Michou L, Kolta S, Debiais F, Cortet B, Guggenbuhl P
Joint Bone Spine 2018 Dec;85(6):693-699. Epub 2018 Mar 2 doi: 10.1016/j.jbspin.2018.01.007. PMID: 29407041
Degenerative Cervical Myelopathy: Epidemiology, Genetics, and Pathogenesis.
Nouri A, Tetreault L, Singh A, Karadimas SK, Fehlings MG
Spine (Phila Pa 1976) 2015 Jun 15;40(12):E675-93. doi: 10.1097/BRS.0000000000000913. PMID: 25839387
Spinal muscular atrophies.
Viollet L, Melki J
Handb Clin Neurol 2013;113:1395-411. doi: 10.1016/B978-0-444-59565-2.00010-1. PMID: 23622363
Greater trochanteric pain syndrome: a review of anatomy, diagnosis and treatment.
Williams BS, Cohen SP
Anesth Analg 2009 May;108(5):1662-70. doi: 10.1213/ane.0b013e31819d6562. PMID: 19372352

Clinical prediction guides

Cervical and Thoracic Spondylotic Myelopathies.
Onofrei LV, Henrie AM
Semin Neurol 2021 Jun;41(3):239-246. Epub 2021 May 19 doi: 10.1055/s-0041-1725144. PMID: 34010970
PREPARE: presurgery physiotherapy for patients with degenerative lumbar spine disorder: a randomized controlled trial.
Lindbäck Y, Tropp H, Enthoven P, Abbott A, Öberg B
Spine J 2018 Aug;18(8):1347-1355. Epub 2017 Dec 15 doi: 10.1016/j.spinee.2017.12.009. PMID: 29253630
Degenerative Cervical Myelopathy: Epidemiology, Genetics, and Pathogenesis.
Nouri A, Tetreault L, Singh A, Karadimas SK, Fehlings MG
Spine (Phila Pa 1976) 2015 Jun 15;40(12):E675-93. doi: 10.1097/BRS.0000000000000913. PMID: 25839387
Polyetheretherketone (PEEK) cages in cervical applications: a systematic review.
Kersten RF, van Gaalen SM, de Gast A, Öner FC
Spine J 2015 Jun 1;15(6):1446-60. Epub 2013 Dec 27 doi: 10.1016/j.spinee.2013.08.030. PMID: 24374100
Symptomatic myoclonus.
Borg M
Neurophysiol Clin 2006 Sep-Dec;36(5-6):309-18. Epub 2007 Jan 17 doi: 10.1016/j.neucli.2006.12.006. PMID: 17336775

Recent systematic reviews

Rehabilitation to improve outcomes of lumbar fusion surgery: a systematic review with meta-analysis.
Bogaert L, Thys T, Depreitere B, Dankaerts W, Amerijckx C, Van Wambeke P, Jacobs K, Boonen H, Brumagne S, Moke L, Schelfaut S, Spriet A, Peers K, Swinnen TW, Janssens L
Eur Spine J 2022 Jun;31(6):1525-1545. Epub 2022 Mar 8 doi: 10.1007/s00586-022-07158-2. PMID: 35258644
Prevalence of Work-Related Musculoskeletal Disorders Among Surgeons and Interventionalists: A Systematic Review and Meta-analysis.
Epstein S, Sparer EH, Tran BN, Ruan QZ, Dennerlein JT, Singhal D, Lee BT
JAMA Surg 2018 Feb 21;153(2):e174947. doi: 10.1001/jamasurg.2017.4947. PMID: 29282463Free PMC Article
The role of physical therapy and rehabilitation after lumbar fusion surgery for degenerative disease: a systematic review.
Madera M, Brady J, Deily S, McGinty T, Moroz L, Singh D, Tipton G, Truumees E;  for the Seton Spine Rehabilitation Study Group
J Neurosurg Spine 2017 Jun;26(6):694-704. Epub 2017 Mar 10 doi: 10.3171/2016.10.SPINE16627. PMID: 28291412
An evidence-based clinical guideline for the diagnosis and treatment of degenerative lumbar spinal stenosis (update).
Kreiner DS, Shaffer WO, Baisden JL, Gilbert TJ, Summers JT, Toton JF, Hwang SW, Mendel RC, Reitman CA; North American Spine Society
Spine J 2013 Jul;13(7):734-43. doi: 10.1016/j.spinee.2012.11.059. PMID: 23830297
An evidence-based clinical guideline for the diagnosis and treatment of cervical radiculopathy from degenerative disorders.
Bono CM, Ghiselli G, Gilbert TJ, Kreiner DS, Reitman C, Summers JT, Baisden JL, Easa J, Fernand R, Lamer T, Matz PG, Mazanec DJ, Resnick DK, Shaffer WO, Sharma AK, Timmons RB, Toton JF; North American Spine Society
Spine J 2011 Jan;11(1):64-72. doi: 10.1016/j.spinee.2010.10.023. PMID: 21168100

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