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Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia

MedGen UID:
236842
•Concept ID:
C1336067
•
Neoplastic Process

Definition

Infiltration and expansion of the red pulp cords and sinusoids of the spleen by T-cell large granular lymphocyte leukemia. The white pulp of the spleen is not involved and is often hyperplastic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia

Recent clinical studies

Diagnosis

Large granular lymphocyte leukemia: An indolent clonal proliferative disease associated with an array of various immunologic disorders.
Drillet G, Pastoret C, Moignet A, Lamy T, Marchand T
Rev Med Interne 2023 Jun;44(6):295-306. Epub 2023 Apr 21 doi: 10.1016/j.revmed.2023.03.014. PMID: 37087371
Hepatosplenic T-Cell Lymphoma: A Clinicopathologic Review With an Emphasis on Diagnostic Differentiation From Other T-Cell/Natural Killer-Cell Neoplasms.
Shi Y, Wang E
Arch Pathol Lab Med 2015 Sep;139(9):1173-80. doi: 10.5858/arpa.2014-0079-RS. PMID: 26317456
De novo CD3 negative hepatosplenic T-cell lymphoma: diagnostic challenges and pitfalls.
Kapur LH, Khaled Y, Solh M, Ward D, Chang CC
Arch Pathol Lab Med 2014 Jul;138(7):969-73. doi: 10.5858/arpa.2013-0074-CR. PMID: 24978925
Aggressive acute CD3+, CD56- T cell large granular lymphocyte leukemia with two stages of maturation arrest.
Tordjman R, Macintyre E, Emile JF, Valensi F, Ribrag V, Burtin ML, Varet B, Brousse N, Hermine O
Leukemia 1996 Sep;10(9):1514-9. PMID: 8751472
The pathology of large granular lymphocyte leukemia.
Agnarsson BA, Loughran TP Jr, Starkebaum G, Kadin ME
Hum Pathol 1989 Jul;20(7):643-51. doi: 10.1016/0046-8177(89)90151-2. PMID: 2661408

Prognosis

Large granular lymphocyte leukemia: An indolent clonal proliferative disease associated with an array of various immunologic disorders.
Drillet G, Pastoret C, Moignet A, Lamy T, Marchand T
Rev Med Interne 2023 Jun;44(6):295-306. Epub 2023 Apr 21 doi: 10.1016/j.revmed.2023.03.014. PMID: 37087371
Hepatosplenic T-Cell Lymphoma: A Clinicopathologic Review With an Emphasis on Diagnostic Differentiation From Other T-Cell/Natural Killer-Cell Neoplasms.
Shi Y, Wang E
Arch Pathol Lab Med 2015 Sep;139(9):1173-80. doi: 10.5858/arpa.2014-0079-RS. PMID: 26317456

Clinical prediction guides

Aggressive acute CD3+, CD56- T cell large granular lymphocyte leukemia with two stages of maturation arrest.
Tordjman R, Macintyre E, Emile JF, Valensi F, Ribrag V, Burtin ML, Varet B, Brousse N, Hermine O
Leukemia 1996 Sep;10(9):1514-9. PMID: 8751472

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