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ACTH-producing pituitary gland adenoma

MedGen UID:
266291
•Concept ID:
C1306214
•
Neoplastic Process
Synonym: Pituitary corticotropic cell adenoma
SNOMED CT: ACTH-secreting pituitary adenoma (254958004); Corticotroph adenoma (254958004)
 
HPO: HP:0008291
Monarch Initiative: MONDO:0006068

Definition

A type of pituitary adenoma that produces adrenocorticotropic hormone (ACTH). [from HPO]

Professional guidelines

PubMed

Pituitary Incidentalomas: Best Practices and Looking Ahead.
Giraldi E, Allen JW, Ioachimescu AG
Endocr Pract 2023 Jan;29(1):60-68. Epub 2022 Oct 18 doi: 10.1016/j.eprac.2022.10.004. PMID: 36270609
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Cushing's disease: pathobiology, diagnosis, and management.
Lonser RR, Nieman L, Oldfield EH
J Neurosurg 2017 Feb;126(2):404-417. Epub 2016 Apr 22 doi: 10.3171/2016.1.JNS152119. PMID: 27104844

Recent clinical studies

Etiology

Epidemiology and mortality of Cushing's syndrome.
Hakami OA, Ahmed S, Karavitaki N
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101521. Epub 2021 Mar 15 doi: 10.1016/j.beem.2021.101521. PMID: 33766428
Molecular Biology of Pituitary Adenomas.
Faltermeier CM, Magill ST, Blevins LS Jr, Aghi MK
Neurosurg Clin N Am 2019 Oct;30(4):391-400. Epub 2019 Jul 5 doi: 10.1016/j.nec.2019.05.001. PMID: 31471046
Comorbidities in Cushing's disease.
Sharma ST, Nieman LK, Feelders RA
Pituitary 2015 Apr;18(2):188-94. doi: 10.1007/s11102-015-0645-6. PMID: 25724314Free PMC Article
Cushing's disease.
Castinetti F, Morange I, Conte-Devolx B, Brue T
Orphanet J Rare Dis 2012 Jun 18;7:41. doi: 10.1186/1750-1172-7-41. PMID: 22710101Free PMC Article
Cushing's disease.
De Martin M, Pecori Giraldi F, Cavagnini F
Pituitary 2006;9(4):279-87. doi: 10.1007/s11102-006-0407-6. PMID: 17077950

Diagnosis

An individualized approach to the management of Cushing disease.
Fleseriu M, Varlamov EV, Hinojosa-Amaya JM, Langlois F, Melmed S
Nat Rev Endocrinol 2023 Oct;19(10):581-599. Epub 2023 Aug 3 doi: 10.1038/s41574-023-00868-7. PMID: 37537306
Epidemiology and mortality of Cushing's syndrome.
Hakami OA, Ahmed S, Karavitaki N
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101521. Epub 2021 Mar 15 doi: 10.1016/j.beem.2021.101521. PMID: 33766428
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Cushing's disease: pathobiology, diagnosis, and management.
Lonser RR, Nieman L, Oldfield EH
J Neurosurg 2017 Feb;126(2):404-417. Epub 2016 Apr 22 doi: 10.3171/2016.1.JNS152119. PMID: 27104844
Cushing syndrome.
Bista B, Beck N
Indian J Pediatr 2014 Feb;81(2):158-64. Epub 2013 Sep 24 doi: 10.1007/s12098-013-1203-8. PMID: 24062268

Therapy

Management of Nelson's Syndrome.
Fountas A, Karavitaki N
Medicina (Kaunas) 2022 Nov 2;58(11) doi: 10.3390/medicina58111580. PMID: 36363537Free PMC Article
Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients.
Burman P, Trouillas J, Losa M, McCormack A, Petersenn S, Popovic V, Theodoropoulou M, Raverot G, Dekkers OM; ESE survey collaborators †
Eur J Endocrinol 2022 Oct 1;187(4):593-605. Epub 2022 Sep 19 doi: 10.1530/EJE-22-0440. PMID: 36018781Free PMC Article
Pediatric pituitary adenomas.
Walz PC, Drapeau A, Shaikhouni A, Eide J, Rugino AJ, Mohyeldin A, Carrau R, Prevedello D
Childs Nerv Syst 2019 Nov;35(11):2107-2118. Epub 2019 Jul 13 doi: 10.1007/s00381-019-04293-y. PMID: 31302729
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Nelson's syndrome.
Barber TM, Adams E, Ansorge O, Byrne JV, Karavitaki N, Wass JA
Eur J Endocrinol 2010 Oct;163(4):495-507. Epub 2010 Jul 28 doi: 10.1530/EJE-10-0466. PMID: 20668020

Prognosis

Pituitary Incidentalomas: Best Practices and Looking Ahead.
Giraldi E, Allen JW, Ioachimescu AG
Endocr Pract 2023 Jan;29(1):60-68. Epub 2022 Oct 18 doi: 10.1016/j.eprac.2022.10.004. PMID: 36270609
Epidemiology and mortality of Cushing's syndrome.
Hakami OA, Ahmed S, Karavitaki N
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101521. Epub 2021 Mar 15 doi: 10.1016/j.beem.2021.101521. PMID: 33766428
Silent corticotroph adenomas.
Ben-Shlomo A, Cooper O
Pituitary 2018 Apr;21(2):183-193. doi: 10.1007/s11102-018-0864-8. PMID: 29344907
Cushing's disease: pathobiology, diagnosis, and management.
Lonser RR, Nieman L, Oldfield EH
J Neurosurg 2017 Feb;126(2):404-417. Epub 2016 Apr 22 doi: 10.3171/2016.1.JNS152119. PMID: 27104844
Cushing's disease.
De Martin M, Pecori Giraldi F, Cavagnini F
Pituitary 2006;9(4):279-87. doi: 10.1007/s11102-006-0407-6. PMID: 17077950

Clinical prediction guides

Management of Nelson's Syndrome.
Fountas A, Karavitaki N
Medicina (Kaunas) 2022 Nov 2;58(11) doi: 10.3390/medicina58111580. PMID: 36363537Free PMC Article
Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients.
Burman P, Trouillas J, Losa M, McCormack A, Petersenn S, Popovic V, Theodoropoulou M, Raverot G, Dekkers OM; ESE survey collaborators †
Eur J Endocrinol 2022 Oct 1;187(4):593-605. Epub 2022 Sep 19 doi: 10.1530/EJE-22-0440. PMID: 36018781Free PMC Article
Nelson's Syndrome: An Update.
Fountas A, Karavitaki N
Endocrinol Metab Clin North Am 2020 Sep;49(3):413-432. doi: 10.1016/j.ecl.2020.05.004. PMID: 32741480
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Neurology of the pituitary.
Samarasinghe S, Emanuele MA, Mazhari A
Handb Clin Neurol 2014;120:685-701. doi: 10.1016/B978-0-7020-4087-0.00047-4. PMID: 24365347

Recent systematic reviews

Reported outcomes in transsphenoidal surgery for pituitary adenomas: a systematic review.
Layard Horsfall H, Lawrence A, Venkatesh A, Loh RTS, Jayapalan R, Koulouri O, Sharma R, Santarius T, Gurnell M, Dorward N, Mannion R, Marcus HJ, Kolias AG
Pituitary 2023 Apr;26(2):171-181. Epub 2023 Mar 2 doi: 10.1007/s11102-023-01303-w. PMID: 36862265Free PMC Article
Pasireotide-Induced Shrinkage in GH and ACTH Secreting Pituitary Adenoma: A Systematic Review and Meta-Analysis.
Mondin A, Manara R, Voltan G, Tizianel I, Denaro L, Ferrari M, Barbot M, Scaroni C, Ceccato F
Front Endocrinol (Lausanne) 2022;13:935759. Epub 2022 Jul 1 doi: 10.3389/fendo.2022.935759. PMID: 35846311Free PMC Article
Immune-checkpoint inhibitors in pituitary malignancies.
Di Nunno V, Franceschi E, Tosoni A, Gatto L, Maggio I, Lodi R, Bartolini S, Brandes AA
Anticancer Drugs 2022 Jan 1;33(1):e28-e35. doi: 10.1097/CAD.0000000000001157. PMID: 34348358
Gene and protein expression in pituitary corticotroph adenomas: a systematic review of the literature.
Seltzer J, Ashton CE, Scotton TC, Pangal D, Carmichael JD, Zada G
Neurosurg Focus 2015 Feb;38(2):E17. doi: 10.3171/2014.10.FOCUS14683. PMID: 25639319
Silent corticotroph adenomas.
Cooper O
Pituitary 2015 Apr;18(2):225-31. doi: 10.1007/s11102-014-0624-3. PMID: 25534889Free PMC Article

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