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Stage IVB Pharyngeal Cancer

MedGen UID:
236929
•Concept ID:
C1336390
•
Neoplastic Process
Synonyms: Pharyngeal Cancer Stage IVB; Stage IVB Carcinoma of Pharynx; Stage IVB Carcinoma of the Pharynx; Stage IVB Pharyngeal Carcinoma; Stage IVB Pharynx Carcinoma

Definition

Stage IVB carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions. [from NCI]

Professional guidelines

PubMed

Juvenile nasopharyngeal angiofibroma with intracranial extension - diagnosis and treatment.
Gołąbek W, Szymańska A, Szymański M, Czekajska-Chehab E, Jargiełło T
Otolaryngol Pol 2019 Oct 24;74(2):1-7. doi: 10.5604/01.3001.0013.5275. PMID: 32022702
Emerging treatment options for nasopharyngeal carcinoma.
Zhang L, Chen QY, Liu H, Tang LQ, Mai HQ
Drug Des Devel Ther 2013;7:37-52. Epub 2013 Feb 1 doi: 10.2147/DDDT.S30753. PMID: 23403548Free PMC Article
Treatment for metastatic nasopharyngeal carcinoma.
Bensouda Y, Kaikani W, Ahbeddou N, Rahhali R, Jabri M, Mrabti H, Boussen H, Errihani H
Eur Ann Otorhinolaryngol Head Neck Dis 2011 Apr;128(2):79-85. Epub 2010 Dec 21 doi: 10.1016/j.anorl.2010.10.003. PMID: 21177151

Recent clinical studies

Etiology

Treatment strategy for de novo metastatic nasopharyngeal carcinoma: a literature review.
Liu Q, Li J, Ng WT, Lee AWM
Chin Clin Oncol 2023 Aug;12(4):43. doi: 10.21037/cco-23-32. PMID: 37699604
Human papillomavirus status and prognosis of oropharyngeal high-grade neuroendocrine carcinoma.
de Sousa LG, Lazar Neto F, Dal Lago EA, Sikora A, Hanna E, Moreno A, Phan J, Glisson BS, Bell D, Ferrarotto R
Oral Oncol 2023 Mar;138:106311. Epub 2023 Jan 24 doi: 10.1016/j.oraloncology.2023.106311. PMID: 36702015
Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.
Li WZ, Lv X, Hu D, Lv SH, Liu GY, Liang H, Ye YF, Yang W, Zhang HX, Yuan TZ, Wang DS, Lu N, Ke LR, Tang WB, Tong LH, Chen ZJ, Liu T, Cao KJ, Mo HY, Guo L, Zhao C, Chen MY, Chen QY, Huang PY, Sun R, Qiu F, Luo DH, Wang L, Hua YJ, Tang LQ, Qian CN, Mai HQ, Guo X, Xiang YQ, Xia WX
JAMA Oncol 2022 May 1;8(5):706-714. doi: 10.1001/jamaoncol.2022.0122. PMID: 35323856Free PMC Article
Clinical Outcomes of Definitive and Postoperative Radiotherapy for Stage I-IVB Hypopharyngeal Cancer.
Shirai K, Saitoh JI, Musha A, Abe T, Kobayashi D, Takakusagi Y, Takaysu Y, Shino M, Toyoda M, Takahashi K, Chikamatsu K, Ohno T, Nakano T
Anticancer Res 2016 Dec;36(12):6571-6578. doi: 10.21873/anticanres.11261. PMID: 27919985
Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial.
Sun Y, Li WF, Chen NY, Zhang N, Hu GQ, Xie FY, Sun Y, Chen XZ, Li JG, Zhu XD, Hu CS, Xu XY, Chen YY, Hu WH, Guo L, Mo HY, Chen L, Mao YP, Sun R, Ai P, Liang SB, Long GX, Zheng BM, Feng XL, Gong XC, Li L, Shen CY, Xu JY, Guo Y, Chen YM, Zhang F, Lin L, Tang LL, Liu MZ, Ma J
Lancet Oncol 2016 Nov;17(11):1509-1520. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30410-7. PMID: 27686945

Diagnosis

The Prognostic and Predictive Effects of Human Papillomavirus Status in Hypopharyngeal Carcinoma: Population-Based Study.
Yang SP, Lin XY, Hu M, Cai CF
JMIR Public Health Surveill 2022 Dec 16;8(12):e40185. doi: 10.2196/40185. PMID: 36525304Free PMC Article
Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma.
Nair V, Auger S, Kochanny S, Howard FM, Ginat D, Pasternak-Wise O, Juloori A, Koshy M, Izumchenko E, Agrawal N, Rosenberg A, Vokes EE, Skandari MR, Pearson AT
JAMA Netw Open 2022 Apr 1;5(4):e227240. doi: 10.1001/jamanetworkopen.2022.7240. PMID: 35416988Free PMC Article
Prognostic significance of human papillomavirus status and treatment modality in hypopharyngeal cancer.
Burbure N, Handorf E, Ridge JA, Bauman J, Liu JC, Giri A, Galloway TJ
Head Neck 2021 Oct;43(10):3042-3052. Epub 2021 Jun 24 doi: 10.1002/hed.26793. PMID: 34165223Free PMC Article
Societal cost of oropharyngeal cancer by human papillomavirus status, cancer stage, and subsite.
Silfverschiöld M, Sjövall J, Wennerberg J, Östensson E, Greiff L
PLoS One 2019;14(7):e0220534. Epub 2019 Jul 29 doi: 10.1371/journal.pone.0220534. PMID: 31356646Free PMC Article
The management of the oropharyngeal anterior wall cancer.
Balica NC, Poenaru M, Doroş CI, Baderca F, Preda MA, Iovan VC, Stanca HT, Busuioc CJ, Oprişcan IC, Boruga O
Rom J Morphol Embryol 2018;59(1):113-119. PMID: 29940618

Therapy

Treatment strategy for de novo metastatic nasopharyngeal carcinoma: a literature review.
Liu Q, Li J, Ng WT, Lee AWM
Chin Clin Oncol 2023 Aug;12(4):43. doi: 10.21037/cco-23-32. PMID: 37699604
Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.
Li WZ, Lv X, Hu D, Lv SH, Liu GY, Liang H, Ye YF, Yang W, Zhang HX, Yuan TZ, Wang DS, Lu N, Ke LR, Tang WB, Tong LH, Chen ZJ, Liu T, Cao KJ, Mo HY, Guo L, Zhao C, Chen MY, Chen QY, Huang PY, Sun R, Qiu F, Luo DH, Wang L, Hua YJ, Tang LQ, Qian CN, Mai HQ, Guo X, Xiang YQ, Xia WX
JAMA Oncol 2022 May 1;8(5):706-714. doi: 10.1001/jamaoncol.2022.0122. PMID: 35323856Free PMC Article
Correlation between plan quality improvements and reduced acute dysphagia and xerostomia in the definitive treatment of oropharyngeal squamous cell carcinoma.
Cui T, Ward MC, Joshi NP, Woody NM, Murray EJ, Potter J, Dorfmeyer AA, Greskovich JF Jr, Koyfman SA, Xia P
Head Neck 2019 Apr;41(4):1096-1103. Epub 2019 Jan 31 doi: 10.1002/hed.25594. PMID: 30702180
Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial.
Sun Y, Li WF, Chen NY, Zhang N, Hu GQ, Xie FY, Sun Y, Chen XZ, Li JG, Zhu XD, Hu CS, Xu XY, Chen YY, Hu WH, Guo L, Mo HY, Chen L, Mao YP, Sun R, Ai P, Liang SB, Long GX, Zheng BM, Feng XL, Gong XC, Li L, Shen CY, Xu JY, Guo Y, Chen YM, Zhang F, Lin L, Tang LL, Liu MZ, Ma J
Lancet Oncol 2016 Nov;17(11):1509-1520. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30410-7. PMID: 27686945
Emerging treatment options for nasopharyngeal carcinoma.
Zhang L, Chen QY, Liu H, Tang LQ, Mai HQ
Drug Des Devel Ther 2013;7:37-52. Epub 2013 Feb 1 doi: 10.2147/DDDT.S30753. PMID: 23403548Free PMC Article

Prognosis

Treatment strategy for de novo metastatic nasopharyngeal carcinoma: a literature review.
Liu Q, Li J, Ng WT, Lee AWM
Chin Clin Oncol 2023 Aug;12(4):43. doi: 10.21037/cco-23-32. PMID: 37699604
Human papillomavirus status and prognosis of oropharyngeal high-grade neuroendocrine carcinoma.
de Sousa LG, Lazar Neto F, Dal Lago EA, Sikora A, Hanna E, Moreno A, Phan J, Glisson BS, Bell D, Ferrarotto R
Oral Oncol 2023 Mar;138:106311. Epub 2023 Jan 24 doi: 10.1016/j.oraloncology.2023.106311. PMID: 36702015
Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma.
Nair V, Auger S, Kochanny S, Howard FM, Ginat D, Pasternak-Wise O, Juloori A, Koshy M, Izumchenko E, Agrawal N, Rosenberg A, Vokes EE, Skandari MR, Pearson AT
JAMA Netw Open 2022 Apr 1;5(4):e227240. doi: 10.1001/jamanetworkopen.2022.7240. PMID: 35416988Free PMC Article
Societal cost of oropharyngeal cancer by human papillomavirus status, cancer stage, and subsite.
Silfverschiöld M, Sjövall J, Wennerberg J, Östensson E, Greiff L
PLoS One 2019;14(7):e0220534. Epub 2019 Jul 29 doi: 10.1371/journal.pone.0220534. PMID: 31356646Free PMC Article
Clinical Outcomes of Definitive and Postoperative Radiotherapy for Stage I-IVB Hypopharyngeal Cancer.
Shirai K, Saitoh JI, Musha A, Abe T, Kobayashi D, Takakusagi Y, Takaysu Y, Shino M, Toyoda M, Takahashi K, Chikamatsu K, Ohno T, Nakano T
Anticancer Res 2016 Dec;36(12):6571-6578. doi: 10.21873/anticanres.11261. PMID: 27919985

Clinical prediction guides

Quantitative prediction of aspiration risk in head and neck cancer patients treated with radiation therapy.
Liu HC, Williamson CW, Zou J, Todd JR, Nelson TJ, Hill LM, Linnemeyer KE, Henderson G, Madgula P, Faung B, Sacco AG, Vitzthum LK, Weissbrod PA, Blumenfeld LS, Mell LK
Oral Oncol 2023 Jan;136:106247. Epub 2022 Nov 19 doi: 10.1016/j.oraloncology.2022.106247. PMID: 36410204
The Prognostic and Predictive Effects of Human Papillomavirus Status in Hypopharyngeal Carcinoma: Population-Based Study.
Yang SP, Lin XY, Hu M, Cai CF
JMIR Public Health Surveill 2022 Dec 16;8(12):e40185. doi: 10.2196/40185. PMID: 36525304Free PMC Article
Comparison of the Seventh and Eighth Edition of American Joint Committee on Cancer (AJCC) Staging for Selected and Nonselected Oropharyngeal Squamous Cell Carcinomas.
Vijayvargiya P, Trivedi S, Rupji M, Song H, Liu Y, Jiang R, Kaka AS, Chen GZ, Stokes W, Steuer C, Shin DM, Beitler JJ, Patel MR, Aiken A, Saba NF
Oncologist 2022 Feb 3;27(1):48-56. doi: 10.1093/oncolo/oyab001. PMID: 35305095Free PMC Article
Correlation between plan quality improvements and reduced acute dysphagia and xerostomia in the definitive treatment of oropharyngeal squamous cell carcinoma.
Cui T, Ward MC, Joshi NP, Woody NM, Murray EJ, Potter J, Dorfmeyer AA, Greskovich JF Jr, Koyfman SA, Xia P
Head Neck 2019 Apr;41(4):1096-1103. Epub 2019 Jan 31 doi: 10.1002/hed.25594. PMID: 30702180
Radiotherapy alone and with concurrent chemotherapy for nasopharyngeal carcinoma: A retrospective study.
Katano A, Takahashi W, Yamashita H, Yamamoto K, Ando M, Yoshida M, Saito Y, Abe O, Nakagawa K
Medicine (Baltimore) 2018 May;97(18):e0502. doi: 10.1097/MD.0000000000010502. PMID: 29718841Free PMC Article

Recent systematic reviews

De-intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV-positive oropharyngeal carcinoma.
Howard J, Dwivedi RC, Masterson L, Kothari P, Quon H, Holsinger FC
Cochrane Database Syst Rev 2018 Dec 14;12(12):CD012939. doi: 10.1002/14651858.CD012939.pub2. PMID: 30550641Free PMC Article

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