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Well Differentiated Leiomyosarcoma

MedGen UID:
237060
•Concept ID:
C1337016
•
Neoplastic Process

Definition

Grade I malignant smooth muscle neoplasm. It is characterized by a proliferation of neoplastic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWell Differentiated Leiomyosarcoma

Professional guidelines

PubMed

First and further-line multidisciplinary treatment of retroperitoneal sarcomas.
D'Ambrosio L, Van Houdt W, Stelmes JJ, Gronchi A
Curr Opin Oncol 2022 Jul 1;34(4):328-334. doi: 10.1097/CCO.0000000000000851. PMID: 35837704
Retroperitoneal sarcomas: from diagnosis to treatment. Case series and review of the literature.
Mantas D, Garmpis N, Polychroni D, Garmpi A, Damaskos C, Liakea A, Sypsa G, Kouskos E
G Chir 2020 Jan-Feb;41(1):18-33. PMID: 32038009
The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.
Rubisz P, Ciebiera M, Hirnle L, Zgliczyńska M, Łoziński T, Dzięgiel P, Kobierzycki C
Int J Mol Sci 2019 Mar 6;20(5) doi: 10.3390/ijms20051136. PMID: 30845657Free PMC Article

Recent clinical studies

Etiology

Smooth muscle tumor developing in an immunocompromised child after therapy for leukemia.
Brichard B, Vermylen C, Gosseye S, Otte JB, Cornu G
J Pediatr Hematol Oncol 2001 Feb;23(2):139-41. doi: 10.1097/00043426-200102000-00015. PMID: 11216708

Diagnosis

Expression of B23/Nucleophosphamine Nonribosomal Nucleolar Protein in Smooth Muscle Tumors of the Corpus Uteri.
Avdalyan AM, Kobyakov DS, Klimachev VV, Bobrov IP, Lazarev AF, Pichigina AK, Lushnikova EL, Nepomnyashchikh LM
Bull Exp Biol Med 2015 Dec;160(2):286-90. Epub 2015 Dec 8 doi: 10.1007/s10517-015-3152-x. PMID: 26642792
Primary low grade intratesticular leiomyosarcoma: case report and review of the literature.
Abdullazade S, Kara O, Akdoğan B, Baydar DE
Turk Patoloji Derg 2013;29(3):227-30. doi: 10.5146/tjpath.2013.01179. PMID: 24022314
Uterine leiomyosarcoma producing granulocyte colony stimulating factor.
Nakayama K, Nakayama N, Rahman MT, Rahman M, Katagiri H, Katagiri A, Ishikawa M, Ishibashi T, Iida K, Harada Y, Miyazaki K
Int J Gynecol Pathol 2012 Mar;31(2):172-177. doi: 10.1097/PGP.0b013e3182359f2f. PMID: 22317876
Primary leiomyosarcoma of the anterior mediastinum.
Eroğlu A, Kürkçüoğlu C, Karaoğlanoğlu N, Gürsan N
Eur J Cardiothorac Surg 2002 May;21(5):943-5. doi: 10.1016/s1010-7940(02)00090-8. PMID: 12062299
Aspiration biopsy cytology of smooth muscle tumors. A cytologic approach to the differentiation between leiomyosarcoma and leiomyoma.
Tao LC, Davidson DD
Acta Cytol 1993 May-Jun;37(3):300-8. PMID: 8498132

Therapy

Smooth muscle tumor developing in an immunocompromised child after therapy for leukemia.
Brichard B, Vermylen C, Gosseye S, Otte JB, Cornu G
J Pediatr Hematol Oncol 2001 Feb;23(2):139-41. doi: 10.1097/00043426-200102000-00015. PMID: 11216708

Prognosis

Portal vein leiomyosarcoma: A rare case of hepatic hilar tumor with review of the literature.
Gaignard E, Bergeat D, Stock N, Robin F, Boudjema K, Sulpice L, Rayar M, Meunier B
Indian J Cancer 2019 Jan-Mar;56(1):83-85. doi: 10.4103/ijc.IJC_199_18. PMID: 30950452
Dumbbell-shaped leiomyosarcoma of the inferior vena cava with foci of rhabdoid changes and osteoclast-type giant cells.
Nikaido T, Endo Y, Nimura S, Ishikura H, Ushigome S
Pathol Int 2004 Apr;54(4):256-60. doi: 10.1111/j.1440-1827.2004.01616.x. PMID: 15028027

Clinical prediction guides

Pulmonary leiomyomatosis in women after hysterectomy for uterine myoma. Benign metastasizing leiomyoma?
Kadry M, Sievers C, Engelmann C
Acta Chir Hung 1999;38(1):57-61. PMID: 10439097
Uterine leiomyosarcoma with osteoclast-like giant cells: histopathological and cytological observations.
Watanabe K, Hiraki H, Ohishi M, Mashiko K, Saginoya H, Suzuki T
Pathol Int 1996 Sep;46(9):656-60. doi: 10.1111/j.1440-1827.1996.tb03668.x. PMID: 8905874
Aspiration biopsy cytology of smooth muscle tumors. A cytologic approach to the differentiation between leiomyosarcoma and leiomyoma.
Tao LC, Davidson DD
Acta Cytol 1993 May-Jun;37(3):300-8. PMID: 8498132
Histological and immunohistochemical observations of dedifferentiated leiomyosarcoma of the uterus.
Fukuda T, Ohnishi Y
Acta Pathol Jpn 1991 Jun;41(6):466-72. doi: 10.1111/j.1440-1827.1991.tb03214.x. PMID: 1719742

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