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Testicular Teratoma with Somatic-Type Malignancy

MedGen UID:
237006
•Concept ID:
C1336729
•
Neoplastic Process
Synonym: Testicular Teratoma with Non-Germ Cell Malignancy

Definition

A testicular teratoma associated with a distinct secondary component that resembles a somatic-type malignant neoplasm (e.g., carcinoma or sarcoma). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Teratoma with Somatic-Type Malignancy

Professional guidelines

PubMed

Treatment and Clinical Outcomes of Patients with Teratoma with Somatic-Type Malignant Transformation: An International Collaboration.
Giannatempo P, Pond GR, Sonpavde G, Albany C, Loriot Y, Sweeney CJ, Salvioni R, Colecchia M, Nicolai N, Raggi D, Rice KR, Flack CK, El Mouallem NR, Feldman H, Fizazi K, Einhorn LH, Foster RS, Necchi A, Cary C
J Urol 2016 Jul;196(1):95-100. Epub 2015 Dec 31 doi: 10.1016/j.juro.2015.12.082. PMID: 26748165
Management of germ cell tumors with somatic type malignancy: pathological features, prognostic factors and survival outcomes.
Rice KR, Magers MJ, Beck SD, Cary KC, Einhorn LH, Ulbright TM, Foster RS
J Urol 2014 Nov;192(5):1403-9. Epub 2014 Jun 18 doi: 10.1016/j.juro.2014.05.118. PMID: 24952240
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Key changes in WHO classification 2022 of testicular tumors.
Michalová K, Hes O, Michal M
Cesk Patol 2022 Fall;67(4):198-204. PMID: 36513505
Late relapsing germ cell tumors with elevated tumor markers.
Che Y, Lusch A, Winter C, Große Siemer R, Buddensieck C, Albers P, Hiester A
World J Urol 2022 Feb;40(2):363-371. Epub 2021 Sep 13 doi: 10.1007/s00345-021-03833-z. PMID: 34518930Free PMC Article
Testicular teratomas: a growing problem?
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327
Update on the pathology of testicular tumors.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):75-85. PMID: 26072638
Secondary malignant transformation of testicular teratomas: case series and literature review.
García-Labastida L, Gómez-Macías GS, Flores-Gutiérrez JP, Ponce-Camacho M, Ancer-Rodríguez J, Barboza-Quintana O, Garza-Guajardo R
Actas Urol Esp 2014 Nov;38(9):622-7. Epub 2014 Jun 6 doi: 10.1016/j.acuro.2014.02.014. PMID: 24909334

Diagnosis

Reprint of: somatic-type malignancies in testicular germ cell tumors.
Guo CC, Czerniak B
Hum Pathol 2023 Mar;133:102-114. Epub 2023 Mar 6 doi: 10.1016/j.humpath.2023.02.008. PMID: 36890027
Key changes in WHO classification 2022 of testicular tumors.
Michalová K, Hes O, Michal M
Cesk Patol 2022 Fall;67(4):198-204. PMID: 36513505
Somatic-type malignancies in testicular germ cell tumors.
Guo CC, Czerniak B
Hum Pathol 2022 Sep;127:123-135. Epub 2022 Jul 5 doi: 10.1016/j.humpath.2022.06.024. PMID: 35803413
Late relapsing germ cell tumors with elevated tumor markers.
Che Y, Lusch A, Winter C, Große Siemer R, Buddensieck C, Albers P, Hiester A
World J Urol 2022 Feb;40(2):363-371. Epub 2021 Sep 13 doi: 10.1007/s00345-021-03833-z. PMID: 34518930Free PMC Article
Secondary malignant transformation of testicular teratomas: case series and literature review.
García-Labastida L, Gómez-Macías GS, Flores-Gutiérrez JP, Ponce-Camacho M, Ancer-Rodríguez J, Barboza-Quintana O, Garza-Guajardo R
Actas Urol Esp 2014 Nov;38(9):622-7. Epub 2014 Jun 6 doi: 10.1016/j.acuro.2014.02.014. PMID: 24909334

Therapy

Late relapsing germ cell tumors with elevated tumor markers.
Che Y, Lusch A, Winter C, Große Siemer R, Buddensieck C, Albers P, Hiester A
World J Urol 2022 Feb;40(2):363-371. Epub 2021 Sep 13 doi: 10.1007/s00345-021-03833-z. PMID: 34518930Free PMC Article
Development of angiosarcoma in a mediastinal non-seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy.
Matsuoka S, Koyama T, Takeda T, Yamada K, Hyogotani A, Hamanaka K, Sekiguchi N, Koizumi T
Thorac Cancer 2019 Jan;10(1):111-115. Epub 2018 Nov 8 doi: 10.1111/1759-7714.12901. PMID: 30407736Free PMC Article
Treatment and Clinical Outcomes of Patients with Teratoma with Somatic-Type Malignant Transformation: An International Collaboration.
Giannatempo P, Pond GR, Sonpavde G, Albany C, Loriot Y, Sweeney CJ, Salvioni R, Colecchia M, Nicolai N, Raggi D, Rice KR, Flack CK, El Mouallem NR, Feldman H, Fizazi K, Einhorn LH, Foster RS, Necchi A, Cary C
J Urol 2016 Jul;196(1):95-100. Epub 2015 Dec 31 doi: 10.1016/j.juro.2015.12.082. PMID: 26748165
Management of germ cell tumors with somatic type malignancy: pathological features, prognostic factors and survival outcomes.
Rice KR, Magers MJ, Beck SD, Cary KC, Einhorn LH, Ulbright TM, Foster RS
J Urol 2014 Nov;192(5):1403-9. Epub 2014 Jun 18 doi: 10.1016/j.juro.2014.05.118. PMID: 24952240
Primitive neuroectodermal tumor (PNET) as somatic-type malignancy arising from an extragonadal germ-cell tumor: clinical, pathological and molecular features of a case.
Garg A, Nahal A, Turcotte R, Tabah R, Alcindor T
Tumori 2013 Jan-Feb;99(1):e24-7. doi: 10.1177/030089161309900128. PMID: 23549017

Prognosis

Reprint of: somatic-type malignancies in testicular germ cell tumors.
Guo CC, Czerniak B
Hum Pathol 2023 Mar;133:102-114. Epub 2023 Mar 6 doi: 10.1016/j.humpath.2023.02.008. PMID: 36890027
Somatic-type malignancies in testicular germ cell tumors.
Guo CC, Czerniak B
Hum Pathol 2022 Sep;127:123-135. Epub 2022 Jul 5 doi: 10.1016/j.humpath.2022.06.024. PMID: 35803413
Testicular teratomas: a growing problem?
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327
Secondary malignant transformation of testicular teratomas: case series and literature review.
García-Labastida L, Gómez-Macías GS, Flores-Gutiérrez JP, Ponce-Camacho M, Ancer-Rodríguez J, Barboza-Quintana O, Garza-Guajardo R
Actas Urol Esp 2014 Nov;38(9):622-7. Epub 2014 Jun 6 doi: 10.1016/j.acuro.2014.02.014. PMID: 24909334
Teratoma with somatic-type malignant components of the testis. A review and an update.
Mikuz G, Colecchia M
Virchows Arch 2012 Jul;461(1):27-32. Epub 2012 May 24 doi: 10.1007/s00428-012-1251-x. PMID: 22622519

Clinical prediction guides

Late relapsing germ cell tumors with elevated tumor markers.
Che Y, Lusch A, Winter C, Große Siemer R, Buddensieck C, Albers P, Hiester A
World J Urol 2022 Feb;40(2):363-371. Epub 2021 Sep 13 doi: 10.1007/s00345-021-03833-z. PMID: 34518930Free PMC Article
Testicular teratomas: a growing problem?
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327
Treatment and Clinical Outcomes of Patients with Teratoma with Somatic-Type Malignant Transformation: An International Collaboration.
Giannatempo P, Pond GR, Sonpavde G, Albany C, Loriot Y, Sweeney CJ, Salvioni R, Colecchia M, Nicolai N, Raggi D, Rice KR, Flack CK, El Mouallem NR, Feldman H, Fizazi K, Einhorn LH, Foster RS, Necchi A, Cary C
J Urol 2016 Jul;196(1):95-100. Epub 2015 Dec 31 doi: 10.1016/j.juro.2015.12.082. PMID: 26748165
Management of germ cell tumors with somatic type malignancy: pathological features, prognostic factors and survival outcomes.
Rice KR, Magers MJ, Beck SD, Cary KC, Einhorn LH, Ulbright TM, Foster RS
J Urol 2014 Nov;192(5):1403-9. Epub 2014 Jun 18 doi: 10.1016/j.juro.2014.05.118. PMID: 24952240
Molecular genetic evidence supporting the origin of somatic-type malignancy and teratoma from the same progenitor cell.
Kum JB, Ulbright TM, Williamson SR, Wang M, Zhang S, Foster RS, Grignon DJ, Eble JN, Beck SD, Cheng L
Am J Surg Pathol 2012 Dec;36(12):1849-56. doi: 10.1097/PAS.0b013e31826df1ab. PMID: 23154771

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