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Poorly differentiated thyroid gland carcinoma

MedGen UID:
266094
•Concept ID:
C1266050
•
Neoplastic Process
Synonyms: Insular carcinoma; Insular Carcinoma; insular carcinoma; Poorly Differentiated Carcinoma of the Thyroid Gland; poorly differentiated carcinoma of the thyroid gland; Poorly Differentiated Carcinoma of Thyroid Gland; poorly differentiated carcinoma of thyroid gland; poorly differentiated thyroid cancer; Poorly Differentiated Thyroid Carcinoma; poorly differentiated thyroid carcinoma; poorly differentiated thyroid gland cancer; Poorly Differentiated Thyroid Gland Carcinoma; poorly differentiated thyroid gland carcinoma; Thyroid Gland Poorly Differentiated Carcinoma; thyroid gland poorly differentiated carcinoma
SNOMED CT: Insular carcinoma (128673009)
 
Monarch Initiative: MONDO:0006382

Definition

A follicular-derived thyroid gland carcinoma that is histologically poorly differentiated and has high-grade features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPoorly differentiated thyroid gland carcinoma

Professional guidelines

PubMed

Combination of Lenvatinib and Pembrolizumab Is an Effective Treatment Option for Anaplastic and Poorly Differentiated Thyroid Carcinoma.
Dierks C, Seufert J, Aumann K, Ruf J, Klein C, Kiefer S, Rassner M, Boerries M, Zielke A, la Rosee P, Meyer PT, Kroiss M, Weißenberger C, Schumacher T, Metzger P, Weiss H, Smaxwil C, Laubner K, Duyster J, von Bubnoff N, Miething C, Thomusch O
Thyroid 2021 Jul;31(7):1076-1085. Epub 2021 Apr 15 doi: 10.1089/thy.2020.0322. PMID: 33509020Free PMC Article
Thyroid pathology: Controversies and best practices.
Nishino M
Semin Diagn Pathol 2020 Sep;37(5):211-212. Epub 2020 Aug 5 doi: 10.1053/j.semdp.2020.07.004. PMID: 32782166
Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer.
Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, Beasley MB, Thunnissen E, Pelosi G, Rekhtman N, Bubendorf L, Mino-Kenudson M, Yoshida A, Geisinger KR, Noguchi M, Chirieac LR, Bolting J, Chung JH, Chou TY, Chen G, Poleri C, Lopez-Rios F, Papotti M, Sholl LM, Roden AC, Travis WD, Hirsch FR, Kerr KM, Tsao MS, Nicholson AG, Wistuba I, Moreira AL
J Thorac Oncol 2019 Mar;14(3):377-407. Epub 2018 Dec 18 doi: 10.1016/j.jtho.2018.12.005. PMID: 30572031Free PMC Article

Recent clinical studies

Etiology

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Update on Fundamental Mechanisms of Thyroid Cancer.
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article
The Current Histologic Classification of Thyroid Cancer.
Asa SL
Endocrinol Metab Clin North Am 2019 Mar;48(1):1-22. doi: 10.1016/j.ecl.2018.10.001. PMID: 30717895
Differentiated thyroid cancer theranostics: radioiodine and beyond.
Choudhury PS, Gupta M
Br J Radiol 2018 Nov;91(1091):20180136. Epub 2018 Oct 11 doi: 10.1259/bjr.20180136. PMID: 30260232Free PMC Article

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Update on Fundamental Mechanisms of Thyroid Cancer.
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article
Diagnosis and pathologic characteristics of medullary thyroid carcinoma-review of current guidelines.
Thomas CM, Asa SL, Ezzat S, Sawka AM, Goldstein D
Curr Oncol 2019 Oct;26(5):338-344. Epub 2019 Oct 1 doi: 10.3747/co.26.5539. PMID: 31708652Free PMC Article
Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.
Ibrahimpasic T, Ghossein R, Shah JP, Ganly I
Thyroid 2019 Mar;29(3):311-321. doi: 10.1089/thy.2018.0509. PMID: 30747050Free PMC Article
Differentiated thyroid cancer theranostics: radioiodine and beyond.
Choudhury PS, Gupta M
Br J Radiol 2018 Nov;91(1091):20180136. Epub 2018 Oct 11 doi: 10.1259/bjr.20180136. PMID: 30260232Free PMC Article

Therapy

Radioiodine adjuvant therapy in differentiated thyroid cancer: An update and reconsideration.
Sun YQ, Sun D, Zhang X, Zhang YQ, Lin YS
Front Endocrinol (Lausanne) 2022;13:994288. Epub 2022 Nov 30 doi: 10.3389/fendo.2022.994288. PMID: 36531486Free PMC Article
Targeted therapy and drug resistance in thyroid cancer.
Zhang Y, Xing Z, Liu T, Tang M, Mi L, Zhu J, Wu W, Wei T
Eur J Med Chem 2022 Aug 5;238:114500. Epub 2022 May 29 doi: 10.1016/j.ejmech.2022.114500. PMID: 35675754
Combination of Lenvatinib and Pembrolizumab Is an Effective Treatment Option for Anaplastic and Poorly Differentiated Thyroid Carcinoma.
Dierks C, Seufert J, Aumann K, Ruf J, Klein C, Kiefer S, Rassner M, Boerries M, Zielke A, la Rosee P, Meyer PT, Kroiss M, Weißenberger C, Schumacher T, Metzger P, Weiss H, Smaxwil C, Laubner K, Duyster J, von Bubnoff N, Miething C, Thomusch O
Thyroid 2021 Jul;31(7):1076-1085. Epub 2021 Apr 15 doi: 10.1089/thy.2020.0322. PMID: 33509020Free PMC Article
Treatment of Aggressive Thyroid Cancer.
Huang J, Harris EJ, Lorch JH
Surg Pathol Clin 2019 Dec;12(4):943-950. doi: 10.1016/j.path.2019.08.004. PMID: 31672300
Differentiated thyroid cancer theranostics: radioiodine and beyond.
Choudhury PS, Gupta M
Br J Radiol 2018 Nov;91(1091):20180136. Epub 2018 Oct 11 doi: 10.1259/bjr.20180136. PMID: 30260232Free PMC Article

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Update on Fundamental Mechanisms of Thyroid Cancer.
Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M
Front Endocrinol (Lausanne) 2020;11:102. Epub 2020 Mar 13 doi: 10.3389/fendo.2020.00102. PMID: 32231639Free PMC Article
Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.
Ibrahimpasic T, Ghossein R, Shah JP, Ganly I
Thyroid 2019 Mar;29(3):311-321. doi: 10.1089/thy.2018.0509. PMID: 30747050Free PMC Article
The Current Histologic Classification of Thyroid Cancer.
Asa SL
Endocrinol Metab Clin North Am 2019 Mar;48(1):1-22. doi: 10.1016/j.ecl.2018.10.001. PMID: 30717895
Heterogeneity of Thyroid Cancer.
Chmielik E, Rusinek D, Oczko-Wojciechowska M, Jarzab M, Krajewska J, Czarniecka A, Jarzab B
Pathobiology 2018;85(1-2):117-129. Epub 2018 Feb 6 doi: 10.1159/000486422. PMID: 29408820

Clinical prediction guides

Combination of Lenvatinib and Pembrolizumab Is an Effective Treatment Option for Anaplastic and Poorly Differentiated Thyroid Carcinoma.
Dierks C, Seufert J, Aumann K, Ruf J, Klein C, Kiefer S, Rassner M, Boerries M, Zielke A, la Rosee P, Meyer PT, Kroiss M, Weißenberger C, Schumacher T, Metzger P, Weiss H, Smaxwil C, Laubner K, Duyster J, von Bubnoff N, Miething C, Thomusch O
Thyroid 2021 Jul;31(7):1076-1085. Epub 2021 Apr 15 doi: 10.1089/thy.2020.0322. PMID: 33509020Free PMC Article
SMARCA4/BRG1-Deficient Non-Small Cell Lung Carcinomas: A Case Series and Review of the Literature.
Nambirajan A, Singh V, Bhardwaj N, Mittal S, Kumar S, Jain D
Arch Pathol Lab Med 2021 Jan 1;145(1):90-98. doi: 10.5858/arpa.2019-0633-OA. PMID: 33367658
Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.
Ibrahimpasic T, Ghossein R, Shah JP, Ganly I
Thyroid 2019 Mar;29(3):311-321. doi: 10.1089/thy.2018.0509. PMID: 30747050Free PMC Article
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.
Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B, Schultz N, Berger MF, Sander C, Taylor BS, Ghossein R, Ganly I, Fagin JA
J Clin Invest 2016 Mar 1;126(3):1052-66. Epub 2016 Feb 15 doi: 10.1172/JCI85271. PMID: 26878173Free PMC Article
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Recent systematic reviews

Programmed Death-Ligand 1 (PD-L1) Is a Potential Biomarker of Disease-Free Survival in Papillary Thyroid Carcinoma: a Systematic Review and Meta-Analysis of PD-L1 Immunoexpression in Follicular Epithelial Derived Thyroid Carcinoma.
Girolami I, Pantanowitz L, Mete O, Brunelli M, Marletta S, Colato C, Trimboli P, Crescenzi A, Bongiovanni M, Barbareschi M, Eccher A
Endocr Pathol 2020 Sep;31(3):291-300. doi: 10.1007/s12022-020-09630-5. PMID: 32468210
Ultrasound characteristics of thyroid nodules facilitate interpretation of the malignant risk of Bethesda system III/IV thyroid nodules and inform therapeutic schedule.
Li F, Pan D, Wu Y, Peng J, Li Q, Gui X, Ma W, Yang H, He Y, Chen J
Diagn Cytopathol 2019 Sep;47(9):881-889. Epub 2019 Jun 18 doi: 10.1002/dc.24248. PMID: 31211509Free PMC Article
Thyrotoxicosis with concomitant thyroid cancer.
Fu H, Cheng L, Jin Y, Chen L
Endocr Relat Cancer 2019 Jul;26(7):R395-R413. doi: 10.1530/ERC-19-0129. PMID: 31026810
Serum calcitonin negative medullary thyroid carcinoma: a systematic review of the literature.
Trimboli P, Giovanella L
Clin Chem Lab Med 2015 Sep 1;53(10):1507-14. doi: 10.1515/cclm-2015-0058. PMID: 25781697
Sorafenib in metastatic thyroid cancer: a systematic review.
Thomas L, Lai SY, Dong W, Feng L, Dadu R, Regone RM, Cabanillas ME
Oncologist 2014 Mar;19(3):251-8. Epub 2014 Feb 21 doi: 10.1634/theoncologist.2013-0362. PMID: 24563075Free PMC Article

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