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Fibroblastic liposarcoma

MedGen UID:
266103
•Concept ID:
C1266130
•
Neoplastic Process
Synonyms: Fibroblastic Liposarcoma; fibroblastic liposarcoma; fibroblastic liposarcoma (morphologic abnormality)
SNOMED CT: Fibroblastic liposarcoma (128883006)
 
Monarch Initiative: MONDO:0003590

Definition

A liposarcoma characterized by the presence of a fibroblastic component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibroblastic liposarcoma

Professional guidelines

PubMed

Low to Intermediate (Borderline) Grade Breast Spindle Cell Lesions on Needle Biopsy: Diagnostic Approach and Clinical Management.
Russell DH, Montgomery EA, Susnik B
Adv Anat Pathol 2022 Sep 1;29(5):309-323. Epub 2022 Jul 12 doi: 10.1097/PAP.0000000000000353. PMID: 35838633
Differential diagnosis of myxoid soft tissue tumors. Experience in the Clinical University Hospital of Valencia.
Alfaro-Cervelló C, Nieto G, Navarro S
Rev Esp Patol 2022 Jul-Sep;55(3):185-191. Epub 2019 Nov 4 doi: 10.1016/j.patol.2019.07.005. PMID: 35779885
FDG-PET for preoperative differential diagnosis between benign and malignant soft tissue masses.
Aoki J, Watanabe H, Shinozaki T, Takagishi K, Tokunaga M, Koyama Y, Sato N, Endo K
Skeletal Radiol 2003 Mar;32(3):133-8. Epub 2003 Jan 24 doi: 10.1007/s00256-002-0586-9. PMID: 12605276

Recent clinical studies

Etiology

Integrated genomic and transcriptomic analysis revealed mutation patterns of de-differentiated liposarcoma and leiomyosarcoma.
Liu W, Tong H, Zhang C, Zhuang R, Guo H, Lv C, Yang H, Lin Q, Guo X, Wang Z, Wang Y, Shen F, Wang S, Dai C, Wang G, Liu J, Lu W, Zhang Y, Zhou Y
BMC Cancer 2020 Oct 28;20(1):1035. doi: 10.1186/s12885-020-07456-2. PMID: 33115433Free PMC Article
Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 2-Uncommon Sarcomas.
Levy AD, Manning MA, Miettinen MM
Radiographics 2017 May-Jun;37(3):797-812. doi: 10.1148/rg.2017160201. PMID: 28493803Free PMC Article
Fat-containing soft-tissue masses in children.
Sheybani EF, Eutsler EP, Navarro OM
Pediatr Radiol 2016 Dec;46(13):1760-1773. Epub 2016 Nov 19 doi: 10.1007/s00247-016-3690-z. PMID: 27866258
Nodular fasciitis.
Zuber TJ, Finley JL
South Med J 1994 Aug;87(8):842-4. doi: 10.1097/00007611-199408000-00020. PMID: 8052900
Spindle cell lipoma.
Enzinger FM, Harvey DA
Cancer 1975 Nov;36(5):1852-9. doi: 10.1002/1097-0142(197511)36:5<1852::aid-cncr2820360542>3.0.co;2-u. PMID: 1192370

Diagnosis

Pearls and Pitfalls in the Imaging of Soft-Tissue Masses in Children.
Navarro OM
Semin Ultrasound CT MR 2020 Oct;41(5):498-512. Epub 2020 May 28 doi: 10.1053/j.sult.2020.05.014. PMID: 32980096
Immunohistochemical correlates of recurrent genetic alterations in sarcomas.
Anderson WJ, Hornick JL
Genes Chromosomes Cancer 2019 Feb;58(2):111-123. Epub 2018 Dec 19 doi: 10.1002/gcc.22700. PMID: 30382607
Dedifferentiated Liposarcoma With Myofibroblastic Differentiation.
Wang GY, Lucas DR
Arch Pathol Lab Med 2018 Oct;142(10):1159-1163. doi: 10.5858/arpa.2018-0205-RA. PMID: 30281365
Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 2-Uncommon Sarcomas.
Levy AD, Manning MA, Miettinen MM
Radiographics 2017 May-Jun;37(3):797-812. doi: 10.1148/rg.2017160201. PMID: 28493803Free PMC Article
Fat-containing soft-tissue masses in children.
Sheybani EF, Eutsler EP, Navarro OM
Pediatr Radiol 2016 Dec;46(13):1760-1773. Epub 2016 Nov 19 doi: 10.1007/s00247-016-3690-z. PMID: 27866258

Therapy

Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma.
Hanes R, Munthe E, Grad I, Han J, Karlsen I, McCormack E, Meza-Zepeda LA, Stratford EW, Myklebost O
Cells 2019 Feb 21;8(2) doi: 10.3390/cells8020189. PMID: 30795553Free PMC Article
Platelets actively sequester angiogenesis regulators.
Klement GL, Yip TT, Cassiola F, Kikuchi L, Cervi D, Podust V, Italiano JE, Wheatley E, Abou-Slaybi A, Bender E, Almog N, Kieran MW, Folkman J
Blood 2009 Mar 19;113(12):2835-42. Epub 2008 Nov 25 doi: 10.1182/blood-2008-06-159541. PMID: 19036702Free PMC Article
Biochemical correlates of thiazolidinedione-induced adipocyte differentiation by high-resolution magic angle spinning NMR spectroscopy.
Chen JH, Enloe BM, Weybright P, Campbell N, Dorfman D, Fletcher CD, Cory DG, Singer S
Magn Reson Med 2002 Oct;48(4):602-10. doi: 10.1002/mrm.10256. PMID: 12353276

Prognosis

Integrated genomic and transcriptomic analysis revealed mutation patterns of de-differentiated liposarcoma and leiomyosarcoma.
Liu W, Tong H, Zhang C, Zhuang R, Guo H, Lv C, Yang H, Lin Q, Guo X, Wang Z, Wang Y, Shen F, Wang S, Dai C, Wang G, Liu J, Lu W, Zhang Y, Zhou Y
BMC Cancer 2020 Oct 28;20(1):1035. doi: 10.1186/s12885-020-07456-2. PMID: 33115433Free PMC Article
Dedifferentiated Liposarcoma With Myofibroblastic Differentiation.
Wang GY, Lucas DR
Arch Pathol Lab Med 2018 Oct;142(10):1159-1163. doi: 10.5858/arpa.2018-0205-RA. PMID: 30281365
Myxoinflammatory fibroblastic sarcoma: morphologic and genetic updates.
Ieremia E, Thway K
Arch Pathol Lab Med 2014 Oct;138(10):1406-11. doi: 10.5858/arpa.2013-0549-RS. PMID: 25268202
Sarcomas of the skin in the elderly.
Mentzel T
Clin Dermatol 2011 Jan-Feb;29(1):80-90. doi: 10.1016/j.clindermatol.2010.07.011. PMID: 21146736
Spindle cell lipoma.
Enzinger FM, Harvey DA
Cancer 1975 Nov;36(5):1852-9. doi: 10.1002/1097-0142(197511)36:5<1852::aid-cncr2820360542>3.0.co;2-u. PMID: 1192370

Clinical prediction guides

A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas.
Lippai Z, Péterfia B, Papp G, Dezső K, Bedics G, Pápai Z, Lamers MH, Kuin RC, Szuhai K, Sápi Z
Eur J Cancer 2024 May;202:114005. Epub 2024 Mar 14 doi: 10.1016/j.ejca.2024.114005. PMID: 38531265
Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma.
Xu C, Yan L, Guan X, Wang Z, Wu J, Lv A, Liu D, Liu F, Dong B, Zhao M, Jia L, Tian X, Hao C
Int J Biol Sci 2022;18(13):5038-5055. Epub 2022 Aug 1 doi: 10.7150/ijbs.70083. PMID: 35982904Free PMC Article
Integrated genomic and transcriptomic analysis revealed mutation patterns of de-differentiated liposarcoma and leiomyosarcoma.
Liu W, Tong H, Zhang C, Zhuang R, Guo H, Lv C, Yang H, Lin Q, Guo X, Wang Z, Wang Y, Shen F, Wang S, Dai C, Wang G, Liu J, Lu W, Zhang Y, Zhou Y
BMC Cancer 2020 Oct 28;20(1):1035. doi: 10.1186/s12885-020-07456-2. PMID: 33115433Free PMC Article
Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma.
Hanes R, Munthe E, Grad I, Han J, Karlsen I, McCormack E, Meza-Zepeda LA, Stratford EW, Myklebost O
Cells 2019 Feb 21;8(2) doi: 10.3390/cells8020189. PMID: 30795553Free PMC Article
Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells.
Donnelly C, Olsen AM, Lewis LD, Eisenberg BL, Eastman A, Kinlaw WB
Nutr Cancer 2009;61(1):114-22. doi: 10.1080/01635580802348666. PMID: 19116881Free PMC Article

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