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Babesiosis

MedGen UID:
2523
•Concept ID:
C0004576
•
Disease or Syndrome
Synonyms: Babesia parasite infection; Human babesiosis
SNOMED CT: Babesiosis (21061004); Piroplasmosis (21061004); Babesiasis (21061004); Infection by Babesia (21061004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005661
Orphanet: ORPHA108

Definition

Babesiosis is an infectious disease caused by protozoa of the genus <i>Babesia</i> and characterized by a febrile illness and hemolytic anemia but with manifestations ranging from an asymptomatic infection to a fulminating illness that can result in death. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBabesiosis
Follow this link to review classifications for Babesiosis in Orphanet.

Professional guidelines

PubMed

Clinical Practice Guidelines by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology: 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease.
Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ Jr, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS
Neurology 2021 Feb 9;96(6):262-273. Epub 2020 Nov 30 doi: 10.1212/WNL.0000000000011151. PMID: 33257476
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article

Recent clinical studies

Therapy

Human Babesiosis.
Waked R, Krause PJ
Infect Dis Clin North Am 2022 Sep;36(3):655-670. doi: 10.1016/j.idc.2022.02.009. PMID: 36116841
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Human babesiosis.
Krause PJ
Int J Parasitol 2019 Feb;49(2):165-174. Epub 2019 Jan 26 doi: 10.1016/j.ijpara.2018.11.007. PMID: 30690090
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article
Babesiosis.
Vannier EG, Diuk-Wasser MA, Ben Mamoun C, Krause PJ
Infect Dis Clin North Am 2015 Jun;29(2):357-70. doi: 10.1016/j.idc.2015.02.008. PMID: 25999229Free PMC Article

Prognosis

Tick-Borne Diseases.
Eilbert W, Matella A
Emerg Med Clin North Am 2024 May;42(2):287-302. Epub 2024 Feb 29 doi: 10.1016/j.emc.2024.01.004. PMID: 38641392
Human babesiosis.
Lukavská A, Kybicová K
Epidemiol Mikrobiol Imunol 2023 Fall;72(3):184-190. PMID: 37871992
Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article
Dermatoses from ticks.
McGinley-Smith DE, Tsao SS
J Am Acad Dermatol 2003 Sep;49(3):363-92; quiz 393-6. doi: 10.1067/s0190-9622(03)01868-1. PMID: 12963900

Clinical prediction guides

Human babesiosis in Alsace.
Paleau A, Candolfi E, Souply L, De Briel D, Delarbre JM, Lipsker D, Jouglin M, Malandrin L, Hansmann Y, Martinot M
Med Mal Infect 2020 Sep;50(6):486-491. Epub 2019 Sep 20 doi: 10.1016/j.medmal.2019.08.007. PMID: 31548143
Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
The use of cytapheresis in the treatment of infectious diseases.
Norgan AP, Juskewitch JE, Pritt BS, Winters JL
J Clin Apher 2018 Aug;33(4):529-537. Epub 2018 Feb 28 doi: 10.1002/jca.21620. PMID: 29488237
Human babesiosis.
Rożej-Bielicka W, Stypułkowska-Misiurewicz H, Gołąb E
Przegl Epidemiol 2015;69(3):489-94, 605-8. PMID: 26519845
Babesia: a world emerging.
Schnittger L, Rodriguez AE, Florin-Christensen M, Morrison DA
Infect Genet Evol 2012 Dec;12(8):1788-809. Epub 2012 Jul 31 doi: 10.1016/j.meegid.2012.07.004. PMID: 22871652

Recent systematic reviews

Transfusion transmitted babesiosis: A systematic review of reported cases.
Tang TTM, Tran MH
Transfus Apher Sci 2020 Oct;59(5):102843. Epub 2020 Jun 5 doi: 10.1016/j.transci.2020.102843. PMID: 32616365
Safety and effectiveness of apheresis in the treatment of infectious diseases: A systematic review.
Odedra A, Lalloo DG, Kennedy G, Llewellyn S, McCarthy JS
J Infect 2019 Dec;79(6):513-520. Epub 2019 Oct 14 doi: 10.1016/j.jinf.2019.09.014. PMID: 31622632
Human Babesiosis in China: a systematic review.
Chen Z, Li H, Gao X, Bian A, Yan H, Kong D, Liu X
Parasitol Res 2019 Apr;118(4):1103-1112. Epub 2019 Feb 15 doi: 10.1007/s00436-019-06250-9. PMID: 30770979
Repellence of essential oils and selected compounds against ticks-A systematic review.
Benelli G, Pavela R
Acta Trop 2018 Mar;179:47-54. Epub 2017 Dec 26 doi: 10.1016/j.actatropica.2017.12.025. PMID: 29287758
Status of babesiosis among domestic herbivores in Iran: a systematic review and meta-analysis.
Haghi MM, Etemadifar F, Fakhar M, Teshnizi SH, Soosaraei M, Shokri A, Hajihasani A, Mashhadi H
Parasitol Res 2017 Apr;116(4):1101-1109. Epub 2017 Jan 4 doi: 10.1007/s00436-016-5368-8. PMID: 28054180

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

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