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Lung Mucosa-Associated Lymphoid Tissue Lymphoma

MedGen UID:
237139
Concept ID:
C1367652
Neoplastic Process
Synonyms: BALT lymphoma; BALT Lymphoma; BALToma; Bronchial MALT Lymphoma; Bronchial Mucosa-Associated Lymphoid Tissue Lymphoma; Bronchial-associated lymphoid tissue lymphoma; Bronchus-Associated Lymphoid Tissue Lymphoma; Lung Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Lung MALT Lymphoma; Pulmonary Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Pulmonary MALT Lymphoma; Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma
SNOMED CT: Bronchial-associated lymphoid tissue lymphoma (128803008); BALT lymphoma (128803008)

Definition

An extranodal marginal zone lymphoma that arises from the lung. It is characterized by the neoplastic proliferation of small B-lymphocytes, monocytoid cells and cells with plasma cell differentiation in the marginal zones of reactive lymphoid follicles. The neoplastic cells infiltrate the interfollicular areas and the bronchial epithelium forming lymphoepithelial lesions. The neoplasm is usually discovered as a mass in a chest x-ray in asymptomatic patients. When symptoms occur, they include cough, dyspnea, hemoptysis, and chest pain. If the lung lesions are resectable, surgery can result in prolonged remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Mucosa-Associated Lymphoid Tissue Lymphoma

Professional guidelines

PubMed

Defrancesco I, Arcaini L
Best Pract Res Clin Haematol 2018 Mar;31(1):57-64. Epub 2017 Nov 14 doi: 10.1016/j.beha.2017.11.001. PMID: 29452667
Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, White CS
Radiographics 2016 Jan-Feb;36(1):53-70. doi: 10.1148/rg.2016140339. PMID: 26761531
Cadranel J, Wislez M, Antoine M
Eur Respir J 2002 Sep;20(3):750-62. doi: 10.1183/09031936.02.00404102. PMID: 12358356

Recent clinical studies

Etiology

Bi W, Zhao S, Wu C, Gao J, Zhao S, Yang S, Deng Y, Nie P, Yu X, Deng H, Zang X, Ma X, Han J, Asuquo I, Wang X, Xue X
J Surg Oncol 2021 Apr;123(5):1336-1344. Epub 2021 Feb 1 doi: 10.1002/jso.26403. PMID: 33523526
GonzÁlez I, Araya P, Rojas A
Zhongguo Fei Ai Za Zhi 2018 Sep 20;21(9):658-662. doi: 10.3779/j.issn.1009-3419.2018.09.03. PMID: 30201063Free PMC Article
Defrancesco I, Arcaini L
Best Pract Res Clin Haematol 2018 Mar;31(1):57-64. Epub 2017 Nov 14 doi: 10.1016/j.beha.2017.11.001. PMID: 29452667
Chmiela M, Gonciarz W
World J Gastroenterol 2017 Jun 14;23(22):3964-3977. doi: 10.3748/wjg.v23.i22.3964. PMID: 28652651Free PMC Article
Diaconu S, Predescu A, Moldoveanu A, Pop CS, Fierbințeanu-Braticevici C
J Med Life 2017 Apr-Jun;10(2):112-117. PMID: 28616085Free PMC Article

Diagnosis

Yell M, Rosado FG
Arch Pathol Lab Med 2019 Sep;143(9):1149-1153. Epub 2019 Feb 6 doi: 10.5858/arpa.2018-0188-RS. PMID: 30720334
Borie R, Wislez M, Antoine M, Cadranel J
Respiration 2017;94(2):157-175. Epub 2017 Jun 14 doi: 10.1159/000477740. PMID: 28609772
Borie R, Wislez M, Antoine M, Copie-Bergman C, Thieblemont C, Cadranel J
Eur Respir J 2016 Apr;47(4):1244-60. Epub 2016 Jan 21 doi: 10.1183/13993003.01701-2015. PMID: 26797028
Piña-Oviedo S, Weissferdt A, Kalhor N, Moran CA
Adv Anat Pathol 2015 Nov;22(6):355-75. doi: 10.1097/PAP.0000000000000090. PMID: 26452211
Chilosi M, Zinzani PL, Poletti V
Semin Respir Crit Care Med 2005 Oct;26(5):490-501. doi: 10.1055/s-2005-922032. PMID: 16267700

Therapy

Defrancesco I, Arcaini L
Best Pract Res Clin Haematol 2018 Mar;31(1):57-64. Epub 2017 Nov 14 doi: 10.1016/j.beha.2017.11.001. PMID: 29452667
Zucca E, Bertoni F
Blood 2016 Apr 28;127(17):2082-92. Epub 2016 Mar 17 doi: 10.1182/blood-2015-12-624304. PMID: 26989205
Bowman SJ
Curr Pharm Biotechnol 2012 Aug;13(10):1997-2008. doi: 10.2174/138920112802273263. PMID: 22208654
Troch M, Kiesewetter B, Raderer M
Curr Hematol Malig Rep 2011 Dec;6(4):216-21. doi: 10.1007/s11899-011-0095-9. PMID: 21808988
Habermann TM, Ryu JH, Inwards DJ, Kurtin PJ
Semin Oncol 1999 Jun;26(3):307-15. PMID: 10375087

Prognosis

Borie R, Wislez M, Antoine M, Cadranel J
Respiration 2017;94(2):157-175. Epub 2017 Jun 14 doi: 10.1159/000477740. PMID: 28609772
Borie R, Wislez M, Antoine M, Copie-Bergman C, Thieblemont C, Cadranel J
Eur Respir J 2016 Apr;47(4):1244-60. Epub 2016 Jan 21 doi: 10.1183/13993003.01701-2015. PMID: 26797028
Papiris SA, Tsonis IA, Moutsopoulos HM
Semin Respir Crit Care Med 2007 Aug;28(4):459-71. doi: 10.1055/s-2007-985667. PMID: 17764063
Cadranel J, Wislez M, Antoine M
Eur Respir J 2002 Sep;20(3):750-62. doi: 10.1183/09031936.02.00404102. PMID: 12358356
Thieblemont C, Berger F, Coiffier B
Curr Opin Oncol 1995 Sep;7(5):415-20. PMID: 8541385

Clinical prediction guides

van Ginkel MS, Arends S, van der Vegt B, Nijland M, Spijkervet FKL, Vissink A, Kroese FGM, Glaudemans AWJM, Bootsma H
Rheumatology (Oxford) 2023 Oct 3;62(10):3323-3331. doi: 10.1093/rheumatology/kead071. PMID: 36759907Free PMC Article
Hu M, Gu W, Chen S, Mei J, Wang W
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221075529. doi: 10.1177/15330338221075529. PMID: 35253550Free PMC Article
Bi W, Zhao S, Wu C, Gao J, Zhao S, Yang S, Deng Y, Nie P, Yu X, Deng H, Zang X, Ma X, Han J, Asuquo I, Wang X, Xue X
J Surg Oncol 2021 Apr;123(5):1336-1344. Epub 2021 Feb 1 doi: 10.1002/jso.26403. PMID: 33523526
Graham BB, Mathisen DJ, Mark EJ, Takvorian RW
Ann Thorac Surg 2005 Oct;80(4):1248-53. doi: 10.1016/j.athoracsur.2005.04.014. PMID: 16181848
Thieblemont C, Berger F, Coiffier B
Curr Opin Oncol 1995 Sep;7(5):415-20. PMID: 8541385

Recent systematic reviews

Xiao J, He B, Zou Y, Chen X, Lu X, Xie M, Li W, He S, You S, Chen Q
Sci Rep 2016 Jul 26;6:30437. doi: 10.1038/srep30437. PMID: 27457567Free PMC Article

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