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Mitochondrial Damage

MedGen UID:
242754
Concept ID:
C1096176
Pathologic Function
Synonym: Mitochondrial Toxicity

Definition

Mitochondrial Damage involves any process that leads to dysfunction of mitochondria, whether by oxidative damage, mutation of mitochondrial DNA or other by means. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMitochondrial Damage

Professional guidelines

PubMed

Zhou X, Liu S, Lu Y, Wan M, Cheng J, Liu J
J Extracell Vesicles 2023 Apr;12(4):e12320. doi: 10.1002/jev2.12320. PMID: 37002588Free PMC Article
Ajoolabady A, Chiong M, Lavandero S, Klionsky DJ, Ren J
Trends Mol Med 2022 Oct;28(10):836-849. Epub 2022 Jul 22 doi: 10.1016/j.molmed.2022.06.007. PMID: 35879138Free PMC Article
Gupta KK, Gupta VK, Shirasaka T
Alcohol Clin Exp Res 2016 Aug;40(8):1594-602. Epub 2016 Jul 4 doi: 10.1111/acer.13135. PMID: 27375266

Recent clinical studies

Etiology

She G, Du JC, Wu W, Pu TT, Zhang Y, Bai RY, Zhang Y, Pang ZD, Wang HF, Ren YJ, Sadoshima J, Deng XL, Du XJ
Theranostics 2023;13(2):560-577. Epub 2023 Jan 1 doi: 10.7150/thno.79227. PMID: 36632235Free PMC Article
Zhao M, Wang Y, Li L, Liu S, Wang C, Yuan Y, Yang G, Chen Y, Cheng J, Lu Y, Liu J
Theranostics 2021;11(4):1845-1863. Epub 2021 Jan 1 doi: 10.7150/thno.50905. PMID: 33408785Free PMC Article
Zuurbier CJ, Bertrand L, Beauloye CR, Andreadou I, Ruiz-Meana M, Jespersen NR, Kula-Alwar D, Prag HA, Eric Botker H, Dambrova M, Montessuit C, Kaambre T, Liepinsh E, Brookes PS, Krieg T
J Cell Mol Med 2020 Jun;24(11):5937-5954. Epub 2020 May 8 doi: 10.1111/jcmm.15180. PMID: 32384583Free PMC Article
Xu X, Fu Z, Le W
Int Rev Neurobiol 2019;147:45-74. Epub 2019 Jun 20 doi: 10.1016/bs.irn.2019.06.003. PMID: 31607362
Gai Z, Wang T, Visentin M, Kullak-Ublick GA, Fu X, Wang Z
Nutrients 2019 Mar 28;11(4) doi: 10.3390/nu11040722. PMID: 30925738Free PMC Article

Diagnosis

Huang XX, Li L, Jiang RH, Yu JB, Sun YQ, Shan J, Yang J, Ji J, Cheng SQ, Dong YF, Zhang XY, Shi HB, Liu S, Sun XL
J Adv Res 2024 Jul;61:133-149. Epub 2023 Aug 11 doi: 10.1016/j.jare.2023.08.007. PMID: 37572732Free PMC Article
Ma J, Liu L, Song L, Liu J, Yang L, Chen Q, Wu JY, Zhu L
Cell Death Dis 2023 Nov 11;14(11):735. doi: 10.1038/s41419-023-06261-6. PMID: 37951930Free PMC Article
Sun Y, Shen W, Hu S, Lyu Q, Wang Q, Wei T, Zhu W, Zhang J
J Exp Clin Cancer Res 2023 Mar 17;42(1):65. doi: 10.1186/s13046-023-02638-9. PMID: 36932427Free PMC Article
Cheng M, Lin N, Dong D, Ma J, Su J, Sun L
Eur J Cell Biol 2021 Jan;100(1):151144. Epub 2020 Dec 7 doi: 10.1016/j.ejcb.2020.151144. PMID: 33370650
Xia Y, Liu N, Xie X, Bi G, Ba H, Li L, Zhang J, Deng X, Yao Y, Tang Z, Yin B, Wang J, Jiang K, Li Z, Choi Y, Gong F, Cheng X, O'Shea JJ, Chae JJ, Laurence A, Yang XP
Autophagy 2019 Jun;15(6):960-975. Epub 2019 Jan 29 doi: 10.1080/15548627.2019.1569916. PMID: 30681394Free PMC Article

Therapy

Sun Y, Shen W, Hu S, Lyu Q, Wang Q, Wei T, Zhu W, Zhang J
J Exp Clin Cancer Res 2023 Mar 17;42(1):65. doi: 10.1186/s13046-023-02638-9. PMID: 36932427Free PMC Article
Yan F, Zhao Q, Li Y, Zheng Z, Kong X, Shu C, Liu Y, Shi Y
J Ovarian Res 2022 Sep 1;15(1):100. doi: 10.1186/s13048-022-01032-x. PMID: 36050696Free PMC Article
Kang Q, Yang C
Redox Biol 2020 Oct;37:101799. Epub 2020 Nov 13 doi: 10.1016/j.redox.2020.101799. PMID: 33248932Free PMC Article
Wallace KB, Sardão VA, Oliveira PJ
Circ Res 2020 Mar 27;126(7):926-941. Epub 2020 Mar 26 doi: 10.1161/CIRCRESAHA.119.314681. PMID: 32213135Free PMC Article
Maekawa H, Inoue T, Ouchi H, Jao TM, Inoue R, Nishi H, Fujii R, Ishidate F, Tanaka T, Tanaka Y, Hirokawa N, Nangaku M, Inagi R
Cell Rep 2019 Oct 29;29(5):1261-1273.e6. doi: 10.1016/j.celrep.2019.09.050. PMID: 31665638

Prognosis

Lira Chavez FM, Gartzke LP, van Beuningen FE, Wink SE, Henning RH, Krenning G, Bouma HR
Redox Biol 2023 Dec;68:102968. Epub 2023 Nov 23 doi: 10.1016/j.redox.2023.102968. PMID: 38039825Free PMC Article
Cao Z, Liu X, Zhang W, Zhang K, Pan L, Zhu M, Qin H, Zou C, Wang W, Zhang C, He Y, Lin W, Zhang Y, Han D, Li M, Gu J
ACS Nano 2023 Dec 12;17(23):23746-23760. Epub 2023 Nov 22 doi: 10.1021/acsnano.3c07555. PMID: 37991252Free PMC Article
Glytsou C, Chen X, Zacharioudakis E, Al-Santli W, Zhou H, Nadorp B, Lee S, Lasry A, Sun Z, Papaioannou D, Cammer M, Wang K, Zal T, Zal MA, Carter BZ, Ishizawa J, Tibes R, Tsirigos A, Andreeff M, Gavathiotis E, Aifantis I
Cancer Discov 2023 Jul 7;13(7):1656-1677. doi: 10.1158/2159-8290.CD-22-0601. PMID: 37088914Free PMC Article
Sun Y, Shen W, Hu S, Lyu Q, Wang Q, Wei T, Zhu W, Zhang J
J Exp Clin Cancer Res 2023 Mar 17;42(1):65. doi: 10.1186/s13046-023-02638-9. PMID: 36932427Free PMC Article
Ito A, Hashimoto M, Tanihata J, Matsubayashi S, Sasaki R, Fujimoto S, Kawamoto H, Hosaka Y, Ichikawa A, Kadota T, Fujita Y, Takekoshi D, Ito S, Minagawa S, Numata T, Hara H, Matsuoka T, Udaka J, Araya J, Saito M, Kuwano K
J Cachexia Sarcopenia Muscle 2022 Jun;13(3):1864-1882. Epub 2022 Apr 3 doi: 10.1002/jcsm.12988. PMID: 35373498Free PMC Article

Clinical prediction guides

Jian Y, Yang Y, Cheng L, Yang X, Liu H, Li W, Wan Y, Yang D
Cell Prolif 2023 Feb;56(2):e13362. Epub 2022 Nov 26 doi: 10.1111/cpr.13362. PMID: 36433732Free PMC Article
Lin S, Zhang H, Wang C, Su XL, Song Y, Wu P, Yang Z, Wong MH, Cai Z, Zheng C
Environ Sci Technol 2022 Sep 6;56(17):12483-12493. Epub 2022 Aug 25 doi: 10.1021/acs.est.2c03980. PMID: 36005547Free PMC Article
Barrera MJ, Aguilera S, Castro I, Carvajal P, Jara D, Molina C, González S, González MJ
Autoimmun Rev 2021 Aug;20(8):102867. Epub 2021 Jun 9 doi: 10.1016/j.autrev.2021.102867. PMID: 34118452
Brissot E, Troadec MB, Loréal O, Brissot P
Am J Hematol 2021 Aug 1;96(8):1008-1016. Epub 2021 May 14 doi: 10.1002/ajh.26189. PMID: 33844865
Slimen IB, Najar T, Ghram A, Dabbebi H, Ben Mrad M, Abdrabbah M
Int J Hyperthermia 2014 Nov;30(7):513-23. doi: 10.3109/02656736.2014.971446. PMID: 25354680

Recent systematic reviews

Qiao JC, Sun LJ, Zhang MY, Gui SY, Wang XC, Hu CY
Sci Total Environ 2024 May 1;923:171423. Epub 2024 Mar 4 doi: 10.1016/j.scitotenv.2024.171423. PMID: 38442762
Menezes Júnior ADS, França-E-Silva ALG, Oliveira JM, Silva DMD
Int J Mol Sci 2023 Dec 30;25(1) doi: 10.3390/ijms25010535. PMID: 38203704Free PMC Article
Vaziri N, Marques D, Greenway SC, Bousman CA
Schizophr Res 2023 Nov;261:206-215. Epub 2023 Oct 3 doi: 10.1016/j.schres.2023.09.039. PMID: 37797362
Singh S, Singh TG
Inflamm Res 2021 Dec;70(10-12):1027-1042. Epub 2021 Oct 15 doi: 10.1007/s00011-021-01511-9. PMID: 34652489
Decloedt EH, Maartens G
Expert Opin Drug Saf 2013 Nov;12(6):841-6. Epub 2013 Jul 29 doi: 10.1517/14740338.2013.823396. PMID: 23889591

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