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Borderline Ovarian Serous Adenofibroma

MedGen UID:
267077
•Concept ID:
C1511266
•
Neoplastic Process

Definition

A low malignant potential adenofibroma arising from the ovary. It is characterized by an atypical epithelial hyperplasia. The epithelial cells are of serous type. There is no evidence of stromal destructive invasion. [from NCI]

Recent clinical studies

Etiology

When to Worry about Cancer: Concurrent Carcinoma and Recurrence in Borderline Ovarian Tumors.
Sullivan MW, Modesitt SC
South Med J 2019 Dec;112(12):634-638. doi: 10.14423/SMJ.0000000000001048. PMID: 31796975
Clinical Predictors of Recurrence and Prognostic Value of Lymph Node Involvement in the Serous Borderline Ovarian Tumor.
Qian XQ, Hua XP, Wu JH, Shen YM, Cheng XD, Wan XY
Int J Gynecol Cancer 2018 Feb;28(2):279-284. doi: 10.1097/IGC.0000000000001154. PMID: 29194193
TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Eosinophilic Cells, Autoimplants, Degree of Cellular Proliferation, and Adenofibroma Pattern are Important Histologic Findings in Ovarian Borderline Tumors.
Karpathiou G, Venet M, Chauleur C, Honeyman F, Casteillo F, Peoc'h M
Int J Gynecol Pathol 2017 Sep;36(5):447-452. doi: 10.1097/PGP.0000000000000361. PMID: 28796659
Is MRI a useful tool to distinguish between serous and mucinous borderline ovarian tumours?
Bazot M, Haouy D, Daraï E, Cortez A, Dechoux-Vodovar S, Thomassin-Naggara I
Clin Radiol 2013 Jan;68(1):e1-8. Epub 2012 Oct 6 doi: 10.1016/j.crad.2012.08.021. PMID: 23044365

Diagnosis

Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Clinical Predictors of Recurrence and Prognostic Value of Lymph Node Involvement in the Serous Borderline Ovarian Tumor.
Qian XQ, Hua XP, Wu JH, Shen YM, Cheng XD, Wan XY
Int J Gynecol Cancer 2018 Feb;28(2):279-284. doi: 10.1097/IGC.0000000000001154. PMID: 29194193
Eosinophilic Cells, Autoimplants, Degree of Cellular Proliferation, and Adenofibroma Pattern are Important Histologic Findings in Ovarian Borderline Tumors.
Karpathiou G, Venet M, Chauleur C, Honeyman F, Casteillo F, Peoc'h M
Int J Gynecol Pathol 2017 Sep;36(5):447-452. doi: 10.1097/PGP.0000000000000361. PMID: 28796659
Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems.
Vang R, Shih IeM, Kurman RJ
Adv Anat Pathol 2009 Sep;16(5):267-82. doi: 10.1097/PAP.0b013e3181b4fffa. PMID: 19700937Free PMC Article

Therapy

Clinical Predictors of Recurrence and Prognostic Value of Lymph Node Involvement in the Serous Borderline Ovarian Tumor.
Qian XQ, Hua XP, Wu JH, Shen YM, Cheng XD, Wan XY
Int J Gynecol Cancer 2018 Feb;28(2):279-284. doi: 10.1097/IGC.0000000000001154. PMID: 29194193
Coffee, tea, and caffeine consumption and risk of epithelial ovarian cancer and borderline ovarian tumors: Results from a Danish case-control study.
Gosvig CF, Kjaer SK, Blaakær J, Høgdall E, Høgdall C, Jensen A
Acta Oncol 2015;54(8):1144-51. Epub 2015 Jan 28 doi: 10.3109/0284186X.2014.1001035. PMID: 25629440

Prognosis

Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Clinical Predictors of Recurrence and Prognostic Value of Lymph Node Involvement in the Serous Borderline Ovarian Tumor.
Qian XQ, Hua XP, Wu JH, Shen YM, Cheng XD, Wan XY
Int J Gynecol Cancer 2018 Feb;28(2):279-284. doi: 10.1097/IGC.0000000000001154. PMID: 29194193
TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Eosinophilic Cells, Autoimplants, Degree of Cellular Proliferation, and Adenofibroma Pattern are Important Histologic Findings in Ovarian Borderline Tumors.
Karpathiou G, Venet M, Chauleur C, Honeyman F, Casteillo F, Peoc'h M
Int J Gynecol Pathol 2017 Sep;36(5):447-452. doi: 10.1097/PGP.0000000000000361. PMID: 28796659
Is MRI a useful tool to distinguish between serous and mucinous borderline ovarian tumours?
Bazot M, Haouy D, Daraï E, Cortez A, Dechoux-Vodovar S, Thomassin-Naggara I
Clin Radiol 2013 Jan;68(1):e1-8. Epub 2012 Oct 6 doi: 10.1016/j.crad.2012.08.021. PMID: 23044365

Clinical prediction guides

Clinical Predictors of Recurrence and Prognostic Value of Lymph Node Involvement in the Serous Borderline Ovarian Tumor.
Qian XQ, Hua XP, Wu JH, Shen YM, Cheng XD, Wan XY
Int J Gynecol Cancer 2018 Feb;28(2):279-284. doi: 10.1097/IGC.0000000000001154. PMID: 29194193
TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Similar expression pattern of NHERF1 and EZRIN in papillary but not in solid areas of human serous ovarian carcinomas.
Demacopulo B, Lema BE, Cabrini RL, Kreimann EL
Acta Histochem 2016 Oct;118(8):797-805. Epub 2016 Nov 4 doi: 10.1016/j.acthis.2016.10.002. PMID: 27823775
Coffee, tea, and caffeine consumption and risk of epithelial ovarian cancer and borderline ovarian tumors: Results from a Danish case-control study.
Gosvig CF, Kjaer SK, Blaakær J, Høgdall E, Høgdall C, Jensen A
Acta Oncol 2015;54(8):1144-51. Epub 2015 Jan 28 doi: 10.3109/0284186X.2014.1001035. PMID: 25629440
Is MRI a useful tool to distinguish between serous and mucinous borderline ovarian tumours?
Bazot M, Haouy D, Daraï E, Cortez A, Dechoux-Vodovar S, Thomassin-Naggara I
Clin Radiol 2013 Jan;68(1):e1-8. Epub 2012 Oct 6 doi: 10.1016/j.crad.2012.08.021. PMID: 23044365

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