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Stage II Skin Cancer

MedGen UID:
236909
Concept ID:
C1336317
Neoplastic Process
Synonyms: Carcinoma of Skin Stage II; Carcinoma of the Skin Stage II; Skin Cancer Stage II; Skin Carcinoma Stage II; Stage II Skin Cancer AJCC v7

Definition

Stage II includes: T2, N0, M0. T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features. High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness; Clark level equal or greater than IV; and perineural invasion. Anatomic location: primary site ear and primary site non-hair-bearing lip. Differentiation: poorly differentiated or undifferentiated. N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis. (AJCC 7th ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage II Skin Cancer

Professional guidelines

PubMed

Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Garbe C, Keim U, Amaral T, Berking C, Eigentler TK, Flatz L, Gesierich A, Leiter U, Stadler R, Sunderkötter C, Tüting T, Utikal J, Wollina U, Zimmer L, Zouboulis CC, Ascierto PA, Eggermont AMM, Grob JJ, Hauschild A, Sekulovic LK, Long GV, Luke JJ, Michielin O, Peris K, Schadendorf D, Kirkwood JM, Lorigan PC; Central Malignant Melanoma Registry (CMMR)
J Clin Oncol 2022 Nov 10;40(32):3741-3749. Epub 2022 Jun 16 doi: 10.1200/JCO.22.00202. PMID: 35709414Free PMC Article
Villani A, Potestio L, Fabbrocini G, Scalvenzi M
Adv Ther 2022 Mar;39(3):1164-1178. Epub 2022 Jan 28 doi: 10.1007/s12325-022-02044-1. PMID: 35089534Free PMC Article

Recent clinical studies

Etiology

Becker JC, Ugurel S, Leiter U, Meier F, Gutzmer R, Haferkamp S, Zimmer L, Livingstone E, Eigentler TK, Hauschild A, Kiecker F, Hassel JC, Mohr P, Fluck M, Thomas I, Garzarolli M, Grimmelmann I, Drexler K, Spillner AN, Eckhardt S, Schadendorf D; DeCOG
Lancet 2023 Sep 2;402(10404):798-808. Epub 2023 Jul 11 doi: 10.1016/S0140-6736(23)00769-9. PMID: 37451295
Garbe C, Keim U, Amaral T, Berking C, Eigentler TK, Flatz L, Gesierich A, Leiter U, Stadler R, Sunderkötter C, Tüting T, Utikal J, Wollina U, Zimmer L, Zouboulis CC, Ascierto PA, Eggermont AMM, Grob JJ, Hauschild A, Sekulovic LK, Long GV, Luke JJ, Michielin O, Peris K, Schadendorf D, Kirkwood JM, Lorigan PC; Central Malignant Melanoma Registry (CMMR)
J Clin Oncol 2022 Nov 10;40(32):3741-3749. Epub 2022 Jun 16 doi: 10.1200/JCO.22.00202. PMID: 35709414Free PMC Article
Luke JJ, Ascierto PA, Carlino MS, Gershenwald JE, Grob JJ, Hauschild A, Kirkwood JM, Long GV, Mohr P, Robert C, Ross M, Scolyer RA, Yoon CH, Poklepovic A, Rutkowski P, Anderson JR, Ahsan S, Ibrahim N, M Eggermont AM
Future Oncol 2020 Jan;16(3):4429-4438. Epub 2019 Dec 24 doi: 10.2217/fon-2019-0666. PMID: 31870188
Pérez LL, Bashline B
FP Essent 2019 Jun;481:11-16. PMID: 31188547
Elder DE
Arch Pathol Lab Med 2011 Mar;135(3):342-6. doi: 10.5858/2009-0479-RA.1. PMID: 21366458

Diagnosis

Garbe C, Keim U, Amaral T, Berking C, Eigentler TK, Flatz L, Gesierich A, Leiter U, Stadler R, Sunderkötter C, Tüting T, Utikal J, Wollina U, Zimmer L, Zouboulis CC, Ascierto PA, Eggermont AMM, Grob JJ, Hauschild A, Sekulovic LK, Long GV, Luke JJ, Michielin O, Peris K, Schadendorf D, Kirkwood JM, Lorigan PC; Central Malignant Melanoma Registry (CMMR)
J Clin Oncol 2022 Nov 10;40(32):3741-3749. Epub 2022 Jun 16 doi: 10.1200/JCO.22.00202. PMID: 35709414Free PMC Article
Manganelli M, Guida S, Ferretta A, Pellacani G, Porcelli L, Azzariti A, Guida G
Genes (Basel) 2021 Jul 19;12(7) doi: 10.3390/genes12071093. PMID: 34356109Free PMC Article
Pérez LL, Bashline B
FP Essent 2019 Jun;481:11-16. PMID: 31188547
Gershenwald JE, Scolyer RA, Hess KR, Sondak VK, Long GV, Ross MI, Lazar AJ, Faries MB, Kirkwood JM, McArthur GA, Haydu LE, Eggermont AMM, Flaherty KT, Balch CM, Thompson JF; for members of the American Joint Committee on Cancer Melanoma Expert Panel and the International Melanoma Database and Discovery Platform
CA Cancer J Clin 2017 Nov;67(6):472-492. Epub 2017 Oct 13 doi: 10.3322/caac.21409. PMID: 29028110Free PMC Article
Elder DE
Arch Pathol Lab Med 2011 Mar;135(3):342-6. doi: 10.5858/2009-0479-RA.1. PMID: 21366458

Therapy

Long GV, Menzies AM, Scolyer RA
J Clin Oncol 2023 Jun 10;41(17):3236-3248. Epub 2023 Apr 27 doi: 10.1200/JCO.22.02575. PMID: 37104746
Patel SP, Othus M, Chen Y, Wright GP Jr, Yost KJ, Hyngstrom JR, Hu-Lieskovan S, Lao CD, Fecher LA, Truong TG, Eisenstein JL, Chandra S, Sosman JA, Kendra KL, Wu RC, Devoe CE, Deutsch GB, Hegde A, Khalil M, Mangla A, Reese AM, Ross MI, Poklepovic AS, Phan GQ, Onitilo AA, Yasar DG, Powers BC, Doolittle GC, In GK, Kokot N, Gibney GT, Atkins MB, Shaheen M, Warneke JA, Ikeguchi A, Najera JE, Chmielowski B, Crompton JG, Floyd JD, Hsueh E, Margolin KA, Chow WA, Grossmann KF, Dietrich E, Prieto VG, Lowe MC, Buchbinder EI, Kirkwood JM, Korde L, Moon J, Sharon E, Sondak VK, Ribas A
N Engl J Med 2023 Mar 2;388(9):813-823. doi: 10.1056/NEJMoa2211437. PMID: 36856617Free PMC Article
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Kaufman HL, Seebach F, Lowy I, Yoo SY, Mathias M, Fenech K, Han H, Fury MG, Rischin D
N Engl J Med 2022 Oct 27;387(17):1557-1568. Epub 2022 Sep 12 doi: 10.1056/NEJMoa2209813. PMID: 36094839Free PMC Article
Gershenwald JE, Scolyer RA, Hess KR, Sondak VK, Long GV, Ross MI, Lazar AJ, Faries MB, Kirkwood JM, McArthur GA, Haydu LE, Eggermont AMM, Flaherty KT, Balch CM, Thompson JF; for members of the American Joint Committee on Cancer Melanoma Expert Panel and the International Melanoma Database and Discovery Platform
CA Cancer J Clin 2017 Nov;67(6):472-492. Epub 2017 Oct 13 doi: 10.3322/caac.21409. PMID: 29028110Free PMC Article
Ascierto PA, Kirkwood JM, Grob JJ, Simeone E, Grimaldi AM, Maio M, Palmieri G, Testori A, Marincola FM, Mozzillo N
J Transl Med 2012 Jul 9;10:85. doi: 10.1186/1479-5876-10-85. PMID: 22554099Free PMC Article

Prognosis

Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Garbe C, Keim U, Amaral T, Berking C, Eigentler TK, Flatz L, Gesierich A, Leiter U, Stadler R, Sunderkötter C, Tüting T, Utikal J, Wollina U, Zimmer L, Zouboulis CC, Ascierto PA, Eggermont AMM, Grob JJ, Hauschild A, Sekulovic LK, Long GV, Luke JJ, Michielin O, Peris K, Schadendorf D, Kirkwood JM, Lorigan PC; Central Malignant Melanoma Registry (CMMR)
J Clin Oncol 2022 Nov 10;40(32):3741-3749. Epub 2022 Jun 16 doi: 10.1200/JCO.22.00202. PMID: 35709414Free PMC Article
Topalian SL, Bhatia S, Amin A, Kudchadkar RR, Sharfman WH, Lebbé C, Delord JP, Dunn LA, Shinohara MM, Kulikauskas R, Chung CH, Martens UM, Ferris RL, Stein JE, Engle EL, Devriese LA, Lao CD, Gu J, Li B, Chen T, Barrows A, Horvath A, Taube JM, Nghiem P
J Clin Oncol 2020 Aug 1;38(22):2476-2487. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00201. PMID: 32324435Free PMC Article
Gershenwald JE, Scolyer RA, Hess KR, Sondak VK, Long GV, Ross MI, Lazar AJ, Faries MB, Kirkwood JM, McArthur GA, Haydu LE, Eggermont AMM, Flaherty KT, Balch CM, Thompson JF; for members of the American Joint Committee on Cancer Melanoma Expert Panel and the International Melanoma Database and Discovery Platform
CA Cancer J Clin 2017 Nov;67(6):472-492. Epub 2017 Oct 13 doi: 10.3322/caac.21409. PMID: 29028110Free PMC Article
Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, Eggermont AM, Flaherty KT, Gimotty PA, Kirkwood JM, McMasters KM, Mihm MC Jr, Morton DL, Ross MI, Sober AJ, Sondak VK
J Clin Oncol 2009 Dec 20;27(36):6199-206. Epub 2009 Nov 16 doi: 10.1200/JCO.2009.23.4799. PMID: 19917835Free PMC Article

Clinical prediction guides

Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Becker JC, Ugurel S, Leiter U, Meier F, Gutzmer R, Haferkamp S, Zimmer L, Livingstone E, Eigentler TK, Hauschild A, Kiecker F, Hassel JC, Mohr P, Fluck M, Thomas I, Garzarolli M, Grimmelmann I, Drexler K, Spillner AN, Eckhardt S, Schadendorf D; DeCOG
Lancet 2023 Sep 2;402(10404):798-808. Epub 2023 Jul 11 doi: 10.1016/S0140-6736(23)00769-9. PMID: 37451295
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Kaufman HL, Seebach F, Lowy I, Yoo SY, Mathias M, Fenech K, Han H, Fury MG, Rischin D
N Engl J Med 2022 Oct 27;387(17):1557-1568. Epub 2022 Sep 12 doi: 10.1056/NEJMoa2209813. PMID: 36094839Free PMC Article
Topalian SL, Bhatia S, Amin A, Kudchadkar RR, Sharfman WH, Lebbé C, Delord JP, Dunn LA, Shinohara MM, Kulikauskas R, Chung CH, Martens UM, Ferris RL, Stein JE, Engle EL, Devriese LA, Lao CD, Gu J, Li B, Chen T, Barrows A, Horvath A, Taube JM, Nghiem P
J Clin Oncol 2020 Aug 1;38(22):2476-2487. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00201. PMID: 32324435Free PMC Article
Huang AC, Orlowski RJ, Xu X, Mick R, George SM, Yan PK, Manne S, Kraya AA, Wubbenhorst B, Dorfman L, D'Andrea K, Wenz BM, Liu S, Chilukuri L, Kozlov A, Carberry M, Giles L, Kier MW, Quagliarello F, McGettigan S, Kreider K, Annamalai L, Zhao Q, Mogg R, Xu W, Blumenschein WM, Yearley JH, Linette GP, Amaravadi RK, Schuchter LM, Herati RS, Bengsch B, Nathanson KL, Farwell MD, Karakousis GC, Wherry EJ, Mitchell TC
Nat Med 2019 Mar;25(3):454-461. Epub 2019 Feb 25 doi: 10.1038/s41591-019-0357-y. PMID: 30804515Free PMC Article

Recent systematic reviews

Shi J, Gao Y, Tian J, Li J, Xu J, Mei F, Li Z
Cochrane Database Syst Rev 2023 May 26;5(5):CD011334. doi: 10.1002/14651858.CD011334.pub3. PMID: 37232410Free PMC Article
Visconti MJ, Archibald LK, Shahwan KT, Kimyon RS, Bakker C, Mattox AR, Alam M, Maher IA
Arch Dermatol Res 2023 Apr;315(3):333-337. Epub 2022 Sep 24 doi: 10.1007/s00403-022-02390-8. PMID: 36152047
Toma AO, Prodan M, Reddyreddy AR, Seclaman E, Crainiceanu Z, Bloanca V, Bratosin F, Dumitru C, Pilut CN, Alambaram S, Vasamsetti NG, Decean L, Pricop M
Int J Environ Res Public Health 2022 Dec 25;20(1) doi: 10.3390/ijerph20010305. PMID: 36612627Free PMC Article
Zikry J, Chapman LW, Korta DZ, Smith J
Dermatol Surg 2017 Jun;43(6):765-770. doi: 10.1097/DSS.0000000000001072. PMID: 28291064
Rosko AJ, Vankoevering KK, McLean SA, Johnson TM, Moyer JS
JAMA Facial Plast Surg 2017 May 1;19(3):232-238. doi: 10.1001/jamafacial.2016.1846. PMID: 28114438

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