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Undifferentiated carcinoma of stomach

MedGen UID:
237029
Concept ID:
C1336858
Neoplastic Process
Synonyms: Anaplastic Carcinoma of Stomach; anaplastic carcinoma of stomach; Anaplastic Carcinoma of the Stomach; anaplastic carcinoma of the stomach; Anaplastic Gastric Carcinoma; anaplastic gastric carcinoma; Gastric Undifferentiated Carcinoma; Gastric undifferentiated carcinoma; stomach undifferentiated carcinoma; Undifferentiated Carcinoma of Stomach; undifferentiated carcinoma of stomach; Undifferentiated Carcinoma of the Stomach; undifferentiated carcinoma of the stomach; undifferentiated gastric (stomach) cancer; Undifferentiated gastric carcinoma; Undifferentiated Gastric Carcinoma; undifferentiated gastric carcinoma; undifferentiated stomach adenocarcinoma
SNOMED CT: Undifferentiated gastric carcinoma (766757006); Undifferentiated carcinoma of stomach (766757006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018504
Orphanet: ORPHA423786

Definition

A rare epithelial tumour of the stomach that lacks any features of differentiation beyond an epithelial phenotype. The presenting symptoms are usually vague and nonspecific, such as weight loss, anorexia, fatigue, epigastric pain and discomfort, heartburn and nausea, vomiting or haematemesis. Patients may also be asymptomatic. Ascites, jaundice, intestinal obstruction and peripheral lymphadenopathy indicate advanced stages and metastatic spread. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated carcinoma of stomach

Professional guidelines

PubMed

Joshi SS, Badgwell BD
CA Cancer J Clin 2021 May;71(3):264-279. Epub 2021 Feb 16 doi: 10.3322/caac.21657. PMID: 33592120Free PMC Article
Hoshi H
Surg Clin North Am 2020 Jun;100(3):523-534. Epub 2020 Mar 18 doi: 10.1016/j.suc.2020.02.004. PMID: 32402298
Johnston FM, Beckman M
Curr Oncol Rep 2019 Jun 24;21(8):67. doi: 10.1007/s11912-019-0820-4. PMID: 31236716

Recent clinical studies

Etiology

Horton RK, Ahadi M, Gill AJ, Said S, Chen ZE, Bakhshwin A, Nichols M, Goldblum JR, Graham RP
Am J Surg Pathol 2021 Mar 1;45(3):414-420. doi: 10.1097/PAS.0000000000001599. PMID: 33027072
Waldum HL, Fossmark R
Int J Mol Sci 2018 Dec 18;19(12) doi: 10.3390/ijms19124109. PMID: 30567376Free PMC Article
Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C
Gut 2018 Feb;67(2):226-236. Epub 2017 Nov 4 doi: 10.1136/gutjnl-2017-314205. PMID: 29102920Free PMC Article
Rice TW, Ishwaran H, Ferguson MK, Blackstone EH, Goldstraw P
J Thorac Oncol 2017 Jan;12(1):36-42. Epub 2016 Oct 31 doi: 10.1016/j.jtho.2016.10.016. PMID: 27810391Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article

Diagnosis

Kushima R
Pathologe 2022 Feb;43(1):8-15. Epub 2021 Nov 22 doi: 10.1007/s00292-021-01023-7. PMID: 34807275
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
Hoshi H
Surg Clin North Am 2020 Jun;100(3):523-534. Epub 2020 Mar 18 doi: 10.1016/j.suc.2020.02.004. PMID: 32402298
Waldum HL, Fossmark R
Int J Mol Sci 2018 Dec 18;19(12) doi: 10.3390/ijms19124109. PMID: 30567376Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article

Therapy

Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
van Workum F, Verstegen MHP, Klarenbeek BR, Bouwense SAW, van Berge Henegouwen MI, Daams F, Gisbertz SS, Hannink G, Haveman JW, Heisterkamp J, Jansen W, Kouwenhoven EA, van Lanschot JJB, Nieuwenhuijzen GAP, van der Peet DL, Polat F, Ubels S, Wijnhoven BPL, Rovers MM, Rosman C; ICAN collaborative research group
JAMA Surg 2021 Jul 1;156(7):601-610. doi: 10.1001/jamasurg.2021.1555. PMID: 33978698Free PMC Article
Kelly RJ, Ajani JA, Kuzdzal J, Zander T, Van Cutsem E, Piessen G, Mendez G, Feliciano J, Motoyama S, Lièvre A, Uronis H, Elimova E, Grootscholten C, Geboes K, Zafar S, Snow S, Ko AH, Feeney K, Schenker M, Kocon P, Zhang J, Zhu L, Lei M, Singh P, Kondo K, Cleary JM, Moehler M; CheckMate 577 Investigators
N Engl J Med 2021 Apr 1;384(13):1191-1203. doi: 10.1056/NEJMoa2032125. PMID: 33789008
Chung HC, Bang YJ, S Fuchs C, Qin SK, Satoh T, Shitara K, Tabernero J, Van Cutsem E, Alsina M, Cao ZA, Lu J, Bhagia P, Shih CS, Janjigian YY
Future Oncol 2021 Feb;17(5):491-501. Epub 2020 Nov 10 doi: 10.2217/fon-2020-0737. PMID: 33167735Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article

Prognosis

Zhang C, Li D, Yu R, Li C, Song Y, Chen X, Fan Y, Liu Y, Qu X
Front Immunol 2021;12:651033. Epub 2021 May 13 doi: 10.3389/fimmu.2021.651033. PMID: 34054812Free PMC Article
Horton RK, Ahadi M, Gill AJ, Said S, Chen ZE, Bakhshwin A, Nichols M, Goldblum JR, Graham RP
Am J Surg Pathol 2021 Mar 1;45(3):414-420. doi: 10.1097/PAS.0000000000001599. PMID: 33027072
Zhou K, Wang A, Ao S, Chen J, Ji K, He Q, Ji X, Wu X, Zhang J, Li Z, Bu Z, Ji J
BMC Cancer 2020 Jul 17;20(1):671. doi: 10.1186/s12885-020-07031-9. PMID: 32680468Free PMC Article
Moradi G, Karimi K, Esmailnasab N, Roshani D
Asian Pac J Cancer Prev 2016;17(7):3243-8. PMID: 27509957
Kwon KJ, Shim KN, Song EM, Choi JY, Kim SE, Jung HK, Jung SA
Gastric Cancer 2014 Jan;17(1):43-53. Epub 2013 Feb 7 doi: 10.1007/s10120-013-0234-1. PMID: 23389081

Clinical prediction guides

Zhong M, Xiong Y, Zhao J, Gao Z, Ma J, Wu Z, Song Y, Hong X
Theranostics 2021;11(10):4945-4956. Epub 2021 Mar 5 doi: 10.7150/thno.55209. PMID: 33754037Free PMC Article
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C
Gut 2018 Feb;67(2):226-236. Epub 2017 Nov 4 doi: 10.1136/gutjnl-2017-314205. PMID: 29102920Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article

Recent systematic reviews

Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Yoon HH, Jin Z, Kour O, Kankeu Fonkoua LA, Shitara K, Gibson MK, Prokop LJ, Moehler M, Kang YK, Shi Q, Ajani JA
JAMA Oncol 2022 Oct 1;8(10):1456-1465. doi: 10.1001/jamaoncol.2022.3707. PMID: 36006624Free PMC Article
Garcia-Pelaez J, Barbosa-Matos R, Gullo I, Carneiro F, Oliveira C
Mol Oncol 2021 Nov;15(11):2841-2867. Epub 2021 May 2 doi: 10.1002/1878-0261.12948. PMID: 33724653Free PMC Article
Klimek M
Postgrad Med 2019 Jun;131(5):309-318. Epub 2019 Apr 5 doi: 10.1080/00325481.2019.1595982. PMID: 30900501
Paley CA, Johnson MI, Tashani OA, Bagnall AM
Cochrane Database Syst Rev 2015 Oct 15;2015(10):CD007753. doi: 10.1002/14651858.CD007753.pub3. PMID: 26468973Free PMC Article

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