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Desmoplastic Trichilemmoma

MedGen UID:
266152
•Concept ID:
C1275206
•
Neoplastic Process
Synonyms: Desmoplastic trichilemmoma; Desmoplastic Tricholemmoma
SNOMED CT: Desmoplastic trichilemmoma (403928006)

Definition

A variant of tricholemmoma that is characterized by extensive sclerotic stroma formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDesmoplastic Trichilemmoma

Recent clinical studies

Etiology

Basaloid neoplasms in nevus sebaceus.
Kaddu S, Schaeppi H, Kerl H, Soyer HP
J Cutan Pathol 2000 Aug;27(7):327-37. doi: 10.1034/j.1600-0560.2000.027007327.x. PMID: 10917159

Diagnosis

Use of Cytokeratin 17 in the Differentiation Between Desmoplastic Trichilemmoma and Cutaneous Basal Cell Carcinoma.
Chaudet KM, Stagner AM, Nazarian RM
Am J Dermatopathol 2022 Dec 1;44(12):886-890. Epub 2022 Sep 27 doi: 10.1097/DAD.0000000000002302. PMID: 36197047
Desmoplastic trichilemmoma of the scalp: case report and literature review of immunohistochemical staining features.
Zhong S, Wang L, Mei XL
J Int Med Res 2019 Aug;47(8):3918-3925. Epub 2019 Jul 15 doi: 10.1177/0300060519859739. PMID: 31304849Free PMC Article
Eyelid desmoplastic trichilemmoma: 2 case reports and review.
Pihlblad M, Chelnis J, Schaefer D
Ophthalmic Plast Reconstr Surg 2014 Sep-Oct;30(5):e136-8. doi: 10.1097/IOP.0b013e3182a65067. PMID: 24777258
CD34-reactive tumors of the skin. An updated review of an ever-growing list of lesions.
Tardío JC
J Cutan Pathol 2009 Jan;36(1):89-102. doi: 10.1111/j.1600-0560.2008.01212.x. PMID: 19125742
CD34-reactive tumors of the skin. An updated review of an ever-growing list of lesions.
Tardío JC
J Cutan Pathol 2008 Dec;35(12):1079-92. doi: 10.1111/j.1600-0560.2008.01124.x. PMID: 18976402

Therapy

Desmoplastic trichilemmoma.
Tellechea O, Reis JP, Baptista AP
Am J Dermatopathol 1992 Apr;14(2):107-4. doi: 10.1097/00000372-199204000-00004. PMID: 1373583

Prognosis

Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases.
Plaza JA, Ortega PF, Stockman DL, Suster S
J Cutan Pathol 2010 Apr;37(4):403-10. doi: 10.1111/j.1600-0560.2010.01517.x. PMID: 20377670
Diagnostic value of CD34 immunostaining in desmoplastic trichilemmoma.
Illueca C, Monteagudo C, Revert A, Llombart-Bosch A
J Cutan Pathol 1998 Sep;25(8):435-9. doi: 10.1111/j.1600-0560.1998.tb01770.x. PMID: 9826169

Clinical prediction guides

Use of Cytokeratin 17 in the Differentiation Between Desmoplastic Trichilemmoma and Cutaneous Basal Cell Carcinoma.
Chaudet KM, Stagner AM, Nazarian RM
Am J Dermatopathol 2022 Dec 1;44(12):886-890. Epub 2022 Sep 27 doi: 10.1097/DAD.0000000000002302. PMID: 36197047
Desmoplastic sebaceoma arising from nevus sebaceus: a new variant.
Chuang HC, Kao PH, Huang YL, Lee LY, Kuo TT
J Cutan Pathol 2014 Jun;41(6):509-12. Epub 2014 Apr 2 doi: 10.1111/cup.12330. PMID: 24698382
Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases.
Plaza JA, Ortega PF, Stockman DL, Suster S
J Cutan Pathol 2010 Apr;37(4):403-10. doi: 10.1111/j.1600-0560.2010.01517.x. PMID: 20377670
Diagnostic value of CD34 immunostaining in desmoplastic trichilemmoma.
Illueca C, Monteagudo C, Revert A, Llombart-Bosch A
J Cutan Pathol 1998 Sep;25(8):435-9. doi: 10.1111/j.1600-0560.1998.tb01770.x. PMID: 9826169
Desmoplastic trichilemmoma arising within a nevus sebaceus.
Rosón E, Gómez Centeno P, Sánchez-Aguilar D, Peteiro C, Toribio J
Am J Dermatopathol 1998 Oct;20(5):495-7. doi: 10.1097/00000372-199810000-00013. PMID: 9790113

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