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Mixed testicular germ cell cancer

MedGen UID:
237005
Concept ID:
C1336720
Neoplastic Process
Synonyms: Mixed Germ Cell Neoplasm of Testis; mixed germ cell neoplasm of testis; Mixed Germ Cell Neoplasm of the Testis; mixed germ cell neoplasm of the testis; mixed germ cell tumor; Mixed Germ Cell Tumor of Testis; mixed germ cell tumor of testis; Mixed Germ Cell Tumor of the Testis; mixed germ cell tumor of the testis; mixed germ cell tumour; mixed germ cell tumour of testis; mixed germ cell tumour of the testis; mixed testicular germ cell cancer; mixed testicular germ cell tumor; mixed testicular germ cell tumour; Testicular Germ Cell Tumor (Mixed); testicular germ cell tumor (mixed); testicular germ cell tumour (mixed); Testicular Mixed Germ Cell Neoplasm; testicular mixed germ cell neoplasm; Testicular Mixed Germ Cell Tumor; testicular mixed germ cell tumor; testicular mixed germ cell tumour; testis mixed germ cell tumor; testis mixed germ cell tumour
 
Monarch Initiative: MONDO:0003120

Definition

A malignant germ cell tumor that arises from the testis and is characterized by the presence of more than one histologic component. Representative examples include mixed choriocarcinoma and embryonal carcinoma, mixed embryonal carcinoma and seminoma, and mixed yolk sac tumor and teratoma. [from NCI]

Professional guidelines

PubMed

Katabathina VS, Vargas-Zapata D, Monge RA, Nazarullah A, Ganeshan D, Tammisetti V, Prasad SR
Radiographics 2021 Oct;41(6):1698-1716. doi: 10.1148/rg.2021210024. PMID: 34597218
Nwosu OI, Jones AJ, Alwani M, Einhorn LH, Moore MG, Mantravadi AV
Laryngoscope 2021 Jul;131(7):1528-1534. Epub 2021 Jan 9 doi: 10.1002/lary.29364. PMID: 33421136
Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415

Recent clinical studies

Etiology

Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Berney DM, Stoneham S, Arora R, Shamash J, Lockley M
Histopathology 2020 Jan;76(1):25-36. doi: 10.1111/his.14016. PMID: 31846529
Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D
JAMA Netw Open 2019 Nov 1;2(11):e1916318. doi: 10.1001/jamanetworkopen.2019.16318. PMID: 31774524Free PMC Article
Fukawa T, Kanayama HO
Int J Urol 2018 Apr;25(4):337-344. Epub 2018 Jan 17 doi: 10.1111/iju.13519. PMID: 29345008
Grantham EC, Caldwell BT, Cost NG
Urol Oncol 2016 Feb;34(2):65-75. Epub 2015 Jul 15 doi: 10.1016/j.urolonc.2015.06.008. PMID: 26187598

Diagnosis

Yao X, Zhou H, Duan C, Wu X, Li B, Liu H, Zhang Y
Front Immunol 2022;13:1096494. Epub 2023 Jan 13 doi: 10.3389/fimmu.2022.1096494. PMID: 36713456Free PMC Article
Katabathina VS, Vargas-Zapata D, Monge RA, Nazarullah A, Ganeshan D, Tammisetti V, Prasad SR
Radiographics 2021 Oct;41(6):1698-1716. doi: 10.1148/rg.2021210024. PMID: 34597218
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Fukawa T, Kanayama HO
Int J Urol 2018 Apr;25(4):337-344. Epub 2018 Jan 17 doi: 10.1111/iju.13519. PMID: 29345008
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298

Therapy

Trpchevska EN, Todorovska B, Todorovska MB, Trajkovska M, Nikolova D, Dzambaz D, Deriban G, Licoska-Josifovikj F
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Jul 1;44(2):47-52. Epub 2023 Jul 15 doi: 10.2478/prilozi-2023-0024. PMID: 37453124
Jørgensen PL, Kreiberg M, Jørgensen N, Juul A, Oturai PS, Dehlendorff C, Lauritsen J, Wagner T, Rosenvilde J, Daugaard G, Medici CR, Jørgensen NR, Bandak M
Acta Oncol 2023 Jul;62(7):689-695. Epub 2023 May 7 doi: 10.1080/0284186X.2023.2207218. PMID: 37151105
Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D
JAMA Netw Open 2019 Nov 1;2(11):e1916318. doi: 10.1001/jamanetworkopen.2019.16318. PMID: 31774524Free PMC Article
Fukawa T, Kanayama HO
Int J Urol 2018 Apr;25(4):337-344. Epub 2018 Jan 17 doi: 10.1111/iju.13519. PMID: 29345008
Hotte SJ, Mayhew LA, Jewett M, Chin J, Winquist E; Genitourinary Cancer Disease Site Group of the Cancer Care Ontario Program in Evidence-based Care
Clin Oncol (R Coll Radiol) 2010 Feb;22(1):17-26. Epub 2009 Oct 17 doi: 10.1016/j.clon.2009.09.005. PMID: 19836934

Prognosis

Hwang MJ, Hamza A, Zhang M, Tu SM, Pisters LL, Czerniak B, Guo CC
Am J Surg Pathol 2022 Jan 1;46(1):11-17. doi: 10.1097/PAS.0000000000001789. PMID: 34334690Free PMC Article
Katabathina VS, Vargas-Zapata D, Monge RA, Nazarullah A, Ganeshan D, Tammisetti V, Prasad SR
Radiographics 2021 Oct;41(6):1698-1716. doi: 10.1148/rg.2021210024. PMID: 34597218
Fukawa T, Kanayama HO
Int J Urol 2018 Apr;25(4):337-344. Epub 2018 Jan 17 doi: 10.1111/iju.13519. PMID: 29345008
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189

Clinical prediction guides

Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Yao X, Zhou H, Duan C, Wu X, Li B, Liu H, Zhang Y
Front Immunol 2022;13:1096494. Epub 2023 Jan 13 doi: 10.3389/fimmu.2022.1096494. PMID: 36713456Free PMC Article
Orsatti A, Sirolli M, Ambrosi F, Franceschini T, Giunchi F, Franchini E, Grillini M, Massari F, Mollica V, Bianchi FM, Colecchia M, Fiorentino M, Ricci C
Pathol Res Pract 2022 Sep;237:154044. Epub 2022 Jul 28 doi: 10.1016/j.prp.2022.154044. PMID: 35930824
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189

Recent systematic reviews

Doyle R, Craft P, Turner M, Paterson C
J Cancer Surviv 2024 Apr;18(2):263-287. Epub 2022 Jul 4 doi: 10.1007/s11764-022-01219-7. PMID: 35781623Free PMC Article
Zhao XY, Gao YL, Li DF, Liu HC, Zhu RF, Zhu CT
Aging (Albany NY) 2021 Aug 3;13(15):19657-19677. doi: 10.18632/aging.203376. PMID: 34343969Free PMC Article
Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D
JAMA Netw Open 2019 Nov 1;2(11):e1916318. doi: 10.1001/jamanetworkopen.2019.16318. PMID: 31774524Free PMC Article
Qin JX, Cai ZL, Yang YF, Xing JC, Zhuang X
Curr Med Sci 2019 Oct;39(5):702-706. Epub 2019 Oct 14 doi: 10.1007/s11596-019-2095-2. PMID: 31612386
Hotte SJ, Mayhew LA, Jewett M, Chin J, Winquist E; Genitourinary Cancer Disease Site Group of the Cancer Care Ontario Program in Evidence-based Care
Clin Oncol (R Coll Radiol) 2010 Feb;22(1):17-26. Epub 2009 Oct 17 doi: 10.1016/j.clon.2009.09.005. PMID: 19836934

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