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Myocardial necrosis

MedGen UID:
254841
Concept ID:
C1442837
Disease or Syndrome
SNOMED CT: Myocardial necrosis (251061000)
 
HPO: HP:0001700

Definition

Irreversible damage to heart tissue (myocardium) due to lack of oxygen after a heart attack (myocardial infarction). [from HPO]

Term Hierarchy

Conditions with this feature

Danon disease
MedGen UID:
209235
Concept ID:
C0878677
Disease or Syndrome
Danon disease is a multisystem condition with predominant involvement of the heart, skeletal muscles, and retina, with overlying cognitive dysfunction. Males are typically more severely affected than females. Males usually present with childhood onset concentric hypertrophic cardiomyopathy that is progressive and often requires heart transplantation. Rarely, hypertrophic cardiomyopathy can evolve to resemble dilated cardiomyopathy. Most affected males also have cardiac conduction abnormalities. Skeletal muscle weakness may lead to delayed acquisition of motor milestones. Learning disability and intellectual disability, most often in the mild range, are common. Additionally, affected males can develop retinopathy with subsequent visual impairment. The clinical features in females are broader and more variable. Females are more likely to have dilated cardiomyopathy, with a smaller proportion requiring heart transplantation compared to affected males. Cardiac conduction abnormalities, skeletal muscle weakness, mild cognitive impairment, and pigmentary retinopathy are variably seen in affected females.
Shwachman-Diamond syndrome 1
MedGen UID:
1640046
Concept ID:
C4692625
Disease or Syndrome
Shwachman-Diamond syndrome (SDS) is characterized by: exocrine pancreatic dysfunction with malabsorption, malnutrition, and growth failure; hematologic abnormalities with single- or multilineage cytopenias and susceptibility to myelodysplasia syndrome (MDS) and acute myelogeneous leukemia (AML); and bone abnormalities. In almost all affected children, persistent or intermittent neutropenia is a common presenting finding, often before the diagnosis of SDS is made. Short stature and recurrent infections are common.

Professional guidelines

PubMed

Shou Y, Li X, Fang Q, Xie A, Zhang Y, Fu X, Wang M, Gong W, Zhang X, Yang D
Pharmacol Res Perspect 2024 Apr;12(2):e1177. doi: 10.1002/prp2.1177. PMID: 38407563Free PMC Article
Ross C, Kumar R, Pelland-Marcotte MC, Mehta S, Kleinman ME, Thiagarajan RR, Ghbeis MB, VanderPluym CJ, Friedman KG, Porras D, Fynn-Thompson F, Goldhaber SZ, Brandão LR
Chest 2022 Mar;161(3):791-802. Epub 2021 Sep 26 doi: 10.1016/j.chest.2021.09.019. PMID: 34587483Free PMC Article
Alpert JS, Thygesen K, Antman E, Bassand JP
J Am Coll Cardiol 2000 Sep;36(3):959-69. doi: 10.1016/s0735-1097(00)00804-4. PMID: 10987628

Recent clinical studies

Etiology

Fonseca DA, Ribeiro DM, Tapadas M, Cotrim MD
Eur J Pharmacol 2021 Jul 15;903:174156. Epub 2021 May 8 doi: 10.1016/j.ejphar.2021.174156. PMID: 33971177
Zhang D, Jiang C, Feng Y, Ni Y, Zhang J
J Drug Target 2020 Jul;28(6):565-573. Epub 2020 Feb 9 doi: 10.1080/1061186X.2020.1725769. PMID: 32037899
Mohebi R, Rosenson R
F1000Res 2019;8 Epub 2019 May 20 doi: 10.12688/f1000research.17572.1. PMID: 31131090Free PMC Article
Javed QA, Sista AK
Int J Cardiovasc Imaging 2019 Aug;35(8):1443-1452. Epub 2019 Mar 15 doi: 10.1007/s10554-019-01567-z. PMID: 30877411
Scheitz JF, Nolte CH, Doehner W, Hachinski V, Endres M
Lancet Neurol 2018 Dec;17(12):1109-1120. Epub 2018 Oct 26 doi: 10.1016/S1474-4422(18)30336-3. PMID: 30509695

Diagnosis

Matthia EL, Setteducato ML, Elzeneini M, Vernace N, Salerno M, Kramer CM, Keeley EC
J Am Heart Assoc 2022 Dec 6;11(23):e027618. Epub 2022 Nov 16 doi: 10.1161/JAHA.122.027618. PMID: 36382968Free PMC Article
Budnik M, Kucharz J, Wiechno P, Demkow T, Kochanowski J, Górska E, Opolski G
Adv Exp Med Biol 2018;1114:19-29. doi: 10.1007/5584_2018_222. PMID: 29884920
Cheung CC, Constantine M, Ahmadi A, Shiau C, Chen LYC
Am J Med Sci 2017 Nov;354(5):486-492. Epub 2017 Apr 6 doi: 10.1016/j.amjms.2017.04.002. PMID: 29173361
Kühl U, Schultheiss HP
Heart Fail Clin 2010 Oct;6(4):483-96, viii-ix. doi: 10.1016/j.hfc.2010.05.009. PMID: 20869648
Sucu M, Davutoglu V, Ozer O
Ann Saudi Med 2009 May-Jun;29(3):201-6. doi: 10.4103/0256-4947.51775. PMID: 19448376Free PMC Article

Therapy

Fonseca DA, Ribeiro DM, Tapadas M, Cotrim MD
Eur J Pharmacol 2021 Jul 15;903:174156. Epub 2021 May 8 doi: 10.1016/j.ejphar.2021.174156. PMID: 33971177
Mohebi R, Rosenson R
F1000Res 2019;8 Epub 2019 May 20 doi: 10.12688/f1000research.17572.1. PMID: 31131090Free PMC Article
Javed QA, Sista AK
Int J Cardiovasc Imaging 2019 Aug;35(8):1443-1452. Epub 2019 Mar 15 doi: 10.1007/s10554-019-01567-z. PMID: 30877411
Budnik M, Kucharz J, Wiechno P, Demkow T, Kochanowski J, Górska E, Opolski G
Adv Exp Med Biol 2018;1114:19-29. doi: 10.1007/5584_2018_222. PMID: 29884920
Kühl U, Schultheiss HP
Heart Fail Clin 2010 Oct;6(4):483-96, viii-ix. doi: 10.1016/j.hfc.2010.05.009. PMID: 20869648

Prognosis

Matthia EL, Setteducato ML, Elzeneini M, Vernace N, Salerno M, Kramer CM, Keeley EC
J Am Heart Assoc 2022 Dec 6;11(23):e027618. Epub 2022 Nov 16 doi: 10.1161/JAHA.122.027618. PMID: 36382968Free PMC Article
Scheitz JF, Nolte CH, Doehner W, Hachinski V, Endres M
Lancet Neurol 2018 Dec;17(12):1109-1120. Epub 2018 Oct 26 doi: 10.1016/S1474-4422(18)30336-3. PMID: 30509695
Budnik M, Kucharz J, Wiechno P, Demkow T, Kochanowski J, Górska E, Opolski G
Adv Exp Med Biol 2018;1114:19-29. doi: 10.1007/5584_2018_222. PMID: 29884920
Kühl U, Schultheiss HP
Heart Fail Clin 2010 Oct;6(4):483-96, viii-ix. doi: 10.1016/j.hfc.2010.05.009. PMID: 20869648
Cohn JN
Clin Cardiol 1993 May;16(5 Suppl 2):II21-4. doi: 10.1002/clc.4960161406. PMID: 8504586

Clinical prediction guides

Matthia EL, Setteducato ML, Elzeneini M, Vernace N, Salerno M, Kramer CM, Keeley EC
J Am Heart Assoc 2022 Dec 6;11(23):e027618. Epub 2022 Nov 16 doi: 10.1161/JAHA.122.027618. PMID: 36382968Free PMC Article
Zhang D, Jiang C, Feng Y, Ni Y, Zhang J
J Drug Target 2020 Jul;28(6):565-573. Epub 2020 Feb 9 doi: 10.1080/1061186X.2020.1725769. PMID: 32037899
Mohebi R, Rosenson R
F1000Res 2019;8 Epub 2019 May 20 doi: 10.12688/f1000research.17572.1. PMID: 31131090Free PMC Article
Vafaie M
Diagnosis (Berl) 2016 Dec 1;3(4):137-142. doi: 10.1515/dx-2016-0024. PMID: 29536900
Rona G
J Mol Cell Cardiol 1985 Apr;17(4):291-306. doi: 10.1016/s0022-2828(85)80130-9. PMID: 3894676

Recent systematic reviews

Shou Y, Li X, Fang Q, Xie A, Zhang Y, Fu X, Wang M, Gong W, Zhang X, Yang D
Pharmacol Res Perspect 2024 Apr;12(2):e1177. doi: 10.1002/prp2.1177. PMID: 38407563Free PMC Article
Almamlouk R, Kashour T, Obeidat S, Bois MC, Maleszewski JJ, Omrani OA, Tleyjeh R, Berbari E, Chakhachiro Z, Zein-Sabatto B, Gerberi D, Tleyjeh IM; Cardiac Autopsy in COVID-19 Study Group, Paniz Mondolfi AE, Finn AV, Duarte-Neto AN, Rapkiewicz AV, Frustaci A, Keresztesi AA, Hanley B, Märkl B, Lardi C, Bryce C, Lindner D, Aguiar D, Westermann D, Stroberg E, Duval EJ, Youd E, Bulfamante GP, Salmon I, Auer J, Maleszewski JJ, Hirschbühl K, Absil L, Barton LM, Ferraz da Silva LF, Moore L, Dolhnikoff M, Lammens M, Bois MC, Osborn M, Remmelink M, Nascimento Saldiva PH, Jorens PG, Craver R, Aparecida de Almeida Monteiro R, Scendoni R, Mukhopadhyay S, Suzuki T, Mauad T, Fracasso T, Grimes Z
Clin Microbiol Infect 2022 Aug;28(8):1066-1075. Epub 2022 Mar 23 doi: 10.1016/j.cmi.2022.03.021. PMID: 35339672Free PMC Article
Rubbo B, Fitzpatrick NK, Denaxas S, Daskalopoulou M, Yu N, Patel RS; UK Biobank Follow-up and Outcomes Working Group, Hemingway H
Int J Cardiol 2015;187:705-11. Epub 2015 Mar 5 doi: 10.1016/j.ijcard.2015.03.075. PMID: 25966015
Liou K, Ho S, Ooi SY
Ann Clin Biochem 2015 May;52(Pt 3):370-81. Epub 2014 Sep 9 doi: 10.1177/0004563214553277. PMID: 25205855
Abdelnoor M, Sandven I, Limalanathan S, Eritsland J
Vasc Health Risk Manag 2014;10:477-91. Epub 2014 Aug 8 doi: 10.2147/VHRM.S67154. PMID: 25143742Free PMC Article

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