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Transformation

MedGen UID:
266929
Concept ID:
C1510411
Pathologic Function
Synonyms: Cell Transformation; Cellular Transformation; Transformed; Transforming

Definition

The conversion of a cell from a normal phenotype, which undergoes a limited number of mitotic divisions, into an aberrant phenotype that is immortal and divides indefinitely. Transformed cells no longer retain cell-cycle checkpoints and may ultimately become malignant cancer cells via additional genetic mutations, or damaging environmental events. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransformation

Professional guidelines

PubMed

Brown ZJ, Baghdadi A, Kamel I, Labiner HE, Hewitt DB, Pawlik TM
HPB (Oxford) 2023 Jan;25(1):14-25. Epub 2022 Oct 5 doi: 10.1016/j.hpb.2022.09.010. PMID: 36257874
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Rao SSC, Bhagatwala J
Clin Transl Gastroenterol 2019 Oct;10(10):e00078. doi: 10.14309/ctg.0000000000000078. PMID: 31584459Free PMC Article

Recent clinical studies

Etiology

Stoumpos AI, Kitsios F, Talias MA
Int J Environ Res Public Health 2023 Feb 15;20(4) doi: 10.3390/ijerph20043407. PMID: 36834105Free PMC Article
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Aguirre-Urizar JM, Lafuente-Ibáñez de Mendoza I, Warnakulasuriya S
Oral Dis 2021 Nov;27(8):1881-1895. Epub 2021 Apr 1 doi: 10.1111/odi.13810. PMID: 33606345
Rossi D, Gaidano G
Adv Exp Med Biol 2013;792:173-91. doi: 10.1007/978-1-4614-8051-8_8. PMID: 24014297
Coppé JP, Desprez PY, Krtolica A, Campisi J
Annu Rev Pathol 2010;5:99-118. doi: 10.1146/annurev-pathol-121808-102144. PMID: 20078217Free PMC Article

Diagnosis

Davalos V, Esteller M
CA Cancer J Clin 2023 Jul-Aug;73(4):376-424. Epub 2022 Dec 13 doi: 10.3322/caac.21765. PMID: 36512337
Atwi D, Kamal M, Quinton M, Hassell LA
J Obstet Gynaecol Res 2022 Dec;48(12):3068-3076. Epub 2022 Sep 2 doi: 10.1111/jog.15409. PMID: 36053141
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Kustanovich A, Schwartz R, Peretz T, Grinshpun A
Cancer Biol Ther 2019;20(8):1057-1067. Epub 2019 Apr 16 doi: 10.1080/15384047.2019.1598759. PMID: 30990132Free PMC Article
Stowell SR, Ju T, Cummings RD
Annu Rev Pathol 2015;10:473-510. doi: 10.1146/annurev-pathol-012414-040438. PMID: 25621663Free PMC Article

Therapy

Neuman MD, Sieber F, Dillane D
Anesthesiology 2023 Aug 1;139(2):211-223. doi: 10.1097/ALN.0000000000004604. PMID: 37278667
Verstovsek S, Mesa R, Gupta V, Lavie D, Dubruille V, Cambier N, Platzbecker U, Hus M, Xicoy B, Oh ST, Kiladjian JJ, Vannucchi AM, Gerds A, Egyed M, Mayer J, Sacha T, Kawashima J, Morris M, Huang M, Harrison C
Blood Adv 2023 Jul 25;7(14):3582-3591. doi: 10.1182/bloodadvances.2022009311. PMID: 37042865Free PMC Article
Xiao Y, Yu D
Pharmacol Ther 2021 May;221:107753. Epub 2020 Nov 28 doi: 10.1016/j.pharmthera.2020.107753. PMID: 33259885Free PMC Article
Sharma A, Harrington RA, McClellan MB, Turakhia MP, Eapen ZJ, Steinhubl S, Mault JR, Majmudar MD, Roessig L, Chandross KJ, Green EM, Patel B, Hamer A, Olgin J, Rumsfeld JS, Roe MT, Peterson ED
J Am Coll Cardiol 2018 Jun 12;71(23):2680-2690. doi: 10.1016/j.jacc.2018.03.523. PMID: 29880129
Gemmell LC, Webster KE, Kirtley S, Vincent K, Zondervan KT, Becker CM
Hum Reprod Update 2017 Jul 1;23(4):481-500. doi: 10.1093/humupd/dmx011. PMID: 28498913Free PMC Article

Prognosis

Wilkinson L, Gathani T
Br J Radiol 2022 Feb 1;95(1130):20211033. Epub 2021 Dec 14 doi: 10.1259/bjr.20211033. PMID: 34905391Free PMC Article
Casulo C
Hematol Oncol Clin North Am 2020 Aug;34(4):785-794. Epub 2020 May 5 doi: 10.1016/j.hoc.2020.03.001. PMID: 32586581
Donadieu J, Beaupain B, Mahlaoui N, Bellanné-Chantelot C
Hematol Oncol Clin North Am 2013 Feb;27(1):1-17, vii. doi: 10.1016/j.hoc.2012.11.003. PMID: 23351985
Poultsides GA, Zhu AX, Choti MA, Pawlik TM
Surg Clin North Am 2010 Aug;90(4):817-37. doi: 10.1016/j.suc.2010.04.011. PMID: 20637950
Delle Fave G, Capurso G, Milione M, Panzuto F
Best Pract Res Clin Gastroenterol 2005 Oct;19(5):659-73. doi: 10.1016/j.bpg.2005.05.002. PMID: 16253892

Clinical prediction guides

Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Ande SR, Grynspan J, Aviv RI, Shankar JJS
Can Assoc Radiol J 2022 Feb;73(1):194-202. Epub 2021 Jun 21 doi: 10.1177/08465371211018369. PMID: 34154379
Gaudi S, Mills O, Goyette EF, Morgan MB
Am J Dermatopathol 2011 Dec;33(8):850-4. doi: 10.1097/DAD.0b013e3181f5df90. PMID: 22042258
Gangat N, Caramazza D, Vaidya R, George G, Begna K, Schwager S, Van Dyke D, Hanson C, Wu W, Pardanani A, Cervantes F, Passamonti F, Tefferi A
J Clin Oncol 2011 Feb 1;29(4):392-7. Epub 2010 Dec 13 doi: 10.1200/JCO.2010.32.2446. PMID: 21149668
Marshall JC, Reinhart K; International Sepsis Forum
Crit Care Med 2009 Jul;37(7):2290-8. doi: 10.1097/CCM.0b013e3181a02afc. PMID: 19487943

Recent systematic reviews

Puyana C, Chandan N, Tsoukas M
J Cosmet Dermatol 2022 Dec;21(12):6636-6643. Epub 2022 Oct 31 doi: 10.1111/jocd.15420. PMID: 36176207
Aguirre-Urizar JM, Lafuente-Ibáñez de Mendoza I, Warnakulasuriya S
Oral Dis 2021 Nov;27(8):1881-1895. Epub 2021 Apr 1 doi: 10.1111/odi.13810. PMID: 33606345
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Gemmell LC, Webster KE, Kirtley S, Vincent K, Zondervan KT, Becker CM
Hum Reprod Update 2017 Jul 1;23(4):481-500. doi: 10.1093/humupd/dmx011. PMID: 28498913Free PMC Article
Critelli JW, Bivona JM
J Sex Res 2008 Jan-Mar;45(1):57-70. doi: 10.1080/00224490701808191. PMID: 18321031

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