U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mandibular osteomyelitis

MedGen UID:
266218
Concept ID:
C1290708
Disease or Syndrome
Synonyms: Lower jaw bone infection; Osteomyelitis of mandible; Osteomyelitis, especially of the mandible
SNOMED CT: Osteomyelitis of mandible (109695005)
 
HPO: HP:0007626

Definition

Osteomyelitis of the lower jaw. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMandibular osteomyelitis

Conditions with this feature

Autosomal recessive osteopetrosis 2
MedGen UID:
342420
Concept ID:
C1850126
Disease or Syndrome
Osteopetrosis is a bone disease that makes bone tissue abnormally compact and dense and also prone to breakage (fracture). Researchers have described several major types of osteopetrosis, which are usually distinguished by their pattern of inheritance: autosomal dominant or autosomal recessive. The different types of the disorder can also be distinguished by the severity of their signs and symptoms.\n\nAutosomal dominant osteopetrosis (ADO), which is also called Albers-Schönberg disease, is typically the mildest type of the disorder. Some affected individuals have no symptoms. In affected people with no symptoms, the unusually dense bones may be discovered by accident when an x-ray is done for another reason. \n\nIn individuals with ADO who develop signs and symptoms, the major features of the condition include multiple bone fractures after minor injury, abnormal side-to-side curvature of the spine (scoliosis) or other spinal abnormalities, arthritis in the hips, and a bone infection called osteomyelitis. These problems usually become apparent in late childhood or adolescence.\n\nAutosomal recessive osteopetrosis (ARO) is a more severe form of the disorder that becomes apparent in early infancy. Affected individuals have a high risk of bone fracture resulting from seemingly minor bumps and falls. Their abnormally dense skull bones pinch nerves in the head and face (cranial nerves), often resulting in vision loss, hearing loss, and paralysis of facial muscles. Dense bones can also impair the function of bone marrow, preventing it from producing new blood cells and immune system cells. As a result, people with severe osteopetrosis are at risk of abnormal bleeding, a shortage of red blood cells (anemia), and recurrent infections. In the most severe cases, these bone marrow abnormalities can be life-threatening in infancy or early childhood.\n\nOther features of autosomal recessive osteopetrosis can include slow growth and short stature, dental abnormalities, and an enlarged liver and spleen (hepatosplenomegaly). Depending on the genetic changes involved, people with severe osteopetrosis can also have brain abnormalities, intellectual disability, or recurrent seizures (epilepsy).\n\nA few individuals have been diagnosed with intermediate autosomal osteopetrosis (IAO), a form of the disorder that can have either an autosomal dominant or an autosomal recessive pattern of inheritance. The signs and symptoms of this condition become noticeable in childhood and include an increased risk of bone fracture and anemia. People with this form of the disorder typically do not have life-threatening bone marrow abnormalities. However, some affected individuals have had abnormal calcium deposits (calcifications) in the brain, intellectual disability, and a form of kidney disease called renal tubular acidosis.
Autosomal dominant osteopetrosis 2
MedGen UID:
465707
Concept ID:
C3179239
Disease or Syndrome
The spectrum of CLCN7-related osteopetrosis includes infantile malignant CLCN7-related autosomal recessive osteopetrosis (ARO), intermediate autosomal osteopetrosis (IAO), and autosomal dominant osteopetrosis type II (ADOII; Albers-Schönberg disease). ARO. Onset is at birth. Findings may include: fractures; reduced growth; sclerosis of the skull base (with or without choanal stenosis or hydrocephalus) resulting in optic nerve compression, facial palsy, and hearing loss; absence of the bone marrow cavity resulting in severe anemia and thrombocytopenia; dental abnormalities, odontomas, and risk for mandibular osteomyelitis; and hypocalcemia with tetanic seizures and secondary hyperparathyroidism. Without treatment maximal life span in ARO is ten years. IAO. Onset is in childhood. Findings may include: fractures after minor trauma, characteristic skeletal radiographic changes found incidentally, mild anemia, and occasional visual impairment secondary to optic nerve compression. Life expectancy in IAO is usually normal. ADOII. Onset is usually late childhood or adolescence. Findings may include: fractures (in any long bone and/or the posterior arch of a vertebra), scoliosis, hip osteoarthritis, and osteomyelitis of the mandible or septic osteitis or osteoarthritis elsewhere. Cranial nerve compression is rare.

Professional guidelines

PubMed

Johnston DT, Phero JA, Hechler BL
Oral Surg Oral Med Oral Pathol Oral Radiol 2023 Jan;135(1):11-23. Epub 2022 May 13 doi: 10.1016/j.oooo.2022.05.001. PMID: 35863960
Re K, Patel S, Gandhi J, Suh Y, Reid I, Joshi G, Smith NL, Khan SA
Med Gas Res 2019 Apr-Jun;9(2):93-100. doi: 10.4103/2045-9912.260651. PMID: 31249258Free PMC Article
Hudson JW, Daly AP, Foster M
J Oral Maxillofac Surg 2017 Oct;75(10):2127-2134. Epub 2017 Mar 18 doi: 10.1016/j.joms.2017.03.008. PMID: 28396232

Recent clinical studies

Etiology

Johnston DT, Phero JA, Hechler BL
Oral Surg Oral Med Oral Pathol Oral Radiol 2023 Jan;135(1):11-23. Epub 2022 May 13 doi: 10.1016/j.oooo.2022.05.001. PMID: 35863960
Wang HC, Wang Y, Long X, Wang X
J Cosmet Dermatol 2021 Feb;20(2):457-459. Epub 2020 Jul 14 doi: 10.1111/jocd.13575. PMID: 32592232
Dias Ferraz A, Spagnol G, Alves Maciel F, Monteiro Pinotti M, De Freitas RR
Cranio 2021 Nov;39(6):541-548. Epub 2019 Sep 3 doi: 10.1080/08869634.2019.1661943. PMID: 31478470
Malina-Altzinger J, Klaeser B, Suter VGA, Schriber M, Vollnberg B, Schaller B
Clin Oral Investig 2019 Dec;23(12):4213-4222. Epub 2019 Feb 26 doi: 10.1007/s00784-019-02862-8. PMID: 30806799
Marschall JS, Flint RL, Kushner GM, Alpert B
J Oral Maxillofac Surg 2019 Jul;77(7):1490-1504. Epub 2019 Jan 31 doi: 10.1016/j.joms.2019.01.036. PMID: 30797754

Diagnosis

Wang HC, Wang Y, Long X, Wang X
J Cosmet Dermatol 2021 Feb;20(2):457-459. Epub 2020 Jul 14 doi: 10.1111/jocd.13575. PMID: 32592232
Schlund M, Raoul G, Ferri J, Nicot R
J Oral Maxillofac Surg 2017 Dec;75(12):2560.e1-2560.e7. Epub 2017 Aug 3 doi: 10.1016/j.joms.2017.07.169. PMID: 28850817
Sharkawy AA
Infect Dis Clin North Am 2007 Jun;21(2):543-56, viii. doi: 10.1016/j.idc.2007.03.007. PMID: 17561082
Suei Y, Taguchi A, Tanimoto K
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005 Aug;100(2):207-14. doi: 10.1016/j.tripleo.2004.11.006. PMID: 16037779
Harris LF
South Med J 1986 Jun;79(6):696-7. doi: 10.1097/00007611-198606000-00012. PMID: 3715533

Therapy

Johnston DT, Phero JA, Hechler BL
Oral Surg Oral Med Oral Pathol Oral Radiol 2023 Jan;135(1):11-23. Epub 2022 May 13 doi: 10.1016/j.oooo.2022.05.001. PMID: 35863960
Wang HC, Wang Y, Long X, Wang X
J Cosmet Dermatol 2021 Feb;20(2):457-459. Epub 2020 Jul 14 doi: 10.1111/jocd.13575. PMID: 32592232
Gupta N, Aggarwal A, Ramteke P, Soneja M
BMJ Case Rep 2020 May 11;13(5) doi: 10.1136/bcr-2020-235744. PMID: 32398252Free PMC Article
Re K, Patel S, Gandhi J, Suh Y, Reid I, Joshi G, Smith NL, Khan SA
Med Gas Res 2019 Apr-Jun;9(2):93-100. doi: 10.4103/2045-9912.260651. PMID: 31249258Free PMC Article
de Oliveira EM, de Arruda JAA, Nascimento PAM, Neiva IM, Mesquita RA, Souza LN
J Oral Maxillofac Surg 2018 Oct;76(10):2136.e1-2136.e10. Epub 2018 Jun 26 doi: 10.1016/j.joms.2018.06.026. PMID: 30030999

Prognosis

Muraoka H, Hirahara N, Ito K, Okada S, Kondo T, Kaneda T
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Jan;133(1):80-87. Epub 2021 Jun 20 doi: 10.1016/j.oooo.2021.06.007. PMID: 34301502
Lertwilaiwittaya P, Suktitipat B, Khongthon P, Pongsapich W, Limwongse C, Pithukpakorn M
Mol Genet Genomic Med 2021 Jul;9(7):e1727. Epub 2021 May 30 doi: 10.1002/mgg3.1727. PMID: 34056870Free PMC Article
Marschall JS, Flint RL, Kushner GM, Alpert B
J Oral Maxillofac Surg 2019 Jul;77(7):1490-1504. Epub 2019 Jan 31 doi: 10.1016/j.joms.2019.01.036. PMID: 30797754
Gams K, Freeman P
J Oral Maxillofac Surg 2016 Apr;74(4):754-63. Epub 2015 Nov 6 doi: 10.1016/j.joms.2015.11.003. PMID: 26657399
Weber PC, Seabold JE, Graham SM, Hoffmann HH, Simonson TM, Thompson BH
Otolaryngol Head Neck Surg 1995 Jul;113(1):36-41. doi: 10.1016/s0194-5998(95)70142-7. PMID: 7603719

Clinical prediction guides

Muraoka H, Hirahara N, Ito K, Okada S, Kondo T, Kaneda T
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Jan;133(1):80-87. Epub 2021 Jun 20 doi: 10.1016/j.oooo.2021.06.007. PMID: 34301502
Asai S, Nakamura S, Toriihara A, Tateishi U, Kurabayashi T
Oral Radiol 2020 Jul;36(3):267-274. Epub 2019 Aug 28 doi: 10.1007/s11282-019-00407-z. PMID: 31463792
Taihi I, Radoi L
Quintessence Int 2018;49(3):219-226. doi: 10.3290/j.qi.a39747. PMID: 29399678
Semel G, Wolff A, Shilo D, Akrish S, Emodi O, Rachmiel A
Eur J Oral Implantol 2016;9(4):435-442. PMID: 27990510
Lu PC, Wu JH, Chen CM, Du JK
J Oral Maxillofac Surg 2015 Sep;73(9):1761-5. Epub 2015 Apr 1 doi: 10.1016/j.joms.2015.03.053. PMID: 25896568

Recent systematic reviews

Johnston DT, Phero JA, Hechler BL
Oral Surg Oral Med Oral Pathol Oral Radiol 2023 Jan;135(1):11-23. Epub 2022 May 13 doi: 10.1016/j.oooo.2022.05.001. PMID: 35863960
Tarfa RA, Melder K, Mady LJ, Eibling D
Am J Otolaryngol 2022 Jan-Feb;43(1):103236. Epub 2021 Sep 15 doi: 10.1016/j.amjoto.2021.103236. PMID: 34583289
Ferreira-Vilaca C, Costa Mendes L, Campana SC, Bailleul-Forestier I, Audouin-Pajot C, Esclassan R, Canceill T
Clin Rheumatol 2020 Nov;39(11):3277-3286. Epub 2020 May 9 doi: 10.1007/s10067-020-05084-6. PMID: 32388746

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...