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Mitochondrial Damage

MedGen UID:
242754
Concept ID:
C1096176
Pathologic Function
Synonym: Mitochondrial Toxicity

Definition

Mitochondrial Damage involves any process that leads to dysfunction of mitochondria, whether by oxidative damage, mutation of mitochondrial DNA or other by means. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMitochondrial Damage

Professional guidelines

PubMed

Zhou X, Liu S, Lu Y, Wan M, Cheng J, Liu J
J Extracell Vesicles 2023 Apr;12(4):e12320. doi: 10.1002/jev2.12320. PMID: 37002588Free PMC Article
Ajoolabady A, Chiong M, Lavandero S, Klionsky DJ, Ren J
Trends Mol Med 2022 Oct;28(10):836-849. Epub 2022 Jul 22 doi: 10.1016/j.molmed.2022.06.007. PMID: 35879138Free PMC Article
Gupta KK, Gupta VK, Shirasaka T
Alcohol Clin Exp Res 2016 Aug;40(8):1594-602. Epub 2016 Jul 4 doi: 10.1111/acer.13135. PMID: 27375266

Recent clinical studies

Etiology

Zhao M, Wang Y, Li L, Liu S, Wang C, Yuan Y, Yang G, Chen Y, Cheng J, Lu Y, Liu J
Theranostics 2021;11(4):1845-1863. Epub 2021 Jan 1 doi: 10.7150/thno.50905. PMID: 33408785Free PMC Article
Zuurbier CJ, Bertrand L, Beauloye CR, Andreadou I, Ruiz-Meana M, Jespersen NR, Kula-Alwar D, Prag HA, Eric Botker H, Dambrova M, Montessuit C, Kaambre T, Liepinsh E, Brookes PS, Krieg T
J Cell Mol Med 2020 Jun;24(11):5937-5954. Epub 2020 May 8 doi: 10.1111/jcmm.15180. PMID: 32384583Free PMC Article
Xu X, Fu Z, Le W
Int Rev Neurobiol 2019;147:45-74. Epub 2019 Jun 20 doi: 10.1016/bs.irn.2019.06.003. PMID: 31607362
Lin Q, Li S, Jiang N, Shao X, Zhang M, Jin H, Zhang Z, Shen J, Zhou Y, Zhou W, Gu L, Lu R, Ni Z
Redox Biol 2019 Sep;26:101254. Epub 2019 Jun 11 doi: 10.1016/j.redox.2019.101254. PMID: 31229841Free PMC Article
Gai Z, Wang T, Visentin M, Kullak-Ublick GA, Fu X, Wang Z
Nutrients 2019 Mar 28;11(4) doi: 10.3390/nu11040722. PMID: 30925738Free PMC Article

Diagnosis

Sun Y, Shen W, Hu S, Lyu Q, Wang Q, Wei T, Zhu W, Zhang J
J Exp Clin Cancer Res 2023 Mar 17;42(1):65. doi: 10.1186/s13046-023-02638-9. PMID: 36932427Free PMC Article
Cheng M, Lin N, Dong D, Ma J, Su J, Sun L
Eur J Cell Biol 2021 Jan;100(1):151144. Epub 2020 Dec 7 doi: 10.1016/j.ejcb.2020.151144. PMID: 33370650
Shum M, Ngo J, Shirihai OS, Liesa M
Mol Metab 2021 Aug;50:101134. Epub 2020 Dec 1 doi: 10.1016/j.molmet.2020.101134. PMID: 33276146Free PMC Article
Chung MP, Richardson C, Kirakossian D, Orandi AB, Saketkoo LA, Rider LG, Schiffenbauer A, von Mühlen CA, Chung L; International Myositis Assessment; Clinical Studies Group (IMACS) Calcinosis Scientific Interest Group
Autoimmun Rev 2020 Jun;19(6):102533. Epub 2020 Mar 28 doi: 10.1016/j.autrev.2020.102533. PMID: 32234404Free PMC Article
Wei PZ, Szeto CC
Clin Chim Acta 2019 Sep;496:108-116. Epub 2019 Jul 2 doi: 10.1016/j.cca.2019.07.005. PMID: 31276635

Therapy

Yan F, Zhao Q, Li Y, Zheng Z, Kong X, Shu C, Liu Y, Shi Y
J Ovarian Res 2022 Sep 1;15(1):100. doi: 10.1186/s13048-022-01032-x. PMID: 36050696Free PMC Article
Kang Q, Yang C
Redox Biol 2020 Oct;37:101799. Epub 2020 Nov 13 doi: 10.1016/j.redox.2020.101799. PMID: 33248932Free PMC Article
Wallace KB, Sardão VA, Oliveira PJ
Circ Res 2020 Mar 27;126(7):926-941. Epub 2020 Mar 26 doi: 10.1161/CIRCRESAHA.119.314681. PMID: 32213135Free PMC Article
Maekawa H, Inoue T, Ouchi H, Jao TM, Inoue R, Nishi H, Fujii R, Ishidate F, Tanaka T, Tanaka Y, Hirokawa N, Nangaku M, Inagi R
Cell Rep 2019 Oct 29;29(5):1261-1273.e6. doi: 10.1016/j.celrep.2019.09.050. PMID: 31665638
Renu K, V G A, P B TP, Arunachalam S
Eur J Pharmacol 2018 Jan 5;818:241-253. Epub 2017 Oct 23 doi: 10.1016/j.ejphar.2017.10.043. PMID: 29074412

Prognosis

Sun Y, Shen W, Hu S, Lyu Q, Wang Q, Wei T, Zhu W, Zhang J
J Exp Clin Cancer Res 2023 Mar 17;42(1):65. doi: 10.1186/s13046-023-02638-9. PMID: 36932427Free PMC Article
Ueda K, Sakai C, Ishida T, Morita K, Kobayashi Y, Horikoshi Y, Baba A, Okazaki Y, Yoshizumi M, Tashiro S, Ishida M
Clin Sci (Lond) 2023 Jan 31;137(2):163-180. doi: 10.1042/CS20220525. PMID: 36598778Free PMC Article
Huang L, Bian M, Zhang J, Jiang L
Oxid Med Cell Longev 2022;2022:5918218. Epub 2022 Dec 2 doi: 10.1155/2022/5918218. PMID: 36506935Free PMC Article
Ito A, Hashimoto M, Tanihata J, Matsubayashi S, Sasaki R, Fujimoto S, Kawamoto H, Hosaka Y, Ichikawa A, Kadota T, Fujita Y, Takekoshi D, Ito S, Minagawa S, Numata T, Hara H, Matsuoka T, Udaka J, Araya J, Saito M, Kuwano K
J Cachexia Sarcopenia Muscle 2022 Jun;13(3):1864-1882. Epub 2022 Apr 3 doi: 10.1002/jcsm.12988. PMID: 35373498Free PMC Article
Tian M, Liu W, Li X, Zhao P, Shereen MA, Zhu C, Huang S, Liu S, Yu X, Yue M, Pan P, Wang W, Li Y, Chen X, Wu K, Luo Z, Zhang Q, Wu J
Signal Transduct Target Ther 2021 Aug 18;6(1):308. doi: 10.1038/s41392-021-00726-w. PMID: 34408131Free PMC Article

Clinical prediction guides

Lin S, Zhang H, Wang C, Su XL, Song Y, Wu P, Yang Z, Wong MH, Cai Z, Zheng C
Environ Sci Technol 2022 Sep 6;56(17):12483-12493. Epub 2022 Aug 25 doi: 10.1021/acs.est.2c03980. PMID: 36005547Free PMC Article
Barrera MJ, Aguilera S, Castro I, Carvajal P, Jara D, Molina C, González S, González MJ
Autoimmun Rev 2021 Aug;20(8):102867. Epub 2021 Jun 9 doi: 10.1016/j.autrev.2021.102867. PMID: 34118452
Brissot E, Troadec MB, Loréal O, Brissot P
Am J Hematol 2021 Aug 1;96(8):1008-1016. Epub 2021 May 14 doi: 10.1002/ajh.26189. PMID: 33844865
Chung KW, Dhillon P, Huang S, Sheng X, Shrestha R, Qiu C, Kaufman BA, Park J, Pei L, Baur J, Palmer M, Susztak K
Cell Metab 2019 Oct 1;30(4):784-799.e5. Epub 2019 Aug 29 doi: 10.1016/j.cmet.2019.08.003. PMID: 31474566Free PMC Article
Slimen IB, Najar T, Ghram A, Dabbebi H, Ben Mrad M, Abdrabbah M
Int J Hyperthermia 2014 Nov;30(7):513-23. doi: 10.3109/02656736.2014.971446. PMID: 25354680

Recent systematic reviews

Mishra P, Kiran NS, Romanholo Ferreira LF, Yadav KK, Mulla SI
Chemosphere 2023 Jun;326:138391. Epub 2023 Mar 16 doi: 10.1016/j.chemosphere.2023.138391. PMID: 36933841
Kose O, Mantecca P, Costa A, Carrière M
Part Fibre Toxicol 2023 Jan 5;20(1):1. doi: 10.1186/s12989-022-00511-9. PMID: 36604752Free PMC Article
Singh S, Singh TG
Inflamm Res 2021 Dec;70(10-12):1027-1042. Epub 2021 Oct 15 doi: 10.1007/s00011-021-01511-9. PMID: 34652489
Decloedt EH, Maartens G
Expert Opin Drug Saf 2013 Nov;12(6):841-6. Epub 2013 Jul 29 doi: 10.1517/14740338.2013.823396. PMID: 23889591

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