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Benign ovarian mucinous tumor

MedGen UID:
267038
•Concept ID:
C1511100
•
Neoplastic Process
Synonyms: Benign Ovarian Mucinous Neoplasm; benign ovarian mucinous neoplasm; Benign Ovarian Mucinous Tumor; benign ovarian mucinous tumor; ovarian mucinous neoplasm, benign
 
Monarch Initiative: MONDO:0036915

Definition

A non-metastasizing neoplasm that arises from the ovary and is characterized by the presence of neoplastic epithelium that resembles the epithelium of the endocervix or gastrointestinal tract. There is no evidence of atypia. It includes mucinous adenofibroma, mucinous cystadenofibroma, and mucinous cystadenoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign ovarian mucinous tumor

Professional guidelines

PubMed

Retrospective Study of the Epidemiology, Pathology, and Therapeutic Management in Patients With Mucinous Ovarian Tumors.
Zhang Y, Li C, Luo S, Su Y, Gang X, Chu P, Zhang J, Wu H, Liu G
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820946423. doi: 10.1177/1533033820946423. PMID: 32783505Free PMC Article

Recent clinical studies

Etiology

Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Recent Insights into Mucinous Ovarian Carcinoma.
Ricci F, Affatato R, Carrassa L, Damia G
Int J Mol Sci 2018 May 24;19(6) doi: 10.3390/ijms19061569. PMID: 29795040Free PMC Article
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Mucinous Neoplasms of the Ovary: Radiologic-Pathologic Correlation.
Marko J, Marko KI, Pachigolla SL, Crothers BA, Mattu R, Wolfman DJ
Radiographics 2019 Jul-Aug;39(4):982-997. doi: 10.1148/rg.2019180221. PMID: 31283462Free PMC Article
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Recent Insights into Mucinous Ovarian Carcinoma.
Ricci F, Affatato R, Carrassa L, Damia G
Int J Mol Sci 2018 May 24;19(6) doi: 10.3390/ijms19061569. PMID: 29795040Free PMC Article
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Pathology of the adnexal mass.
Bennett JA, Oliva E
Clin Obstet Gynecol 2015 Mar;58(1):3-27. doi: 10.1097/GRF.0000000000000082. PMID: 25608250

Therapy

Fibronectin and Periostin as Prognostic Markers in Ovarian Cancer.
Kujawa KA, Zembala-Nożyńska E, Cortez AJ, Kujawa T, Kupryjańczyk J, Lisowska KM
Cells 2020 Jan 8;9(1) doi: 10.3390/cells9010149. PMID: 31936272Free PMC Article
New sonographic marker of borderline ovarian tumor: microcystic pattern of papillae and solid components.
Timor-Tritsch IE, Foley CE, Brandon C, Yoon E, Ciaffarrano J, Monteagudo A, Mittal K, Boyd L
Ultrasound Obstet Gynecol 2019 Sep;54(3):395-402. Epub 2019 Aug 8 doi: 10.1002/uog.20283. PMID: 30950132
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Mucinous tumors of the ovary: current thoughts on diagnosis and management.
Brown J, Frumovitz M
Curr Oncol Rep 2014 Jun;16(6):389. doi: 10.1007/s11912-014-0389-x. PMID: 24777667Free PMC Article
Risk factors for benign serous and mucinous epithelial ovarian tumors.
Jordan SJ, Green AC, Whiteman DC, Webb PM
Obstet Gynecol 2007 Mar;109(3):647-54. doi: 10.1097/01.AOG.0000254159.75977.fa. PMID: 17329516

Prognosis

Mucinous Neoplasms of the Ovary: Radiologic-Pathologic Correlation.
Marko J, Marko KI, Pachigolla SL, Crothers BA, Mattu R, Wolfman DJ
Radiographics 2019 Jul-Aug;39(4):982-997. doi: 10.1148/rg.2019180221. PMID: 31283462Free PMC Article
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Pathology of primary and metastatic mucinous ovarian neoplasms.
Leen SL, Singh N
J Clin Pathol 2012 Jul;65(7):591-5. Epub 2011 Nov 10 doi: 10.1136/jclinpath-2011-200162. PMID: 22075188
TP53 and ovarian cancer.
Schuijer M, Berns EM
Hum Mutat 2003 Mar;21(3):285-91. doi: 10.1002/humu.10181. PMID: 12619114

Clinical prediction guides

Ciliated Cells in Ovarian Cancer Decrease with Increasing Tumor Grade and Disease Progression.
Richardson MT, Recouvreux MS, Karlan BY, Walts AE, Orsulic S
Cells 2022 Dec 11;11(24) doi: 10.3390/cells11244009. PMID: 36552773Free PMC Article
Characterization and clinical significance of the CADM1/HER2/STAT3 axis in serous ovarian tumors.
Wu D, Lei Y, Liu Q, Hu H, Li H, Xie L, Zhou J
Medicine (Baltimore) 2021 Feb 26;100(8):e23777. doi: 10.1097/MD.0000000000023777. PMID: 33663040Free PMC Article
Clinical and morphological features of the ovarian brenner tumour: current state of the problem.
Myroshnychenko MS, Dyadyk OO, Urzhumov VD, Kapustnyk NV, Borzenkova IV, Selivanova LI, Torianyk II, Fedulenkova YY, Kalashnyk IM, Tkachenko PV, Hryhorenko VR, Molodan DV, Myroshnychenko SS
Wiad Lek 2020;73(7):1420-1426. PMID: 32759431
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Clinical and ultrasound features of benign, borderline, and malignant invasive mucinous ovarian tumors.
Pascual A, Guerriero S, Rams N, Juez L, Ajossa S, Graupera B, Hereter L, Cappai A, Pero M, Perniciano M, Errasti T, Parra J, Solis M, Alcázar JL
Eur J Gynaecol Oncol 2017;38(3):382-386. PMID: 29693878

Recent systematic reviews

Simple mucinous cyst: another potential cancer precursor in the pancreas? Case report with molecular characterization and systematic review of the literature.
Milanetto AC, Tonello AS, Valotto G, Munari G, Luchini C, Fassan M, Pasquali C
Virchows Arch 2021 Jul;479(1):179-189. Epub 2021 Jan 28 doi: 10.1007/s00428-021-03029-1. PMID: 33511431Free PMC Article
Role of Imaging Tools for the Diagnosis of Borderline Ovarian Tumors: A Systematic Review and Meta-Analysis.
Borrelli GM, de Mattos LA, Andres MP, Gonçalves MO, Kho RM, Abrão MS
J Minim Invasive Gynecol 2017 Mar-Apr;24(3):353-363. Epub 2016 Dec 24 doi: 10.1016/j.jmig.2016.12.012. PMID: 28027973
Accuracy of serum human epididymis protein 4 in ovarian cancer diagnosis: a systematic review and meta-analysis.
Macedo AC, da Rosa MI, Lumertz S, Medeiros LR
Int J Gynecol Cancer 2014 Sep;24(7):1222-31. doi: 10.1097/IGC.0000000000000192. PMID: 25078339
A systematic review of papers examining the use of intraoperative frozen section in predicting the final diagnosis of ovarian lesions.
Heatley MK
Int J Gynecol Pathol 2012 Mar;31(2):111-5. doi: 10.1097/PGP.0b013e318226043b. PMID: 22317865

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