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Juvenile nasopharyngeal angiofibroma

MedGen UID:
237137
•Concept ID:
C1367536
•
Neoplastic Process
Synonyms: JNA; Juvenile angiofibroma of nasopharynx; juvenile nasopharyngeal angiofibroma; juvenile nasopharyngeal angiofibroma (disease); Nasopharyngeal Angiofibroma; nasopharyngeal angiofibroma; nasopharyngeal juvenile angiofibroma; Sinonasal Angiofibroma
SNOMED CT: Juvenile angiofibroma of nasopharynx (716590006); Juvenile nasopharyngeal angiofibroma (716590006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0030429
Monarch Initiative: MONDO:0017340
Orphanet: ORPHA289596

Definition

A benign but highly vascular nasopharyngeal neoplasm. The tumor originates from the sphenopalatine foramen and involves both the pterygopalatine fossa and the posterior nasal cavity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJuvenile nasopharyngeal angiofibroma

Professional guidelines

PubMed

Preoperative Embolization Techniques in the Treatment of Juvenile Nasopharyngeal Angiofibroma: A Systematic Review.
Kothari DS, Linker LA, Tham T, Maroda AJ, McElfresh JM, Fastenberg JH, Hachem RA, Elijovich L, Michael LM, Rangarajan SV
Otolaryngol Head Neck Surg 2023 Sep;169(3):454-466. Epub 2023 Feb 17 doi: 10.1002/ohn.303. PMID: 36808756
Nasal juvenile angiofibroma: Current perspectives with emphasis on management.
López F, Triantafyllou A, Snyderman CH, Hunt JL, Suárez C, Lund VJ, Strojan P, Saba NF, Nixon IJ, Devaney KO, Alobid I, Bernal-Sprekelsen M, Hanna EY, Rinaldo A, Ferlito A
Head Neck 2017 May;39(5):1033-1045. Epub 2017 Feb 15 doi: 10.1002/hed.24696. PMID: 28199045
Imaging Evaluation and Treatment of Vascular Lesions at the Skull Base.
Jindal G, Miller T, Raghavan P, Gandhi D
Radiol Clin North Am 2017 Jan;55(1):151-166. Epub 2016 Oct 25 doi: 10.1016/j.rcl.2016.08.003. PMID: 27890183

Recent clinical studies

Etiology

Embolization in Juvenile Nasopharyngeal Angiofibroma Surgery: A Systematic Review and Meta-Analysis.
Diaz A, Wang E, Bujnowski D, Arimoto R, Armstrong M, Cyberski T, Nordgren R, Seal SM, Kass-Hout T, Roxbury C
Laryngoscope 2023 Jul;133(7):1529-1539. Epub 2023 Feb 15 doi: 10.1002/lary.30616. PMID: 36789781
Preoperative emobilisation of juvenile nasopharyngeal angiofibroma.
Meher R, Kathuria S, Wadhwa V, Ali MR, Shah B, Bansal A, Goel P
Am J Otolaryngol 2022 Sep-Oct;43(5):103532. Epub 2022 Jun 11 doi: 10.1016/j.amjoto.2022.103532. PMID: 35714497
Electron microscopy of juvenile nasopharyngeal angiofibroma: clinical and histopathological correlates.
Hage A, Singhai A, Mishra A, Mishra SC
Eur Arch Otorhinolaryngol 2022 Jan;279(1):233-247. Epub 2021 Apr 29 doi: 10.1007/s00405-021-06815-4. PMID: 33912996
Juvenile nasopharyngeal angiofibroma-20 years of experience in endoscopic treatment.
Szyfter W, Balcerowiak A, Gawęcki W, Juszkat R, Wierzbicka M
Otolaryngol Pol 2021 Feb 16;75(2):9-14. doi: 10.5604/01.3001.0014.5220. PMID: 33949314
Juvenile Nasopharyngeal Angiofibroma Outcomes and Cost: Analysis of the Kids' Inpatient Database.
Yu J, Choi JS, Giannoni C, Patel AJ, Gallagher KK
Ann Otol Rhinol Laryngol 2020 May;129(5):498-504. Epub 2019 Dec 26 doi: 10.1177/0003489419896597. PMID: 31876164

Diagnosis

MRI features of sinonasal tract angiofibroma/juvenile nasopharyngeal angiofibroma: Case series and systematic review.
Baba A, Kurokawa R, Kurokawa M, Srinivasan A
J Neuroimaging 2023 Sep-Oct;33(5):675-687. Epub 2023 May 10 doi: 10.1111/jon.13116. PMID: 37164909
Nasal Septal Angiofibroma.
Thobejane O, Maharaj S
Ear Nose Throat J 2023 Oct;102(10):NP483-NP484. Epub 2021 Jun 16 doi: 10.1177/01455613211026517. PMID: 34134540
Juvenile nasopharyngeal angiofibroma: National practice patterns and resource utilization via HCUP KID.
Pool C, Gates CJ, Patel VA, Carr MM
Int J Pediatr Otorhinolaryngol 2021 Oct;149:110871. Epub 2021 Aug 5 doi: 10.1016/j.ijporl.2021.110871. PMID: 34385042
Juvenile Nasopharyngeal Angiofibroma Outcomes and Cost: Analysis of the Kids' Inpatient Database.
Yu J, Choi JS, Giannoni C, Patel AJ, Gallagher KK
Ann Otol Rhinol Laryngol 2020 May;129(5):498-504. Epub 2019 Dec 26 doi: 10.1177/0003489419896597. PMID: 31876164
Juvenile nasopharyngeal angiofibroma.
Zito J, Fitzpatrick P, Amedee R
J La State Med Soc 2001 Aug;153(8):395-8. PMID: 11565634

Therapy

Juvenile Nasopharyngeal Angiofibroma: Outcomes Analysis Based Upon Hospital Volume.
Adil EA, Francisco S, Morgan E, Kawai K, Cunningham MJ
Laryngoscope 2023 Nov;133(11):3216-3220. Epub 2023 Mar 10 doi: 10.1002/lary.30640. PMID: 36896888
Embolization in Juvenile Nasopharyngeal Angiofibroma Surgery: A Systematic Review and Meta-Analysis.
Diaz A, Wang E, Bujnowski D, Arimoto R, Armstrong M, Cyberski T, Nordgren R, Seal SM, Kass-Hout T, Roxbury C
Laryngoscope 2023 Jul;133(7):1529-1539. Epub 2023 Feb 15 doi: 10.1002/lary.30616. PMID: 36789781
Managing Vascular Tumors-Open Approaches.
Schmalbach CE, Gourin C
Otolaryngol Clin North Am 2016 Jun;49(3):777-90. doi: 10.1016/j.otc.2016.03.001. PMID: 27267025
Juvenile nasopharyngeal angiofibroma.
Blount A, Riley KO, Woodworth BA
Otolaryngol Clin North Am 2011 Aug;44(4):989-1004, ix. doi: 10.1016/j.otc.2011.06.003. PMID: 21819885
Juvenile nasopharyngeal angiofibroma.
Wilson WR, Miller D, Lee KJ, Yules RB
Laryngoscope 1972 Jun;82(6):985-97. doi: 10.1288/00005537-197206000-00006. PMID: 4338568

Prognosis

Electron microscopy of juvenile nasopharyngeal angiofibroma: clinical and histopathological correlates.
Hage A, Singhai A, Mishra A, Mishra SC
Eur Arch Otorhinolaryngol 2022 Jan;279(1):233-247. Epub 2021 Apr 29 doi: 10.1007/s00405-021-06815-4. PMID: 33912996
Juvenile Nasopharyngeal Angiofibroma Outcomes and Cost: Analysis of the Kids' Inpatient Database.
Yu J, Choi JS, Giannoni C, Patel AJ, Gallagher KK
Ann Otol Rhinol Laryngol 2020 May;129(5):498-504. Epub 2019 Dec 26 doi: 10.1177/0003489419896597. PMID: 31876164
Juvenile nasopharyngeal angiofibroma staging: An overview.
Alshaikh NA, Eleftheriadou A
Ear Nose Throat J 2015 Jun;94(6):E12-22. doi: 10.1177/014556131509400615. PMID: 26053985
Endoscopic treatment of juvenile nasopharyngeal angiofibromas: our experience and review of the literature.
Fyrmpas G, Konstantinidis I, Constantinidis J
Eur Arch Otorhinolaryngol 2012 Feb;269(2):523-9. Epub 2011 Jul 26 doi: 10.1007/s00405-011-1708-6. PMID: 21789677
Juvenile nasopharyngeal angiofibroma.
Zito J, Fitzpatrick P, Amedee R
J La State Med Soc 2001 Aug;153(8):395-8. PMID: 11565634

Clinical prediction guides

Electron microscopy of juvenile nasopharyngeal angiofibroma: clinical and histopathological correlates.
Hage A, Singhai A, Mishra A, Mishra SC
Eur Arch Otorhinolaryngol 2022 Jan;279(1):233-247. Epub 2021 Apr 29 doi: 10.1007/s00405-021-06815-4. PMID: 33912996
Endoscopic Endonasal and Transmaxillary Resection of a Nasopharyngeal Angiofibroma.
Singh R, Thorwarth R, Bendok BR, Lal D
World Neurosurg 2021 Nov;155:180. Epub 2021 Aug 25 doi: 10.1016/j.wneu.2021.08.064. PMID: 34450322
Juvenile Nasopharyngeal Angiofibroma Outcomes and Cost: Analysis of the Kids' Inpatient Database.
Yu J, Choi JS, Giannoni C, Patel AJ, Gallagher KK
Ann Otol Rhinol Laryngol 2020 May;129(5):498-504. Epub 2019 Dec 26 doi: 10.1177/0003489419896597. PMID: 31876164
Molecular interactions in juvenile nasopharyngeal angiofibroma: preliminary signature and relevant review.
Mishra A, Jaiswal R, Amita P, Mishra SC
Eur Arch Otorhinolaryngol 2019 Jan;276(1):93-100. Epub 2018 Nov 1 doi: 10.1007/s00405-018-5178-y. PMID: 30387011
Juvenile nasopharyngeal angiofibroma staging: An overview.
Alshaikh NA, Eleftheriadou A
Ear Nose Throat J 2015 Jun;94(6):E12-22. doi: 10.1177/014556131509400615. PMID: 26053985

Recent systematic reviews

Early-onset juvenile nasopharyngeal angiofibroma (JNA): a systematic review.
Newman M, Nguyen TBV, McHugh T, Reddy K, Sommer DD
J Otolaryngol Head Neck Surg 2023 Dec 19;52(1):85. doi: 10.1186/s40463-023-00687-w. PMID: 38115030Free PMC Article
MRI features of sinonasal tract angiofibroma/juvenile nasopharyngeal angiofibroma: Case series and systematic review.
Baba A, Kurokawa R, Kurokawa M, Srinivasan A
J Neuroimaging 2023 Sep-Oct;33(5):675-687. Epub 2023 May 10 doi: 10.1111/jon.13116. PMID: 37164909
Preoperative Embolization Techniques in the Treatment of Juvenile Nasopharyngeal Angiofibroma: A Systematic Review.
Kothari DS, Linker LA, Tham T, Maroda AJ, McElfresh JM, Fastenberg JH, Hachem RA, Elijovich L, Michael LM, Rangarajan SV
Otolaryngol Head Neck Surg 2023 Sep;169(3):454-466. Epub 2023 Feb 17 doi: 10.1002/ohn.303. PMID: 36808756
Embolization in Juvenile Nasopharyngeal Angiofibroma Surgery: A Systematic Review and Meta-Analysis.
Diaz A, Wang E, Bujnowski D, Arimoto R, Armstrong M, Cyberski T, Nordgren R, Seal SM, Kass-Hout T, Roxbury C
Laryngoscope 2023 Jul;133(7):1529-1539. Epub 2023 Feb 15 doi: 10.1002/lary.30616. PMID: 36789781
Exclusive endoscopic resection of juvenile nasopharyngeal angiofibroma: a systematic review of the literature.
Khoueir N, Nicolas N, Rohayem Z, Haddad A, Abou Hamad W
Otolaryngol Head Neck Surg 2014 Mar;150(3):350-8. Epub 2013 Dec 31 doi: 10.1177/0194599813516605. PMID: 24381014

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