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Borderline Fallopian Tube Serous Tumor

MedGen UID:
267074
•Concept ID:
C1511257
•
Neoplastic Process
Synonyms: Borderline Fallopian Tube Serous Neoplasm; Borderline Fallopian Tube Serous Tumor/Atypical Proliferative Serous Tumor

Definition

A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by an atypical proliferation of serous-type epithelial cells without evidence of stromal invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Fallopian Tube Serous Tumor

Professional guidelines

PubMed

SOX6 Expression Is Sensitive for Peritoneal Epithelioid Malignant Mesothelioma, But Not Specific in the Differential Diagnosis With Tubo-ovarian Serous Neoplasia.
Chapel DB, Hirsch MS
Am J Surg Pathol 2022 Feb 1;46(2):213-219. doi: 10.1097/PAS.0000000000001792. PMID: 34411029
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Optimal primary management of bulky stage IIIC ovarian, fallopian tube and peritoneal carcinoma: Are the only options complete gross resection at primary debulking surgery or neoadjuvant chemotherapy?
Sioulas VD, Schiavone MB, Kadouri D, Zivanovic O, Roche KL, O'Cearbhaill R, Abu-Rustum NR, Levine DA, Sonoda Y, Gardner GJ, Leitao MM Jr, Chi DS
Gynecol Oncol 2017 Apr;145(1):15-20. Epub 2017 Feb 21 doi: 10.1016/j.ygyno.2017.02.023. PMID: 28238354Free PMC Article

Recent clinical studies

Etiology

Clinical Presentation of Paraovarian Cysts.
Tzur T, Tzur Y, Baruch S, Smorgick N, Melcer Y
Isr Med Assoc J 2022 Jan;24(1):15-19. PMID: 35077040
New insights in the pathophysiology of ovarian cancer and implications for screening and prevention.
Nezhat FR, Apostol R, Nezhat C, Pejovic T
Am J Obstet Gynecol 2015 Sep;213(3):262-7. Epub 2015 Mar 25 doi: 10.1016/j.ajog.2015.03.044. PMID: 25818671
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
Origin and molecular pathogenesis of ovarian high-grade serous carcinoma.
Kurman RJ
Ann Oncol 2013 Dec;24 Suppl 10:x16-21. doi: 10.1093/annonc/mdt463. PMID: 24265397
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Clinical Presentation of Paraovarian Cysts.
Tzur T, Tzur Y, Baruch S, Smorgick N, Melcer Y
Isr Med Assoc J 2022 Jan;24(1):15-19. PMID: 35077040
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Origin and molecular pathogenesis of ovarian high-grade serous carcinoma.
Kurman RJ
Ann Oncol 2013 Dec;24 Suppl 10:x16-21. doi: 10.1093/annonc/mdt463. PMID: 24265397
Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems.
Vang R, Shih IeM, Kurman RJ
Adv Anat Pathol 2009 Sep;16(5):267-82. doi: 10.1097/PAP.0b013e3181b4fffa. PMID: 19700937Free PMC Article

Therapy

Low grade serous ovarian cancer - A rare disease with increasing therapeutic options.
Zwimpfer TA, Tal O, Geissler F, Coelho R, Rimmer N, Jacob F, Heinzelmann-Schwarz V
Cancer Treat Rev 2023 Jan;112:102497. Epub 2022 Dec 10 doi: 10.1016/j.ctrv.2022.102497. PMID: 36525716
Impact of levonorgestrel-releasing intrauterine system use on the cancer risk of the ovary and fallopian tube.
Soini T, Hurskainen R, Grénman S, Mäenpää J, Paavonen J, Pukkala E
Acta Oncol 2016 Nov;55(11):1281-1284. Epub 2016 May 5 doi: 10.1080/0284186X.2016.1175660. PMID: 27148621
Origin and molecular pathogenesis of ovarian high-grade serous carcinoma.
Kurman RJ
Ann Oncol 2013 Dec;24 Suppl 10:x16-21. doi: 10.1093/annonc/mdt463. PMID: 24265397
Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance.
Ahmed N, Abubaker K, Findlay J, Quinn M
J Cell Biochem 2013 Jan;114(1):21-34. doi: 10.1002/jcb.24317. PMID: 22887554
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article

Prognosis

Alteration of BRCA-1 tumor suppressor gene expression in serous and mucinous ovarian neoplasms in the benign-borderline-malignant pathway.
Yousif HMA, Mohammed RAA
Curr Probl Cancer 2019 Aug;43(4):377-385. Epub 2018 Nov 6 doi: 10.1016/j.currproblcancer.2018.10.003. PMID: 30446260
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
Origin and molecular pathogenesis of ovarian high-grade serous carcinoma.
Kurman RJ
Ann Oncol 2013 Dec;24 Suppl 10:x16-21. doi: 10.1093/annonc/mdt463. PMID: 24265397
Precursors and pathogenesis of ovarian carcinoma.
Lim D, Oliva E
Pathology 2013 Apr;45(3):229-42. doi: 10.1097/PAT.0b013e32835f2264. PMID: 23478230
Peritoneal carcinoma in women with genetic susceptibility: implications for Jewish populations.
Casey MJ, Bewtra C
Fam Cancer 2004;3(3-4):265-81. doi: 10.1007/s10689-004-9554-y. PMID: 15516851

Clinical prediction guides

Ciliated Cells in Ovarian Cancer Decrease with Increasing Tumor Grade and Disease Progression.
Richardson MT, Recouvreux MS, Karlan BY, Walts AE, Orsulic S
Cells 2022 Dec 11;11(24) doi: 10.3390/cells11244009. PMID: 36552773Free PMC Article
Differential epithelial and stromal LGR5 expression in ovarian carcinogenesis.
Kim H, Lee DH, Park E, Myung JK, Park JH, Kim DI, Kim SI, Lee M, Kim Y, Park CM, Hyun CL, Maeng YH, Lee C, Jang B
Sci Rep 2022 Jul 1;12(1):11200. doi: 10.1038/s41598-022-15234-2. PMID: 35778589Free PMC Article
Precursors in the ovarian stroma: another pathway to explain the origin of ovarian serous neoplasms.
Silva EG, Lawson BC, Ramalingam P, Liu J, Shehabeldin A, Marques-Piubelli ML, Malpica A
Hum Pathol 2022 Sep;127:136-145. Epub 2022 Apr 12 doi: 10.1016/j.humpath.2022.04.008. PMID: 35427637
Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53.
Ramraj SK, Elayapillai SP, Pelikan RC, Zhao YD, Isingizwe ZR, Kennedy AL, Lightfoot SA, Benbrook DM
Int J Cancer 2020 Aug 15;147(4):1086-1097. Epub 2020 Jan 8 doi: 10.1002/ijc.32830. PMID: 31845320Free PMC Article
Alteration of BRCA-1 tumor suppressor gene expression in serous and mucinous ovarian neoplasms in the benign-borderline-malignant pathway.
Yousif HMA, Mohammed RAA
Curr Probl Cancer 2019 Aug;43(4):377-385. Epub 2018 Nov 6 doi: 10.1016/j.currproblcancer.2018.10.003. PMID: 30446260

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