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Background diabetic retinopathy

MedGen UID:
2531
•Concept ID:
C0004606
•
Disease or Syndrome
Synonyms: Background Diabetic Retinopathy; background diabetic retinopathy; BDR - Background diabetic retinopathy; Non proliferative diabetic retinopathy; non proliferative diabetic retinopathy; Non-Proliferative Diabetic Retinopathy; non-proliferative diabetic retinopathy; Nonproliferative diabetic retinopathy; Nonproliferative retinopathy due to diabetes mellitus; NPDR - Non proliferative diabetic retinopathy
SNOMED CT: Non proliferative diabetic retinopathy (390834004); Background diabetic retinopathy (390834004); NPDR - Non proliferative diabetic retinopathy (390834004); BDR - Background diabetic retinopathy (390834004); Nonproliferative diabetic retinopathy (390834004); Nonproliferative retinopathy due to diabetes mellitus (390834004)
 
Monarch Initiative: MONDO:0001661

Definition

An early stage of diabetic retinopathy that is characterized by retinal hemorrhage and exudate, but without proliferation of the blood vessels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBackground diabetic retinopathy

Professional guidelines

PubMed

Identification of differential immune cells and related diagnostic genes in patients with diabetic retinopathy.
Yuan L, Zhang L, Liu X, Li S, Zou J
Medicine (Baltimore) 2023 Sep 29;102(39):e35331. doi: 10.1097/MD.0000000000035331. PMID: 37773794Free PMC Article
Depression in Diabetic Retinopathy: A Review and Recommendation for Psychiatric Management.
Chen X, Lu L
Psychosomatics 2016 Sep-Oct;57(5):465-71. Epub 2016 Apr 22 doi: 10.1016/j.psym.2016.04.003. PMID: 27380941
Diabetic retinopathy: Early diagnosis and effective treatment.
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article

Recent clinical studies

Etiology

Statins as a risk factor for diabetic retinopathy: a Mendelian randomization and cross-sectional observational study.
Chen C, Zhang H, Lan Y, Yan W, Liu S, Chen Y, Xie T, Ning J, Yan X, Shang L, Han J
J Transl Med 2024 Mar 22;22(1):298. doi: 10.1186/s12967-024-05097-8. PMID: 38520016Free PMC Article
Association between adipocytokines and diabetic retinopathy: a systematic review and meta-analysis.
Jiang Y, Fan H, Xie J, Xu Y, Sun X
Front Endocrinol (Lausanne) 2023;14:1271027. Epub 2023 Oct 6 doi: 10.3389/fendo.2023.1271027. PMID: 37867518Free PMC Article
Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy.
Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
Prevalence, risk factors and burden of diabetic retinopathy in China: a systematic review and meta-analysis.
Song P, Yu J, Chan KY, Theodoratou E, Rudan I
J Glob Health 2018 Jun;8(1):010803. doi: 10.7189/jogh.08.010803. PMID: 29899983Free PMC Article
Diabetic retinopathy: Early diagnosis and effective treatment.
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article

Diagnosis

Statins as a risk factor for diabetic retinopathy: a Mendelian randomization and cross-sectional observational study.
Chen C, Zhang H, Lan Y, Yan W, Liu S, Chen Y, Xie T, Ning J, Yan X, Shang L, Han J
J Transl Med 2024 Mar 22;22(1):298. doi: 10.1186/s12967-024-05097-8. PMID: 38520016Free PMC Article
Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy.
Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
Potential Biomarkers in Diabetic Retinopathy.
Adki KM, Kulkarni YA
Curr Diabetes Rev 2020;16(9):971-983. doi: 10.2174/1573399816666200217092022. PMID: 32065092
Diabetic retinopathy: Early diagnosis and effective treatment.
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article
Retinal arterial macroaneurysms.
Rabb MF, Gagliano DA, Teske MP
Surv Ophthalmol 1988 Sep-Oct;33(2):73-96. doi: 10.1016/0039-6257(88)90160-9. PMID: 3055391

Therapy

Statins as a risk factor for diabetic retinopathy: a Mendelian randomization and cross-sectional observational study.
Chen C, Zhang H, Lan Y, Yan W, Liu S, Chen Y, Xie T, Ning J, Yan X, Shang L, Han J
J Transl Med 2024 Mar 22;22(1):298. doi: 10.1186/s12967-024-05097-8. PMID: 38520016Free PMC Article
Blood pressure control for diabetic retinopathy.
Do DV, Han G, Abariga SA, Sleilati G, Vedula SS, Hawkins BS
Cochrane Database Syst Rev 2023 Mar 28;3(3):CD006127. doi: 10.1002/14651858.CD006127.pub3. PMID: 36975019Free PMC Article
Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy.
Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
Prevalence, risk factors and burden of diabetic retinopathy in China: a systematic review and meta-analysis.
Song P, Yu J, Chan KY, Theodoratou E, Rudan I
J Glob Health 2018 Jun;8(1):010803. doi: 10.7189/jogh.08.010803. PMID: 29899983Free PMC Article
Retinal arterial macroaneurysms.
Rabb MF, Gagliano DA, Teske MP
Surv Ophthalmol 1988 Sep-Oct;33(2):73-96. doi: 10.1016/0039-6257(88)90160-9. PMID: 3055391

Prognosis

Causal relationships between blood metabolites and diabetic retinopathy: a two-sample Mendelian randomization study.
Yang C, Ma Y, Yao M, Jiang Q, Xue J
Front Endocrinol (Lausanne) 2024;15:1383035. Epub 2024 May 1 doi: 10.3389/fendo.2024.1383035. PMID: 38752182Free PMC Article
Potential disease biomarkers for diabetic retinopathy identified through Mendelian randomization analysis.
Zou X, Ye S, Tan Y
Front Endocrinol (Lausanne) 2023;14:1339374. Epub 2024 Jan 11 doi: 10.3389/fendo.2023.1339374. PMID: 38274229Free PMC Article
Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy.
Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
Molecular investigation of candidate genes for pyroptosis-induced inflammation in diabetic retinopathy.
Wang N, Ding L, Liu D, Zhang Q, Zheng G, Xia X, Xiong S
Front Endocrinol (Lausanne) 2022;13:918605. Epub 2022 Jul 25 doi: 10.3389/fendo.2022.918605. PMID: 35957838Free PMC Article
Association between diabetic retinopathy and interleukin-related gene polymorphisms: a machine learning aided meta-analysis.
Sun X, Guo S
Ophthalmic Genet 2020 Jun;41(3):216-222. Epub 2020 Apr 13 doi: 10.1080/13816810.2020.1747091. PMID: 32281460

Clinical prediction guides

Causal relationships between blood metabolites and diabetic retinopathy: a two-sample Mendelian randomization study.
Yang C, Ma Y, Yao M, Jiang Q, Xue J
Front Endocrinol (Lausanne) 2024;15:1383035. Epub 2024 May 1 doi: 10.3389/fendo.2024.1383035. PMID: 38752182Free PMC Article
Statins as a risk factor for diabetic retinopathy: a Mendelian randomization and cross-sectional observational study.
Chen C, Zhang H, Lan Y, Yan W, Liu S, Chen Y, Xie T, Ning J, Yan X, Shang L, Han J
J Transl Med 2024 Mar 22;22(1):298. doi: 10.1186/s12967-024-05097-8. PMID: 38520016Free PMC Article
Potential disease biomarkers for diabetic retinopathy identified through Mendelian randomization analysis.
Zou X, Ye S, Tan Y
Front Endocrinol (Lausanne) 2023;14:1339374. Epub 2024 Jan 11 doi: 10.3389/fendo.2023.1339374. PMID: 38274229Free PMC Article
Fenofibrate for diabetic retinopathy.
Kataoka SY, Lois N, Kawano S, Kataoka Y, Inoue K, Watanabe N
Cochrane Database Syst Rev 2023 Jun 13;6(6):CD013318. doi: 10.1002/14651858.CD013318.pub2. PMID: 37310870Free PMC Article
Molecular investigation of candidate genes for pyroptosis-induced inflammation in diabetic retinopathy.
Wang N, Ding L, Liu D, Zhang Q, Zheng G, Xia X, Xiong S
Front Endocrinol (Lausanne) 2022;13:918605. Epub 2022 Jul 25 doi: 10.3389/fendo.2022.918605. PMID: 35957838Free PMC Article

Recent systematic reviews

Association between adipocytokines and diabetic retinopathy: a systematic review and meta-analysis.
Jiang Y, Fan H, Xie J, Xu Y, Sun X
Front Endocrinol (Lausanne) 2023;14:1271027. Epub 2023 Oct 6 doi: 10.3389/fendo.2023.1271027. PMID: 37867518Free PMC Article
Fenofibrate for diabetic retinopathy.
Kataoka SY, Lois N, Kawano S, Kataoka Y, Inoue K, Watanabe N
Cochrane Database Syst Rev 2023 Jun 13;6(6):CD013318. doi: 10.1002/14651858.CD013318.pub2. PMID: 37310870Free PMC Article
Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy.
Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
Association Between Diabetic Retinopathy and Periodontitis-A Systematic Review.
Alvarenga MOP, Miranda GHN, Ferreira RO, Saito MT, Fagundes NCF, Maia LC, Lima RR
Front Public Health 2020;8:550614. Epub 2021 Jan 8 doi: 10.3389/fpubh.2020.550614. PMID: 33490007Free PMC Article
Prevalence, risk factors and burden of diabetic retinopathy in China: a systematic review and meta-analysis.
Song P, Yu J, Chan KY, Theodoratou E, Rudan I
J Glob Health 2018 Jun;8(1):010803. doi: 10.7189/jogh.08.010803. PMID: 29899983Free PMC Article

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