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Ectopic Hamartomatous Thymoma

MedGen UID:
266100
•Concept ID:
C1266098
•
Neoplastic Process
Synonyms: Branchial Anlage Mixed Tumor; Ectopic hamartomatous thymoma
SNOMED CT: Ectopic hamartomatous thymoma (128718003)

Definition

A benign, well-circumscribed tumor of the neck occurring in adults. It is characterized by the presence of spindle cells, epithelial islands, and adipose tissue. There is no evidence of thymic origin or differentiation, despite the use of the term thymoma in the literature. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEctopic Hamartomatous Thymoma

Recent clinical studies

Etiology

Carcinoma showing thymus-like differentiation of the thyroid (CASTLE).
Huang C, Wang L, Wang Y, Yang X, Li Q
Pathol Res Pract 2013 Oct;209(10):662-5. Epub 2013 Jul 15 doi: 10.1016/j.prp.2013.06.021. PMID: 23920320
Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part XII: appendix.
Bisceglia M, Spagnolo D, Galliani C, Fisher C, Suster S, Kazakov DV, Cooper K, Michal M
Pathologica 2006 Aug;98(4):239-98. PMID: 17175794
Ectopic hamartomatous thymoma: a clinicopathologic and immunohistochemical analysis of 21 cases with data supporting reclassification as a branchial anlage mixed tumor.
Fetsch JF, Laskin WB, Michal M, Remotti F, Heffner D, Ellis G, Furlong M, Miettinen M
Am J Surg Pathol 2004 Oct;28(10):1360-70. doi: 10.1097/01.pas.0000135518.27224.3f. PMID: 15371953
Carcinoma arising in ectopic hamartomatous thymoma. A previously unpublished occurrence. Report of two cases.
Michal M, Neubauer L
Zentralbl Pathol 1993 Nov;139(4-5):381-6. PMID: 8130171

Diagnosis

Ectopic hamartomatous thymoma in an immunocompromised male.
Waters D, Obeidin F, Alexiev BA, Rao MS, Peabody TD, Agulnik M, Yeldandi A
Pathol Res Pract 2019 Sep;215(9):152497. Epub 2019 Jun 10 doi: 10.1016/j.prp.2019.152497. PMID: 31257088
Ectopic hamartomatous thymoma (biphenotypic branchioma): A case report and review of the literature.
Cui W, Li D, Liu Y, Pang Y, Zhang L, Liu C, Li F
Medicine (Baltimore) 2018 Jul;97(28):e11459. doi: 10.1097/MD.0000000000011459. PMID: 29995801Free PMC Article
Ectopic Hamartomatous Thymoma-New Insights Into a Challenging Entity: A Clinicopathologic and Immunohistochemical Study of 9 Cases.
Weissferdt A, Kalhor N, Petersson F, Moran CA
Am J Surg Pathol 2016 Nov;40(11):1571-1576. doi: 10.1097/PAS.0000000000000699. PMID: 27428736
An ectopic hamartomatous thymoma compressing left jugular vein.
Huang L, Zhao L, Chai Y
Niger J Clin Pract 2014 Nov-Dec;17(6):814-6. doi: 10.4103/1119-3077.144407. PMID: 25385925
An ectopic hamartomatous thymoma.
Shim DB, Song JS, Baek SJ
Auris Nasus Larynx 2012 Feb;39(1):110-3. Epub 2011 Sep 1 doi: 10.1016/j.anl.2011.07.016. PMID: 21889280

Prognosis

A Rare Presternal Soft Tissue Tumor: Ectopic Hamartomatous Thymoma (Branchial Anlage Mixed Tumor).
Reusens H, Van den Broecke C, Creytens D, Fierens K
Acta Chir Belg 2015 Nov-Dec;115(6):418-22. doi: 10.1080/00015458.2015.11681144. PMID: 26763841
An ectopic hamartomatous thymoma.
Shim DB, Song JS, Baek SJ
Auris Nasus Larynx 2012 Feb;39(1):110-3. Epub 2011 Sep 1 doi: 10.1016/j.anl.2011.07.016. PMID: 21889280
Ectopic hamartomatous thymoma: a case demonstrating skin adnexal differentiation with positivity for epithelial membrane antigen, androgen receptors, and BRST-2 by immunohistochemistry.
Weinreb I, O'Malley F, Ghazarian D
Hum Pathol 2007 Jul;38(7):1092-1095. doi: 10.1016/j.humpath.2007.01.029. PMID: 17574947
Ectopic hamartomatous thymoma: a clinicopathologic and immunohistochemical analysis of 21 cases with data supporting reclassification as a branchial anlage mixed tumor.
Fetsch JF, Laskin WB, Michal M, Remotti F, Heffner D, Ellis G, Furlong M, Miettinen M
Am J Surg Pathol 2004 Oct;28(10):1360-70. doi: 10.1097/01.pas.0000135518.27224.3f. PMID: 15371953
The sarcomatous guise of cervical ectopic hamartomatous thymoma.
Marschall J, Kanthan R
Head Neck 2002 Aug;24(8):800-4. doi: 10.1002/hed.10091. PMID: 12203807

Clinical prediction guides

Ectopic hamartomatous thymoma: a clinicopathologic and immunohistochemical analysis of 21 cases with data supporting reclassification as a branchial anlage mixed tumor.
Fetsch JF, Laskin WB, Michal M, Remotti F, Heffner D, Ellis G, Furlong M, Miettinen M
Am J Surg Pathol 2004 Oct;28(10):1360-70. doi: 10.1097/01.pas.0000135518.27224.3f. PMID: 15371953
Ectopic hamartomatous thymoma: a case report with immunohistochemical and ultrastructural studies.
Fukunaga M
APMIS 2002 Aug;110(7-8):565-70. doi: 10.1034/j.1600-0463.2002.11007808.x. PMID: 12390415
Two cases of ectopic hamartomatous thymoma.
Zhao C, Yamada T, Kuramochi S, Yamazaki K, Mukai M, Kameyama K, Hata J
Virchows Arch 2000 Dec;437(6):643-7. doi: 10.1007/s004280000309. PMID: 11193476

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