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Calciphylaxis

MedGen UID:
2404
Concept ID:
C0006666
Disease or Syndrome
Synonym: Idiopathic calciphylaxis
SNOMED CT: Calciphylaxis (237900002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017215
Orphanet: ORPHA280062

Definition

A rare vascular calcification disorder typically characterized by occlusion of microvessels in the cutaneous tissue resulting in painful cutaneous lesions. The disorder is often life-limiting. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCalciphylaxis
Follow this link to review classifications for Calciphylaxis in Orphanet.

Professional guidelines

PubMed

Rick J, Rrapi R, Chand S, Shinohara MM, Strowd L, Pasieka HB, Micheletti R, Kroshinsky D, Ortega-Loayza AG
J Am Acad Dermatol 2022 May;86(5):985-992. Epub 2022 Feb 22 doi: 10.1016/j.jaad.2021.10.063. PMID: 35202773
Chang JJ
Adv Skin Wound Care 2019 May;32(5):205-215. doi: 10.1097/01.ASW.0000554443.14002.13. PMID: 31008757
Lau WL, Obi Y, Kalantar-Zadeh K
Clin J Am Soc Nephrol 2018 Jun 7;13(6):952-961. Epub 2018 Mar 9 doi: 10.2215/CJN.10390917. PMID: 29523679Free PMC Article

Recent clinical studies

Etiology

Rick J, Strowd L, Pasieka HB, Saardi K, Micheletti R, Zhao M, Kroshinsky D, Shinohara MM, Ortega-Loayza AG
J Am Acad Dermatol 2022 May;86(5):973-982. Epub 2022 Feb 1 doi: 10.1016/j.jaad.2021.10.064. PMID: 35114300
Chang JJ
Adv Skin Wound Care 2019 May;32(5):205-215. doi: 10.1097/01.ASW.0000554443.14002.13. PMID: 31008757
Nigwekar SU, Thadhani R, Brandenburg VM
N Engl J Med 2018 May 3;378(18):1704-1714. doi: 10.1056/NEJMra1505292. PMID: 29719190
Lau WL, Obi Y, Kalantar-Zadeh K
Clin J Am Soc Nephrol 2018 Jun 7;13(6):952-961. Epub 2018 Mar 9 doi: 10.2215/CJN.10390917. PMID: 29523679Free PMC Article
Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, Kamdar MM, Steele DJ, Thadhani RI
Am J Kidney Dis 2015 Jul;66(1):133-46. Epub 2015 May 7 doi: 10.1053/j.ajkd.2015.01.034. PMID: 25960299Free PMC Article

Diagnosis

Gallo Marin B, Aghagoli G, Hu SL, Massoud CM, Robinson-Bostom L
Am J Kidney Dis 2023 Feb;81(2):232-239. Epub 2022 Aug 12 doi: 10.1053/j.ajkd.2022.06.011. PMID: 35970430
Rick J, Rrapi R, Chand S, Shinohara MM, Strowd L, Pasieka HB, Micheletti R, Kroshinsky D, Ortega-Loayza AG
J Am Acad Dermatol 2022 May;86(5):985-992. Epub 2022 Feb 22 doi: 10.1016/j.jaad.2021.10.063. PMID: 35202773
Rick J, Strowd L, Pasieka HB, Saardi K, Micheletti R, Zhao M, Kroshinsky D, Shinohara MM, Ortega-Loayza AG
J Am Acad Dermatol 2022 May;86(5):973-982. Epub 2022 Feb 1 doi: 10.1016/j.jaad.2021.10.064. PMID: 35114300
Chang JJ
Adv Skin Wound Care 2019 May;32(5):205-215. doi: 10.1097/01.ASW.0000554443.14002.13. PMID: 31008757
Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, Kamdar MM, Steele DJ, Thadhani RI
Am J Kidney Dis 2015 Jul;66(1):133-46. Epub 2015 May 7 doi: 10.1053/j.ajkd.2015.01.034. PMID: 25960299Free PMC Article

Therapy

Chang JJ
Adv Skin Wound Care 2019 May;32(5):205-215. doi: 10.1097/01.ASW.0000554443.14002.13. PMID: 31008757
Nigwekar SU, Thadhani R, Brandenburg VM
N Engl J Med 2018 May 3;378(18):1704-1714. doi: 10.1056/NEJMra1505292. PMID: 29719190
Lau WL, Obi Y, Kalantar-Zadeh K
Clin J Am Soc Nephrol 2018 Jun 7;13(6):952-961. Epub 2018 Mar 9 doi: 10.2215/CJN.10390917. PMID: 29523679Free PMC Article
Nigwekar SU
Curr Opin Nephrol Hypertens 2017 Jul;26(4):276-281. doi: 10.1097/MNH.0000000000000328. PMID: 28375870Free PMC Article
Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, Kamdar MM, Steele DJ, Thadhani RI
Am J Kidney Dis 2015 Jul;66(1):133-46. Epub 2015 May 7 doi: 10.1053/j.ajkd.2015.01.034. PMID: 25960299Free PMC Article

Prognosis

Nigwekar SU, Thadhani R, Brandenburg VM
N Engl J Med 2018 May 3;378(18):1704-1714. doi: 10.1056/NEJMra1505292. PMID: 29719190
Nigwekar SU
Curr Opin Nephrol Hypertens 2017 Jul;26(4):276-281. doi: 10.1097/MNH.0000000000000328. PMID: 28375870Free PMC Article
Yu WY, Bhutani T, Kornik R, Pincus LB, Mauro T, Rosenblum MD, Fox LP
JAMA Dermatol 2017 Mar 1;153(3):309-314. doi: 10.1001/jamadermatol.2016.4821. PMID: 28099971Free PMC Article
Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, Kamdar MM, Steele DJ, Thadhani RI
Am J Kidney Dis 2015 Jul;66(1):133-46. Epub 2015 May 7 doi: 10.1053/j.ajkd.2015.01.034. PMID: 25960299Free PMC Article
Ng AT, Peng DH
Dermatol Ther 2011 Mar-Apr;24(2):256-62. doi: 10.1111/j.1529-8019.2011.01401.x. PMID: 21410615

Clinical prediction guides

Wen W, Portales-Castillo I, Seethapathy R, Durant O, Mengesha B, Krinsky S, Kroshinsky D, Kalim S, Goverman J, Nazarian RM, Chitalia V, Malhotra R, Kramann R, Malhotra CK, Nigwekar SU
JAMA Netw Open 2023 Apr 3;6(4):e2310068. doi: 10.1001/jamanetworkopen.2023.10068. PMID: 37099293Free PMC Article
Seethapathy H, Nigwekar SU
Curr Opin Nephrol Hypertens 2019 Sep;28(5):448-454. doi: 10.1097/MNH.0000000000000520. PMID: 31169527
Lau WL, Obi Y, Kalantar-Zadeh K
Clin J Am Soc Nephrol 2018 Jun 7;13(6):952-961. Epub 2018 Mar 9 doi: 10.2215/CJN.10390917. PMID: 29523679Free PMC Article
Hayashi M
Clin Exp Nephrol 2013 Aug;17(4):498-503. Epub 2013 Feb 21 doi: 10.1007/s10157-013-0782-z. PMID: 23430392
Ng AT, Peng DH
Dermatol Ther 2011 Mar-Apr;24(2):256-62. doi: 10.1111/j.1529-8019.2011.01401.x. PMID: 21410615

Recent systematic reviews

Wipattanakitcharoen A, Takkavatakarn K, Susantitaphong P
World J Urol 2023 Nov;41(11):2959-2966. Epub 2023 Oct 2 doi: 10.1007/s00345-023-04611-9. PMID: 37782324
Gossett C, Suppadungsuk S, Krisanapan P, Tangpanithandee S, Thongprayoon C, Mao MA, Cheungpasitporn W
Medicina (Kaunas) 2023 Jul 14;59(7) doi: 10.3390/medicina59071306. PMID: 37512116Free PMC Article
Wen W, Portales-Castillo I, Seethapathy R, Durant O, Mengesha B, Krinsky S, Kroshinsky D, Kalim S, Goverman J, Nazarian RM, Chitalia V, Malhotra R, Kramann R, Malhotra CK, Nigwekar SU
JAMA Netw Open 2023 Apr 3;6(4):e2310068. doi: 10.1001/jamanetworkopen.2023.10068. PMID: 37099293Free PMC Article
Nowaczyk J, Zawistowski M, Fiedor P
Arch Dermatol Res 2022 Aug;314(6):515-525. Epub 2021 Jun 24 doi: 10.1007/s00403-021-02264-5. PMID: 34165603Free PMC Article
Nigwekar SU, Wolf M, Sterns RH, Hix JK
Clin J Am Soc Nephrol 2008 Jul;3(4):1139-43. Epub 2008 Apr 16 doi: 10.2215/CJN.00530108. PMID: 18417747Free PMC Article

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