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Endometrial Endometrioid Adenocarcinoma with Metaplastic Changes

MedGen UID:
237040
•Concept ID:
C1336909
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial Endometrioid Adenocarcinoma with Metaplastic Changes

Professional guidelines

PubMed

Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341

Recent clinical studies

Etiology

Incidence of Mismatch Repair Protein Deficiency and Associated Clinicopathologic Features in a Cohort of 104 Ovarian Endometrioid Carcinomas.
Bennett JA, Pesci A, Morales-Oyarvide V, Da Silva A, Nardi V, Oliva E
Am J Surg Pathol 2019 Feb;43(2):235-243. doi: 10.1097/PAS.0000000000001165. PMID: 30256257
Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia.
Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2013 Feb;37(2):167-77. doi: 10.1097/PAS.0b013e318272d428. PMID: 23211295
Routinely assessed morphological features correlate with microsatellite instability status in endometrial cancer.
Shia J, Black D, Hummer AJ, Boyd J, Soslow RA
Hum Pathol 2008 Jan;39(1):116-25. Epub 2007 Oct 18 doi: 10.1016/j.humpath.2007.05.022. PMID: 17949789
Human papillomavirus and mixed epithelial tumors of the endometrium.
O'Leary JJ, Landers RJ, Crowley M, Healy I, O'Donovan M, Healy V, Kealy WF, Hogan J, Doyle CT
Hum Pathol 1998 Apr;29(4):383-9. doi: 10.1016/s0046-8177(98)90120-4. PMID: 9563789

Diagnosis

The expression pattern of CD10 and CD31 identifies fine fibrovascular stroma of grade 1-endometrial endometrioid carcinomas in cytology.
Norimatsu Y, Nishikawa T, Suzuki H, Hosokawa S, Yano H, Maeda Y, Kurokawa T, Shinagawa A, Kobayashi TK, Fulciniti F
Cytopathology 2022 May;33(3):362-373. Epub 2021 Nov 7 doi: 10.1111/cyt.13070. PMID: 34689374
Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia.
Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2013 Feb;37(2):167-77. doi: 10.1097/PAS.0b013e318272d428. PMID: 23211295
Molecular genetic changes in epithelial, stromal and mixed neoplasms of the endometrium.
Lax SF
Pathology 2007 Feb;39(1):46-54. doi: 10.1080/00313020601146822. PMID: 17365822
Endometrioid carcinoma of the uterine corpus: a review of its pathology with emphasis on recent advances and problematic aspects.
Clement PB, Young RH
Adv Anat Pathol 2002 May;9(3):145-84. doi: 10.1097/00125480-200205000-00001. PMID: 11981113
Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341

Prognosis

Clinicopathologic Evaluation and Molecular Profiling of Recurrent Stage IA Endometrial Endometrioid Carcinoma: A Case-control Study.
Sharma AE, Moran A, Somasegar S, Steinhardt G, Chapel DB, Lastra RR, Lee NK, Ritterhouse LL, Bennett JA
Int J Gynecol Pathol 2023 Jan 1;42(1):26-34. Epub 2022 Feb 4 doi: 10.1097/PGP.0000000000000856. PMID: 35125405
Incidence of Mismatch Repair Protein Deficiency and Associated Clinicopathologic Features in a Cohort of 104 Ovarian Endometrioid Carcinomas.
Bennett JA, Pesci A, Morales-Oyarvide V, Da Silva A, Nardi V, Oliva E
Am J Surg Pathol 2019 Feb;43(2):235-243. doi: 10.1097/PAS.0000000000001165. PMID: 30256257
Routinely assessed morphological features correlate with microsatellite instability status in endometrial cancer.
Shia J, Black D, Hummer AJ, Boyd J, Soslow RA
Hum Pathol 2008 Jan;39(1):116-25. Epub 2007 Oct 18 doi: 10.1016/j.humpath.2007.05.022. PMID: 17949789
Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341

Clinical prediction guides

The expression pattern of CD10 and CD31 identifies fine fibrovascular stroma of grade 1-endometrial endometrioid carcinomas in cytology.
Norimatsu Y, Nishikawa T, Suzuki H, Hosokawa S, Yano H, Maeda Y, Kurokawa T, Shinagawa A, Kobayashi TK, Fulciniti F
Cytopathology 2022 May;33(3):362-373. Epub 2021 Nov 7 doi: 10.1111/cyt.13070. PMID: 34689374
Relationship between morular metaplasia and squamous differentiation in endometrial carcinoma.
Travaglino A, Raffone A, Gencarelli A, Raimondo D, Moretta P, Pignatiello S, Granata M, Seracchioli R, Zullo F, Insabato L
Pathol Res Pract 2021 Jan;217:153307. Epub 2020 Nov 30 doi: 10.1016/j.prp.2020.153307. PMID: 33316539
Clinicopathological and immunohistochemical characterization of papillary proliferation of the endometrium: A single institutional experience.
Park CK, Yoon G, Cho YA, Kim HS
Oncotarget 2016 Jun 28;7(26):39197-39206. doi: 10.18632/oncotarget.10049. PMID: 27322430Free PMC Article
Routinely assessed morphological features correlate with microsatellite instability status in endometrial cancer.
Shia J, Black D, Hummer AJ, Boyd J, Soslow RA
Hum Pathol 2008 Jan;39(1):116-25. Epub 2007 Oct 18 doi: 10.1016/j.humpath.2007.05.022. PMID: 17949789
Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation.
Saegusa M, Okayasu I
J Pathol 2001 May;194(1):59-67. doi: 10.1002/path.856. PMID: 11329142

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