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Undifferentiated pancreatic carcinoma

MedGen UID:
237030
Concept ID:
C1336861
Neoplastic Process
Synonyms: pancreas undifferentiated carcinoma; Pancreatic Carcinosarcoma; pancreatic carcinosarcoma; Pancreatic Undifferentiated Carcinoma; Pleomorphic Large Cell Pancreatic Carcinoma; pleomorphic large cell pancreatic carcinoma; Sarcomatoid Pancreatic Carcinoma; sarcomatoid pancreatic carcinoma; Spindle Cell Pancreatic Carcinoma; spindle cell pancreatic carcinoma; UCP; Undifferentiated (Anaplastic) Pancreatic Carcinoma; undifferentiated (anaplastic) pancreatic carcinoma; Undifferentiated Carcinoma of Pancreas; undifferentiated carcinoma of pancreas; Undifferentiated Carcinoma of the Pancreas; undifferentiated carcinoma of the pancreas; Undifferentiated Pancreatic Carcinoma; undifferentiated pancreatic carcinoma
 
Monarch Initiative: MONDO:0006478

Definition

A carcinoma with poor prognosis that arises from the pancreas. It is characterized by the presence of a significant malignant component that does not show differentiation. The malignant cells represent a mixture of large, pleomorphic cells and giant cells, or adenocarcinoma cells and spindle cells, or spindle cells. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Baxter NN, Kennedy EB, Bergsland E, Berlin J, George TJ, Gill S, Gold PJ, Hantel A, Jones L, Lieu C, Mahmoud N, Morris AM, Ruiz-Garcia E, You YN, Meyerhardt JA
J Clin Oncol 2022 Mar 10;40(8):892-910. Epub 2021 Dec 22 doi: 10.1200/JCO.21.02538. PMID: 34936379
Roch AM, Bigelow K, Schmidt CM 2nd, Carr RA, Jester AL, Ceppa EP, House MG, Zyromski NJ, Nakeeb A, Schmidt CM
J Am Coll Surg 2017 Apr;224(4):717-723. Epub 2017 Jan 24 doi: 10.1016/j.jamcollsurg.2016.12.045. PMID: 28126546
Lamberts SW, Krenning EP, Klijn JG, Reubi JC
Baillieres Clin Endocrinol Metab 1990 Mar;4(1):29-49. doi: 10.1016/s0950-351x(05)80314-3. PMID: 1975166

Recent clinical studies

Etiology

Blair AB, Burkhart RA, Griffin JF, Miller JA, Weiss MJ, Cameron JL, Wolfgang CL, He J
J Surg Res 2017 Nov;219:238-243. Epub 2017 Jul 3 doi: 10.1016/j.jss.2017.05.065. PMID: 29078888Free PMC Article
Lehrke HD, Graham RP, McWilliams RR, Lam-Himlin DM, Smyrk TC, Jenkins S, Dong H, Zhang L
Am J Clin Pathol 2017 Nov 2;148(5):441-449. doi: 10.1093/ajcp/aqx092. PMID: 29069274
Bergmann F, Moldenhauer G, Herpel E, Gaida MM, Strobel O, Werner J, Esposito I, Müerköster SS, Schirmacher P, Kern MA
Histopathology 2010 Mar;56(4):440-8. doi: 10.1111/j.1365-2559.2010.03499.x. PMID: 20459551

Diagnosis

Cavalcanti E, Schena N, Serino G, Lantone G, Armentano R
BMC Gastroenterol 2021 Jun 2;21(1):247. doi: 10.1186/s12876-021-01779-5. PMID: 34078293Free PMC Article
Askan G, Basturk O
Turk Patoloji Derg 2021;37(2):115-120. doi: 10.5146/tjpath.2020.01519. PMID: 33432559Free PMC Article
Blair AB, Burkhart RA, Griffin JF, Miller JA, Weiss MJ, Cameron JL, Wolfgang CL, He J
J Surg Res 2017 Nov;219:238-243. Epub 2017 Jul 3 doi: 10.1016/j.jss.2017.05.065. PMID: 29078888Free PMC Article
Reid MD, Muraki T, HooKim K, Memis B, Graham RP, Allende D, Shi J, Schaeffer DF, Singh R, Basturk O, Adsay V
Cancer Cytopathol 2017 Jul;125(7):563-575. Epub 2017 Apr 3 doi: 10.1002/cncy.21859. PMID: 28371566
Abe S, Kubota T, Otani Y, Furukawa T, Watanabe M, Kumai K, Kitajima M
Jpn J Cancer Res 2000 Nov;91(11):1192-8. doi: 10.1111/j.1349-7006.2000.tb00904.x. PMID: 11092986Free PMC Article

Therapy

Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Bergmann F, Moldenhauer G, Herpel E, Gaida MM, Strobel O, Werner J, Esposito I, Müerköster SS, Schirmacher P, Kern MA
Histopathology 2010 Mar;56(4):440-8. doi: 10.1111/j.1365-2559.2010.03499.x. PMID: 20459551
Abe S, Kubota T, Otani Y, Furukawa T, Watanabe M, Kumai K, Kitajima M
Jpn J Cancer Res 2000 Nov;91(11):1192-8. doi: 10.1111/j.1349-7006.2000.tb00904.x. PMID: 11092986Free PMC Article

Prognosis

Cavalcanti E, Schena N, Serino G, Lantone G, Armentano R
BMC Gastroenterol 2021 Jun 2;21(1):247. doi: 10.1186/s12876-021-01779-5. PMID: 34078293Free PMC Article
Kharkhach A, Bouhout T, Serji B, El Harroudi T
J Gastrointest Cancer 2021 Sep;52(3):1106-1113. Epub 2021 Jan 14 doi: 10.1007/s12029-021-00583-4. PMID: 33447945
Askan G, Basturk O
Turk Patoloji Derg 2021;37(2):115-120. doi: 10.5146/tjpath.2020.01519. PMID: 33432559Free PMC Article
Blair AB, Burkhart RA, Griffin JF, Miller JA, Weiss MJ, Cameron JL, Wolfgang CL, He J
J Surg Res 2017 Nov;219:238-243. Epub 2017 Jul 3 doi: 10.1016/j.jss.2017.05.065. PMID: 29078888Free PMC Article
Reid MD, Muraki T, HooKim K, Memis B, Graham RP, Allende D, Shi J, Schaeffer DF, Singh R, Basturk O, Adsay V
Cancer Cytopathol 2017 Jul;125(7):563-575. Epub 2017 Apr 3 doi: 10.1002/cncy.21859. PMID: 28371566

Clinical prediction guides

Cavalcanti E, Schena N, Serino G, Lantone G, Armentano R
BMC Gastroenterol 2021 Jun 2;21(1):247. doi: 10.1186/s12876-021-01779-5. PMID: 34078293Free PMC Article
Hirakawa Y, Tago M, Katsuki NE, Makio S, Yamashita SI
Am J Case Rep 2021 Mar 26;22:e929678. doi: 10.12659/AJCR.929678. PMID: 33767127Free PMC Article
Askan G, Basturk O
Turk Patoloji Derg 2021;37(2):115-120. doi: 10.5146/tjpath.2020.01519. PMID: 33432559Free PMC Article
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Reid MD, Muraki T, HooKim K, Memis B, Graham RP, Allende D, Shi J, Schaeffer DF, Singh R, Basturk O, Adsay V
Cancer Cytopathol 2017 Jul;125(7):563-575. Epub 2017 Apr 3 doi: 10.1002/cncy.21859. PMID: 28371566

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